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The map label for this gene is pcaK [H]

Identifier: 110635243

GI number: 110635243

Start: 3166550

End: 3167914

Strand: Reverse

Name: pcaK [H]

Synonym: Meso_2913

Alternate gene names: 110635243

Gene position: 3167914-3166550 (Counterclockwise)

Preceding gene: 110635244

Following gene: 110635242

Centisome position: 71.79

GC content: 54.36

Gene sequence:

>1365_bases
GTGCTCGAAGCCGCACGCATAGATGCCGCTGCAGTCATCAATGACAACAATATTAGTCGGTTCCAGTACAGAATTTTCAT
ATTAGCCACGTTGATCATGATGTGCGACGGCTTTGATACCCAAGCCGTAGCATATGTGGCGCCGAGCATCGTGGCCGAGT
GGAATATGGCACCGGGTTCATTTGGTCCAGTGTTTGCCGCGCTGTTGCTTGGCAGCATGGTGGGCGCGTTCGCGTTTGGC
TATTTGGCTGACAAAATTGGACGCAAATACACGCTGGCCGGATGCGTCGCGCTGTTTGGGATCCTGAACTTTGCGTCGGC
ATACGCGACTTCCATTGAAACATTCACTGTGCTGCGGTTTCTGTGCGGAATCGGGCTCGGCGGCACTGTTCCCAATGTGA
CGTCGTTGGTTTCTGAGTATGCGCCGGCAAGAAAAAGGGCGACACTCGTCGCGATCACCTGGGCAGGTTTCGGGCTTGGC
GCCGTCGTTGGTGGATTGATCAGCGTGCCATTGATCTCACACTTTGGCTGGCCGGCCGTTTTCATCGCCGGAGGGATTCT
TCCGCTGCTGCTGCTGCCTTTCATATTTTTCTCAGTGCCGGAATCGATCAAATTCTTGATCCTGGCCGGAGGCAAAGGTG
CGGCGGTTGCTTCGATTCTCAAGCTGATCTGTCCTAGCGGCTCTTTCAAGGACAATGATGTTTTTGTTCTTGAAGAAAGC
CGGCCGGGACGAGGGCAGATTTCCGCCTTGTTCAAAGATGGACTGGCGATAGGCAGCATTTTCCTTTGCCTCGCCTTCTT
CATGAGTCTTCTGCTGGTCTATCTCTTCATCAACTGGATACCGCTGCTTCTGCGCCAGGCAGGCCTTCCCCTTCAGCATG
CAGTTATGGGAACGATAATTTTCAACCTGGCTGGCATTATCGGTAGTGTCTTTTGCACACAGCTCATCGACCGCAAGGTG
GCTCGGCCGGTATCGATCCTGATCGCCGCCTACTTTATCGGAGCCGCTGCCGTGTTCTCTATTGGGTATGCTGGAACAGC
GTTTTGGCCGATCATGATCACAATCTTCCTGAGCGGCTTCTTCATTATCGGAGTCCAGTTGTCGTTGAACGCCTTCATCA
CGAACTACTATCCGACTTCAATCCGCGGTACGGGGGTCGGCTGGTCGCAAGTTATTGGCCGGCTGGGTTCTCTTCTTGGT
CCGTTGATTGGGGGTGCACTGGTGTCGCAGGGTATGGCACCGAGCCAACTGTTCCAGGTAAGCGCCGTTGCACCGCTTCT
TGCGTGCGTATCTTTGTTGATTTTCGCAAGGCTATCGAGGGCGGATCCGAAGGGGCAGCCTGCAATATCTGATGCCGCCG
CCTGA

Upstream 100 bases:

>100_bases
GCTGGTGTGTAGACGCAAGCCGTCCGTGCCGGCGTTACATCTTTAAAAAAGCAAACGTCCTGCTCCAGCTCTCGCTGGAG
CCATCACGGAGGATATAGTT

Downstream 100 bases:

>100_bases
CAGCCCCATTCTCGGATGCGTTAACGGCATGCGCGTTTCTTCCAGGGTTACGGATATTTTGGGAAGAATGGAGCATTCCT
GATCGTTGCCTTGAAGGCAA

Product: major facilitator transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MLEAARIDAAAVINDNNISRFQYRIFILATLIMMCDGFDTQAVAYVAPSIVAEWNMAPGSFGPVFAALLLGSMVGAFAFG
YLADKIGRKYTLAGCVALFGILNFASAYATSIETFTVLRFLCGIGLGGTVPNVTSLVSEYAPARKRATLVAITWAGFGLG
AVVGGLISVPLISHFGWPAVFIAGGILPLLLLPFIFFSVPESIKFLILAGGKGAAVASILKLICPSGSFKDNDVFVLEES
RPGRGQISALFKDGLAIGSIFLCLAFFMSLLLVYLFINWIPLLLRQAGLPLQHAVMGTIIFNLAGIIGSVFCTQLIDRKV
ARPVSILIAAYFIGAAAVFSIGYAGTAFWPIMITIFLSGFFIIGVQLSLNAFITNYYPTSIRGTGVGWSQVIGRLGSLLG
PLIGGALVSQGMAPSQLFQVSAVAPLLACVSLLIFARLSRADPKGQPAISDAAA

Sequences:

>Translated_454_residues
MLEAARIDAAAVINDNNISRFQYRIFILATLIMMCDGFDTQAVAYVAPSIVAEWNMAPGSFGPVFAALLLGSMVGAFAFG
YLADKIGRKYTLAGCVALFGILNFASAYATSIETFTVLRFLCGIGLGGTVPNVTSLVSEYAPARKRATLVAITWAGFGLG
AVVGGLISVPLISHFGWPAVFIAGGILPLLLLPFIFFSVPESIKFLILAGGKGAAVASILKLICPSGSFKDNDVFVLEES
RPGRGQISALFKDGLAIGSIFLCLAFFMSLLLVYLFINWIPLLLRQAGLPLQHAVMGTIIFNLAGIIGSVFCTQLIDRKV
ARPVSILIAAYFIGAAAVFSIGYAGTAFWPIMITIFLSGFFIIGVQLSLNAFITNYYPTSIRGTGVGWSQVIGRLGSLLG
PLIGGALVSQGMAPSQLFQVSAVAPLLACVSLLIFARLSRADPKGQPAISDAAA
>Mature_454_residues
MLEAARIDAAAVINDNNISRFQYRIFILATLIMMCDGFDTQAVAYVAPSIVAEWNMAPGSFGPVFAALLLGSMVGAFAFG
YLADKIGRKYTLAGCVALFGILNFASAYATSIETFTVLRFLCGIGLGGTVPNVTSLVSEYAPARKRATLVAITWAGFGLG
AVVGGLISVPLISHFGWPAVFIAGGILPLLLLPFIFFSVPESIKFLILAGGKGAAVASILKLICPSGSFKDNDVFVLEES
RPGRGQISALFKDGLAIGSIFLCLAFFMSLLLVYLFINWIPLLLRQAGLPLQHAVMGTIIFNLAGIIGSVFCTQLIDRKV
ARPVSILIAAYFIGAAAVFSIGYAGTAFWPIMITIFLSGFFIIGVQLSLNAFITNYYPTSIRGTGVGWSQVIGRLGSLLG
PLIGGALVSQGMAPSQLFQVSAVAPLLACVSLLIFARLSRADPKGQPAISDAAA

Specific function: Could Be A Transporter For 3-Phenylpropionate (Hydrocinnamic Acid). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=413, Percent_Identity=22.5181598062954, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI73695465, Length=224, Percent_Identity=30.3571428571429, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI216548223, Length=226, Percent_Identity=27.4336283185841, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI7662270, Length=232, Percent_Identity=27.5862068965517, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI8923870, Length=371, Percent_Identity=23.4501347708895, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI166064021, Length=381, Percent_Identity=24.9343832020997, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI213021148, Length=433, Percent_Identity=23.3256351039261, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI87081723, Length=414, Percent_Identity=31.1594202898551, Blast_Score=161, Evalue=8e-41,
Organism=Escherichia coli, GI87082231, Length=424, Percent_Identity=24.5283018867925, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87082159, Length=414, Percent_Identity=24.3961352657005, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1786229, Length=392, Percent_Identity=22.4489795918367, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790463, Length=417, Percent_Identity=23.9808153477218, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788068, Length=445, Percent_Identity=23.5955056179775, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87082404, Length=378, Percent_Identity=23.2804232804233, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32564663, Length=445, Percent_Identity=22.6966292134831, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24640198, Length=469, Percent_Identity=23.8805970149254, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24640196, Length=469, Percent_Identity=23.8805970149254, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24640200, Length=469, Percent_Identity=23.8805970149254, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI19922874, Length=429, Percent_Identity=21.9114219114219, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161077756, Length=494, Percent_Identity=22.4696356275304, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47850; Mature: 47850

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEAARIDAAAVINDNNISRFQYRIFILATLIMMCDGFDTQAVAYVAPSIVAEWNMAPGS
CCCCHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
FGPVFAALLLGSMVGAFAFGYLADKIGRKYTLAGCVALFGILNFASAYATSIETFTVLRF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LCGIGLGGTVPNVTSLVSEYAPARKRATLVAITWAGFGLGAVVGGLISVPLISHFGWPAV
HHCCCCCCCCCHHHHHHHHHCCHHHCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHH
FIAGGILPLLLLPFIFFSVPESIKFLILAGGKGAAVASILKLICPSGSFKDNDVFVLEES
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCEEEEECC
RPGRGQISALFKDGLAIGSIFLCLAFFMSLLLVYLFINWIPLLLRQAGLPLQHAVMGTII
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
FNLAGIIGSVFCTQLIDRKVARPVSILIAAYFIGAAAVFSIGYAGTAFWPIMITIFLSGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
FIIGVQLSLNAFITNYYPTSIRGTGVGWSQVIGRLGSLLGPLIGGALVSQGMAPSQLFQV
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
SAVAPLLACVSLLIFARLSRADPKGQPAISDAAA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLEAARIDAAAVINDNNISRFQYRIFILATLIMMCDGFDTQAVAYVAPSIVAEWNMAPGS
CCCCHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
FGPVFAALLLGSMVGAFAFGYLADKIGRKYTLAGCVALFGILNFASAYATSIETFTVLRF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LCGIGLGGTVPNVTSLVSEYAPARKRATLVAITWAGFGLGAVVGGLISVPLISHFGWPAV
HHCCCCCCCCCHHHHHHHHHCCHHHCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHH
FIAGGILPLLLLPFIFFSVPESIKFLILAGGKGAAVASILKLICPSGSFKDNDVFVLEES
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCEEEEECC
RPGRGQISALFKDGLAIGSIFLCLAFFMSLLLVYLFINWIPLLLRQAGLPLQHAVMGTII
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
FNLAGIIGSVFCTQLIDRKVARPVSILIAAYFIGAAAVFSIGYAGTAFWPIMITIFLSGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
FIIGVQLSLNAFITNYYPTSIRGTGVGWSQVIGRLGSLLGPLIGGALVSQGMAPSQLFQV
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
SAVAPLLACVSLLIFARLSRADPKGQPAISDAAA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8063101 [H]