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The map label for this gene is serA [H]

Identifier: 110635490

GI number: 110635490

Start: 3430521

End: 3432119

Strand: Reverse

Name: serA [H]

Synonym: Meso_3161

Alternate gene names: 110635490

Gene position: 3432119-3430521 (Counterclockwise)

Preceding gene: 110635491

Following gene: 110635488

Centisome position: 77.78

GC content: 60.66

Gene sequence:

>1599_bases
ATGGCACCTCGCGTTCTCGTTTCCGACAAGCTTTCCCCGACCGCGGTCGACATCTTCCGTCAGCACGGCGTGGAGGTGGA
TTACCAGCCGGACCTCGGCAAGGATAAGGACAAGCTTCTTTCCGTCATCGACCAGTATGACGGCCTCGCCATTCGTTCCG
CCACGAAGGTGACGGAAAAGCTGATCGCCGCCGCCACAAATCTGAAGGTGATCGGGCGTGCGGGTATCGGCGTCGATAAT
GTCGATATCCCCGCCGCGTCGCGGCGAGGCATCATCGTGATGAACACGCCTTTCGGCAATTCCATCACCACGGCTGAGCA
CGCTGTCGCCATGATCTTTGCCGTGGCGCGGCAGATCCCCGAAGCCAATGCTTCCACCCATGCGGGCAAGTGGGAGAAAA
ACCGCTTCATGGGGGTGGAGATCACCGGCAAAACGCTGGGCGTAATCGGCTGCGGCAATATCGGCTCGGTGGTCGCAATG
CGCGCCATCGGCCTCAAGATGCATGTGATTGCCTACGATCCGTTCCTTTCGGAAGACAGAGCGGAGGAACTGGGCGTGGA
GAAGGTGGAGCTCAACGAGCTCTTCGCCCGCGCCGATTTCATTACCCTGCATACTCCGCTGACCGAAAAGACGCGCGGCA
TCATCAATGCGGCTGCGATCGCCAAGATGAAAGACGGTGTGCGCATCGTCAATTGCGCGCGCGGCGGCCTCATTGTCGAA
GCCGACCTGGTCGAGGGGCTGAAATCCGGCAAGGTGGCGGGCGCCGGCATCGACGTTTTCGAGAACGAGCCGGCGACCGA
GAACCCGCTCTTCAACCTGCCCAACGTGGTCTGCACGCCGCATTTGGGCGCCTCTACCACCGAGGCGCAGGAAAATGTGG
CGCTGCAGATTGCCGAGCAGATGTCGGAGTACCTCATCAAAGGCGCTGTGACCAACGCGATCAACATGCCTTCCATCACC
GCCGAGGAAGCGCCGCGTCTTAAGCCTTTCATCAAGCTGGCCGAAGTGCTGGGCGCGTTCGTGGGCCAAGTGACCGACGA
GCCGATCGCGGGCGTGGAGATACTTTTCGACGGCTCAACCGCCGCCATGAATACCCGAGCCCTCATCAGTGCCGCACTTG
CCGGCCTGATCCGCCCGCAGGTGAATGACGTCAATATGGTCTCCGCCCCCATCATGGTAAAGGAGCGCGGCATCATCGTC
TCGGAGGTGAAGCGCGACAAGTCGGGCGTGTTCGACGGCTATATCAAGCTGACGGTAAAGACACCGGAGCGGACGCGCTC
CATCGCCGGTACGGTGTTTTCCGACGGGAAGCCCAGGTTCATCCAGATCAAGGGCATCAATCTTGACGCGGAAGTAGGCG
AGCACATGCTCTACACCACGAACAATGACACGCCTGGCATTATCGGCCAGCTCGGCACAATCTGCGGCAAGCACGGGGTG
AACATCGCCAATTTCCAGCTCGGCCGGAATCGGCCCGGCGGCGATGCCATCGCGCTGCTTTATCTCGATGCCCCGTTTCC
GCAGCCCGTACTGGAAGAGCTCAAGTCCACCGGCTCTATTATTTCGGCCAAGCCGCTGCGGTTCGACGTCGGCAACTGA

Upstream 100 bases:

>100_bases
CCTTTCAAGAGCAAAAAACCGCGCTCCAGGCAGCCTGAGTTCTTTCGGCCGCAGCCATGCGGCCCCCCTTTCCTCAATTC
GTCAAACAAGGAGCCTGGAT

Downstream 100 bases:

>100_bases
GCCCTCAAGACCCATCCACCGGCGCTCGCACGCGTGCGAGCGCCGCTTCGCTCTTGCGGCCGCTATACTCGGCTAGCCAG
ATGCCGCAGATGACGAGGGC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MAPRVLVSDKLSPTAVDIFRQHGVEVDYQPDLGKDKDKLLSVIDQYDGLAIRSATKVTEKLIAAATNLKVIGRAGIGVDN
VDIPAASRRGIIVMNTPFGNSITTAEHAVAMIFAVARQIPEANASTHAGKWEKNRFMGVEITGKTLGVIGCGNIGSVVAM
RAIGLKMHVIAYDPFLSEDRAEELGVEKVELNELFARADFITLHTPLTEKTRGIINAAAIAKMKDGVRIVNCARGGLIVE
ADLVEGLKSGKVAGAGIDVFENEPATENPLFNLPNVVCTPHLGASTTEAQENVALQIAEQMSEYLIKGAVTNAINMPSIT
AEEAPRLKPFIKLAEVLGAFVGQVTDEPIAGVEILFDGSTAAMNTRALISAALAGLIRPQVNDVNMVSAPIMVKERGIIV
SEVKRDKSGVFDGYIKLTVKTPERTRSIAGTVFSDGKPRFIQIKGINLDAEVGEHMLYTTNNDTPGIIGQLGTICGKHGV
NIANFQLGRNRPGGDAIALLYLDAPFPQPVLEELKSTGSIISAKPLRFDVGN

Sequences:

>Translated_532_residues
MAPRVLVSDKLSPTAVDIFRQHGVEVDYQPDLGKDKDKLLSVIDQYDGLAIRSATKVTEKLIAAATNLKVIGRAGIGVDN
VDIPAASRRGIIVMNTPFGNSITTAEHAVAMIFAVARQIPEANASTHAGKWEKNRFMGVEITGKTLGVIGCGNIGSVVAM
RAIGLKMHVIAYDPFLSEDRAEELGVEKVELNELFARADFITLHTPLTEKTRGIINAAAIAKMKDGVRIVNCARGGLIVE
ADLVEGLKSGKVAGAGIDVFENEPATENPLFNLPNVVCTPHLGASTTEAQENVALQIAEQMSEYLIKGAVTNAINMPSIT
AEEAPRLKPFIKLAEVLGAFVGQVTDEPIAGVEILFDGSTAAMNTRALISAALAGLIRPQVNDVNMVSAPIMVKERGIIV
SEVKRDKSGVFDGYIKLTVKTPERTRSIAGTVFSDGKPRFIQIKGINLDAEVGEHMLYTTNNDTPGIIGQLGTICGKHGV
NIANFQLGRNRPGGDAIALLYLDAPFPQPVLEELKSTGSIISAKPLRFDVGN
>Mature_531_residues
APRVLVSDKLSPTAVDIFRQHGVEVDYQPDLGKDKDKLLSVIDQYDGLAIRSATKVTEKLIAAATNLKVIGRAGIGVDNV
DIPAASRRGIIVMNTPFGNSITTAEHAVAMIFAVARQIPEANASTHAGKWEKNRFMGVEITGKTLGVIGCGNIGSVVAMR
AIGLKMHVIAYDPFLSEDRAEELGVEKVELNELFARADFITLHTPLTEKTRGIINAAAIAKMKDGVRIVNCARGGLIVEA
DLVEGLKSGKVAGAGIDVFENEPATENPLFNLPNVVCTPHLGASTTEAQENVALQIAEQMSEYLIKGAVTNAINMPSITA
EEAPRLKPFIKLAEVLGAFVGQVTDEPIAGVEILFDGSTAAMNTRALISAALAGLIRPQVNDVNMVSAPIMVKERGIIVS
EVKRDKSGVFDGYIKLTVKTPERTRSIAGTVFSDGKPRFIQIKGINLDAEVGEHMLYTTNNDTPGIIGQLGTICGKHGVN
IANFQLGRNRPGGDAIALLYLDAPFPQPVLEELKSTGSIISAKPLRFDVGN

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=400, Percent_Identity=42.75, Blast_Score=333, Evalue=3e-91,
Organism=Homo sapiens, GI61743967, Length=297, Percent_Identity=31.986531986532, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI4557497, Length=297, Percent_Identity=31.986531986532, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI145580578, Length=287, Percent_Identity=34.8432055749129, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI4557499, Length=287, Percent_Identity=34.8432055749129, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI145580575, Length=287, Percent_Identity=34.8432055749129, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI6912396, Length=248, Percent_Identity=35.4838709677419, Blast_Score=136, Evalue=5e-32,
Organism=Escherichia coli, GI1789279, Length=292, Percent_Identity=37.3287671232877, Blast_Score=185, Evalue=7e-48,
Organism=Escherichia coli, GI87082289, Length=281, Percent_Identity=30.6049822064057, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1787645, Length=198, Percent_Identity=41.4141414141414, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87081824, Length=249, Percent_Identity=29.3172690763052, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1788660, Length=263, Percent_Identity=28.1368821292776, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=302, Percent_Identity=47.0198675496689, Blast_Score=287, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI25147481, Length=272, Percent_Identity=33.4558823529412, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322116, Length=331, Percent_Identity=34.1389728096677, Blast_Score=217, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6320925, Length=332, Percent_Identity=34.3373493975904, Blast_Score=214, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6324055, Length=294, Percent_Identity=29.9319727891156, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324964, Length=277, Percent_Identity=30.6859205776173, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6324980, Length=198, Percent_Identity=30.3030303030303, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6325144, Length=115, Percent_Identity=38.2608695652174, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19921140, Length=302, Percent_Identity=45.0331125827815, Blast_Score=267, Evalue=2e-71,
Organism=Drosophila melanogaster, GI28574286, Length=242, Percent_Identity=35.5371900826446, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI45551003, Length=242, Percent_Identity=34.297520661157, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24585514, Length=242, Percent_Identity=34.297520661157, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI28574282, Length=242, Percent_Identity=34.297520661157, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI45552429, Length=242, Percent_Identity=34.297520661157, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI28574284, Length=242, Percent_Identity=34.297520661157, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24646446, Length=248, Percent_Identity=36.2903225806452, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646448, Length=248, Percent_Identity=36.2903225806452, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646452, Length=248, Percent_Identity=36.2903225806452, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646450, Length=248, Percent_Identity=36.2903225806452, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI62472511, Length=248, Percent_Identity=36.2903225806452, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24585516, Length=291, Percent_Identity=29.2096219931272, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI28571528, Length=265, Percent_Identity=31.6981132075472, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56730; Mature: 56599

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPRVLVSDKLSPTAVDIFRQHGVEVDYQPDLGKDKDKLLSVIDQYDGLAIRSATKVTEK
CCCCEEECCCCCCHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHH
LIAAATNLKVIGRAGIGVDNVDIPAASRRGIIVMNTPFGNSITTAEHAVAMIFAVARQIP
HHHHHCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
EANASTHAGKWEKNRFMGVEITGKTLGVIGCGNIGSVVAMRAIGLKMHVIAYDPFLSEDR
CCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHCEEEEEEEECCCCCCCH
AEELGVEKVELNELFARADFITLHTPLTEKTRGIINAAAIAKMKDGVRIVNCARGGLIVE
HHHCCCCEEEHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEE
ADLVEGLKSGKVAGAGIDVFENEPATENPLFNLPNVVCTPHLGASTTEAQENVALQIAEQ
HHHHHHHHCCCEECCCCEEECCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHH
MSEYLIKGAVTNAINMPSITAEEAPRLKPFIKLAEVLGAFVGQVTDEPIAGVEILFDGST
HHHHHHHHHHHCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
AAMNTRALISAALAGLIRPQVNDVNMVSAPIMVKERGIIVSEVKRDKSGVFDGYIKLTVK
HHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEEECCCCCHHHHHCCCCCCEEEEEEEEEE
TPERTRSIAGTVFSDGKPRFIQIKGINLDAEVGEHMLYTTNNDTPGIIGQLGTICGKHGV
CCHHHHHHHCEEECCCCCCEEEEEECCCCHHHCCEEEEEECCCCCHHHHHHHHHHHHCCC
NIANFQLGRNRPGGDAIALLYLDAPFPQPVLEELKSTGSIISAKPLRFDVGN
EEEEEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCEEECCCEEEECCC
>Mature Secondary Structure 
APRVLVSDKLSPTAVDIFRQHGVEVDYQPDLGKDKDKLLSVIDQYDGLAIRSATKVTEK
CCCEEECCCCCCHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHH
LIAAATNLKVIGRAGIGVDNVDIPAASRRGIIVMNTPFGNSITTAEHAVAMIFAVARQIP
HHHHHCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
EANASTHAGKWEKNRFMGVEITGKTLGVIGCGNIGSVVAMRAIGLKMHVIAYDPFLSEDR
CCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHCEEEEEEEECCCCCCCH
AEELGVEKVELNELFARADFITLHTPLTEKTRGIINAAAIAKMKDGVRIVNCARGGLIVE
HHHCCCCEEEHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEE
ADLVEGLKSGKVAGAGIDVFENEPATENPLFNLPNVVCTPHLGASTTEAQENVALQIAEQ
HHHHHHHHCCCEECCCCEEECCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHH
MSEYLIKGAVTNAINMPSITAEEAPRLKPFIKLAEVLGAFVGQVTDEPIAGVEILFDGST
HHHHHHHHHHHCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
AAMNTRALISAALAGLIRPQVNDVNMVSAPIMVKERGIIVSEVKRDKSGVFDGYIKLTVK
HHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEEECCCCCHHHHHCCCCCCEEEEEEEEEE
TPERTRSIAGTVFSDGKPRFIQIKGINLDAEVGEHMLYTTNNDTPGIIGQLGTICGKHGV
CCHHHHHHHCEEECCCCCCEEEEEECCCCHHHCCEEEEEECCCCCHHHHHHHHHHHHCCC
NIANFQLGRNRPGGDAIALLYLDAPFPQPVLEELKSTGSIISAKPLRFDVGN
EEEEEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCEEECCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]