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The map label for this gene is yleA [C]

Identifier: 110635718

GI number: 110635718

Start: 3664218

End: 3665498

Strand: Reverse

Name: yleA [C]

Synonym: Meso_3390

Alternate gene names: 110635718

Gene position: 3665498-3664218 (Counterclockwise)

Preceding gene: 110635719

Following gene: 110635717

Centisome position: 83.07

GC content: 64.87

Gene sequence:

>1281_bases
ATGTCGGTCGATGTCCTGACCTTTGGCTGCCGGCTTAACGCATACGAATCCGAGGTGATCCGGCGCGAGGCCGAAGCTGC
CGGCCTCTCCGCGCTCGAAGGCGGCGCGGTGATCGTCAACACCTGCGCCGTGACGGCGGAGGCGGTGCGCCAGGCGCGAC
AGGCAATACGAAGGGCGAGGCGCGAGAACCCGGACGCACGCATCATCGTCACCGGATGCGCGGCGCAGACTGAGCCCGGA
ACCTTCGGCTCCATGGAAGAGGTGGACCTTGTTCTGGGCAACGAAGAGAAGCTGAAGGCCCACAGCTATCGCGCTTTGCC
CGATTTCGGGGTCAACCAGTTCGAGAAGGTGCGCGTCAACGACATCATGGAGGTGCGCGAGACCGCCTCGCACATGGTGG
ATGCCATCGAGGGGCGCGCCCGCGCCTTCGTGCAGGTGCAGAACGGCTGCGATCATCGCTGCACCTTCTGCATCATCCCC
TATGGCCGCGGCAATTCCCGCTCGGTGCCCATGGGTGCGGTGGTGGACCAGGTGCGCCGGCTGGTCGAAAACGGCTATGC
CGAGGTGGTGCTCACCGGCGTGGACCTGACCAGCTTCGGTGCCGACCTGCCGGGAAGCCCGAGGCTGGGCAAGCTGGTGC
GCACGATCCTTGCTCAGGTGCCGGACCTGAAGCGGCTGCGCCTCTCCTCCATCGATTCCATAGAGGCCGACCAAGACCTG
ATGCGCGCGCTTGCCGAGGAAGCGCGGCTCATGCCGCATCTGCATCTTTCCCTGCAGGCGGGCGACGACATGATCCTGAA
GCGCATGAAGCGGCGGCACCTGCGCGCCGACTCGATCCGCTTTTGTGACGAGGTGCGGCGGTTGCGGACCGATATTGTCT
TCGGTGCGGATATCATCGCCGGCTTTCCTACCGAGACGGAGGCGATGTTCGAAAACTCGCTCAGGATCGTTGAGGAATGT
GGGCTGACGCACCTGCATGTCTTTCCGTTTTCGCCGCGCAAGGGCACGCCGGCATCGCGTATGCCGCAACTGCCGCGCAA
TACTGTGAAGGAGCGGGCGGCGCGCTTGCGCGCGGCGGGTGACGCCGCTTATGCAAGGCATCTTGCTTCTCTCGAAGGAA
CGCGCCAGCGGGTCTTGGTCGAGCGGGAGGGCTTGGGCCGCACCGAGGGTTTCACGCTGGTTGCGGTCGAGGGAGGCAAG
CCGGGCGAAATCGTCGAAAGTCTCATTACCGGCCATGACGGCGAACGGCTGACAGCAACGCCGCTGCTGGAAGCGGCTTG
A

Upstream 100 bases:

>100_bases
ATGACCATGTAATCATGACCGGACCGGCGGAATGGGAGTTCTCTGGCCGTTTTGATCCCGCTACCGGTGCTTGGGAGCGC
GAGACGGAAGGGGCCGCCTG

Downstream 100 bases:

>100_bases
GGATCTGAGAGGCCAATGGCATTCGGCTTCATCAAGAAAGTCTTTTCCTTCGGCAAGAAGGAGGTCGAGGAGCGGACTGA
ACCAGCCGAAGCCGCTTCTG

Product: MiaB-like tRNA modifying enzyme

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSVDVLTFGCRLNAYESEVIRREAEAAGLSALEGGAVIVNTCAVTAEAVRQARQAIRRARRENPDARIIVTGCAAQTEPG
TFGSMEEVDLVLGNEEKLKAHSYRALPDFGVNQFEKVRVNDIMEVRETASHMVDAIEGRARAFVQVQNGCDHRCTFCIIP
YGRGNSRSVPMGAVVDQVRRLVENGYAEVVLTGVDLTSFGADLPGSPRLGKLVRTILAQVPDLKRLRLSSIDSIEADQDL
MRALAEEARLMPHLHLSLQAGDDMILKRMKRRHLRADSIRFCDEVRRLRTDIVFGADIIAGFPTETEAMFENSLRIVEEC
GLTHLHVFPFSPRKGTPASRMPQLPRNTVKERAARLRAAGDAAYARHLASLEGTRQRVLVEREGLGRTEGFTLVAVEGGK
PGEIVESLITGHDGERLTATPLLEAA

Sequences:

>Translated_426_residues
MSVDVLTFGCRLNAYESEVIRREAEAAGLSALEGGAVIVNTCAVTAEAVRQARQAIRRARRENPDARIIVTGCAAQTEPG
TFGSMEEVDLVLGNEEKLKAHSYRALPDFGVNQFEKVRVNDIMEVRETASHMVDAIEGRARAFVQVQNGCDHRCTFCIIP
YGRGNSRSVPMGAVVDQVRRLVENGYAEVVLTGVDLTSFGADLPGSPRLGKLVRTILAQVPDLKRLRLSSIDSIEADQDL
MRALAEEARLMPHLHLSLQAGDDMILKRMKRRHLRADSIRFCDEVRRLRTDIVFGADIIAGFPTETEAMFENSLRIVEEC
GLTHLHVFPFSPRKGTPASRMPQLPRNTVKERAARLRAAGDAAYARHLASLEGTRQRVLVEREGLGRTEGFTLVAVEGGK
PGEIVESLITGHDGERLTATPLLEAA
>Mature_425_residues
SVDVLTFGCRLNAYESEVIRREAEAAGLSALEGGAVIVNTCAVTAEAVRQARQAIRRARRENPDARIIVTGCAAQTEPGT
FGSMEEVDLVLGNEEKLKAHSYRALPDFGVNQFEKVRVNDIMEVRETASHMVDAIEGRARAFVQVQNGCDHRCTFCIIPY
GRGNSRSVPMGAVVDQVRRLVENGYAEVVLTGVDLTSFGADLPGSPRLGKLVRTILAQVPDLKRLRLSSIDSIEADQDLM
RALAEEARLMPHLHLSLQAGDDMILKRMKRRHLRADSIRFCDEVRRLRTDIVFGADIIAGFPTETEAMFENSLRIVEECG
LTHLHVFPFSPRKGTPASRMPQLPRNTVKERAARLRAAGDAAYARHLASLEGTRQRVLVEREGLGRTEGFTLVAVEGGKP
GEIVESLITGHDGERLTATPLLEAA

Specific function: Unknown

COG id: COG0621

COG function: function code J; 2-methylthioadenine synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MTTase N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI93277076, Length=410, Percent_Identity=27.3170731707317, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI28872782, Length=370, Percent_Identity=23.7837837837838, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI28872784, Length=370, Percent_Identity=23.7837837837838, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1786882, Length=420, Percent_Identity=28.3333333333333, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1787057, Length=405, Percent_Identity=28.3950617283951, Blast_Score=138, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17553146, Length=468, Percent_Identity=26.0683760683761, Blast_Score=140, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI71996771, Length=379, Percent_Identity=26.3852242744063, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21356207, Length=416, Percent_Identity=25, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI19922432, Length=378, Percent_Identity=27.7777777777778, Blast_Score=137, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR005839
- InterPro:   IPR020612
- InterPro:   IPR013848
- InterPro:   IPR006467
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM; PF00919 UPF0004 [H]

EC number: NA

Molecular weight: Translated: 46828; Mature: 46697

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS50926 TRAM ; PS01278 UPF0004

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVDVLTFGCRLNAYESEVIRREAEAAGLSALEGGAVIVNTCAVTAEAVRQARQAIRRAR
CCCEEEEECCCCCHHHHHHHHHHHHHCCCHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
RENPDARIIVTGCAAQTEPGTFGSMEEVDLVLGNEEKLKAHSYRALPDFGVNQFEKVRVN
HCCCCCEEEEEECCCCCCCCCCCCHHHEEEEECCCHHHHHHHCCCCCCCCCCHHHHHHHH
DIMEVRETASHMVDAIEGRARAFVQVQNGCDHRCTFCIIPYGRGNSRSVPMGAVVDQVRR
HHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHH
LVENGYAEVVLTGVDLTSFGADLPGSPRLGKLVRTILAQVPDLKRLRLSSIDSIEADQDL
HHHCCCEEEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHH
MRALAEEARLMPHLHLSLQAGDDMILKRMKRRHLRADSIRFCDEVRRLRTDIVFGADIIA
HHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHC
GFPTETEAMFENSLRIVEECGLTHLHVFPFSPRKGTPASRMPQLPRNTVKERAARLRAAG
CCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHCCCCCHHHHHHHHHHHHHCC
DAAYARHLASLEGTRQRVLVEREGLGRTEGFTLVAVEGGKPGEIVESLITGHDGERLTAT
HHHHHHHHHHHCCCHHHHEEECCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCEEEEC
PLLEAA
CCCCCC
>Mature Secondary Structure 
SVDVLTFGCRLNAYESEVIRREAEAAGLSALEGGAVIVNTCAVTAEAVRQARQAIRRAR
CCEEEEECCCCCHHHHHHHHHHHHHCCCHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
RENPDARIIVTGCAAQTEPGTFGSMEEVDLVLGNEEKLKAHSYRALPDFGVNQFEKVRVN
HCCCCCEEEEEECCCCCCCCCCCCHHHEEEEECCCHHHHHHHCCCCCCCCCCHHHHHHHH
DIMEVRETASHMVDAIEGRARAFVQVQNGCDHRCTFCIIPYGRGNSRSVPMGAVVDQVRR
HHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHH
LVENGYAEVVLTGVDLTSFGADLPGSPRLGKLVRTILAQVPDLKRLRLSSIDSIEADQDL
HHHCCCEEEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHH
MRALAEEARLMPHLHLSLQAGDDMILKRMKRRHLRADSIRFCDEVRRLRTDIVFGADIIA
HHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHC
GFPTETEAMFENSLRIVEECGLTHLHVFPFSPRKGTPASRMPQLPRNTVKERAARLRAAG
CCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHCCCCCHHHHHHHHHHHHHCC
DAAYARHLASLEGTRQRVLVEREGLGRTEGFTLVAVEGGKPGEIVESLITGHDGERLTAT
HHHHHHHHHHHCCCHHHHEEECCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCEEEEC
PLLEAA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]