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The map label for this gene is ldh [H]

Identifier: 110635876

GI number: 110635876

Start: 3823127

End: 3824203

Strand: Reverse

Name: ldh [H]

Synonym: Meso_3548

Alternate gene names: 110635876

Gene position: 3824203-3823127 (Counterclockwise)

Preceding gene: 110635877

Following gene: 110635875

Centisome position: 86.67

GC content: 68.43

Gene sequence:

>1077_bases
ATGAGTACGACGACAAACCCCCAAGCTACCCGATACCGTGCGGAAGATCTCGAAGCACTCGCGCGGGGGCTTTTCGAACG
CGCCGGGATGCCGGCGGAGAAGGCCAGCGATGTCGCCGCGGTGTTGGTCGAGGGCGACCTCTTCGGCAAATCGACCCATG
GGCTCGCACTGCTGCCGCTCTATCTGCGCGACATCGAGGCCGGCGGCATGACGCTCGACGGCGATCCCGAGGTACTCAAC
GATCTCGGCGCTTGCCTCACCTGGGACGGGCGCAAGCTGCCCGGCCCCTGGTTGCTGCGGCGCGCTACCGCCGAGGCGCT
GAGCCGGGCGAAGCGCTTCGGCCTGGGTGCGGTCGCGATCCAGCGAAGCCACCACACCGCCTGTCTCGGTGCCTATCTGG
AGCCGGCGGTCGCGGCCGGCTGCATGGTTCTGGTGACGTTGACCGATCCTGGCCATAGCAGCGTCGCGCCCTTCGGCGGC
GTCACGCCGGTGCTGACCTCGAACCCGATCGCCTTCGGCGCGCCATCGCCCGACAGGCCGATATTGATCGACATGTCTAC
GGCGCTGATGACCAATGGCGGCGTCGCCGCCTACCGCCAGCGAGGTGAGGCGCTGCCGCATCCCTTCCTGATGGATGCGC
AGGGCAAACCCTCGACCGATCCCAACATCATTGCCGCCGATCCGCCGGGCACGATCCTGCCGCTCGGCGGGCTGGAAGCG
GGCCACAAGGGCTTCTCGATCGGACTCATCGTCGAACTGCTGACCGGCTGCCTGAGCGGCCGCGGCCGGGCCGAAGGCGA
CGACGGCTGGAGCGCAGCGGTCTTCGTCCTGGTTGTCGATCCGGCCGCTTTCGGCGGCGAGGAGGATTTCCAGCGTCAAG
TCGCGGCGCTGGTGGACCTTTGCCATGGCTCGGCACTGCGCCCCGGCTTCAACCATGTCGACTTGCCCGGCGCGCAAGCG
TTTAGCCGCCGCGAAGGCCAGCGCCGTGACGGCGTGCTGCTGTCTCCCGGCATCGTTGCCGGTCTTGCCGAAAGCGCGAG
CCGCTTCGGCCTCACCATGCCCGCCGCCGTTTCCTGA

Upstream 100 bases:

>100_bases
ATGCACAGCACCCAGCTCGCGATCAACGTCATCGCCGGCATGATGGTGCTGGCCGGGGTGCTCGTCCTCCTGTTCTGGCC
ATCGGGGAGACAGTGAAGCC

Downstream 100 bases:

>100_bases
CGGCGGTCACCATCAACGACAATAACGTTTGGAGGAATTCCCATGACAATGTCCATCGCGGTGGGGAAGAGCCCCGCCGA
GCAGGCCAACATTCGGCGCG

Product: malate/L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MSTTTNPQATRYRAEDLEALARGLFERAGMPAEKASDVAAVLVEGDLFGKSTHGLALLPLYLRDIEAGGMTLDGDPEVLN
DLGACLTWDGRKLPGPWLLRRATAEALSRAKRFGLGAVAIQRSHHTACLGAYLEPAVAAGCMVLVTLTDPGHSSVAPFGG
VTPVLTSNPIAFGAPSPDRPILIDMSTALMTNGGVAAYRQRGEALPHPFLMDAQGKPSTDPNIIAADPPGTILPLGGLEA
GHKGFSIGLIVELLTGCLSGRGRAEGDDGWSAAVFVLVVDPAAFGGEEDFQRQVAALVDLCHGSALRPGFNHVDLPGAQA
FSRREGQRRDGVLLSPGIVAGLAESASRFGLTMPAAVS

Sequences:

>Translated_358_residues
MSTTTNPQATRYRAEDLEALARGLFERAGMPAEKASDVAAVLVEGDLFGKSTHGLALLPLYLRDIEAGGMTLDGDPEVLN
DLGACLTWDGRKLPGPWLLRRATAEALSRAKRFGLGAVAIQRSHHTACLGAYLEPAVAAGCMVLVTLTDPGHSSVAPFGG
VTPVLTSNPIAFGAPSPDRPILIDMSTALMTNGGVAAYRQRGEALPHPFLMDAQGKPSTDPNIIAADPPGTILPLGGLEA
GHKGFSIGLIVELLTGCLSGRGRAEGDDGWSAAVFVLVVDPAAFGGEEDFQRQVAALVDLCHGSALRPGFNHVDLPGAQA
FSRREGQRRDGVLLSPGIVAGLAESASRFGLTMPAAVS
>Mature_357_residues
STTTNPQATRYRAEDLEALARGLFERAGMPAEKASDVAAVLVEGDLFGKSTHGLALLPLYLRDIEAGGMTLDGDPEVLND
LGACLTWDGRKLPGPWLLRRATAEALSRAKRFGLGAVAIQRSHHTACLGAYLEPAVAAGCMVLVTLTDPGHSSVAPFGGV
TPVLTSNPIAFGAPSPDRPILIDMSTALMTNGGVAAYRQRGEALPHPFLMDAQGKPSTDPNIIAADPPGTILPLGGLEAG
HKGFSIGLIVELLTGCLSGRGRAEGDDGWSAAVFVLVVDPAAFGGEEDFQRQVAALVDLCHGSALRPGFNHVDLPGAQAF
SRREGQRRDGVLLSPGIVAGLAESASRFGLTMPAAVS

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=351, Percent_Identity=26.2108262108262, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1786727, Length=344, Percent_Identity=27.906976744186, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1790000, Length=329, Percent_Identity=24.0121580547112, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17536633, Length=308, Percent_Identity=26.9480519480519, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17507179, Length=283, Percent_Identity=27.9151943462898, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24667904, Length=285, Percent_Identity=27.3684210526316, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24667908, Length=285, Percent_Identity=27.3684210526316, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI45553211, Length=285, Percent_Identity=27.3684210526316, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24667912, Length=285, Percent_Identity=27.3684210526316, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24658010, Length=234, Percent_Identity=22.6495726495727, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648360, Length=241, Percent_Identity=24.0663900414938, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 37173; Mature: 37042

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTTNPQATRYRAEDLEALARGLFERAGMPAEKASDVAAVLVEGDLFGKSTHGLALLPL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEEEECCCCCCCCCCEEEHHH
YLRDIEAGGMTLDGDPEVLNDLGACLTWDGRKLPGPWLLRRATAEALSRAKRFGLGAVAI
HHHHHCCCCEEECCCHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
QRSHHTACLGAYLEPAVAAGCMVLVTLTDPGHSSVAPFGGVTPVLTSNPIAFGAPSPDRP
ECCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCC
ILIDMSTALMTNGGVAAYRQRGEALPHPFLMDAQGKPSTDPNIIAADPPGTILPLGGLEA
EEEEEHHHHHCCCCHHHHHHCCCCCCCCEEECCCCCCCCCCCEEEECCCCCEEECCCCCC
GHKGFSIGLIVELLTGCLSGRGRAEGDDGWSAAVFVLVVDPAAFGGEEDFQRQVAALVDL
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHH
CHGSALRPGFNHVDLPGAQAFSRREGQRRDGVLLSPGIVAGLAESASRFGLTMPAAVS
HCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
STTTNPQATRYRAEDLEALARGLFERAGMPAEKASDVAAVLVEGDLFGKSTHGLALLPL
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEEEECCCCCCCCCCEEEHHH
YLRDIEAGGMTLDGDPEVLNDLGACLTWDGRKLPGPWLLRRATAEALSRAKRFGLGAVAI
HHHHHCCCCEEECCCHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
QRSHHTACLGAYLEPAVAAGCMVLVTLTDPGHSSVAPFGGVTPVLTSNPIAFGAPSPDRP
ECCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCC
ILIDMSTALMTNGGVAAYRQRGEALPHPFLMDAQGKPSTDPNIIAADPPGTILPLGGLEA
EEEEEHHHHHCCCCHHHHHHCCCCCCCCEEECCCCCCCCCCCEEEECCCCCEEECCCCCC
GHKGFSIGLIVELLTGCLSGRGRAEGDDGWSAAVFVLVVDPAAFGGEEDFQRQVAALVDL
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHH
CHGSALRPGFNHVDLPGAQAFSRREGQRRDGVLLSPGIVAGLAESASRFGLTMPAAVS
HCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8405966 [H]