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The map label for this gene is hemC [H]

Identifier: 110635531

GI number: 110635531

Start: 3471831

End: 3472760

Strand: Reverse

Name: hemC [H]

Synonym: Meso_3202

Alternate gene names: 110635531

Gene position: 3472760-3471831 (Counterclockwise)

Preceding gene: 110635537

Following gene: 110635530

Centisome position: 78.7

GC content: 65.16

Gene sequence:

>930_bases
ATGCAAACTGATGTGATAAAAATCGGAACGCGCGGCAGCGCCTTGGCCTTGGCACAGGCTGCCGAGACGCGGGCGCGGCT
CATGGTTGCGCATGGCCTGCCGGAAGATGCGTTTGAAATCGTCGTCATCCGCACGTCCGGCGACCGCATCCAGGACCGCC
CCCTCTCCGAGGCGGGCGGCAAGGGGCTCTTTACCAAAGAAATCGAGGAAGCGCTGCTCGAAGGCCGCATCGATCTTGCG
GTACATTCTTCGAAGGACATGCCCACCTTCCTGCCTGATGGGCTGGAGCTTTCGGCCTTTCTTGAGCGTGAAGACGTGCG
CGACGTGTTCATCGGGCGCGCGGCCAAGCGGCTGGAGGACCTTCCGCATGGGGCCAATCTCGGCACCTCGTCGCTGCGCC
GGCAGGCGCTGGCGCTGAGGCTGCGGCCCGATCTCAAGGTGGGTGTCTTCCGTGGCAATGTGCAGACGCGATTGAGAAAG
CTCGAAGACGGCGCGGCCGACGGCACGCTGCTCGCGCTCGCCGGCCTGAAACGCCTCAAGCTGGAGCACGTGGCGACCGA
ACTCATGGACCCCGTCATCTTCCCGCCGGCGCTCGGGCAGGGCGCGATCTGCATTGAAAGCCGGACCGGAGATACGCGGA
TCGCTAAGCTGGTCGAAGCCATTCATCACCCGGCCACCGGTTTCGCGCTCTCCTGCGAACGGGCTTTTCTCGCTGCCCTC
GATGGCTCCTGCCGCACACCCATGGCCGGTCTTGCGACGGTCGATGGCGACCGGATCGCCTTCTCCGGCATGATTCTCAC
CCCCGATGGACGAGAGGTCCACGAGATTGGCGGCGACGGCGCGGCGCAGGACGCGGCCGAAATCGGGAGGGATGCCGGCC
GGCGCATCCGGCAGAAGGCGGGGGCCGGTTTTTTCGAAAGCTGGAGTTAA

Upstream 100 bases:

>100_bases
TCGATGCCCAGCACGCGCGTCATTCGGTCCAGCCCACTTCGGTTGCCGAGGAGGTCAATCCCCGATAGGTAGGAATGCCG
GTTAGCACGGACATGACGGC

Downstream 100 bases:

>100_bases
CGCCCGTGCGGCGCGTCCTTGTCACGCGTCCAGAGCCCGGCGCGTCGCGAACCGCTGGCAGGCTTGCCGCGCTCGGTTTC
GAACCCGTGCTCCTCCCTCT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MQTDVIKIGTRGSALALAQAAETRARLMVAHGLPEDAFEIVVIRTSGDRIQDRPLSEAGGKGLFTKEIEEALLEGRIDLA
VHSSKDMPTFLPDGLELSAFLEREDVRDVFIGRAAKRLEDLPHGANLGTSSLRRQALALRLRPDLKVGVFRGNVQTRLRK
LEDGAADGTLLALAGLKRLKLEHVATELMDPVIFPPALGQGAICIESRTGDTRIAKLVEAIHHPATGFALSCERAFLAAL
DGSCRTPMAGLATVDGDRIAFSGMILTPDGREVHEIGGDGAAQDAAEIGRDAGRRIRQKAGAGFFESWS

Sequences:

>Translated_309_residues
MQTDVIKIGTRGSALALAQAAETRARLMVAHGLPEDAFEIVVIRTSGDRIQDRPLSEAGGKGLFTKEIEEALLEGRIDLA
VHSSKDMPTFLPDGLELSAFLEREDVRDVFIGRAAKRLEDLPHGANLGTSSLRRQALALRLRPDLKVGVFRGNVQTRLRK
LEDGAADGTLLALAGLKRLKLEHVATELMDPVIFPPALGQGAICIESRTGDTRIAKLVEAIHHPATGFALSCERAFLAAL
DGSCRTPMAGLATVDGDRIAFSGMILTPDGREVHEIGGDGAAQDAAEIGRDAGRRIRQKAGAGFFESWS
>Mature_309_residues
MQTDVIKIGTRGSALALAQAAETRARLMVAHGLPEDAFEIVVIRTSGDRIQDRPLSEAGGKGLFTKEIEEALLEGRIDLA
VHSSKDMPTFLPDGLELSAFLEREDVRDVFIGRAAKRLEDLPHGANLGTSSLRRQALALRLRPDLKVGVFRGNVQTRLRK
LEDGAADGTLLALAGLKRLKLEHVATELMDPVIFPPALGQGAICIESRTGDTRIAKLVEAIHHPATGFALSCERAFLAAL
DGSCRTPMAGLATVDGDRIAFSGMILTPDGREVHEIGGDGAAQDAAEIGRDAGRRIRQKAGAGFFESWS

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=272, Percent_Identity=39.7058823529412, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI66933009, Length=272, Percent_Identity=39.7058823529412, Blast_Score=173, Evalue=2e-43,
Organism=Escherichia coli, GI48994974, Length=289, Percent_Identity=44.636678200692, Blast_Score=224, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6319996, Length=257, Percent_Identity=38.9105058365759, Blast_Score=162, Evalue=5e-41,
Organism=Drosophila melanogaster, GI20130425, Length=261, Percent_Identity=38.6973180076628, Blast_Score=171, Evalue=7e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33102; Mature: 33102

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTDVIKIGTRGSALALAQAAETRARLMVAHGLPEDAFEIVVIRTSGDRIQDRPLSEAGG
CCCCEEEECCCCCHHHHHHHHHHHHHHHEECCCCCCCEEEEEEECCCCCCCCCCCHHCCC
KGLFTKEIEEALLEGRIDLAVHSSKDMPTFLPDGLELSAFLEREDVRDVFIGRAAKRLED
CCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LPHGANLGTSSLRRQALALRLRPDLKVGVFRGNVQTRLRKLEDGAADGTLLALAGLKRLK
CCCCCCCCHHHHHHHHHHHEECCCCEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHH
LEHVATELMDPVIFPPALGQGAICIESRTGDTRIAKLVEAIHHPATGFALSCERAFLAAL
HHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHH
DGSCRTPMAGLATVDGDRIAFSGMILTPDGREVHEIGGDGAAQDAAEIGRDAGRRIRQKA
CCCCCCCCCCEEEECCCEEEEEEEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GAGFFESWS
CCCCCCCCC
>Mature Secondary Structure
MQTDVIKIGTRGSALALAQAAETRARLMVAHGLPEDAFEIVVIRTSGDRIQDRPLSEAGG
CCCCEEEECCCCCHHHHHHHHHHHHHHHEECCCCCCCEEEEEEECCCCCCCCCCCHHCCC
KGLFTKEIEEALLEGRIDLAVHSSKDMPTFLPDGLELSAFLEREDVRDVFIGRAAKRLED
CCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LPHGANLGTSSLRRQALALRLRPDLKVGVFRGNVQTRLRKLEDGAADGTLLALAGLKRLK
CCCCCCCCHHHHHHHHHHHEECCCCEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHH
LEHVATELMDPVIFPPALGQGAICIESRTGDTRIAKLVEAIHHPATGFALSCERAFLAAL
HHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHH
DGSCRTPMAGLATVDGDRIAFSGMILTPDGREVHEIGGDGAAQDAAEIGRDAGRRIRQKA
CCCCCCCCCCEEEECCCEEEEEEEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GAGFFESWS
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]