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The map label for this gene is hutH [H]

Identifier: 110634881

GI number: 110634881

Start: 2721237

End: 2722781

Strand: Reverse

Name: hutH [H]

Synonym: Meso_2540

Alternate gene names: 110634881

Gene position: 2722781-2721237 (Counterclockwise)

Preceding gene: 110634882

Following gene: 110634880

Centisome position: 61.71

GC content: 63.43

Gene sequence:

>1545_bases
ATGACGGCTGACTTCATGGCTGGCCAGACGACCGCCGAGCTCCGACAGGGCAACGTACGACAACTCACGGAGGCTGCGCT
CTCCTGCGCCGAGGTTGCCGCTATCGCAAGCGGCGAAGAGCTTGTTCTCTCGCCAGAGGTCAGGGCCTTGGTGGAGGCCA
GCCGGGAAATCGTCGATGAGGCCGTACAACGCACGGAGCCGGTTTATGGTCTGAACACTGGATTGGGCCATCGGCGAAAC
GAGAGAGTATCGGCCGCGCTCCTGCAGGACTACCAGCCCTATATCATTCGCACGCATGCGGGGGCCATCGGTGCTCCGTT
AAGCGAGTCCGACGTTAGAGCCACCATGGTTGCGCGGATCGTCGGTATCGCTCGTGGTGGCGCGGGAGTGGGACTGGAGA
CCTTGGACCTGCTGGTGGCCATGCTGAATAGGCGCGTTCATCCGCAAGTCCCGGAATTCGGCTCGGTCGGCGCTTCGGAC
CTGTGCTCGATGTCGGCAATTGCCGAAGTCATGATCGGCCGCGGCGTCGCCATGTATCAAGGTGAACTGATGCCGGCGCT
GCAAGCGCTGGCAGCGGCCGGCCTAGCGCCGGTCAGGCTCAAGCCCAAGGAGGGGTTGGCTCTCATCAGCGGCAACGGAT
TGGCAATCGGCGCCGGCGCATTGACGGTCGAGCGCGCACGCCGGGTGCTGCGGCTCGCCGACCTGGCCGGAGCGCTGAGC
TTGGACGCATATGGCGGCAATCCGGTGCCCCTCGATTCTCGGGTGCAGGCTGCTAAATCCTATCCCGAGCAAGCCGAAAC
GGGACAGAGGCTGCGCGAGCTTTTGGCCGGCAGCGCCATCTGGACACCGAGCCCAACCGCTCGGTCGCTGCAGGACCCGG
TTTCGTTCCGCACTATCCCGCAGGTCCACGGTGCCGTTCGCCGTCAGGTCTGCGAAGCCGCAACCGTGGTCGAGGTGGAA
CTCAACAGCCGTTCGGACAACCCCTTGGTCGATGTGGGCAGCGGCGCGATCCTTTCCAACGGAAATTTCCAGGCGCTCCC
GATTGCGCTGGCATTCGACGGATTGCGAACCGGGATTTGCCATATAGCCTCGATGTCCGAGCGGCGCTGCTCGCATGTTT
TCCGCAAGCTGCAGGCGATGAGCAGCATAGACGATGCGATCCAGAATGCGGAAATGCCCGTCACCTCTCTGGTTGCCTAT
TCCGCGGCCGAGCTTTCGGCTCGCCTGCGCACTTTGGCCGCGCCGGCCTCGATCCATGTTCCATCGCTGGCGCATGATGT
TGAGGATCATGGCTCGCTCGGTCCGGGAACAATCGCTTTCACCGCGCAAAGCCTGGACCTTCTGGAGATGTTGCTGGCGG
TGGAGATCCACCTGTCCGCCGCGCTTGCCGATTGCGCAGGCGTTTCCGATGGATTGGGCGAGGGGACGCGTGCCGCCTAT
CGTCTGGCTGGGCAAGCGATGCGCCGGTCTCAGGAGACGGGCCGGCCGACTACGGCTGGCATTATCGATCTGCTGCGAAA
CATGCTAATCGAGCACTGTGCCTAA

Upstream 100 bases:

>100_bases
CGGGGCTGCCCGACGACATACTCAGAAATCCGGCGAATGACTACGTAGCCCGTTTTGTCGAGCGCAGGGTCCATATTCCG
GCCCAAGCCGGCGTGTCGAA

Downstream 100 bases:

>100_bases
GCGATTGTTCAACAGCGAGCCGGTCGCCGAACAGCCTTGCACCACGTGCCGGGAAGCGCCGGCTGGAGGTTGACAATATG
AACAAGTCCCACCGGACTGT

Product: phenylalanine/histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MTADFMAGQTTAELRQGNVRQLTEAALSCAEVAAIASGEELVLSPEVRALVEASREIVDEAVQRTEPVYGLNTGLGHRRN
ERVSAALLQDYQPYIIRTHAGAIGAPLSESDVRATMVARIVGIARGGAGVGLETLDLLVAMLNRRVHPQVPEFGSVGASD
LCSMSAIAEVMIGRGVAMYQGELMPALQALAAAGLAPVRLKPKEGLALISGNGLAIGAGALTVERARRVLRLADLAGALS
LDAYGGNPVPLDSRVQAAKSYPEQAETGQRLRELLAGSAIWTPSPTARSLQDPVSFRTIPQVHGAVRRQVCEAATVVEVE
LNSRSDNPLVDVGSGAILSNGNFQALPIALAFDGLRTGICHIASMSERRCSHVFRKLQAMSSIDDAIQNAEMPVTSLVAY
SAAELSARLRTLAAPASIHVPSLAHDVEDHGSLGPGTIAFTAQSLDLLEMLLAVEIHLSAALADCAGVSDGLGEGTRAAY
RLAGQAMRRSQETGRPTTAGIIDLLRNMLIEHCA

Sequences:

>Translated_514_residues
MTADFMAGQTTAELRQGNVRQLTEAALSCAEVAAIASGEELVLSPEVRALVEASREIVDEAVQRTEPVYGLNTGLGHRRN
ERVSAALLQDYQPYIIRTHAGAIGAPLSESDVRATMVARIVGIARGGAGVGLETLDLLVAMLNRRVHPQVPEFGSVGASD
LCSMSAIAEVMIGRGVAMYQGELMPALQALAAAGLAPVRLKPKEGLALISGNGLAIGAGALTVERARRVLRLADLAGALS
LDAYGGNPVPLDSRVQAAKSYPEQAETGQRLRELLAGSAIWTPSPTARSLQDPVSFRTIPQVHGAVRRQVCEAATVVEVE
LNSRSDNPLVDVGSGAILSNGNFQALPIALAFDGLRTGICHIASMSERRCSHVFRKLQAMSSIDDAIQNAEMPVTSLVAY
SAAELSARLRTLAAPASIHVPSLAHDVEDHGSLGPGTIAFTAQSLDLLEMLLAVEIHLSAALADCAGVSDGLGEGTRAAY
RLAGQAMRRSQETGRPTTAGIIDLLRNMLIEHCA
>Mature_513_residues
TADFMAGQTTAELRQGNVRQLTEAALSCAEVAAIASGEELVLSPEVRALVEASREIVDEAVQRTEPVYGLNTGLGHRRNE
RVSAALLQDYQPYIIRTHAGAIGAPLSESDVRATMVARIVGIARGGAGVGLETLDLLVAMLNRRVHPQVPEFGSVGASDL
CSMSAIAEVMIGRGVAMYQGELMPALQALAAAGLAPVRLKPKEGLALISGNGLAIGAGALTVERARRVLRLADLAGALSL
DAYGGNPVPLDSRVQAAKSYPEQAETGQRLRELLAGSAIWTPSPTARSLQDPVSFRTIPQVHGAVRRQVCEAATVVEVEL
NSRSDNPLVDVGSGAILSNGNFQALPIALAFDGLRTGICHIASMSERRCSHVFRKLQAMSSIDDAIQNAEMPVTSLVAYS
AAELSARLRTLAAPASIHVPSLAHDVEDHGSLGPGTIAFTAQSLDLLEMLLAVEIHLSAALADCAGVSDGLGEGTRAAYR
LAGQAMRRSQETGRPTTAGIIDLLRNMLIEHCA

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=488, Percent_Identity=32.172131147541, Blast_Score=217, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17567831, Length=439, Percent_Identity=30.9794988610478, Blast_Score=169, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53954; Mature: 53823

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADFMAGQTTAELRQGNVRQLTEAALSCAEVAAIASGEELVLSPEVRALVEASREIVDE
CCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHH
AVQRTEPVYGLNTGLGHRRNERVSAALLQDYQPYIIRTHAGAIGAPLSESDVRATMVARI
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHH
VGIARGGAGVGLETLDLLVAMLNRRVHPQVPEFGSVGASDLCSMSAIAEVMIGRGVAMYQ
HHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
GELMPALQALAAAGLAPVRLKPKEGLALISGNGLAIGAGALTVERARRVLRLADLAGALS
HHHHHHHHHHHHCCCCCEEECCCCCEEEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHE
LDAYGGNPVPLDSRVQAAKSYPEQAETGQRLRELLAGSAIWTPSPTARSLQDPVSFRTIP
EECCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHH
QVHGAVRRQVCEAATVVEVELNSRSDNPLVDVGSGAILSNGNFQALPIALAFDGLRTGIC
HHHHHHHHHHHHHHEEEEEEECCCCCCCCEECCCCCEEECCCCEEEEHEEEHHHHHHHHH
HIASMSERRCSHVFRKLQAMSSIDDAIQNAEMPVTSLVAYSAAELSARLRTLAAPASIHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
PSLAHDVEDHGSLGPGTIAFTAQSLDLLEMLLAVEIHLSAALADCAGVSDGLGEGTRAAY
CHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
RLAGQAMRRSQETGRPTTAGIIDLLRNMLIEHCA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TADFMAGQTTAELRQGNVRQLTEAALSCAEVAAIASGEELVLSPEVRALVEASREIVDE
CCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHH
AVQRTEPVYGLNTGLGHRRNERVSAALLQDYQPYIIRTHAGAIGAPLSESDVRATMVARI
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHH
VGIARGGAGVGLETLDLLVAMLNRRVHPQVPEFGSVGASDLCSMSAIAEVMIGRGVAMYQ
HHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
GELMPALQALAAAGLAPVRLKPKEGLALISGNGLAIGAGALTVERARRVLRLADLAGALS
HHHHHHHHHHHHCCCCCEEECCCCCEEEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHE
LDAYGGNPVPLDSRVQAAKSYPEQAETGQRLRELLAGSAIWTPSPTARSLQDPVSFRTIP
EECCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHH
QVHGAVRRQVCEAATVVEVELNSRSDNPLVDVGSGAILSNGNFQALPIALAFDGLRTGIC
HHHHHHHHHHHHHHEEEEEEECCCCCCCCEECCCCCEEECCCCEEEEHEEEHHHHHHHHH
HIASMSERRCSHVFRKLQAMSSIDDAIQNAEMPVTSLVAYSAAELSARLRTLAAPASIHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
PSLAHDVEDHGSLGPGTIAFTAQSLDLLEMLLAVEIHLSAALADCAGVSDGLGEGTRAAY
CHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
RLAGQAMRRSQETGRPTTAGIIDLLRNMLIEHCA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA