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The map label for this gene is mdlA [H]

Identifier: 110635877

GI number: 110635877

Start: 3824834

End: 3825964

Strand: Reverse

Name: mdlA [H]

Synonym: Meso_3550

Alternate gene names: 110635877

Gene position: 3825964-3824834 (Counterclockwise)

Preceding gene: 110635878

Following gene: 110635876

Centisome position: 86.71

GC content: 63.84

Gene sequence:

>1131_bases
ATGACCAAGATCGTATCCGTTGAGGTTCTTCAAGCGGACCTAAAGCCCAAGGTAAAGCGCACCGACGCGGTGCAGGCCTT
CGAATTGCAGGAGACACCGATGGTCCGCATCACCGATGCGGACGGTGCGACCGGAACCGGCTACAGCTATACAATCGGCA
CAGGCGGCTCCTCGGTCTGCAAGCTGATCGACGACCATCTTGCCCCGGTACTGATCGGCCGCGAGGCGGAGGAGATTGAA
GGGCTCTGGCGGACCCTGTTCTTCCGCGTTCATGCAACGACGGTCGGCGCCATCACCTCAATCGCGCTCGCCGCGATCGA
CACCGCACTCTGGGATTTGCGCGCCCGCAAAGCAGGGCTGCCGCTGCACCGGCTCGCAGGCGGCGCGAAGAACGCGATCG
ACCTCTATTACACCGAGGGCGGCTGGCTCCACATGTCGGAGTCTGAACTGGTCGAGGAGGCGCTCAAGGCCAAGGAGAGC
GGGTTCGGCGGCACCAAAGTCAAAGTGGGCCGTCCGCATGTATTCGAGGACGTGAAGCGGCTTTCCGCGGTGCGCGACAC
GGTCGGCTGGGACTGGGAGGTGATGACCGACGCCAATCAGGGCCTTTCGCTCGACGAGGCGATCCGCCGGGCACGGCACT
ACGAGAAGCTCGACGTCGCTTGGTTCGAGGAGCCGATTCATGCCGACGATGTCGGCGCGCATCGGCGCCTTTCGCAGTCG
ACAACGGTGCCGATCGCGGTTGGCGAGTCGATGTATTCGGTCTCGCAGTTCAAGGACTATCTCGAGGCCGGCGCCTGCTC
AATCGTTCAGGTCGATGTCGGCCGCGTCGGCGGCATCACACCCTGGCTCAAGGTCGCGCATATGGCTGAGGCCTTCAACG
TGCCGGTCTGCCCGCATTTCCTTATGGAGATCCATCTCGCGCTCTGCTGCGCCGTGCCGAACAGCCGCTGGCTCGAATAC
ATCCCGCAGCTCGACCTCGTGACCTCTTCGCCGATCCGTATCGAGAACGGCAAGGCGATCCCCTCCGACCAGCCGGGCCT
CGGCATCGACTGGGATTGGGAGGCGCTGGAGAAAACCATCGTTCACCGCAAGAGCCACGGCGCCGCGCCGGCCCTGAAGG
CGGGAGCCTAA

Upstream 100 bases:

>100_bases
TCGGCGCCAGCCTTACAGCGGCTGCCATCGCTCACGTGGCCTTGCGTGCGCGCCTGACGCACGCCGCCGCCTGATTTTCA
AAGCAAAGGACGAATTCATT

Downstream 100 bases:

>100_bases
GATGGGTGCACTCGCGCCGATCCCATCGCCTCGGAGACAGATGTCAACCGGGCGGCGCTCACCCGGATCGAAACGCAGCT
GAAGCCGCATACCATCGACG

Product: mandelate racemase/muconate lactonizing-like protein

Products: NA

Alternate protein names: MR [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MTKIVSVEVLQADLKPKVKRTDAVQAFELQETPMVRITDADGATGTGYSYTIGTGGSSVCKLIDDHLAPVLIGREAEEIE
GLWRTLFFRVHATTVGAITSIALAAIDTALWDLRARKAGLPLHRLAGGAKNAIDLYYTEGGWLHMSESELVEEALKAKES
GFGGTKVKVGRPHVFEDVKRLSAVRDTVGWDWEVMTDANQGLSLDEAIRRARHYEKLDVAWFEEPIHADDVGAHRRLSQS
TTVPIAVGESMYSVSQFKDYLEAGACSIVQVDVGRVGGITPWLKVAHMAEAFNVPVCPHFLMEIHLALCCAVPNSRWLEY
IPQLDLVTSSPIRIENGKAIPSDQPGLGIDWDWEALEKTIVHRKSHGAAPALKAGA

Sequences:

>Translated_376_residues
MTKIVSVEVLQADLKPKVKRTDAVQAFELQETPMVRITDADGATGTGYSYTIGTGGSSVCKLIDDHLAPVLIGREAEEIE
GLWRTLFFRVHATTVGAITSIALAAIDTALWDLRARKAGLPLHRLAGGAKNAIDLYYTEGGWLHMSESELVEEALKAKES
GFGGTKVKVGRPHVFEDVKRLSAVRDTVGWDWEVMTDANQGLSLDEAIRRARHYEKLDVAWFEEPIHADDVGAHRRLSQS
TTVPIAVGESMYSVSQFKDYLEAGACSIVQVDVGRVGGITPWLKVAHMAEAFNVPVCPHFLMEIHLALCCAVPNSRWLEY
IPQLDLVTSSPIRIENGKAIPSDQPGLGIDWDWEALEKTIVHRKSHGAAPALKAGA
>Mature_375_residues
TKIVSVEVLQADLKPKVKRTDAVQAFELQETPMVRITDADGATGTGYSYTIGTGGSSVCKLIDDHLAPVLIGREAEEIEG
LWRTLFFRVHATTVGAITSIALAAIDTALWDLRARKAGLPLHRLAGGAKNAIDLYYTEGGWLHMSESELVEEALKAKESG
FGGTKVKVGRPHVFEDVKRLSAVRDTVGWDWEVMTDANQGLSLDEAIRRARHYEKLDVAWFEEPIHADDVGAHRRLSQST
TVPIAVGESMYSVSQFKDYLEAGACSIVQVDVGRVGGITPWLKVAHMAEAFNVPVCPHFLMEIHLALCCAVPNSRWLEYI
PQLDLVTSSPIRIENGKAIPSDQPGLGIDWDWEALEKTIVHRKSHGAAPALKAGA

Specific function: Probably Involved In The Degradation Of Homoserine Lactone (Hsl) Or Of A Metabolite Of Hsl That Signals Starvation. [C]

COG id: COG4948

COG function: function code MR; L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544119, Length=387, Percent_Identity=27.390180878553, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI42544117, Length=384, Percent_Identity=26.8229166666667, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI186972148, Length=237, Percent_Identity=30.8016877637131, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1787864, Length=367, Percent_Identity=28.8828337874659, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI48994953, Length=311, Percent_Identity=28.6173633440514, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI226510960, Length=344, Percent_Identity=24.7093023255814, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018110
- InterPro:   IPR015654
- InterPro:   IPR013342
- InterPro:   IPR013341
- InterPro:   IPR001354 [H]

Pfam domain/function: PF01188 MR_MLE; PF02746 MR_MLE_N [H]

EC number: =5.1.2.2 [H]

Molecular weight: Translated: 41112; Mature: 40981

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIVSVEVLQADLKPKVKRTDAVQAFELQETPMVRITDADGATGTGYSYTIGTGGSSVC
CCCEEEHHHHHHCCCCCHHHHCCHHEEEECCCCEEEEECCCCCCCCCEEEEECCCHHHHH
KLIDDHLAPVLIGREAEEIEGLWRTLFFRVHATTVGAITSIALAAIDTALWDLRARKAGL
HHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PLHRLAGGAKNAIDLYYTEGGWLHMSESELVEEALKAKESGFGGTKVKVGRPHVFEDVKR
CHHHHCCCCCCCEEEEEECCCEEECCHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHH
LSAVRDTVGWDWEVMTDANQGLSLDEAIRRARHYEKLDVAWFEEPIHADDVGAHRRLSQS
HHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHCCC
TTVPIAVGESMYSVSQFKDYLEAGACSIVQVDVGRVGGITPWLKVAHMAEAFNVPVCPHF
CEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCHHH
LMEIHLALCCAVPNSRWLEYIPQLDLVTSSPIRIENGKAIPSDQPGLGIDWDWEALEKTI
HHHHHHHHHHCCCCHHHHHHCCCCEEECCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHH
VHRKSHGAAPALKAGA
HHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TKIVSVEVLQADLKPKVKRTDAVQAFELQETPMVRITDADGATGTGYSYTIGTGGSSVC
CCEEEHHHHHHCCCCCHHHHCCHHEEEECCCCEEEEECCCCCCCCCEEEEECCCHHHHH
KLIDDHLAPVLIGREAEEIEGLWRTLFFRVHATTVGAITSIALAAIDTALWDLRARKAGL
HHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PLHRLAGGAKNAIDLYYTEGGWLHMSESELVEEALKAKESGFGGTKVKVGRPHVFEDVKR
CHHHHCCCCCCCEEEEEECCCEEECCHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHH
LSAVRDTVGWDWEVMTDANQGLSLDEAIRRARHYEKLDVAWFEEPIHADDVGAHRRLSQS
HHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHCCC
TTVPIAVGESMYSVSQFKDYLEAGACSIVQVDVGRVGGITPWLKVAHMAEAFNVPVCPHF
CEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCHHH
LMEIHLALCCAVPNSRWLEYIPQLDLVTSSPIRIENGKAIPSDQPGLGIDWDWEALEKTI
HHHHHHHHHHCCCCHHHHHHCCCCEEECCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHH
VHRKSHGAAPALKAGA
HHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2831968; 2271624; 2215699; 1909893; 1892834; 7893689; 7893690 [H]