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The map label for this gene is pcaR [H]

Identifier: 110635155

GI number: 110635155

Start: 3070952

End: 3071746

Strand: Reverse

Name: pcaR [H]

Synonym: Meso_2822

Alternate gene names: 110635155

Gene position: 3071746-3070952 (Counterclockwise)

Preceding gene: 110635159

Following gene: 110635154

Centisome position: 69.62

GC content: 64.65

Gene sequence:

>795_bases
ATGAGTGAGACGGTTGCGTCAATGGAACGCGAGCCTGAACAGCGTGACCTGGTGGGGTCGCTGGCAAAAGGGCTTGGCGT
GCTGGAAATCCTGTCGGCGGCGCCTGGCGGCCTGAGGCTGACGGAGGTGGCGGAGGCGGCAGGGCTGACGCGCGCGGGCG
CACGCCGGCTGCTGCTTACGCTGGTTGCTGAAGGCTATGCCCAGCAGAAGGGGCGGCAATTCGTGCTTTCGGCCAAGCTG
ATCTCGCTGTGCCGGGTGTGGCTGGGCGGAGGGTCCATCTGGTCCCTCGCTGAACCTATCCTGCGCGAGGTTTCACAGGA
CGTGGGCGAATCCTGTTCGGCGGCGGTTCTGGAGGGTGAAGATGTCGTCTATGTGGCTCGTGTGGCCGGAAGGCGCATCG
TTTCCGTCTCCCTGTCGGTAGGAACGCGATTGCCGGCCTACTGCACTTCCATGGGGCGGGTGCTTCTTTCAGGCCTGGAC
GATGCCGAACTCGCCCGTCTTCTGGACAAGGCGAGCATTCGCGCCAACACGCCCAAGACGTTGACGGACCGGCAGGCCCT
TGCGGCCCGCGTGGCTGATGTCCGGCGGGCAGGCTATGCCATCGTTGACGAGGAACTCGAGCTGGGGCTGCGGTCGATTG
CCGTGCCCGTGCGATCGCGGACGGGTGCCGTGGTGGCGGCGGTCAACATCTCCACGCAATCGGCACGTTTTTCCTGTGAG
GAGATGCGGGAGATCCTCCTGCCGCCCCTTCTTGAGGCCGCGGCCAAAATCGAGGACCTTCTCGCATTCCAATAA

Upstream 100 bases:

>100_bases
ATTCTCTCGTACCGCCTGTTCCAGCGGCATGAAGCGCGCCATCATCGCCTCCAAAATGTTCGTATTGCGAACATAAGTTT
TTTATGCGATACGTAATTAG

Downstream 100 bases:

>100_bases
GCACCTGGGCGCTTTCATGCGGCGCTCCGCGAATTATCAGGTTCCTTTGCGTTCTCCAGCACCTCCCGCATCTTCCGGGT
GAGGCGCGTTTGAAGCCGCG

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSETVASMEREPEQRDLVGSLAKGLGVLEILSAAPGGLRLTEVAEAAGLTRAGARRLLLTLVAEGYAQQKGRQFVLSAKL
ISLCRVWLGGGSIWSLAEPILREVSQDVGESCSAAVLEGEDVVYVARVAGRRIVSVSLSVGTRLPAYCTSMGRVLLSGLD
DAELARLLDKASIRANTPKTLTDRQALAARVADVRRAGYAIVDEELELGLRSIAVPVRSRTGAVVAAVNISTQSARFSCE
EMREILLPPLLEAAAKIEDLLAFQ

Sequences:

>Translated_264_residues
MSETVASMEREPEQRDLVGSLAKGLGVLEILSAAPGGLRLTEVAEAAGLTRAGARRLLLTLVAEGYAQQKGRQFVLSAKL
ISLCRVWLGGGSIWSLAEPILREVSQDVGESCSAAVLEGEDVVYVARVAGRRIVSVSLSVGTRLPAYCTSMGRVLLSGLD
DAELARLLDKASIRANTPKTLTDRQALAARVADVRRAGYAIVDEELELGLRSIAVPVRSRTGAVVAAVNISTQSARFSCE
EMREILLPPLLEAAAKIEDLLAFQ
>Mature_263_residues
SETVASMEREPEQRDLVGSLAKGLGVLEILSAAPGGLRLTEVAEAAGLTRAGARRLLLTLVAEGYAQQKGRQFVLSAKLI
SLCRVWLGGGSIWSLAEPILREVSQDVGESCSAAVLEGEDVVYVARVAGRRIVSVSLSVGTRLPAYCTSMGRVLLSGLDD
AELARLLDKASIRANTPKTLTDRQALAARVADVRRAGYAIVDEELELGLRSIAVPVRSRTGAVVAAVNISTQSARFSCEE
MREILLPPLLEAAAKIEDLLAFQ

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1786468, Length=228, Percent_Identity=31.140350877193, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788131, Length=253, Percent_Identity=30.4347826086957, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87082359, Length=232, Percent_Identity=28.8793103448276, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1789999, Length=268, Percent_Identity=29.1044776119403, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1786715, Length=230, Percent_Identity=25.2173913043478, Blast_Score=86, Evalue=2e-18,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 28096; Mature: 27965

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETVASMEREPEQRDLVGSLAKGLGVLEILSAAPGGLRLTEVAEAAGLTRAGARRLLLT
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHH
LVAEGYAQQKGRQFVLSAKLISLCRVWLGGGSIWSLAEPILREVSQDVGESCSAAVLEGE
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHCHHEECCC
DVVYVARVAGRRIVSVSLSVGTRLPAYCTSMGRVLLSGLDDAELARLLDKASIRANTPKT
CEEEEEEHHCCEEEEEEHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
LTDRQALAARVADVRRAGYAIVDEELELGLRSIAVPVRSRTGAVVAAVNISTQSARFSCE
HHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHCCHH
EMREILLPPLLEAAAKIEDLLAFQ
HHHHHHCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SETVASMEREPEQRDLVGSLAKGLGVLEILSAAPGGLRLTEVAEAAGLTRAGARRLLLT
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHH
LVAEGYAQQKGRQFVLSAKLISLCRVWLGGGSIWSLAEPILREVSQDVGESCSAAVLEGE
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHCHHEECCC
DVVYVARVAGRRIVSVSLSVGTRLPAYCTSMGRVLLSGLDDAELARLLDKASIRANTPKT
CEEEEEEHHCCEEEEEEHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
LTDRQALAARVADVRRAGYAIVDEELELGLRSIAVPVRSRTGAVVAAVNISTQSARFSCE
HHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHCCHH
EMREILLPPLLEAAAKIEDLLAFQ
HHHHHHCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]