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The map label for this gene is hemH

Identifier: 110635058

GI number: 110635058

Start: 2961319

End: 2962380

Strand: Reverse

Name: hemH

Synonym: Meso_2724

Alternate gene names: 110635058

Gene position: 2962380-2961319 (Counterclockwise)

Preceding gene: 110635059

Following gene: 110635057

Centisome position: 67.14

GC content: 61.39

Gene sequence:

>1062_bases
ATGACACTCGAAAGGACCGGCCGGGACGAAGAGAAGGCTTTGACGCAGCCGCCCTCGGGGCATTCCTCCGTTCAGGCCGG
CAAGGTCGGCGTTCTTCTTGTCAATCTTGGCACTCCCGACGGCACGGATTACTGGCCCATGCGGCGCTATCTTGGCGAGT
TCCTGTCCGACCGCCGGGTGATCGAGTGGCCGCGGGCGGTCTGGTATCCGATCCTTTACGGAATCATCCTTGCCCGGAGG
CCAAAGAAATCCGGCGCGCTCTACGCGAAGATCTGGAACAGGGAGCAAAATGAATCGCCTCTGCGCACTTTCACCCGCGC
GCAGGGGCAGAAGCTCGCCACCGCTCTCGCAGACAAGGAGAACGTCATCGTCGATTGGGCGATGCGCTATGGCAGCCCTT
CGATCGAAACGGTGACGAAGAGCCTCATCGAGCGCGGTTGCGACCGTATCGTGATGTTTCCGCTTTATCCGCAATATTCG
GCAACGACCACGGCGACGGTGAACGACAAGTTCTTCGAAGCGCTGATTGAGATGCGTCACCAGCCGGCGGTCCGCACCGT
GCCCGCCTATCCGGAAGAGCCGGTCTATATCGATGCGCTTGTCCGTTCCATCGAGCGGCATTTGGCGACCCTTGACTTCG
AGCCGGAGGTGGTGGTCGCGTCCTATCATGGCATCCCGCAGAGCTACGCGCGGCGCGGCGATCCATATTATGAGCAGTGC
CTGGCGACCACGGCGCGCGTGCGCGAGCGGCTCGGCTGGGACGAGAAGAAGCTCATCACCACCTTCCAATCCCGCTTCGG
CCCGGAAGAATGGCTACAGCCCTACACGGACAAGACCGTGGAGCAGTTGGCGCGCGACGGTGTGAGGTCCATCGCCGTGA
TCAACCCTGGCTTTGTCTCCGACTGCCTGGAGACGCTGGAAGAAATCGCCGTCGAGGCCGACAGAACTTTCCGCGAGGCC
GGTGGCAAAAACTTCACCCACATCCCCTGTCTGAACGACAGCGATGAAGGCATGGCTGTCATCGAGTCGCTTATCCGCCG
CGAGATGTCAGGCTGGGCCTAA

Upstream 100 bases:

>100_bases
ATGCCGCGCGCCGCAGCGGCATTTTCCCTCCTGCGGCTAGAAGTGGCATTGCTTTCGCGCCGAAATCATCTACCTGCCAT
GGTTATCCAAGGAGCGTAAG

Downstream 100 bases:

>100_bases
TAGCCCGGCGCCTTCGCCTTCGCGCCGAGAATTTTAACCTGCCCCCCCAACGGGCGCCTTCCATCTTCACAGTATTCCAA
ACAGCCCCTTTCCATCGGGC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MTLERTGRDEEKALTQPPSGHSSVQAGKVGVLLVNLGTPDGTDYWPMRRYLGEFLSDRRVIEWPRAVWYPILYGIILARR
PKKSGALYAKIWNREQNESPLRTFTRAQGQKLATALADKENVIVDWAMRYGSPSIETVTKSLIERGCDRIVMFPLYPQYS
ATTTATVNDKFFEALIEMRHQPAVRTVPAYPEEPVYIDALVRSIERHLATLDFEPEVVVASYHGIPQSYARRGDPYYEQC
LATTARVRERLGWDEKKLITTFQSRFGPEEWLQPYTDKTVEQLARDGVRSIAVINPGFVSDCLETLEEIAVEADRTFREA
GGKNFTHIPCLNDSDEGMAVIESLIRREMSGWA

Sequences:

>Translated_353_residues
MTLERTGRDEEKALTQPPSGHSSVQAGKVGVLLVNLGTPDGTDYWPMRRYLGEFLSDRRVIEWPRAVWYPILYGIILARR
PKKSGALYAKIWNREQNESPLRTFTRAQGQKLATALADKENVIVDWAMRYGSPSIETVTKSLIERGCDRIVMFPLYPQYS
ATTTATVNDKFFEALIEMRHQPAVRTVPAYPEEPVYIDALVRSIERHLATLDFEPEVVVASYHGIPQSYARRGDPYYEQC
LATTARVRERLGWDEKKLITTFQSRFGPEEWLQPYTDKTVEQLARDGVRSIAVINPGFVSDCLETLEEIAVEADRTFREA
GGKNFTHIPCLNDSDEGMAVIESLIRREMSGWA
>Mature_352_residues
TLERTGRDEEKALTQPPSGHSSVQAGKVGVLLVNLGTPDGTDYWPMRRYLGEFLSDRRVIEWPRAVWYPILYGIILARRP
KKSGALYAKIWNREQNESPLRTFTRAQGQKLATALADKENVIVDWAMRYGSPSIETVTKSLIERGCDRIVMFPLYPQYSA
TTTATVNDKFFEALIEMRHQPAVRTVPAYPEEPVYIDALVRSIERHLATLDFEPEVVVASYHGIPQSYARRGDPYYEQCL
ATTARVRERLGWDEKKLITTFQSRFGPEEWLQPYTDKTVEQLARDGVRSIAVINPGFVSDCLETLEEIAVEADRTFREAG
GKNFTHIPCLNDSDEGMAVIESLIRREMSGWA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=336, Percent_Identity=25.5952380952381, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI60499021, Length=330, Percent_Identity=25.7575757575758, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI1786681, Length=318, Percent_Identity=42.7672955974843, Blast_Score=246, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6324750, Length=329, Percent_Identity=23.1003039513678, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17864156, Length=312, Percent_Identity=25.3205128205128, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24651774, Length=271, Percent_Identity=25.0922509225092, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_MESSB (Q11ES4)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_675266.1
- ProteinModelPortal:   Q11ES4
- SMR:   Q11ES4
- STRING:   Q11ES4
- GeneID:   4180424
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_2724
- NMPDR:   fig|266779.1.peg.1258
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   IRPAKSA
- PhylomeDB:   Q11ES4
- ProtClustDB:   PRK00035
- BioCyc:   MSP266779:MESO_2724-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 40169; Mature: 40038

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLERTGRDEEKALTQPPSGHSSVQAGKVGVLLVNLGTPDGTDYWPMRRYLGEFLSDRRV
CCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCC
IEWPRAVWYPILYGIILARRPKKSGALYAKIWNREQNESPLRTFTRAQGQKLATALADKE
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCC
NVIVDWAMRYGSPSIETVTKSLIERGCDRIVMFPLYPQYSATTTATVNDKFFEALIEMRH
CEEEEHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHC
QPAVRTVPAYPEEPVYIDALVRSIERHLATLDFEPEVVVASYHGIPQSYARRGDPYYEQC
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHCCCHHHHHH
LATTARVRERLGWDEKKLITTFQSRFGPEEWLQPYTDKTVEQLARDGVRSIAVINPGFVS
HHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHCCHHEEEEECCHHHH
DCLETLEEIAVEADRTFREAGGKNFTHIPCLNDSDEGMAVIESLIRREMSGWA
HHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TLERTGRDEEKALTQPPSGHSSVQAGKVGVLLVNLGTPDGTDYWPMRRYLGEFLSDRRV
CCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCC
IEWPRAVWYPILYGIILARRPKKSGALYAKIWNREQNESPLRTFTRAQGQKLATALADKE
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCC
NVIVDWAMRYGSPSIETVTKSLIERGCDRIVMFPLYPQYSATTTATVNDKFFEALIEMRH
CEEEEHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHC
QPAVRTVPAYPEEPVYIDALVRSIERHLATLDFEPEVVVASYHGIPQSYARRGDPYYEQC
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHCCCHHHHHH
LATTARVRERLGWDEKKLITTFQSRFGPEEWLQPYTDKTVEQLARDGVRSIAVINPGFVS
HHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHCCHHEEEEECCHHHH
DCLETLEEIAVEADRTFREAGGKNFTHIPCLNDSDEGMAVIESLIRREMSGWA
HHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA