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The map label for this gene is fdh [H]

Identifier: 110636008

GI number: 110636008

Start: 3970602

End: 3971795

Strand: Reverse

Name: fdh [H]

Synonym: Meso_3683

Alternate gene names: 110636008

Gene position: 3971795-3970602 (Counterclockwise)

Preceding gene: 110636009

Following gene: 110636007

Centisome position: 90.01

GC content: 58.63

Gene sequence:

>1194_bases
ATGCGCGCCCTCGTCTGGCATGGAAAGCATGACGTTCGCGTGGAGACAGTTGACGATCCAAAGATCGTCAACCCGCGCGA
CGCGATCATAAAAATAACCTCGACTGCGATCTGCGGCTCGGATCTTCACCTTTACGACGGCGTCATCCCCGCGATCCGTC
CGGGGGATATTCTGGGCCACGAATTCATGGGCGAGGTCGTCGAGGTAGGAAAGGGCAATAGCCGGCTAAGCAAGGGTGAC
CGCGTCGTCGTTCCTTTTGTGATTGCCTGCGGCAAGTGCTTCTTCTGCCAGAAGCAGCAATATTCAGCCTGCGACAATTC
CAATCCCGCCGAGAAGGCCGATATGTCGGAAATGCTTTACGGCCACCATATGGCCGGCCTGTTCGGCTACTCGCACTTAA
CGGGCGGCTATGCCGGCGGGCAGGCGGAGTATGTGCGCGTGCCCTATTCGGACATTGGCCCCATCGTAGTACCCGACGAT
CTCGATGACGATGAGGTCTTGTTCCTATCGGATATCCTCCCGACGGGATGGATGGCGGCGGAAAATTGCGAGATCGAGGA
GGGCGACACGGTTGCCGTCTGGGGCTGCGGACCGGTGGGGCTTTTCGCCATTCAAAGCGCGCTTATCATGGGCGCGGCGC
AGGTTATCGCCATCGATCATTATCCACACCGGCTGGAACTGGCCAGCAGGATCGGCGCAAAGGTAATCAACTATAAGAAC
AGCCGGGTGTACGAGGCTCTCATGGACATGACCGGCGGGATAGGGCCGGATGCCGTGATCGATGCGGTGGGCATGGAGAG
CCACGGCTTTGCTCCGGACAACCTCTACGATTACGCTAAGCAGACGCTGAAATTGGAGACTGACCGCCCGCACGTGCTGC
GCCAAGCCATTTATGCCTGCCGCAAGGGCGGGCGCGTCTCGGTCCCCGGCGTTTATGGAGGCTTCGTCGACAAGTTCCCC
GTGGGCGCTTTCATGCAGAAGGGCCTTACGCTCAGAACCGGGCAAACACATGTGCAGAAATACCTGTCGTCGCTGCTCGA
TATGATCCGTGAGCGCAAGATCGATACGACCTTTCTCATCAGCCACCGCCTGTCCTTGGAAGCAGGGCCGGAGGGCTACC
GGAAATTCGCCTTTGAGCAGAATGAGACGACCAAGGTGGTTCTGAAGCCGGGATGGGAGAACGCAAATGGCTGA

Upstream 100 bases:

>100_bases
CAAAGCGGGAGCTCCGCCGTTTCAAGCAACTGATGGAAACGGGCGAGATCGCTACCGCCGCCTCCGGCTCAGCCGCACCC
AGCACTTGAGGGTGTAGCGA

Downstream 100 bases:

>100_bases
TAAGGCAGGGCTGGCCGTGATTACCGGCGCATCCACCGGTATTGGTTACGAACTGGCGAAATGTTGCGCGGCGGCAGGTT
ACGACATGGTGGTGGCCGCC

Product: alcohol dehydrogenase GroES-like protein

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MRALVWHGKHDVRVETVDDPKIVNPRDAIIKITSTAICGSDLHLYDGVIPAIRPGDILGHEFMGEVVEVGKGNSRLSKGD
RVVVPFVIACGKCFFCQKQQYSACDNSNPAEKADMSEMLYGHHMAGLFGYSHLTGGYAGGQAEYVRVPYSDIGPIVVPDD
LDDDEVLFLSDILPTGWMAAENCEIEEGDTVAVWGCGPVGLFAIQSALIMGAAQVIAIDHYPHRLELASRIGAKVINYKN
SRVYEALMDMTGGIGPDAVIDAVGMESHGFAPDNLYDYAKQTLKLETDRPHVLRQAIYACRKGGRVSVPGVYGGFVDKFP
VGAFMQKGLTLRTGQTHVQKYLSSLLDMIRERKIDTTFLISHRLSLEAGPEGYRKFAFEQNETTKVVLKPGWENANG

Sequences:

>Translated_397_residues
MRALVWHGKHDVRVETVDDPKIVNPRDAIIKITSTAICGSDLHLYDGVIPAIRPGDILGHEFMGEVVEVGKGNSRLSKGD
RVVVPFVIACGKCFFCQKQQYSACDNSNPAEKADMSEMLYGHHMAGLFGYSHLTGGYAGGQAEYVRVPYSDIGPIVVPDD
LDDDEVLFLSDILPTGWMAAENCEIEEGDTVAVWGCGPVGLFAIQSALIMGAAQVIAIDHYPHRLELASRIGAKVINYKN
SRVYEALMDMTGGIGPDAVIDAVGMESHGFAPDNLYDYAKQTLKLETDRPHVLRQAIYACRKGGRVSVPGVYGGFVDKFP
VGAFMQKGLTLRTGQTHVQKYLSSLLDMIRERKIDTTFLISHRLSLEAGPEGYRKFAFEQNETTKVVLKPGWENANG
>Mature_397_residues
MRALVWHGKHDVRVETVDDPKIVNPRDAIIKITSTAICGSDLHLYDGVIPAIRPGDILGHEFMGEVVEVGKGNSRLSKGD
RVVVPFVIACGKCFFCQKQQYSACDNSNPAEKADMSEMLYGHHMAGLFGYSHLTGGYAGGQAEYVRVPYSDIGPIVVPDD
LDDDEVLFLSDILPTGWMAAENCEIEEGDTVAVWGCGPVGLFAIQSALIMGAAQVIAIDHYPHRLELASRIGAKVINYKN
SRVYEALMDMTGGIGPDAVIDAVGMESHGFAPDNLYDYAKQTLKLETDRPHVLRQAIYACRKGGRVSVPGVYGGFVDKFP
VGAFMQKGLTLRTGQTHVQKYLSSLLDMIRERKIDTTFLISHRLSLEAGPEGYRKFAFEQNETTKVVLKPGWENANG

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501929, Length=277, Percent_Identity=29.2418772563177, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI34577061, Length=390, Percent_Identity=27.9487179487179, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI71565154, Length=375, Percent_Identity=26.6666666666667, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI4501933, Length=277, Percent_Identity=28.158844765343, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI4501939, Length=375, Percent_Identity=25.6, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI156523966, Length=268, Percent_Identity=27.6119402985075, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI71565152, Length=278, Percent_Identity=27.6978417266187, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI71743840, Length=261, Percent_Identity=27.9693486590038, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI262073058, Length=261, Percent_Identity=27.9693486590038, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786825, Length=399, Percent_Identity=49.874686716792, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI226510992, Length=363, Percent_Identity=25.068870523416, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87082125, Length=264, Percent_Identity=29.1666666666667, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787863, Length=365, Percent_Identity=24.6575342465753, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790045, Length=374, Percent_Identity=25.1336898395722, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788073, Length=369, Percent_Identity=22.4932249322493, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788075, Length=389, Percent_Identity=24.6786632390745, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790718, Length=393, Percent_Identity=24.4274809160305, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788407, Length=241, Percent_Identity=29.4605809128631, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081918, Length=257, Percent_Identity=30.7392996108949, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786552, Length=209, Percent_Identity=30.1435406698565, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=385, Percent_Identity=27.2727272727273, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71997431, Length=321, Percent_Identity=29.2834890965732, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17565904, Length=298, Percent_Identity=28.5234899328859, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=313, Percent_Identity=30.0319488817891, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319257, Length=427, Percent_Identity=25.5269320843091, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6323099, Length=394, Percent_Identity=25.8883248730964, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=251, Percent_Identity=31.8725099601594, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17737895, Length=276, Percent_Identity=28.9855072463768, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 43485; Mature: 43485

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALVWHGKHDVRVETVDDPKIVNPRDAIIKITSTAICGSDLHLYDGVIPAIRPGDILGH
CCEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEHEECCCCCHHHCCCCCCCCCCCHHHH
EFMGEVVEVGKGNSRLSKGDRVVVPFVIACGKCFFCQKQQYSACDNSNPAEKADMSEMLY
HHHHHHHHHCCCCCCCCCCCEEEEEHHHHCCCCEEECCHHHCCCCCCCCHHHHHHHHHHH
GHHMAGLFGYSHLTGGYAGGQAEYVRVPYSDIGPIVVPDDLDDDEVLFLSDILPTGWMAA
HHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEECCCCCCCCEEEEECCCCCCCEEC
ENCEIEEGDTVAVWGCGPVGLFAIQSALIMGAAQVIAIDHYPHRLELASRIGAKVINYKN
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHCCCCC
SRVYEALMDMTGGIGPDAVIDAVGMESHGFAPDNLYDYAKQTLKLETDRPHVLRQAIYAC
HHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHEEECCCCHHHHHHHHHHH
RKGGRVSVPGVYGGFVDKFPVGAFMQKGLTLRTGQTHVQKYLSSLLDMIRERKIDTTFLI
HCCCCEECCCCCCCHHHHCCHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHCCCCEEEEE
SHRLSLEAGPEGYRKFAFEQNETTKVVLKPGWENANG
EEEEECCCCCHHHHHHEECCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MRALVWHGKHDVRVETVDDPKIVNPRDAIIKITSTAICGSDLHLYDGVIPAIRPGDILGH
CCEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEHEECCCCCHHHCCCCCCCCCCCHHHH
EFMGEVVEVGKGNSRLSKGDRVVVPFVIACGKCFFCQKQQYSACDNSNPAEKADMSEMLY
HHHHHHHHHCCCCCCCCCCCEEEEEHHHHCCCCEEECCHHHCCCCCCCCHHHHHHHHHHH
GHHMAGLFGYSHLTGGYAGGQAEYVRVPYSDIGPIVVPDDLDDDEVLFLSDILPTGWMAA
HHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEECCCCCCCCEEEEECCCCCCCEEC
ENCEIEEGDTVAVWGCGPVGLFAIQSALIMGAAQVIAIDHYPHRLELASRIGAKVINYKN
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHCCCCC
SRVYEALMDMTGGIGPDAVIDAVGMESHGFAPDNLYDYAKQTLKLETDRPHVLRQAIYAC
HHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHEEECCCCHHHHHHHHHHH
RKGGRVSVPGVYGGFVDKFPVGAFMQKGLTLRTGQTHVQKYLSSLLDMIRERKIDTTFLI
HCCCCEECCCCCCCHHHHCCHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHCCCCEEEEE
SHRLSLEAGPEGYRKFAFEQNETTKVVLKPGWENANG
EEEEECCCCCHHHHHHEECCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]