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The map label for this gene is hutH [H]

Identifier: 110634966

GI number: 110634966

Start: 2840746

End: 2842353

Strand: Reverse

Name: hutH [H]

Synonym: Meso_2632

Alternate gene names: 110634966

Gene position: 2842353-2840746 (Counterclockwise)

Preceding gene: 110634967

Following gene: 110634965

Centisome position: 64.42

GC content: 60.26

Gene sequence:

>1608_bases
ATGTCGAGTTCTGACAAAGACCTAGTTCTGGGCACAGGCGCGCTGAAGCCCGAGGACGTTGCCGCGGCGGCGGCAACGTC
CTGCAAGGTACTGCCAAGCCCGCAGGGCATGGAAAGGGCAGACCTCTCCAGAAGTGCCCTGGCATGGGCGGCACGCGCCG
ACATTCCGATCTATGGTGTGAACCGCGGCGTGGGCATGGCACGCCAGGTCAGGATAGATGACTATCGGGAATTCGCCGCT
CTTGACGAAGAGGAGCGCAGCCGGCAGTTCAATCGCAATCTGCTGCTCTCCCATTGTCGGGCGATCGGCCAGCCCATTGA
TCGTGTGGAAGTCCGGGCGGCCATGATCGTGCGGCTCAACACGCTGCTTGCTGGTGGTTCGGGCATTAGCGCCGAGGCGA
TCCAGCTCTTGCTGGCGATGGTCAATAGGAGCCTTTCGCCCATTGTCCCCGGAACGGGGTCGGTGGGCGTCGGCGACCTC
TCCAGCCTTTCCTATATCGGCGCCGCGATGATGGGCGTGGGGCACATCCAAATAGAGGACGGCACTGTTCTTCCCGCAGA
TGAGGCGCTGCGCAGGGCCAGTCTTCCCATTCTGCGTCCAGTTGGTCGAGATGCCATGGCGCTCATGTCGTCCAACGCTT
TGTCTGCTGGCCAGGGGTGCCTGCTGCTGGAGGCAGCCCGGACAGTATTGGCAGCGGGCAACATTACCTATGCCATGAGC
CTTGAGGCGCTGAATGGCAATGTGGCTCCGCTGCTTGAAATCGCAGGCATTACCCGGCCGTTCATGCATTATACCGACAT
CCTGGCGCAGCTTCGCGACATTCTCGATGGCAGCTATTTGTGGCGTCCATCCCCGGAGCGATATCTTCAGGATCCCCTGA
GCTTTCGCACAGCACCGCTGATGCATGCAGTATGTGCCGAAAGCATCGATCGGCTAGGAAAAAATCTGTCGGTGCAGATC
AATAGCATCGAAGACAATCCCAGCATTGTGACATGCCGGGCTGACGATGTTTCCGAGCATCTGCGCCCCTATTTCGGCGG
GGGTGACGATCATCTGTTCGGTGGCGCGATACCCACCGCTTATTTCGATCCGTTGCCTTGGGTGCTCGACATACAGTCTA
TGGCCGTCGCCTTTGCCCATCTCTCCAATGCGTCCATGCAGCGCGCCGGTCGCCTGATCAACACGCATTTCACCAAGATT
GACATGCTGGCGCGGCAGCCGACGGCAAGCGCCTTCGGCTTCGCCAAAATCTGCAATGTCCTGCAGGCTCAGATCGCGGC
TTCCCTTCAGCCGCTATCCACCCTTGTTCAGCCATCCGCCGGCGATATCGAAGACGTCGGCAACCATGCGCCCACCATTG
TCCGCCGCGCGGCCCAGGCCATGGACGACGTTCTGCGAATGCTGTCGGTCGAACTGGTCGTGGCCGACAGCCTGATAACC
GCAAGGCGCGACGACCAGCCGGGGCTCTCACTCGGCCGCGGCTCGGCAGAGCTCCACCAATCGATACGAGATCTTCTTTC
AAAATCACCCGATCCGAGGCCCGGGACCGCCATCGATCGCATCTATGATGCCCTTAAAGCCGGGAAGTTGGATAATGCGC
AACACTAG

Upstream 100 bases:

>100_bases
TCGACTGCCAATACGCCTATTTCAGGCGCGCCTAACAATCACTGCCACCAAGCTGCCGGGGCTTCACGTCTGAAGAGCAC
CGGCCAAGAACCGGATCAAT

Downstream 100 bases:

>100_bases
CCAGGCAAGCATCGATCCTGCCACGCCCCTTCTGTTTTCTCCCCTGAGCCTTCGTTCGGTTCATCTTAAGAACCGTATCG
TTGTCGCGCCAATGTGCCAG

Product: phenylalanine/histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MSSSDKDLVLGTGALKPEDVAAAAATSCKVLPSPQGMERADLSRSALAWAARADIPIYGVNRGVGMARQVRIDDYREFAA
LDEEERSRQFNRNLLLSHCRAIGQPIDRVEVRAAMIVRLNTLLAGGSGISAEAIQLLLAMVNRSLSPIVPGTGSVGVGDL
SSLSYIGAAMMGVGHIQIEDGTVLPADEALRRASLPILRPVGRDAMALMSSNALSAGQGCLLLEAARTVLAAGNITYAMS
LEALNGNVAPLLEIAGITRPFMHYTDILAQLRDILDGSYLWRPSPERYLQDPLSFRTAPLMHAVCAESIDRLGKNLSVQI
NSIEDNPSIVTCRADDVSEHLRPYFGGGDDHLFGGAIPTAYFDPLPWVLDIQSMAVAFAHLSNASMQRAGRLINTHFTKI
DMLARQPTASAFGFAKICNVLQAQIAASLQPLSTLVQPSAGDIEDVGNHAPTIVRRAAQAMDDVLRMLSVELVVADSLIT
ARRDDQPGLSLGRGSAELHQSIRDLLSKSPDPRPGTAIDRIYDALKAGKLDNAQH

Sequences:

>Translated_535_residues
MSSSDKDLVLGTGALKPEDVAAAAATSCKVLPSPQGMERADLSRSALAWAARADIPIYGVNRGVGMARQVRIDDYREFAA
LDEEERSRQFNRNLLLSHCRAIGQPIDRVEVRAAMIVRLNTLLAGGSGISAEAIQLLLAMVNRSLSPIVPGTGSVGVGDL
SSLSYIGAAMMGVGHIQIEDGTVLPADEALRRASLPILRPVGRDAMALMSSNALSAGQGCLLLEAARTVLAAGNITYAMS
LEALNGNVAPLLEIAGITRPFMHYTDILAQLRDILDGSYLWRPSPERYLQDPLSFRTAPLMHAVCAESIDRLGKNLSVQI
NSIEDNPSIVTCRADDVSEHLRPYFGGGDDHLFGGAIPTAYFDPLPWVLDIQSMAVAFAHLSNASMQRAGRLINTHFTKI
DMLARQPTASAFGFAKICNVLQAQIAASLQPLSTLVQPSAGDIEDVGNHAPTIVRRAAQAMDDVLRMLSVELVVADSLIT
ARRDDQPGLSLGRGSAELHQSIRDLLSKSPDPRPGTAIDRIYDALKAGKLDNAQH
>Mature_534_residues
SSSDKDLVLGTGALKPEDVAAAAATSCKVLPSPQGMERADLSRSALAWAARADIPIYGVNRGVGMARQVRIDDYREFAAL
DEEERSRQFNRNLLLSHCRAIGQPIDRVEVRAAMIVRLNTLLAGGSGISAEAIQLLLAMVNRSLSPIVPGTGSVGVGDLS
SLSYIGAAMMGVGHIQIEDGTVLPADEALRRASLPILRPVGRDAMALMSSNALSAGQGCLLLEAARTVLAAGNITYAMSL
EALNGNVAPLLEIAGITRPFMHYTDILAQLRDILDGSYLWRPSPERYLQDPLSFRTAPLMHAVCAESIDRLGKNLSVQIN
SIEDNPSIVTCRADDVSEHLRPYFGGGDDHLFGGAIPTAYFDPLPWVLDIQSMAVAFAHLSNASMQRAGRLINTHFTKID
MLARQPTASAFGFAKICNVLQAQIAASLQPLSTLVQPSAGDIEDVGNHAPTIVRRAAQAMDDVLRMLSVELVVADSLITA
RRDDQPGLSLGRGSAELHQSIRDLLSKSPDPRPGTAIDRIYDALKAGKLDNAQH

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=487, Percent_Identity=25.4620123203285, Blast_Score=124, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17567831, Length=479, Percent_Identity=25.0521920668058, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 57261; Mature: 57130

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSDKDLVLGTGALKPEDVAAAAATSCKVLPSPQGMERADLSRSALAWAARADIPIYGV
CCCCCCCEEEECCCCCCHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEC
NRGVGMARQVRIDDYREFAALDEEERSRQFNRNLLLSHCRAIGQPIDRVEVRAAMIVRLN
CCCCCCCEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TLLAGGSGISAEAIQLLLAMVNRSLSPIVPGTGSVGVGDLSSLSYIGAAMMGVGHIQIED
HHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECC
GTVLPADEALRRASLPILRPVGRDAMALMSSNALSAGQGCLLLEAARTVLAAGNITYAMS
CEECCHHHHHHHHCCCHHCCCCHHHHHHHHCCCCCCCCCEEHHHHHHHHHHCCCEEEEEE
LEALNGNVAPLLEIAGITRPFMHYTDILAQLRDILDGSYLWRPSPERYLQDPLSFRTAPL
EECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHCHHHHHHHHH
MHAVCAESIDRLGKNLSVQINSIEDNPSIVTCRADDVSEHLRPYFGGGDDHLFGGAIPTA
HHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEECCCHHHHHCCCCCCCCCCCCCCCCCHH
YFDPLPWVLDIQSMAVAFAHLSNASMQRAGRLINTHFTKIDMLARQPTASAFGFAKICNV
HCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LQAQIAASLQPLSTLVQPSAGDIEDVGNHAPTIVRRAAQAMDDVLRMLSVELVVADSLIT
HHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARRDDQPGLSLGRGSAELHQSIRDLLSKSPDPRPGTAIDRIYDALKAGKLDNAQH
HCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SSSDKDLVLGTGALKPEDVAAAAATSCKVLPSPQGMERADLSRSALAWAARADIPIYGV
CCCCCCEEEECCCCCCHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEC
NRGVGMARQVRIDDYREFAALDEEERSRQFNRNLLLSHCRAIGQPIDRVEVRAAMIVRLN
CCCCCCCEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TLLAGGSGISAEAIQLLLAMVNRSLSPIVPGTGSVGVGDLSSLSYIGAAMMGVGHIQIED
HHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECC
GTVLPADEALRRASLPILRPVGRDAMALMSSNALSAGQGCLLLEAARTVLAAGNITYAMS
CEECCHHHHHHHHCCCHHCCCCHHHHHHHHCCCCCCCCCEEHHHHHHHHHHCCCEEEEEE
LEALNGNVAPLLEIAGITRPFMHYTDILAQLRDILDGSYLWRPSPERYLQDPLSFRTAPL
EECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHCHHHHHHHHH
MHAVCAESIDRLGKNLSVQINSIEDNPSIVTCRADDVSEHLRPYFGGGDDHLFGGAIPTA
HHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEECCCHHHHHCCCCCCCCCCCCCCCCCHH
YFDPLPWVLDIQSMAVAFAHLSNASMQRAGRLINTHFTKIDMLARQPTASAFGFAKICNV
HCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LQAQIAASLQPLSTLVQPSAGDIEDVGNHAPTIVRRAAQAMDDVLRMLSVELVVADSLIT
HHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARRDDQPGLSLGRGSAELHQSIRDLLSKSPDPRPGTAIDRIYDALKAGKLDNAQH
HCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]