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The map label for this gene is cyoB [H]

Identifier: 110635863

GI number: 110635863

Start: 3808345

End: 3810375

Strand: Reverse

Name: cyoB [H]

Synonym: Meso_3535

Alternate gene names: 110635863

Gene position: 3810375-3808345 (Counterclockwise)

Preceding gene: 110635864

Following gene: 110635862

Centisome position: 86.36

GC content: 61.15

Gene sequence:

>2031_bases
ATGCTTGGCAAACTGACGATCGACGCGCTGCCCTTCTACAGCTGGGTGGCCATGGGCGGAGCGGCTGTCACAGTGCTGTG
CGGGCTCCTCTTTCTGGGCGTCATAACCTGGCTCGGCGCATGGCGTTATGTCTGGAAGGAGTGGCTGACCAGCGTCGACC
ATAAACGCATCGGCGTTATGTATGTGATGCTGGCGCTTGCAATGTTGCTGCGCGGCTTCATCGACGCCCTCATGATGCGG
GCGCAACAGGCCTTCGCGCTCAACTCCGATGGTTATCTGCCGCCCGACCACTTCGACCAGATCTTCTCTTCCCATGGCAC
GATCATGATCTTCTTCATGGCGATGCCGTTCATGACCGGTCTCGTCAATATCGTCGTGCCCCAGCAGATCGGTGCGCGCG
ACGTTGCCTTCCCGTTCCTCAATTCGGTAAGCTTCTGGCTAACTTCTGCCGGCGCCGGGCTGGTTATGATTTCGCTGGTG
ATCGGAACCTTCTCCACCGCTGGCTGGACCGGCTATCCCCCCTATTCGGGCATCGCCTACAGCCCGGATGTGGGCGTCGA
TTACTGGATCTGGGCGCTGCTGATCAGCGGCGTCGGATCGACGCTCACCGGCATCAACTTTGTCGTCACGATCCTGAAGC
GCCGCGCTCCCGGCATGAAGCTGATGCGCATGCCGCTCTTCACATGGACGGCGCTGTGCTCCTCGATCCTGATGATCTTC
GCCTTTCCTGCCCTCACGGTTGTCTGTTCGATGCTGGCGCTCGACCGCCTGCTCGGCATGCATTTCTTCACCAATGAGGC
GGGCGGCAACATGATGAACTACATCAACCTGTTCTGGATCTGGGGACACCCGGAGGTGTATATCCTCATCCTGCCGGCTT
TCGGCGTCTTCTCGGAGGTGGTGGCAACCTTCTCACGCAAGCGACTGTTCGGCTATCGCTCTCTCGTCTACGCGACTGCG
GCCATCGCCCTCCTCTCCTTCACGGTGTGGCTGCACCACTTCTTCACCATGGGCTCCAGCGCCAGCGTCAACGCCTTCTT
TGGCGTGGCCACCATGATTATCGCCGTGCCGACGGGGGTGAAGGTCTTCGACTGGCTCTTCACCATGTATCGCGGGCGCA
TCGAGTTCACCCCGCCGATGCTGTGGACCGTCGGCTTCATCGTGACCTTCGTCATTGGCGGCATGACCGGCGTGCTCCTG
GCTCTGCCGCCGGCCGACTATCTGATGCACAACACGACCTTTCTGGTCGCCCATTTCCACAACATGCTCATACCCGGGGT
CCTTTTCGGCTTCCTTGCGGGCTACATGTACTGGTTCCCCAAGGCCTTCGGCTTCACCCTCGACGAGCGTTGGGGCGCGC
GCTCCTTCTGGTGCTGGCTCGTGGGCTTCTATCTCGCCTTCATGCCGCTCTACGCGTTGGGCTTCATGGGCATGCCGCGC
CGCATGGAACACTACAACGCTCCCGAATGGCAGCCGCTCCTGATCGTCGCAGCACTTGGAGCCATGGTCATCCTCCTCGG
CATCGTTTGCCTGATCGTGCAACTCATCGTCAGCATCCGACGGCGCCATGAGACGCGCGAGCTTACGGGAGACCCGTGGA
ACGGGCGCACGCTGGAATGGCTAACCTCGTCGCCGCCCGCGCCATATAATTTCGCCGTTCTGCCGCGGGCGGACGAGATC
GACGCCTTCCATGAGATGAGGAAGCGCGGCGTGGCCTATAAGCGGCCCAAGCATTATGCCGATATTGAAATGCCCAAAAA
CACCGCGGTCGGTATCCTGCTGGGCGGCCTTGGTTTCGTGCTCGGCTTCGGCGTCGTCTGGCATATCTGGTGGCTGGCGC
TTGCGTCGCTCCTTGGCGTGGCAGCCGCGCTCATCGCGCGTGCCTTCAACGACGACACTGAGTTCCGCATCTCTGCCGCC
GAGGTCGAGGAGATCGAGAACGCGCGTTATGGTGCACTTGCCAGGGCGGTGCCCAAGAGCGTGGATCAACCTTCAACCGC
CGCCGAACCGCTTCCAGGAAGCGCTGCATGA

Upstream 100 bases:

>100_bases
GGCGTCCAGCCGGGCCTGTTCGAAAGCGTCATTGCAAAATACGCCGCGCATCCCGCTGCCGGCCATTCAGGCCACGAATA
GGGCCGAGGGAGGTCGTTTA

Downstream 100 bases:

>100_bases
CAGAAGCCGCCGCCGCAGCCAGCGACGCGCATTCCCATTCCACTCCGCGGGAAGAAAAGGCGTTTGGGTTCTGGCTCTAT
CTGATGAGCGACGCGATCAT

Product: cytochrome c oxidase, subunit I

Products: NA

Alternate protein names: Cytochrome o subunit 1; Cytochrome o ubiquinol oxidase subunit 1; Oxidase BO(3) subunit 1; Ubiquinol oxidase chain A; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 676; Mature: 676

Protein sequence:

>676_residues
MLGKLTIDALPFYSWVAMGGAAVTVLCGLLFLGVITWLGAWRYVWKEWLTSVDHKRIGVMYVMLALAMLLRGFIDALMMR
AQQAFALNSDGYLPPDHFDQIFSSHGTIMIFFMAMPFMTGLVNIVVPQQIGARDVAFPFLNSVSFWLTSAGAGLVMISLV
IGTFSTAGWTGYPPYSGIAYSPDVGVDYWIWALLISGVGSTLTGINFVVTILKRRAPGMKLMRMPLFTWTALCSSILMIF
AFPALTVVCSMLALDRLLGMHFFTNEAGGNMMNYINLFWIWGHPEVYILILPAFGVFSEVVATFSRKRLFGYRSLVYATA
AIALLSFTVWLHHFFTMGSSASVNAFFGVATMIIAVPTGVKVFDWLFTMYRGRIEFTPPMLWTVGFIVTFVIGGMTGVLL
ALPPADYLMHNTTFLVAHFHNMLIPGVLFGFLAGYMYWFPKAFGFTLDERWGARSFWCWLVGFYLAFMPLYALGFMGMPR
RMEHYNAPEWQPLLIVAALGAMVILLGIVCLIVQLIVSIRRRHETRELTGDPWNGRTLEWLTSSPPAPYNFAVLPRADEI
DAFHEMRKRGVAYKRPKHYADIEMPKNTAVGILLGGLGFVLGFGVVWHIWWLALASLLGVAAALIARAFNDDTEFRISAA
EVEEIENARYGALARAVPKSVDQPSTAAEPLPGSAA

Sequences:

>Translated_676_residues
MLGKLTIDALPFYSWVAMGGAAVTVLCGLLFLGVITWLGAWRYVWKEWLTSVDHKRIGVMYVMLALAMLLRGFIDALMMR
AQQAFALNSDGYLPPDHFDQIFSSHGTIMIFFMAMPFMTGLVNIVVPQQIGARDVAFPFLNSVSFWLTSAGAGLVMISLV
IGTFSTAGWTGYPPYSGIAYSPDVGVDYWIWALLISGVGSTLTGINFVVTILKRRAPGMKLMRMPLFTWTALCSSILMIF
AFPALTVVCSMLALDRLLGMHFFTNEAGGNMMNYINLFWIWGHPEVYILILPAFGVFSEVVATFSRKRLFGYRSLVYATA
AIALLSFTVWLHHFFTMGSSASVNAFFGVATMIIAVPTGVKVFDWLFTMYRGRIEFTPPMLWTVGFIVTFVIGGMTGVLL
ALPPADYLMHNTTFLVAHFHNMLIPGVLFGFLAGYMYWFPKAFGFTLDERWGARSFWCWLVGFYLAFMPLYALGFMGMPR
RMEHYNAPEWQPLLIVAALGAMVILLGIVCLIVQLIVSIRRRHETRELTGDPWNGRTLEWLTSSPPAPYNFAVLPRADEI
DAFHEMRKRGVAYKRPKHYADIEMPKNTAVGILLGGLGFVLGFGVVWHIWWLALASLLGVAAALIARAFNDDTEFRISAA
EVEEIENARYGALARAVPKSVDQPSTAAEPLPGSAA
>Mature_676_residues
MLGKLTIDALPFYSWVAMGGAAVTVLCGLLFLGVITWLGAWRYVWKEWLTSVDHKRIGVMYVMLALAMLLRGFIDALMMR
AQQAFALNSDGYLPPDHFDQIFSSHGTIMIFFMAMPFMTGLVNIVVPQQIGARDVAFPFLNSVSFWLTSAGAGLVMISLV
IGTFSTAGWTGYPPYSGIAYSPDVGVDYWIWALLISGVGSTLTGINFVVTILKRRAPGMKLMRMPLFTWTALCSSILMIF
AFPALTVVCSMLALDRLLGMHFFTNEAGGNMMNYINLFWIWGHPEVYILILPAFGVFSEVVATFSRKRLFGYRSLVYATA
AIALLSFTVWLHHFFTMGSSASVNAFFGVATMIIAVPTGVKVFDWLFTMYRGRIEFTPPMLWTVGFIVTFVIGGMTGVLL
ALPPADYLMHNTTFLVAHFHNMLIPGVLFGFLAGYMYWFPKAFGFTLDERWGARSFWCWLVGFYLAFMPLYALGFMGMPR
RMEHYNAPEWQPLLIVAALGAMVILLGIVCLIVQLIVSIRRRHETRELTGDPWNGRTLEWLTSSPPAPYNFAVLPRADEI
DAFHEMRKRGVAYKRPKHYADIEMPKNTAVGILLGGLGFVLGFGVVWHIWWLALASLLGVAAALIARAFNDDTEFRISAA
EVEEIENARYGALARAVPKSVDQPSTAAEPLPGSAA

Specific function: Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=509, Percent_Identity=37.9174852652259, Blast_Score=325, Evalue=7e-89,
Organism=Escherichia coli, GI1786634, Length=661, Percent_Identity=61.1195158850227, Blast_Score=875, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=530, Percent_Identity=36.6037735849057, Blast_Score=332, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6226524, Length=322, Percent_Identity=40.6832298136646, Blast_Score=233, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6226523, Length=248, Percent_Identity=33.0645161290323, Blast_Score=118, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 75224; Mature: 75224

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGKLTIDALPFYSWVAMGGAAVTVLCGLLFLGVITWLGAWRYVWKEWLTSVDHKRIGVM
CCCCEEHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
YVMLALAMLLRGFIDALMMRAQQAFALNSDGYLPPDHFDQIFSSHGTIMIFFMAMPFMTG
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHCCCCEEHHHHHHHHHHH
LVNIVVPQQIGARDVAFPFLNSVSFWLTSAGAGLVMISLVIGTFSTAGWTGYPPYSGIAY
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
SPDVGVDYWIWALLISGVGSTLTGINFVVTILKRRAPGMKLMRMPLFTWTALCSSILMIF
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AFPALTVVCSMLALDRLLGMHFFTNEAGGNMMNYINLFWIWGHPEVYILILPAFGVFSEV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCEEEEEECHHHHHHHH
VATFSRKRLFGYRSLVYATAAIALLSFTVWLHHFFTMGSSASVNAFFGVATMIIAVPTGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCH
KVFDWLFTMYRGRIEFTPPMLWTVGFIVTFVIGGMTGVLLALPPADYLMHNTTFLVAHFH
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHHHH
NMLIPGVLFGFLAGYMYWFPKAFGFTLDERWGARSFWCWLVGFYLAFMPLYALGFMGMPR
HHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
RMEHYNAPEWQPLLIVAALGAMVILLGIVCLIVQLIVSIRRRHETRELTGDPWNGRTLEW
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
LTSSPPAPYNFAVLPRADEIDAFHEMRKRGVAYKRPKHYADIEMPKNTAVGILLGGLGFV
ECCCCCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LGFGVVWHIWWLALASLLGVAAALIARAFNDDTEFRISAAEVEEIENARYGALARAVPKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCHHHHHHHHHHHC
VDQPSTAAEPLPGSAA
CCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLGKLTIDALPFYSWVAMGGAAVTVLCGLLFLGVITWLGAWRYVWKEWLTSVDHKRIGVM
CCCCEEHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
YVMLALAMLLRGFIDALMMRAQQAFALNSDGYLPPDHFDQIFSSHGTIMIFFMAMPFMTG
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHCCCCEEHHHHHHHHHHH
LVNIVVPQQIGARDVAFPFLNSVSFWLTSAGAGLVMISLVIGTFSTAGWTGYPPYSGIAY
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
SPDVGVDYWIWALLISGVGSTLTGINFVVTILKRRAPGMKLMRMPLFTWTALCSSILMIF
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AFPALTVVCSMLALDRLLGMHFFTNEAGGNMMNYINLFWIWGHPEVYILILPAFGVFSEV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCEEEEEECHHHHHHHH
VATFSRKRLFGYRSLVYATAAIALLSFTVWLHHFFTMGSSASVNAFFGVATMIIAVPTGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCH
KVFDWLFTMYRGRIEFTPPMLWTVGFIVTFVIGGMTGVLLALPPADYLMHNTTFLVAHFH
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHHHH
NMLIPGVLFGFLAGYMYWFPKAFGFTLDERWGARSFWCWLVGFYLAFMPLYALGFMGMPR
HHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
RMEHYNAPEWQPLLIVAALGAMVILLGIVCLIVQLIVSIRRRHETRELTGDPWNGRTLEW
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
LTSSPPAPYNFAVLPRADEIDAFHEMRKRGVAYKRPKHYADIEMPKNTAVGILLGGLGFV
ECCCCCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LGFGVVWHIWWLALASLLGVAAALIARAFNDDTEFRISAAEVEEIENARYGALARAVPKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCHHHHHHHHHHHC
VDQPSTAAEPLPGSAA
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]