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The map label for this gene is nrdB [H]

Identifier: 110635036

GI number: 110635036

Start: 2937619

End: 2938728

Strand: Reverse

Name: nrdB [H]

Synonym: Meso_2702

Alternate gene names: 110635036

Gene position: 2938728-2937619 (Counterclockwise)

Preceding gene: 110635037

Following gene: 110635035

Centisome position: 66.6

GC content: 59.73

Gene sequence:

>1110_bases
ATGCTGACTTGGAACGAATATACCGATCCTTCCCAATCGCCCTCCGCCGGCGAGACAGACGCCACCGGCCTCGGCACAAT
CGAACGGGGGGCGGGGCGCGTGTCGGTGGACGACAAGCGCATGATCAATGCGCGGGCGGACGTAAACCAGCTGCTACCGC
TGAAATACCGCTGGGCATGGGAAAAATATCTGTCGGGGTGCAACAATCATTGGATGCCGACTGAGGTTTCCATGCAGGCC
GACATCGCGCTGTGGAAGTCGCGCGACGGGCTGACGGAGGACGAGAGGCGCATGGTCAAGCGCAATCTCGGCTTCTTCGC
GGCTTCCGAATCGCTGGTGGCCAACAACATCGTGCTTGCGATCTACCGCCACCTGACCAATCCCGAATGCCGGCAGTATC
TCCTGCGCCAGGCTTTCGAGGAGGCGGTGCACACGCACACATTCCAATACATTGTGGAAAGCCTGGGCCTGGACGAGGGC
GAGCTGTTCAACATGTATCGCGAGGTGCCGTCCATCACCGACAAGGCGGCCTGGGCGCTGGAATACACACGCCATCTGGA
CGACCCGAATTTCCGCACCGGCACACCCGAAGCCGACCAGGCCTTCCTGCGCGATCTCGTGGCCTTCTACGTGATTTTCG
AGGGGATGTGGTTCTATACTGGGTTCGCGCAGATCCTCTCGCTCGGCCGGCGCAACAAAATGGTGGGGATTGCCGAGCAG
TACCAGTATATCCTGCGCGACGAGTCGATCCATTTGAATTTCGGCATCGATGTCATCAACCAGATCAAGCACGAGAACCC
GCATCTGTGGACGCCTGAATTTCAGGAGGAGTTGCGCCGCATGTTGAAGGACGCCGCCGAGCTGGAGGCGGCCTATGGGC
GCGATACCATGCCGCGTGGCTTTCTCGGCCTCAATGCCGGGCAGTGCGAGCAGTATATGCATTTCATCGCCAACCGGCGT
TGCGCCCAGCTTGGGCTCCCGCCGGTGTTCCCAGAGACGGAAAACCCGTTCCCATGGATGTCGGAAGCGATGGACCTCAA
GAAAGAGAAGAACTTCTTCGAGACGCGGGTGATCGAATACCAGAACGGAGGGGCGCTCAGTTGGGATTGA

Upstream 100 bases:

>100_bases
CAACCCCGCCCTCGCTGACTTCGTTCGCGACCACCCATCTCACAAGGGGGAGGGTGGGCCGCCGGCTCACAAAGAGCCAC
AAGAATCTCCGGAGAACCAA

Downstream 100 bases:

>100_bases
GCATCGGCCCAAGCGTCAGCTAGGACTTAAAGACATAAACATTTCTTTATATCATTCTTGACTCTCAACCTCGTTTGAGC
AAATCTGCACACGTCGTGGT

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MLTWNEYTDPSQSPSAGETDATGLGTIERGAGRVSVDDKRMINARADVNQLLPLKYRWAWEKYLSGCNNHWMPTEVSMQA
DIALWKSRDGLTEDERRMVKRNLGFFAASESLVANNIVLAIYRHLTNPECRQYLLRQAFEEAVHTHTFQYIVESLGLDEG
ELFNMYREVPSITDKAAWALEYTRHLDDPNFRTGTPEADQAFLRDLVAFYVIFEGMWFYTGFAQILSLGRRNKMVGIAEQ
YQYILRDESIHLNFGIDVINQIKHENPHLWTPEFQEELRRMLKDAAELEAAYGRDTMPRGFLGLNAGQCEQYMHFIANRR
CAQLGLPPVFPETENPFPWMSEAMDLKKEKNFFETRVIEYQNGGALSWD

Sequences:

>Translated_369_residues
MLTWNEYTDPSQSPSAGETDATGLGTIERGAGRVSVDDKRMINARADVNQLLPLKYRWAWEKYLSGCNNHWMPTEVSMQA
DIALWKSRDGLTEDERRMVKRNLGFFAASESLVANNIVLAIYRHLTNPECRQYLLRQAFEEAVHTHTFQYIVESLGLDEG
ELFNMYREVPSITDKAAWALEYTRHLDDPNFRTGTPEADQAFLRDLVAFYVIFEGMWFYTGFAQILSLGRRNKMVGIAEQ
YQYILRDESIHLNFGIDVINQIKHENPHLWTPEFQEELRRMLKDAAELEAAYGRDTMPRGFLGLNAGQCEQYMHFIANRR
CAQLGLPPVFPETENPFPWMSEAMDLKKEKNFFETRVIEYQNGGALSWD
>Mature_369_residues
MLTWNEYTDPSQSPSAGETDATGLGTIERGAGRVSVDDKRMINARADVNQLLPLKYRWAWEKYLSGCNNHWMPTEVSMQA
DIALWKSRDGLTEDERRMVKRNLGFFAASESLVANNIVLAIYRHLTNPECRQYLLRQAFEEAVHTHTFQYIVESLGLDEG
ELFNMYREVPSITDKAAWALEYTRHLDDPNFRTGTPEADQAFLRDLVAFYVIFEGMWFYTGFAQILSLGRRNKMVGIAEQ
YQYILRDESIHLNFGIDVINQIKHENPHLWTPEFQEELRRMLKDAAELEAAYGRDTMPRGFLGLNAGQCEQYMHFIANRR
CAQLGLPPVFPETENPFPWMSEAMDLKKEKNFFETRVIEYQNGGALSWD

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI4557845, Length=359, Percent_Identity=28.6908077994429, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI42544136, Length=362, Percent_Identity=27.0718232044199, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI260064013, Length=359, Percent_Identity=28.6908077994429, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI289177074, Length=364, Percent_Identity=26.6483516483516, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI289177076, Length=296, Percent_Identity=29.7297297297297, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1788567, Length=292, Percent_Identity=23.6301369863014, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17551968, Length=319, Percent_Identity=28.2131661442006, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI193206379, Length=304, Percent_Identity=23.6842105263158, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17567153, Length=224, Percent_Identity=25, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322434, Length=331, Percent_Identity=31.1178247734139, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6321619, Length=330, Percent_Identity=22.1212121212121, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI18079279, Length=320, Percent_Identity=28.4375, Blast_Score=141, Evalue=9e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 42738; Mature: 42738

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTWNEYTDPSQSPSAGETDATGLGTIERGAGRVSVDDKRMINARADVNQLLPLKYRWAW
CCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHCHHHHCCCHHHHHH
EKYLSGCNNHWMPTEVSMQADIALWKSRDGLTEDERRMVKRNLGFFAASESLVANNIVLA
HHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHCCCHHHHHHHHHH
IYRHLTNPECRQYLLRQAFEEAVHTHTFQYIVESLGLDEGELFNMYREVPSITDKAAWAL
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHH
EYTRHLDDPNFRTGTPEADQAFLRDLVAFYVIFEGMWFYTGFAQILSLGRRNKMVGIAEQ
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHH
YQYILRDESIHLNFGIDVINQIKHENPHLWTPEFQEELRRMLKDAAELEAAYGRDTMPRG
HHHHHCCCCEEEEECHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
FLGLNAGQCEQYMHFIANRRCAQLGLPPVFPETENPFPWMSEAMDLKKEKNFFETRVIEY
CCCCCHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEE
QNGGALSWD
CCCCCCCCC
>Mature Secondary Structure
MLTWNEYTDPSQSPSAGETDATGLGTIERGAGRVSVDDKRMINARADVNQLLPLKYRWAW
CCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHCHHHHCCCHHHHHH
EKYLSGCNNHWMPTEVSMQADIALWKSRDGLTEDERRMVKRNLGFFAASESLVANNIVLA
HHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHCCCHHHHHHHHHH
IYRHLTNPECRQYLLRQAFEEAVHTHTFQYIVESLGLDEGELFNMYREVPSITDKAAWAL
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHH
EYTRHLDDPNFRTGTPEADQAFLRDLVAFYVIFEGMWFYTGFAQILSLGRRNKMVGIAEQ
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHH
YQYILRDESIHLNFGIDVINQIKHENPHLWTPEFQEELRRMLKDAAELEAAYGRDTMPRG
HHHHHCCCCEEEEECHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
FLGLNAGQCEQYMHFIANRRCAQLGLPPVFPETENPFPWMSEAMDLKKEKNFFETRVIEY
CCCCCHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEE
QNGGALSWD
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]