Click here to switch to the map view.

The map label for this gene is fadH [C]

Identifier: 110635957

GI number: 110635957

Start: 3920385

End: 3922337

Strand: Reverse

Name: fadH [C]

Synonym: Meso_3631

Alternate gene names: 110635957

Gene position: 3922337-3920385 (Counterclockwise)

Preceding gene: 110635958

Following gene: 110635956

Centisome position: 88.89

GC content: 65.03

Gene sequence:

>1953_bases
ATGACCTCCGCATTCAAGCATCTCCTCTCGCCGATCCGGATCGGCAACAACCTCGTCCGCAACCGCTCCATGTCGACAGC
GCACGGCACTGGCTACGCCGTCGACGGAAAGATCTCGGACCAGCTGATAGAATACCACATGGCCCGGGCCAGGGGCGGTA
TCGGCCTGATCGTGTTGGAAGCGACGGGCGTCAACGCCGCGCCAATCGGCGCCAAGGGCGGCTCCTATCTGCGCAATTCG
GACGACAGCGTCCTTCCCGGCTACCGCAAGCTGTCGAAGGCGCTGCACGAGGAGGGAGTCGTGGTCTACACGATGCTCTC
GCACTCCGGCCGCAATACTACGATGGGGATTAACGGCACACCGCCCCGCGCTCCCTCGCCGATCCCCTTCGATCGCGCGC
GCGACATTCCGCGCCCGCTCGAAATCGAGGAGATCAAAGGTATCGTGAAAGCGTTCGCCGACGCCGCGTGCCGAGCGCGC
GAGGGCGGGCTGGACGGCGTCGAACTCTCCTACACCCACGGCAATCTGGTGCAGCAGTTCCTGTCACCGCTGACCAACAT
CCGCGAGGACGAATATGGCGGCTCGGAGGAGAACCGCCTGCGCCTGGCGCGCGAGATCCTGGAAGCGGTGCGCACGGCGC
TCGGCGACGATTACACGCTCGGCATACGCTTCTCCGCCGATGAACTGGTTCCCGGCGGCTACACGATCGATGATGGCGAG
CGCTATGCCCGCATGATGGTTGAGTGGGGCAAGCTCGACTACGTATCCGTCTCGGCCGGCACCAACGGCTCGATGTGGAG
CCGCTCCATCCACTATCCGAGCATCTCGATGCCGGAAAAGGTGCTCATCCCTTATTCGAAGCGGGTGAAGCAGGCCGTCG
ACGTGCCGGTCTTCTGCATCGGCAAGATCACCGATCCCGCCGAGGCGGAGGGCATACTTGCGCAAGGCGAGGCCGACATT
GTCGGCATGACCCGCGCCCACATTGCCGAGCCCGCCATCATCCGCAAGCTGATGGATGACCGGATCGAGGATATCCGGCC
CTGCATCCACTGGAACGAGGGGTGCTTCGCACGCAAGCAGCGCGGTGGCGATCTCGGCTGCGTCTTCAATCCCCGTACCG
GCCGAGAGGCCGATTGGGACCCGATAGTGCCGGTTGAAGACTACAAGACGGTGATGATCATCGGCGGCGGTCCCGCCGGC
CTCGAGGCGGGCCGCGTTGCAGCCAAGCGCGGGCACGACGTCGTCCTGCACGAAAAGCTGGACGTTCTCGGCGGCCAGGT
TCGCCAGCTGGCGCTGACGCCCCATCGCCGCGACTACCGCATCCTGACGGACTGGCTGGAGAGGCAGGCGCGCAAGGCGG
GCGTGCTGATCCGCACCGGCAGCGAGATGACTGCGGAGAAGGTGCTCGAAGCTGCGCCGGATGTCGTCATAATCGCCACG
GGGGCAAAAGACACGCTACCGCGCATCAAGGGCGCGGATCGTCCGGGTGTCATAACGGCCCGGCAGCTGCTGGACGGCGC
GAATGTCGGCAAGAGGGTGGTGGTTGGCGACTGGGACGGCCGAAACATGGGCATGTCGATCGCCGAGCACCTCGCCGTAC
GCGGCCACGAGGTCGAGATCGTCTCGACCACCATGTATATCGGTGAGGACGCCGAGCTGATGACCTGGCACCCGGCCTAT
GAACGGCTGCAGAATCTCGGGGTGAAGCTTACCGCCCTTGCCGAGCTGGTGGAGGTGCGTGATGGCGCCGCCGTCGTGCG
CGCGCTCAACGGTGCGCTGACCGAGGTGGCGTGCGACAACGTCGTCACCTGCACGCGCGGCAGCGCCGCCGAGGACCTTT
ATCTCGGCCTCAAAGGCAAGGTGCCGCACCTCTATACAATCGGCGACGCCTTCACGCCGCGGCAGCTGGAACAAGCCGTC
TACGAAGGAGCGAAAGTTGCCCGCCAGATATAG

Upstream 100 bases:

>100_bases
CGAAGGCGAGCGGGCACGCTATGCGCTGCCATCACGATATCAACACACTCAAGGCTCTGCAGAGTGCTGAGCTAGAAAAC
AGGACGGAGCCAGCGAGACC

Downstream 100 bases:

>100_bases
ACCGGGGGCATATCTGGCGGAAACAGCTGAAGGAGGCCATCATGACTGATCCGCTTGTCGACCCCGCCTGGCTCACCGCA
CGGCTGGACGATCCGCTGGT

Product: NADH:flavin oxidoreductase/NADH oxidase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 650; Mature: 649

Protein sequence:

>650_residues
MTSAFKHLLSPIRIGNNLVRNRSMSTAHGTGYAVDGKISDQLIEYHMARARGGIGLIVLEATGVNAAPIGAKGGSYLRNS
DDSVLPGYRKLSKALHEEGVVVYTMLSHSGRNTTMGINGTPPRAPSPIPFDRARDIPRPLEIEEIKGIVKAFADAACRAR
EGGLDGVELSYTHGNLVQQFLSPLTNIREDEYGGSEENRLRLAREILEAVRTALGDDYTLGIRFSADELVPGGYTIDDGE
RYARMMVEWGKLDYVSVSAGTNGSMWSRSIHYPSISMPEKVLIPYSKRVKQAVDVPVFCIGKITDPAEAEGILAQGEADI
VGMTRAHIAEPAIIRKLMDDRIEDIRPCIHWNEGCFARKQRGGDLGCVFNPRTGREADWDPIVPVEDYKTVMIIGGGPAG
LEAGRVAAKRGHDVVLHEKLDVLGGQVRQLALTPHRRDYRILTDWLERQARKAGVLIRTGSEMTAEKVLEAAPDVVIIAT
GAKDTLPRIKGADRPGVITARQLLDGANVGKRVVVGDWDGRNMGMSIAEHLAVRGHEVEIVSTTMYIGEDAELMTWHPAY
ERLQNLGVKLTALAELVEVRDGAAVVRALNGALTEVACDNVVTCTRGSAAEDLYLGLKGKVPHLYTIGDAFTPRQLEQAV
YEGAKVARQI

Sequences:

>Translated_650_residues
MTSAFKHLLSPIRIGNNLVRNRSMSTAHGTGYAVDGKISDQLIEYHMARARGGIGLIVLEATGVNAAPIGAKGGSYLRNS
DDSVLPGYRKLSKALHEEGVVVYTMLSHSGRNTTMGINGTPPRAPSPIPFDRARDIPRPLEIEEIKGIVKAFADAACRAR
EGGLDGVELSYTHGNLVQQFLSPLTNIREDEYGGSEENRLRLAREILEAVRTALGDDYTLGIRFSADELVPGGYTIDDGE
RYARMMVEWGKLDYVSVSAGTNGSMWSRSIHYPSISMPEKVLIPYSKRVKQAVDVPVFCIGKITDPAEAEGILAQGEADI
VGMTRAHIAEPAIIRKLMDDRIEDIRPCIHWNEGCFARKQRGGDLGCVFNPRTGREADWDPIVPVEDYKTVMIIGGGPAG
LEAGRVAAKRGHDVVLHEKLDVLGGQVRQLALTPHRRDYRILTDWLERQARKAGVLIRTGSEMTAEKVLEAAPDVVIIAT
GAKDTLPRIKGADRPGVITARQLLDGANVGKRVVVGDWDGRNMGMSIAEHLAVRGHEVEIVSTTMYIGEDAELMTWHPAY
ERLQNLGVKLTALAELVEVRDGAAVVRALNGALTEVACDNVVTCTRGSAAEDLYLGLKGKVPHLYTIGDAFTPRQLEQAV
YEGAKVARQI
>Mature_649_residues
TSAFKHLLSPIRIGNNLVRNRSMSTAHGTGYAVDGKISDQLIEYHMARARGGIGLIVLEATGVNAAPIGAKGGSYLRNSD
DSVLPGYRKLSKALHEEGVVVYTMLSHSGRNTTMGINGTPPRAPSPIPFDRARDIPRPLEIEEIKGIVKAFADAACRARE
GGLDGVELSYTHGNLVQQFLSPLTNIREDEYGGSEENRLRLAREILEAVRTALGDDYTLGIRFSADELVPGGYTIDDGER
YARMMVEWGKLDYVSVSAGTNGSMWSRSIHYPSISMPEKVLIPYSKRVKQAVDVPVFCIGKITDPAEAEGILAQGEADIV
GMTRAHIAEPAIIRKLMDDRIEDIRPCIHWNEGCFARKQRGGDLGCVFNPRTGREADWDPIVPVEDYKTVMIIGGGPAGL
EAGRVAAKRGHDVVLHEKLDVLGGQVRQLALTPHRRDYRILTDWLERQARKAGVLIRTGSEMTAEKVLEAAPDVVIIATG
AKDTLPRIKGADRPGVITARQLLDGANVGKRVVVGDWDGRNMGMSIAEHLAVRGHEVEIVSTTMYIGEDAELMTWHPAYE
RLQNLGVKLTALAELVEVRDGAAVVRALNGALTEVACDNVVTCTRGSAAEDLYLGLKGKVPHLYTIGDAFTPRQLEQAVY
EGAKVARQI

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=689, Percent_Identity=27.7213352685051, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1787939, Length=356, Percent_Identity=30.0561797752809, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17564188, Length=319, Percent_Identity=26.6457680250784, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17565138, Length=317, Percent_Identity=28.7066246056782, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI72001454, Length=283, Percent_Identity=29.6819787985866, Blast_Score=108, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17559802, Length=264, Percent_Identity=31.0606060606061, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17559804, Length=319, Percent_Identity=26.6457680250784, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17540738, Length=341, Percent_Identity=25.8064516129032, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17566914, Length=313, Percent_Identity=26.517571884984, Blast_Score=95, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321973, Length=240, Percent_Identity=29.5833333333333, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325086, Length=93, Percent_Identity=37.6344086021505, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 70774; Mature: 70643

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAFKHLLSPIRIGNNLVRNRSMSTAHGTGYAVDGKISDQLIEYHMARARGGIGLIVLE
CCHHHHHHHHHHHHCCHHHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCEEEEEEE
ATGVNAAPIGAKGGSYLRNSDDSVLPGYRKLSKALHEEGVVVYTMLSHSGRNTTMGINGT
ECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCCEECCCCC
PPRAPSPIPFDRARDIPRPLEIEEIKGIVKAFADAACRAREGGLDGVELSYTHGNLVQQF
CCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHH
LSPLTNIREDEYGGSEENRLRLAREILEAVRTALGDDYTLGIRFSADELVPGGYTIDDGE
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEECCHH
RYARMMVEWGKLDYVSVSAGTNGSMWSRSIHYPSISMPEKVLIPYSKRVKQAVDVPVFCI
HHHHHHHHCCCCEEEEEECCCCCCCCCCEECCCCCCCCCCEECCCHHHHHHHHCCCEEEE
GKITDPAEAEGILAQGEADIVGMTRAHIAEPAIIRKLMDDRIEDIRPCIHWNEGCFARKQ
ECCCCCHHCCCEEECCCCCEEECHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCHHHHH
RGGDLGCVFNPRTGREADWDPIVPVEDYKTVMIIGGGPAGLEAGRVAAKRGHDVVLHEKL
CCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCEEEEEHHH
DVLGGQVRQLALTPHRRDYRILTDWLERQARKAGVLIRTGSEMTAEKVLEAAPDVVIIAT
HHHCCHHEEEEECCCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHCCCEEEEEC
GAKDTLPRIKGADRPGVITARQLLDGANVGKRVVVGDWDGRNMGMSIAEHLAVRGHEVEI
CCCCCCHHCCCCCCCCEEHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEE
VSTTMYIGEDAELMTWHPAYERLQNLGVKLTALAELVEVRDGAAVVRALNGALTEVACDN
EEEEEEECCCCCEEEECHHHHHHHHCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
VVTCTRGSAAEDLYLGLKGKVPHLYTIGDAFTPRQLEQAVYEGAKVARQI
EEEECCCCCCCEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSAFKHLLSPIRIGNNLVRNRSMSTAHGTGYAVDGKISDQLIEYHMARARGGIGLIVLE
CHHHHHHHHHHHHCCHHHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCEEEEEEE
ATGVNAAPIGAKGGSYLRNSDDSVLPGYRKLSKALHEEGVVVYTMLSHSGRNTTMGINGT
ECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCCEECCCCC
PPRAPSPIPFDRARDIPRPLEIEEIKGIVKAFADAACRAREGGLDGVELSYTHGNLVQQF
CCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHH
LSPLTNIREDEYGGSEENRLRLAREILEAVRTALGDDYTLGIRFSADELVPGGYTIDDGE
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEECCHH
RYARMMVEWGKLDYVSVSAGTNGSMWSRSIHYPSISMPEKVLIPYSKRVKQAVDVPVFCI
HHHHHHHHCCCCEEEEEECCCCCCCCCCEECCCCCCCCCCEECCCHHHHHHHHCCCEEEE
GKITDPAEAEGILAQGEADIVGMTRAHIAEPAIIRKLMDDRIEDIRPCIHWNEGCFARKQ
ECCCCCHHCCCEEECCCCCEEECHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCHHHHH
RGGDLGCVFNPRTGREADWDPIVPVEDYKTVMIIGGGPAGLEAGRVAAKRGHDVVLHEKL
CCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCEEEEEHHH
DVLGGQVRQLALTPHRRDYRILTDWLERQARKAGVLIRTGSEMTAEKVLEAAPDVVIIAT
HHHCCHHEEEEECCCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHCCCEEEEEC
GAKDTLPRIKGADRPGVITARQLLDGANVGKRVVVGDWDGRNMGMSIAEHLAVRGHEVEI
CCCCCCHHCCCCCCCCEEHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEE
VSTTMYIGEDAELMTWHPAYERLQNLGVKLTALAELVEVRDGAAVVRALNGALTEVACDN
EEEEEEECCCCCEEEECHHHHHHHHCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
VVTCTRGSAAEDLYLGLKGKVPHLYTIGDAFTPRQLEQAVYEGAKVARQI
EEEECCCCCCCEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]