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The map label for this gene is clpB [H]

Identifier: 110635325

GI number: 110635325

Start: 3262040

End: 3264715

Strand: Reverse

Name: clpB [H]

Synonym: Meso_2996

Alternate gene names: 110635325

Gene position: 3264715-3262040 (Counterclockwise)

Preceding gene: 110635326

Following gene: 110635324

Centisome position: 73.99

GC content: 62.18

Gene sequence:

>2676_bases
TTGGGGGTCCGTCACATTGGCCTGCTCGATGCCGCCAAGCGGGTCGGCACGGAGATGGAGACGTGGAACATGGACATCGA
AAAATATTCCGAGCGCGTGCGTGGCTTTATTCAGGCTGCCCAGACGCTCGCCCTTTCCAGAAATCACCAGCAGTTTTCGC
CTGAGCACATCCTGAAAGTGCTCGTTGATGACGAGGAAGGACTCGCGGCGAATCTCATCGAGCGTGCCGGCGGGCGGGCG
CGGGATGTGAAACTGGGCGTCGACGCCGCGCTTGAGGCGTTGCCGCGTGTCGAAGGCGGCAGCGGCCAGCTTTATCTGGC
GCAGCCGCTGGCAAAGGTTTTCTCCACCGCTGAAGAACTCGCGAAGAAGGCCGGGGACAGTTTCGTTACCGTCGAGCGCC
TGCTCATGGCGCTGGCCATGGAGAAATCCGCCAAGAGCGCGGATATTCTGGCAAAGGCCGGTGTCACTCCGACGGCTCTC
AATCAGGTCATAAACGATATCCGCAAGGGCCGAACCGCCGATTCGCCGAATGCGGAGCAGGGCTATGACGCGCTGAAGAA
ATATGCGCGCGATCTGACAGCCGAGGCGCGGGCGGGCAAGCTTGATCCCGTGATCGGCCGCGATGACGAGATCCGCCGCA
CGATCCAGGTCCTTTCCAGGCGCACAAAAAACAATCCGGTGCTGATCGGCGAACCCGGCGTAGGCAAAACCGCCATCGCC
GAGGGGCTGGCGCTCAGGATCGTGAACGGCGACGTGCCCGAATCGCTCAAGGACAAGCAGCTCATGGCGCTCGACATGGG
TGCGCTGATCGCCGGCGCCAAATATCGCGGCGAGTTCGAGGAGCGGCTGAAGGCCGTGCTTTCCGAGATTCAGGCCGCGG
CCGGCGGTGTCATCCTCTTCATCGACGAGATGCACACGCTGGTTGGCGCCGGTAAAGCGGATGGCGCGATGGACGCTTCC
AATCTTCTGAAGCCCGCGCTGGCGCGGGGCGAGCTGCACTGTGTGGGCGCGACGACGCTCGATGAATACCGGAAATATGT
GGAAAAGGACGCGGCGCTCGCCCGCCGCTTTCAGCCTGTCTACGTGAACGAGCCTTCGGTGGAGGACACTATCTCCATCC
TGCGCGGGCTGAAGGAGAAATACGAGCAGCACCACAAGGTGCGCGTCTCCGATTCCGCTCTTGTGGCGGCGGCCAACCTG
TCGAACCGCTACATCACCGATCGTTTCCTGCCCGACAAGGCCATCGACCTGGTGGACGAGGCGGCATCGCGCCTGCGCAT
GCAGGTGGATTCCAAGCCGGAGGAACTGGATGAGGTCGACCGGCGCATCATGCAGCTCAAGATCGAACGCGAGGCGCTGC
GGGTCGAGAAGGACGAGGCTTCGAAGGATCGGCTTGAACGGCTAGAGAGGGAATTGGCCGAGCTCGAGGAGCAGTCGGCC
AATATCACCGCCAAATGGCAGGCCGAAAAGCAGAAACTGGGCCTTGCCGCCGAACTCAAGAAGCAGCTTGACGAAGCGCG
CAACGATCTTGCGATTGCTCAGCGCAAAGGCGAGTTCCAGCGCGCGGGCGAGCTGGCCTATGGCCGTATCCCCGAGCTTG
AGAAGAAGCTGAAGGAGGCTGAGGAGCAGGACGGCAAGGGCTCGCTCGTCGAAGAGACGGTGACGCCTGACCATGTGGCG
CATATCGTTTCCCGCTGGACCGGCATTCCCGTCGACAAGATGCTCCAGGGCGAGCGTGAAAAGCTGCTCAGGATGGAAGA
CGAGCTCGCCAAGCGTGTGATTGGGCAAGGTGAGGCGGTGCAAGCGGTTTCCAAAGCCGTGCGGCGCGCGCGCGCCGGGT
TGCAGGATCCGAACCGGCCGCTCGGCTCGTTCATGTTCCTGGGGCCCACGGGCGTGGGTAAGACGGAGCTGACCAAGGCG
CTCGCCGCTTTCCTATTCGATGACGAGCAGGCGATGGTGCGCATCGACATGTCGGAGTTCATGGAGAAGCACTCGGTTGC
CCGGCTGATCGGCGCTCCTCCCGGCTATGTGGGTTATGACGAGGGCGGCGTGTTGACCGAAGCTGTCCGCCGCAGGCCCT
ATCAGGTGATCCTGTTCGACGAGATCGAGAAAGCGCACCCGGATGTCTTTAATGTGCTGCTCCAGGTGCTGGACGACGGC
AGGCTCACGGATGGCCAAGGCCGGACGGTCGACTTCCGCAACACTCTGATCATCATGACGTCCAATCTGGGCGCGGAGTA
CCTTGTCAATCTGGCCGAAGGCGAGGACGTGGACAAGGTGCGCGACGAGGTGATGGCTGTCGTGCAGGCTTCGTTCCGGC
CTGAATTCCTGAACCGTGTGGACGAGATCATCCTCTTCCACCGCCTGCGCCGGCAGGATATGGGCGATATCGTCCGCATC
CAGCTCAAGCGCATCGGGCGGCTGCTGGAAGACCGCAAGATCACGCTCGAGCTCGACCAGGAGGCAATCGACTGGCTTGC
CGACAAGGGCTACGATCCTGCCTATGGCGCTCGTCCGCTGAAGCGGGTCATGCAGAAGGAACTGCAGGATCCGCTGGCCG
AGAAGATCCTGATGGGAGAGATCTTCGATGGCTCGACCGTCAAGATCACCGCCGGTTCAGATAGGCTGATCTTCCGCCCG
CGGAAGAATTCGGAGGCTGCGGCGGAAGCAGCGTGA

Upstream 100 bases:

>100_bases
GCCGTTTTGTGTTTTGCGGGTGATCTTGAGACGATGCAAAAAAGCTCCCATATTTCCATCGGTTGGACTTGCCGCTAGGC
GTTGACTTGGGTCAACTCCG

Downstream 100 bases:

>100_bases
TATCAGCCATGCCCGGCGCGCAAACGCGCCGGGCTGTCGTGCGGAGGGGGCGAGTGCTGCTTGAGGACTACAATAGCTTC
TGCTCTTCCCTTCCGCACGC

Product: ATPase AAA-2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 891; Mature: 890

Protein sequence:

>891_residues
MGVRHIGLLDAAKRVGTEMETWNMDIEKYSERVRGFIQAAQTLALSRNHQQFSPEHILKVLVDDEEGLAANLIERAGGRA
RDVKLGVDAALEALPRVEGGSGQLYLAQPLAKVFSTAEELAKKAGDSFVTVERLLMALAMEKSAKSADILAKAGVTPTAL
NQVINDIRKGRTADSPNAEQGYDALKKYARDLTAEARAGKLDPVIGRDDEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIA
EGLALRIVNGDVPESLKDKQLMALDMGALIAGAKYRGEFEERLKAVLSEIQAAAGGVILFIDEMHTLVGAGKADGAMDAS
NLLKPALARGELHCVGATTLDEYRKYVEKDAALARRFQPVYVNEPSVEDTISILRGLKEKYEQHHKVRVSDSALVAAANL
SNRYITDRFLPDKAIDLVDEAASRLRMQVDSKPEELDEVDRRIMQLKIEREALRVEKDEASKDRLERLERELAELEEQSA
NITAKWQAEKQKLGLAAELKKQLDEARNDLAIAQRKGEFQRAGELAYGRIPELEKKLKEAEEQDGKGSLVEETVTPDHVA
HIVSRWTGIPVDKMLQGEREKLLRMEDELAKRVIGQGEAVQAVSKAVRRARAGLQDPNRPLGSFMFLGPTGVGKTELTKA
LAAFLFDDEQAMVRIDMSEFMEKHSVARLIGAPPGYVGYDEGGVLTEAVRRRPYQVILFDEIEKAHPDVFNVLLQVLDDG
RLTDGQGRTVDFRNTLIIMTSNLGAEYLVNLAEGEDVDKVRDEVMAVVQASFRPEFLNRVDEIILFHRLRRQDMGDIVRI
QLKRIGRLLEDRKITLELDQEAIDWLADKGYDPAYGARPLKRVMQKELQDPLAEKILMGEIFDGSTVKITAGSDRLIFRP
RKNSEAAAEAA

Sequences:

>Translated_891_residues
MGVRHIGLLDAAKRVGTEMETWNMDIEKYSERVRGFIQAAQTLALSRNHQQFSPEHILKVLVDDEEGLAANLIERAGGRA
RDVKLGVDAALEALPRVEGGSGQLYLAQPLAKVFSTAEELAKKAGDSFVTVERLLMALAMEKSAKSADILAKAGVTPTAL
NQVINDIRKGRTADSPNAEQGYDALKKYARDLTAEARAGKLDPVIGRDDEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIA
EGLALRIVNGDVPESLKDKQLMALDMGALIAGAKYRGEFEERLKAVLSEIQAAAGGVILFIDEMHTLVGAGKADGAMDAS
NLLKPALARGELHCVGATTLDEYRKYVEKDAALARRFQPVYVNEPSVEDTISILRGLKEKYEQHHKVRVSDSALVAAANL
SNRYITDRFLPDKAIDLVDEAASRLRMQVDSKPEELDEVDRRIMQLKIEREALRVEKDEASKDRLERLERELAELEEQSA
NITAKWQAEKQKLGLAAELKKQLDEARNDLAIAQRKGEFQRAGELAYGRIPELEKKLKEAEEQDGKGSLVEETVTPDHVA
HIVSRWTGIPVDKMLQGEREKLLRMEDELAKRVIGQGEAVQAVSKAVRRARAGLQDPNRPLGSFMFLGPTGVGKTELTKA
LAAFLFDDEQAMVRIDMSEFMEKHSVARLIGAPPGYVGYDEGGVLTEAVRRRPYQVILFDEIEKAHPDVFNVLLQVLDDG
RLTDGQGRTVDFRNTLIIMTSNLGAEYLVNLAEGEDVDKVRDEVMAVVQASFRPEFLNRVDEIILFHRLRRQDMGDIVRI
QLKRIGRLLEDRKITLELDQEAIDWLADKGYDPAYGARPLKRVMQKELQDPLAEKILMGEIFDGSTVKITAGSDRLIFRP
RKNSEAAAEAA
>Mature_890_residues
GVRHIGLLDAAKRVGTEMETWNMDIEKYSERVRGFIQAAQTLALSRNHQQFSPEHILKVLVDDEEGLAANLIERAGGRAR
DVKLGVDAALEALPRVEGGSGQLYLAQPLAKVFSTAEELAKKAGDSFVTVERLLMALAMEKSAKSADILAKAGVTPTALN
QVINDIRKGRTADSPNAEQGYDALKKYARDLTAEARAGKLDPVIGRDDEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIAE
GLALRIVNGDVPESLKDKQLMALDMGALIAGAKYRGEFEERLKAVLSEIQAAAGGVILFIDEMHTLVGAGKADGAMDASN
LLKPALARGELHCVGATTLDEYRKYVEKDAALARRFQPVYVNEPSVEDTISILRGLKEKYEQHHKVRVSDSALVAAANLS
NRYITDRFLPDKAIDLVDEAASRLRMQVDSKPEELDEVDRRIMQLKIEREALRVEKDEASKDRLERLERELAELEEQSAN
ITAKWQAEKQKLGLAAELKKQLDEARNDLAIAQRKGEFQRAGELAYGRIPELEKKLKEAEEQDGKGSLVEETVTPDHVAH
IVSRWTGIPVDKMLQGEREKLLRMEDELAKRVIGQGEAVQAVSKAVRRARAGLQDPNRPLGSFMFLGPTGVGKTELTKAL
AAFLFDDEQAMVRIDMSEFMEKHSVARLIGAPPGYVGYDEGGVLTEAVRRRPYQVILFDEIEKAHPDVFNVLLQVLDDGR
LTDGQGRTVDFRNTLIIMTSNLGAEYLVNLAEGEDVDKVRDEVMAVVQASFRPEFLNRVDEIILFHRLRRQDMGDIVRIQ
LKRIGRLLEDRKITLELDQEAIDWLADKGYDPAYGARPLKRVMQKELQDPLAEKILMGEIFDGSTVKITAGSDRLIFRPR
KNSEAAAEAA

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=448, Percent_Identity=32.3660714285714, Blast_Score=213, Evalue=9e-55,
Organism=Escherichia coli, GI1788943, Length=856, Percent_Identity=58.9953271028037, Blast_Score=1022, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=404, Percent_Identity=42.0792079207921, Blast_Score=290, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6320464, Length=711, Percent_Identity=55.8368495077356, Blast_Score=799, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=863, Percent_Identity=44.7276940903824, Blast_Score=702, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 98930; Mature: 98799

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVRHIGLLDAAKRVGTEMETWNMDIEKYSERVRGFIQAAQTLALSRNHQQFSPEHILKV
CCCCHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LVDDEEGLAANLIERAGGRARDVKLGVDAALEALPRVEGGSGQLYLAQPLAKVFSTAEEL
HCCCCCCHHHHHHHHCCCCCEEEEECHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHH
AKKAGDSFVTVERLLMALAMEKSAKSADILAKAGVTPTALNQVINDIRKGRTADSPNAEQ
HHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHH
GYDALKKYARDLTAEARAGKLDPVIGRDDEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
EGLALRIVNGDVPESLKDKQLMALDMGALIAGAKYRGEFEERLKAVLSEIQAAAGGVILF
CCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHCCCEEEE
IDEMHTLVGAGKADGAMDASNLLKPALARGELHCVGATTLDEYRKYVEKDAALARRFQPV
HHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCE
YVNEPSVEDTISILRGLKEKYEQHHKVRVSDSALVAAANLSNRYITDRFLPDKAIDLVDE
ECCCCCHHHHHHHHHHHHHHHHHHCCEEECCCCEEEECCCCCCCHHHHCCCHHHHHHHHH
AASRLRMQVDSKPEELDEVDRRIMQLKIEREALRVEKDEASKDRLERLERELAELEEQSA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHCC
NITAKWQAEKQKLGLAAELKKQLDEARNDLAIAQRKGEFQRAGELAYGRIPELEKKLKEA
CEEEEECHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHH
EEQDGKGSLVEETVTPDHVAHIVSRWTGIPVDKMLQGEREKLLRMEDELAKRVIGQGEAV
HCCCCCCCCHHHCCCHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCHHH
QAVSKAVRRARAGLQDPNRPLGSFMFLGPTGVGKTELTKALAAFLFDDEQAMVRIDMSEF
HHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHHEEECHHHH
MEKHSVARLIGAPPGYVGYDEGGVLTEAVRRRPYQVILFDEIEKAHPDVFNVLLQVLDDG
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCC
RLTDGQGRTVDFRNTLIIMTSNLGAEYLVNLAEGEDVDKVRDEVMAVVQASFRPEFLNRV
CCCCCCCCEEEECCEEEEEECCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHH
DEIILFHRLRRQDMGDIVRIQLKRIGRLLEDRKITLELDQEAIDWLADKGYDPAYGARPL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCCCCCCCHHH
KRVMQKELQDPLAEKILMGEIFDGSTVKITAGSDRLIFRPRKNSEAAAEAA
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
GVRHIGLLDAAKRVGTEMETWNMDIEKYSERVRGFIQAAQTLALSRNHQQFSPEHILKV
CCCHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LVDDEEGLAANLIERAGGRARDVKLGVDAALEALPRVEGGSGQLYLAQPLAKVFSTAEEL
HCCCCCCHHHHHHHHCCCCCEEEEECHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHH
AKKAGDSFVTVERLLMALAMEKSAKSADILAKAGVTPTALNQVINDIRKGRTADSPNAEQ
HHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHH
GYDALKKYARDLTAEARAGKLDPVIGRDDEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
EGLALRIVNGDVPESLKDKQLMALDMGALIAGAKYRGEFEERLKAVLSEIQAAAGGVILF
CCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHCCCEEEE
IDEMHTLVGAGKADGAMDASNLLKPALARGELHCVGATTLDEYRKYVEKDAALARRFQPV
HHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCE
YVNEPSVEDTISILRGLKEKYEQHHKVRVSDSALVAAANLSNRYITDRFLPDKAIDLVDE
ECCCCCHHHHHHHHHHHHHHHHHHCCEEECCCCEEEECCCCCCCHHHHCCCHHHHHHHHH
AASRLRMQVDSKPEELDEVDRRIMQLKIEREALRVEKDEASKDRLERLERELAELEEQSA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHCC
NITAKWQAEKQKLGLAAELKKQLDEARNDLAIAQRKGEFQRAGELAYGRIPELEKKLKEA
CEEEEECHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHH
EEQDGKGSLVEETVTPDHVAHIVSRWTGIPVDKMLQGEREKLLRMEDELAKRVIGQGEAV
HCCCCCCCCHHHCCCHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCHHH
QAVSKAVRRARAGLQDPNRPLGSFMFLGPTGVGKTELTKALAAFLFDDEQAMVRIDMSEF
HHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHHEEECHHHH
MEKHSVARLIGAPPGYVGYDEGGVLTEAVRRRPYQVILFDEIEKAHPDVFNVLLQVLDDG
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCC
RLTDGQGRTVDFRNTLIIMTSNLGAEYLVNLAEGEDVDKVRDEVMAVVQASFRPEFLNRV
CCCCCCCCEEEECCEEEEEECCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHH
DEIILFHRLRRQDMGDIVRIQLKRIGRLLEDRKITLELDQEAIDWLADKGYDPAYGARPL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCCCCCCCHHH
KRVMQKELQDPLAEKILMGEIFDGSTVKITAGSDRLIFRPRKNSEAAAEAA
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]