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The map label for this gene is argG [H]

Identifier: 110635672

GI number: 110635672

Start: 3615883

End: 3617142

Strand: Reverse

Name: argG [H]

Synonym: Meso_3344

Alternate gene names: 110635672

Gene position: 3617142-3615883 (Counterclockwise)

Preceding gene: 110635673

Following gene: 110635670

Centisome position: 81.98

GC content: 60.87

Gene sequence:

>1260_bases
ATGCCCGCGACACGAACTCACTCGGAAAAGACGATGGCGACACATAAAGATGTTAAGAAGGTCGTGCTGGCCTATTCCGG
CGGCCTCGACACCTCGATCATCCTGAAATGGCTGCAGACGGAACTCGGCGCCGAGGTGGTGACCTTCACCGCCGACCTTG
GCCAGGGCGAGGAGCTTGAGCCCGCTCGCCGTAAGGCCGAGATGCTGGGTATCAAGGAGATCCACATCGAGGATCTGCGC
GAGGAATTCGTCCGCGATTTCGTCTTCCCGATGTTCCGCGCAAATGCGCTTTACGAAGGCACTTATCTGCTCGGCACTTC
CATTGCACGGCCGCTGATCGCCAAGCGCCTTGTCGAAATCGCCGCCGAAACGGGGGCAGACGCCATCGCTCACGGCGCGA
CGGGCAAGGGCAACGACCAGGTCCGCTTCGAACTCACCGCCTATGCGCTGAACCCCGACATCAAGGTGATCGCTCCGTGG
CGTGACTGGACGTTCAAGTCCCGCACGGACCTTCTGAACTTCGCGCGCGACCATCAGATTCCAGTGCCCAGCGACAAGCA
GGGTGAGGCGCCCTTCTCCGTCGACGCCAATCTTCTGCACTCTTCCTCCGAGGGGAAAGTGCTGGAAGATCCATGGAGCG
AGCCCCCGGAATATGTCCACCAGCGCACGGTTTCGCCCTTCGATGCGCCGGACCGGGCAACGGAGATCACGATCGGCTTC
AAGCGCGGCGACGCCGTGTCGCTCAACGGCGAGGCGGTGTCCCCCGCCACGTTGTTGGCCAAGCTGAACGATCTTGGCCG
CGACAATGGCATCGGCCGCATCGACCTGGTTGAAAACCGCTTTGTCGGCATGAAATCCCGCGGCGTCTATGAAACGCCAG
GAGGCACGATCCTTCTTGCCGCCCATCGCGCAATCGAATCGATCACGCTCGACCGGGGCGCCGCGCACCTTAAGGATGAG
CTCATGCCACGCTATGCCGAGCTCATTTATAACGGGTTCTGGTACTCGCCCGAGCGTGAGATGCTCCAGGCGCTCATCGA
CAAGAGCCAGGAGGATGTCGAGGGCGAAGTGCGGCTGAAGCTCTATAAGGGCAACGTCATCGTCACGGGCCGTCGTTCGG
ACAAGTCTCTTTATTCGGATGCGCTCGTCACTTTCGAGGATGATCGCGGCGCCTATGATCAAAAGGATGCGGCAGGGTTC
ATCCGCCTCAATGCGCTAAGATTGAGGACGCTCGCGGCGCGCAAGCGGCTTCAAGGCTGA

Upstream 100 bases:

>100_bases
GCGCGGCCACGTGATTTCGGCGCTGCCGGCCGCGCGCCCTTGCCCGCGCGTCTTTTCCTGCTAATAGTTCGCCCGGCACC
GGGATCGCGCTTCATCGCGG

Downstream 100 bases:

>100_bases
CCGAGCGGGCGGGCGCTGTTCACCACAACGCCCGCCAATCGCCAGCATCGATTATCCGTCGATTTCCTTGGCTATGATCG
CAATGGCTTGCTGGTAGACG

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MPATRTHSEKTMATHKDVKKVVLAYSGGLDTSIILKWLQTELGAEVVTFTADLGQGEELEPARRKAEMLGIKEIHIEDLR
EEFVRDFVFPMFRANALYEGTYLLGTSIARPLIAKRLVEIAAETGADAIAHGATGKGNDQVRFELTAYALNPDIKVIAPW
RDWTFKSRTDLLNFARDHQIPVPSDKQGEAPFSVDANLLHSSSEGKVLEDPWSEPPEYVHQRTVSPFDAPDRATEITIGF
KRGDAVSLNGEAVSPATLLAKLNDLGRDNGIGRIDLVENRFVGMKSRGVYETPGGTILLAAHRAIESITLDRGAAHLKDE
LMPRYAELIYNGFWYSPEREMLQALIDKSQEDVEGEVRLKLYKGNVIVTGRRSDKSLYSDALVTFEDDRGAYDQKDAAGF
IRLNALRLRTLAARKRLQG

Sequences:

>Translated_419_residues
MPATRTHSEKTMATHKDVKKVVLAYSGGLDTSIILKWLQTELGAEVVTFTADLGQGEELEPARRKAEMLGIKEIHIEDLR
EEFVRDFVFPMFRANALYEGTYLLGTSIARPLIAKRLVEIAAETGADAIAHGATGKGNDQVRFELTAYALNPDIKVIAPW
RDWTFKSRTDLLNFARDHQIPVPSDKQGEAPFSVDANLLHSSSEGKVLEDPWSEPPEYVHQRTVSPFDAPDRATEITIGF
KRGDAVSLNGEAVSPATLLAKLNDLGRDNGIGRIDLVENRFVGMKSRGVYETPGGTILLAAHRAIESITLDRGAAHLKDE
LMPRYAELIYNGFWYSPEREMLQALIDKSQEDVEGEVRLKLYKGNVIVTGRRSDKSLYSDALVTFEDDRGAYDQKDAAGF
IRLNALRLRTLAARKRLQG
>Mature_418_residues
PATRTHSEKTMATHKDVKKVVLAYSGGLDTSIILKWLQTELGAEVVTFTADLGQGEELEPARRKAEMLGIKEIHIEDLRE
EFVRDFVFPMFRANALYEGTYLLGTSIARPLIAKRLVEIAAETGADAIAHGATGKGNDQVRFELTAYALNPDIKVIAPWR
DWTFKSRTDLLNFARDHQIPVPSDKQGEAPFSVDANLLHSSSEGKVLEDPWSEPPEYVHQRTVSPFDAPDRATEITIGFK
RGDAVSLNGEAVSPATLLAKLNDLGRDNGIGRIDLVENRFVGMKSRGVYETPGGTILLAAHRAIESITLDRGAAHLKDEL
MPRYAELIYNGFWYSPEREMLQALIDKSQEDVEGEVRLKLYKGNVIVTGRRSDKSLYSDALVTFEDDRGAYDQKDAAGFI
RLNALRLRTLAARKRLQG

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=398, Percent_Identity=49.2462311557789, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI16950633, Length=398, Percent_Identity=49.2462311557789, Blast_Score=369, Evalue=1e-102,
Organism=Escherichia coli, GI1789563, Length=417, Percent_Identity=28.0575539568345, Blast_Score=129, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6324514, Length=414, Percent_Identity=43.9613526570048, Blast_Score=344, Evalue=2e-95,
Organism=Drosophila melanogaster, GI21358151, Length=402, Percent_Identity=47.5124378109453, Blast_Score=347, Evalue=1e-95,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 46624; Mature: 46493

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPATRTHSEKTMATHKDVKKVVLAYSGGLDTSIILKWLQTELGAEVVTFTADLGQGEELE
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCC
PARRKAEMLGIKEIHIEDLREEFVRDFVFPMFRANALYEGTYLLGTSIARPLIAKRLVEI
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCEEEHHHHHHHHHHHHHHHHH
AAETGADAIAHGATGKGNDQVRFELTAYALNPDIKVIAPWRDWTFKSRTDLLNFARDHQI
HHHCCCHHHHCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHCCCC
PVPSDKQGEAPFSVDANLLHSSSEGKVLEDPWSEPPEYVHQRTVSPFDAPDRATEITIGF
CCCCCCCCCCCCCCCHHHHCCCCCCCEECCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEE
KRGDAVSLNGEAVSPATLLAKLNDLGRDNGIGRIDLVENRFVGMKSRGVYETPGGTILLA
ECCCEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEECCCCEEEEE
AHRAIESITLDRGAAHLKDELMPRYAELIYNGFWYSPEREMLQALIDKSQEDVEGEVRLK
EHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCEEEEE
LYKGNVIVTGRRSDKSLYSDALVTFEDDRGAYDQKDAAGFIRLNALRLRTLAARKRLQG
EEECCEEEECCCCCHHHHHCEEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PATRTHSEKTMATHKDVKKVVLAYSGGLDTSIILKWLQTELGAEVVTFTADLGQGEELE
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCC
PARRKAEMLGIKEIHIEDLREEFVRDFVFPMFRANALYEGTYLLGTSIARPLIAKRLVEI
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCEEEHHHHHHHHHHHHHHHHH
AAETGADAIAHGATGKGNDQVRFELTAYALNPDIKVIAPWRDWTFKSRTDLLNFARDHQI
HHHCCCHHHHCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHCCCC
PVPSDKQGEAPFSVDANLLHSSSEGKVLEDPWSEPPEYVHQRTVSPFDAPDRATEITIGF
CCCCCCCCCCCCCCCHHHHCCCCCCCEECCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEE
KRGDAVSLNGEAVSPATLLAKLNDLGRDNGIGRIDLVENRFVGMKSRGVYETPGGTILLA
ECCCEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEECCCCEEEEE
AHRAIESITLDRGAAHLKDELMPRYAELIYNGFWYSPEREMLQALIDKSQEDVEGEVRLK
EHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCEEEEE
LYKGNVIVTGRRSDKSLYSDALVTFEDDRGAYDQKDAAGFIRLNALRLRTLAARKRLQG
EEECCEEEECCCCCHHHHHCEEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA