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The map label for this gene is patB [H]

Identifier: 110634977

GI number: 110634977

Start: 2854831

End: 2856375

Strand: Reverse

Name: patB [H]

Synonym: Meso_2643

Alternate gene names: 110634977

Gene position: 2856375-2854831 (Counterclockwise)

Preceding gene: 110634978

Following gene: 110634976

Centisome position: 64.73

GC content: 60.39

Gene sequence:

>1545_bases
ATGCCGGATAGCAAAATCGGGATAGTCGAAAAGATCGCCCTCCTCAGTGAGGCAGATTTCAACGCCATCCTAAGGCAAGC
CGGTAAACCCGTTGCGGTGTTATTCGGTGCGGCATGGTCGTCGTCGTTCCGCGAGATGCGTCAACGGCTAGGAGAGGTTG
CGGACGCTTTGGGAAACTCGGTCAGGATTGCCGCGGTCGACACCGACGAAAACCCCGATCTGACCAAGAGGCTGCGTCTC
CGCTCGCTGCCGACAACGGCGCTTTTAGTCGACGGAGTGGAGATCGCCCGTAACGCATCGCCCATGAGCGTTCCGGAGGC
GGCAGCATGGATCAGGTCCAAACTGGCCAGCCCTGCTGGGGCGCACAACGCCGAAGAGCATTTCTTCCTGGCGCCAGATT
TTCTGCGCAGCCGCGGAAACGTCAAGTGGACGCAGTATGGGCAAGATGTGCTTCCGGCTTTCGTGGCCGAAATGGATTTC
GCGATTGCGCCGCCCATCCAGGCCGCCATCAAGCGGATCGTGGAAAACGAGGACTACGGTTACCCGAAGAGAAAGGGCTT
CGACCGCCCCGAACACTCGATCTCGCAGGCCTTCGCGGATCGAATGGCGCGGCTGTATGGCTGGAAGATAAACCGAGACG
ACGTGCAGCCGCTCGCGGATCTCGTACAGGCGACCTATGCGACCATTCAGGCGTTTTCCGACGAAGGTGATGGGGTTCTG
CTCCAGACTCCGGCCTATCCGCCGTTTTATGAAGCCATCAAGGATACGAGACGCGTCTTGCTTTCCGTTCCGATGGTCAG
CACGGGAACGCGTTTCGAATTCGATTTTGCCAGCCTCGAGGCACAGGCGGGCAAAGCGCGGATGATTGCCCTCTGCAATC
CCCACAATCCCGTGGGGCGGGTTTTGACCCGGGAAGAGCTTACGGAGATAGGGCGCATCGCGATCGCCCATAATCTTGTC
ATCGTTTCCGACGAGATTCATTCCGAACTGATCTACGACGGCGAAAGCCATACGCCGATCGCCTCCATCAGCCCGCAGAT
CGCAGCGCGGACCGTGACGATCAACTCGCCCACCAAAGCTTTCAACATTCCGGGACTGCGCTGCGCCGTCATGCATTTCG
GCTCTTCCGAGCTTCGCGACCGTTTCCTCCGGCGTGTGCCGAAGAAGACATTGGGCCAGGTCAGCGTTATCGGCATCGAG
GCCGCGGTGGCCGCATGGCGGGACGGCGACGCTTGGCTCGAGAAGACCGTGGCACACCTGAAGAGGATGCGCGATCTCTG
CGCGCGGCAGATCGCCGAGACGATGCCAAAGATAAAATTCATAAAGCCGGAAGCCACCTATCTTGCCTGGCTCGACTGCT
CGGCACTCGGCTTGAACAAGCCTGCCGCAGCCTTCTTCGCGGAGCATGCGAAGGTGGGACTAAGCGCGGGAGAGACCTTC
GACCCCGAGGCGCACCAGTTCGTCCGGCTGAACTTCGCCGCGTCGGAGCCGGTGCTGCGGGACATTTTGGGTCGCATGGC
CGGCGCCGCCGCAAAGCTCGGATAA

Upstream 100 bases:

>100_bases
CGACGATCGACCTTTCGCCCTTTGCCTTCGAGCGCTTCACCAAAGGCAACAGCCCCTGGGACCTCATTAATCACCAGCTG
CAGGAAGTGGGATGATGGAT

Downstream 100 bases:

>100_bases
GGCAGCCGGAGCAAAACAGGGAGGCTGGAATGTCAACAAATCAGAAAGCGCCGCCGGTCGTTTCGGCAGAGTGGCTGCTC
GCCCATCTTAACGACGCCGA

Product: aminotransferase, class I and II

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MPDSKIGIVEKIALLSEADFNAILRQAGKPVAVLFGAAWSSSFREMRQRLGEVADALGNSVRIAAVDTDENPDLTKRLRL
RSLPTTALLVDGVEIARNASPMSVPEAAAWIRSKLASPAGAHNAEEHFFLAPDFLRSRGNVKWTQYGQDVLPAFVAEMDF
AIAPPIQAAIKRIVENEDYGYPKRKGFDRPEHSISQAFADRMARLYGWKINRDDVQPLADLVQATYATIQAFSDEGDGVL
LQTPAYPPFYEAIKDTRRVLLSVPMVSTGTRFEFDFASLEAQAGKARMIALCNPHNPVGRVLTREELTEIGRIAIAHNLV
IVSDEIHSELIYDGESHTPIASISPQIAARTVTINSPTKAFNIPGLRCAVMHFGSSELRDRFLRRVPKKTLGQVSVIGIE
AAVAAWRDGDAWLEKTVAHLKRMRDLCARQIAETMPKIKFIKPEATYLAWLDCSALGLNKPAAAFFAEHAKVGLSAGETF
DPEAHQFVRLNFAASEPVLRDILGRMAGAAAKLG

Sequences:

>Translated_514_residues
MPDSKIGIVEKIALLSEADFNAILRQAGKPVAVLFGAAWSSSFREMRQRLGEVADALGNSVRIAAVDTDENPDLTKRLRL
RSLPTTALLVDGVEIARNASPMSVPEAAAWIRSKLASPAGAHNAEEHFFLAPDFLRSRGNVKWTQYGQDVLPAFVAEMDF
AIAPPIQAAIKRIVENEDYGYPKRKGFDRPEHSISQAFADRMARLYGWKINRDDVQPLADLVQATYATIQAFSDEGDGVL
LQTPAYPPFYEAIKDTRRVLLSVPMVSTGTRFEFDFASLEAQAGKARMIALCNPHNPVGRVLTREELTEIGRIAIAHNLV
IVSDEIHSELIYDGESHTPIASISPQIAARTVTINSPTKAFNIPGLRCAVMHFGSSELRDRFLRRVPKKTLGQVSVIGIE
AAVAAWRDGDAWLEKTVAHLKRMRDLCARQIAETMPKIKFIKPEATYLAWLDCSALGLNKPAAAFFAEHAKVGLSAGETF
DPEAHQFVRLNFAASEPVLRDILGRMAGAAAKLG
>Mature_513_residues
PDSKIGIVEKIALLSEADFNAILRQAGKPVAVLFGAAWSSSFREMRQRLGEVADALGNSVRIAAVDTDENPDLTKRLRLR
SLPTTALLVDGVEIARNASPMSVPEAAAWIRSKLASPAGAHNAEEHFFLAPDFLRSRGNVKWTQYGQDVLPAFVAEMDFA
IAPPIQAAIKRIVENEDYGYPKRKGFDRPEHSISQAFADRMARLYGWKINRDDVQPLADLVQATYATIQAFSDEGDGVLL
QTPAYPPFYEAIKDTRRVLLSVPMVSTGTRFEFDFASLEAQAGKARMIALCNPHNPVGRVLTREELTEIGRIAIAHNLVI
VSDEIHSELIYDGESHTPIASISPQIAARTVTINSPTKAFNIPGLRCAVMHFGSSELRDRFLRRVPKKTLGQVSVIGIEA
AVAAWRDGDAWLEKTVAHLKRMRDLCARQIAETMPKIKFIKPEATYLAWLDCSALGLNKPAAAFFAEHAKVGLSAGETFD
PEAHQFVRLNFAASEPVLRDILGRMAGAAAKLG

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=289, Percent_Identity=28.0276816608997, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI56713256, Length=289, Percent_Identity=28.0276816608997, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI95147551, Length=257, Percent_Identity=26.0700389105058, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI169881279, Length=257, Percent_Identity=26.0700389105058, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1787909, Length=347, Percent_Identity=29.6829971181556, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI1788627, Length=193, Percent_Identity=28.4974093264249, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786816, Length=316, Percent_Identity=22.7848101265823, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788722, Length=360, Percent_Identity=24.4444444444444, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994476, Length=181, Percent_Identity=30.3867403314917, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71994472, Length=181, Percent_Identity=30.3867403314917, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17567369, Length=172, Percent_Identity=29.0697674418605, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17567663, Length=190, Percent_Identity=26.8421052631579, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322401, Length=218, Percent_Identity=28.4403669724771, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28573069, Length=282, Percent_Identity=27.3049645390071, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646114, Length=282, Percent_Identity=27.3049645390071, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28573067, Length=282, Percent_Identity=27.3049645390071, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28573065, Length=282, Percent_Identity=27.3049645390071, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 56421; Mature: 56290

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDSKIGIVEKIALLSEADFNAILRQAGKPVAVLFGAAWSSSFREMRQRLGEVADALGNS
CCCCHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCC
VRIAAVDTDENPDLTKRLRLRSLPTTALLVDGVEIARNASPMSVPEAAAWIRSKLASPAG
EEEEEECCCCCCCHHHHHHHHCCCCHHHEECCHHHHCCCCCCCCHHHHHHHHHHHCCCCC
AHNAEEHFFLAPDFLRSRGNVKWTQYGQDVLPAFVAEMDFAIAPPIQAAIKRIVENEDYG
CCCCCCCEEECHHHHHCCCCCCHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCC
YPKRKGFDRPEHSISQAFADRMARLYGWKINRDDVQPLADLVQATYATIQAFSDEGDGVL
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LQTPAYPPFYEAIKDTRRVLLSVPMVSTGTRFEFDFASLEAQAGKARMIALCNPHNPVGR
EECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHCCCCEEEEEEECCCCHHHH
VLTREELTEIGRIAIAHNLVIVSDEIHSELIYDGESHTPIASISPQIAARTVTINSPTKA
HHHHHHHHHHHHHHHHEEEEEEECHHHHHHEECCCCCCCHHHCCCCCEEEEEEECCCCCC
FNIPGLRCAVMHFGSSELRDRFLRRVPKKTLGQVSVIGIEAAVAAWRDGDAWLEKTVAHL
CCCCCCEEEEEECCCHHHHHHHHHHCCHHHHCCEEEEEHHHHHHHCCCCHHHHHHHHHHH
KRMRDLCARQIAETMPKIKFIKPEATYLAWLDCSALGLNKPAAAFFAEHAKVGLSAGETF
HHHHHHHHHHHHHHCCCEEEECCCCCEEEEEECHHCCCCCCHHHHHHHHHHHCCCCCCCC
DPEAHQFVRLNFAASEPVLRDILGRMAGAAAKLG
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PDSKIGIVEKIALLSEADFNAILRQAGKPVAVLFGAAWSSSFREMRQRLGEVADALGNS
CCCHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCC
VRIAAVDTDENPDLTKRLRLRSLPTTALLVDGVEIARNASPMSVPEAAAWIRSKLASPAG
EEEEEECCCCCCCHHHHHHHHCCCCHHHEECCHHHHCCCCCCCCHHHHHHHHHHHCCCCC
AHNAEEHFFLAPDFLRSRGNVKWTQYGQDVLPAFVAEMDFAIAPPIQAAIKRIVENEDYG
CCCCCCCEEECHHHHHCCCCCCHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCC
YPKRKGFDRPEHSISQAFADRMARLYGWKINRDDVQPLADLVQATYATIQAFSDEGDGVL
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LQTPAYPPFYEAIKDTRRVLLSVPMVSTGTRFEFDFASLEAQAGKARMIALCNPHNPVGR
EECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHCCCCEEEEEEECCCCHHHH
VLTREELTEIGRIAIAHNLVIVSDEIHSELIYDGESHTPIASISPQIAARTVTINSPTKA
HHHHHHHHHHHHHHHHEEEEEEECHHHHHHEECCCCCCCHHHCCCCCEEEEEEECCCCCC
FNIPGLRCAVMHFGSSELRDRFLRRVPKKTLGQVSVIGIEAAVAAWRDGDAWLEKTVAHL
CCCCCCEEEEEECCCHHHHHHHHHHCCHHHHCCEEEEEHHHHHHHCCCCHHHHHHHHHHH
KRMRDLCARQIAETMPKIKFIKPEATYLAWLDCSALGLNKPAAAFFAEHAKVGLSAGETF
HHHHHHHHHHHHHHCCCEEEECCCCCEEEEEECHHCCCCCCHHHHHHHHHHHCCCCCCCC
DPEAHQFVRLNFAASEPVLRDILGRMAGAAAKLG
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]