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The map label for this gene is hisN [H]

Identifier: 110635082

GI number: 110635082

Start: 2994379

End: 2995158

Strand: Reverse

Name: hisN [H]

Synonym: Meso_2748

Alternate gene names: 110635082

Gene position: 2995158-2994379 (Counterclockwise)

Preceding gene: 110635083

Following gene: 110635080

Centisome position: 67.88

GC content: 63.97

Gene sequence:

>780_bases
ATGGCCAACCACCCTTCGCCCGACTTCCTGCGTCGAATTGCTGCTGCGGCGGCGGCTGAAACCTTACCGCGCTTCCGCCA
GAACGGCGCCGTCGTTAATAAGGCTTCAGGCTCTTTCGATCCGGTGACGGAGGCGGACCGGGCGGCGGAAGAGGCCATCC
GCCGCCTTATCCGCGAGCATTTCCCCGATCACGGCATCATAGGTGAAGAGTTCGGTGCGGAAAAAGGCGACAGCAGCCAT
CTCTGGATTATCGATCCCATCGACGGTACGCGCGCCTTCATTTCGGGCTTGCCGCTCTGGGGCACCCTCGTCGGACTGAC
GGTGGAAGGCGACGCGGTGGCGGGCCTGATGTCGCAGCCCTTTACGGGTGAGCTCTATTACGCGGATGGCGGCGGAGCAT
ATTATGAGGGGCCGGGCAGCCCACGCAGGTTAACGACGCGCCGCACCACCACCCTCGCCGATGCAACGCTGTGCACCACG
ACACCTTCGCTCTTCGATGGCAAGCGGCGTCCCCTTTATGACAGGGTGGAGCAGGCGGTGAGGCTGCCGCGCTACGGCAC
CGATTGCTATGGCTATGCTATGGTCGCCGCGGGCCACGTGGATCTGGTGATAGAAAGCGGTTTGCAGTCCTACGATATCG
TCGCGCTGATCCCCATTATCGAGCAGGCCGGGGGCGTGGTGACCACCTGGGCGGGAGCGCCGGCTGAGGCGGGAGGAGAT
ATCGTTGCCGCCGCGACGCCGGAGCTGCATTCACGGGCGCTGGAATTCCTGCAGGGGTAA

Upstream 100 bases:

>100_bases
CTATAAACTTTTTGGATCTACGCATCGTGCTTCCGAAACCGCTTTCGGATTTTTGGAGCGATGCGCTAGCCACTCGCTTC
GCGCGCCCCTGGGGACCAAA

Downstream 100 bases:

>100_bases
CTACATCCCCACAGGCTCGTTTGCGGCGGCTCTTTCCTGGTGGCCCTTTGCGAAGGTCTCGAAGGCGGCGAGAGCCTGTT
CCCGAAACATATCGACCTCC

Product: histidinol-phosphate phosphatase, putative

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MANHPSPDFLRRIAAAAAAETLPRFRQNGAVVNKASGSFDPVTEADRAAEEAIRRLIREHFPDHGIIGEEFGAEKGDSSH
LWIIDPIDGTRAFISGLPLWGTLVGLTVEGDAVAGLMSQPFTGELYYADGGGAYYEGPGSPRRLTTRRTTTLADATLCTT
TPSLFDGKRRPLYDRVEQAVRLPRYGTDCYGYAMVAAGHVDLVIESGLQSYDIVALIPIIEQAGGVVTTWAGAPAEAGGD
IVAAATPELHSRALEFLQG

Sequences:

>Translated_259_residues
MANHPSPDFLRRIAAAAAAETLPRFRQNGAVVNKASGSFDPVTEADRAAEEAIRRLIREHFPDHGIIGEEFGAEKGDSSH
LWIIDPIDGTRAFISGLPLWGTLVGLTVEGDAVAGLMSQPFTGELYYADGGGAYYEGPGSPRRLTTRRTTTLADATLCTT
TPSLFDGKRRPLYDRVEQAVRLPRYGTDCYGYAMVAAGHVDLVIESGLQSYDIVALIPIIEQAGGVVTTWAGAPAEAGGD
IVAAATPELHSRALEFLQG
>Mature_258_residues
ANHPSPDFLRRIAAAAAAETLPRFRQNGAVVNKASGSFDPVTEADRAAEEAIRRLIREHFPDHGIIGEEFGAEKGDSSHL
WIIDPIDGTRAFISGLPLWGTLVGLTVEGDAVAGLMSQPFTGELYYADGGGAYYEGPGSPRRLTTRRTTTLADATLCTTT
PSLFDGKRRPLYDRVEQAVRLPRYGTDCYGYAMVAAGHVDLVIESGLQSYDIVALIPIIEQAGGVVTTWAGAPAEAGGDI
VAAATPELHSRALEFLQG

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI7657236, Length=241, Percent_Identity=30.2904564315353, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI5031789, Length=251, Percent_Identity=28.6852589641434, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI221625487, Length=251, Percent_Identity=28.6852589641434, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI1788882, Length=237, Percent_Identity=31.6455696202532, Blast_Score=93, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI193202570, Length=254, Percent_Identity=31.8897637795276, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI193202572, Length=253, Percent_Identity=31.2252964426877, Blast_Score=100, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6320493, Length=209, Percent_Identity=29.6650717703349, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357329, Length=226, Percent_Identity=32.7433628318584, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24664922, Length=233, Percent_Identity=32.1888412017167, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24664918, Length=253, Percent_Identity=30.4347826086957, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21357957, Length=260, Percent_Identity=26.9230769230769, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24664926, Length=236, Percent_Identity=27.5423728813559, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21357303, Length=235, Percent_Identity=29.3617021276596, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 27628; Mature: 27497

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANHPSPDFLRRIAAAAAAETLPRFRQNGAVVNKASGSFDPVTEADRAAEEAIRRLIREH
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
FPDHGIIGEEFGAEKGDSSHLWIIDPIDGTRAFISGLPLWGTLVGLTVEGDAVAGLMSQP
CCCCCCCCHHHCCCCCCCCEEEEEECCCCHHHHHCCCCHHHEEEEEEECCHHHHHHHCCC
FTGELYYADGGGAYYEGPGSPRRLTTRRTTTLADATLCTTTPSLFDGKRRPLYDRVEQAV
CCCEEEEECCCCCEECCCCCCCEEEECHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHH
RLPRYGTDCYGYAMVAAGHVDLVIESGLQSYDIVALIPIIEQAGGVVTTWAGAPAEAGGD
HCCCCCCCHHHHHHHHCCHHHHHHHCCCCCCCHHHHEEHHHHCCCEEEECCCCCCCCCCC
IVAAATPELHSRALEFLQG
EEEECCHHHHHHHHHHHCC
>Mature Secondary Structure 
ANHPSPDFLRRIAAAAAAETLPRFRQNGAVVNKASGSFDPVTEADRAAEEAIRRLIREH
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
FPDHGIIGEEFGAEKGDSSHLWIIDPIDGTRAFISGLPLWGTLVGLTVEGDAVAGLMSQP
CCCCCCCCHHHCCCCCCCCEEEEEECCCCHHHHHCCCCHHHEEEEEEECCHHHHHHHCCC
FTGELYYADGGGAYYEGPGSPRRLTTRRTTTLADATLCTTTPSLFDGKRRPLYDRVEQAV
CCCEEEEECCCCCEECCCCCCCEEEECHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHH
RLPRYGTDCYGYAMVAAGHVDLVIESGLQSYDIVALIPIIEQAGGVVTTWAGAPAEAGGD
HCCCCCCCHHHHHHHHCCHHHHHHHCCCCCCCHHHHEEHHHHCCCEEEECCCCCCCCCCC
IVAAATPELHSRALEFLQG
EEEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]