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The map label for this gene is siaT [H]

Identifier: 110634859

GI number: 110634859

Start: 2696203

End: 2697477

Strand: Reverse

Name: siaT [H]

Synonym: Meso_2518

Alternate gene names: 110634859

Gene position: 2697477-2696203 (Counterclockwise)

Preceding gene: 110634860

Following gene: 110634858

Centisome position: 61.13

GC content: 58.9

Gene sequence:

>1275_bases
ATGTCACTAGAAGCGTTCTACGCGGTGAGCGCGCTCATCGTGTTGCTCCTCACCGGAATCCCGATTGCTCTTGCGCTGAC
GCTGGCAGGTGCCTTCGGCCTGTGGCTTCTCGACTTCCCTATGCTTGTGGTGATCCAGCGTTTCGCGGCGGGATCTGAAA
GCTTCGTTCTGCTCGCCATTCCCTTTTTCATCCTGGCAGGCGCGGTCATGGAAGCCGGCGGTATATCGAGGCGCCTCATA
GGTTTTTGCGATGCTTGTCTGGGGTATCTTCCCGGCGGGCTTGCGAACGCGAATATCGGTGCCTCCATGGTCTTTGGCGG
CATATCAGGGTCTGCGGTTGCGGATACCTCGGCGGTCGGGTCGGTCATGATCCCGGCGATGGAACGAGAGGGATACTCAC
GCCGCTACAGCGCGGCGGTGACGGCGGCCGCTTCCCCGGTCGGCATGATCATCCCGCCATCGATCCCGATGATCGTCTGG
AGCTATATTTCAGGCCAGTCCCTCAATGAGCTTTTCATGGCGGGTATCGTGCCCGGCATCTTGATCACTCTGGCGCTTGC
ATTGGTCAGCACCTGGATTTGCCAACGCCGCGGGTTCCAACGAGGATTTCGTCCGTTCCGTGCGGGCTTTTTCCTGTCGT
CCTTGAAGGATGGCCTGCTGGCCCTCGGTGCCCCGGTCATCATCATCGGAGGCATTCTGATCGGTGCCTTCACACCGACC
GAAGCCTCCGTCGTCGCGCTCGCCTATGCGCTTATCCTTAGTTTCGGAGTTTATCGCGAGCTGTCACCCCGAAAGCTTGC
AGCGGTGTTCGTCCAGGCCGGCAAGACCAGCGCCTCGATCATGTTCATCATCTGCGGCGCCACCGTATTCTCCTTTTTTC
TGACGGTTTCCGGAATGCCGGCGCAAATCGGCAGCTTGATCCTCAGCGTATCCGAAACGCCGCTTGGCTTCATCATTGCT
GCGGGGCTGCTGATGTTCGTGTTGGGAATGTTTCTGGATACCACCACGACCATTCTGATGGCCGGGCCGATCATCATTCC
CCTGTTCAGCCAAGTCGGAGTTGATCCGTTGGTCGCTACCATGGTCATCATGGTGATCCTGGCCATCGGTCTCATCACGC
CGCCTGTGGGGTTGTGCCTTTTCGTCGTCTCGTCGATCACCCCGGTCAAAGTTTGGGACGTGGCGCGGGAATGCGTGCCG
TTCATTCTCGCAATGACCGCCGTCGCTGCCTTGATCTGGATCTTTCCTCCTCTGGTTACGTGGGTCGTGCCATGA

Upstream 100 bases:

>100_bases
ATGCCGCGGGCAAGTGGCTCGATGCCATCGACGCAGCCCGCTGAGTTACGCACAGGCGGAGAGTGCTAACCGCTCTCCGC
CTAGCCCAAGGTAAAACTCC

Downstream 100 bases:

>100_bases
GCGGCTTTGATACTTTCTTCCACCGGACATGCCAGGTGCTTGCGTATGTCCTGTCGGCGCTGACGGTCCTTTCCCTGGCC
GCGATGTTTGTCGGTATCGT

Product: TRAP dicarboxylate transporter, DctM subunit

Products: NA

Alternate protein names: N-acetylneuraminic acid permease; N-acetylneuraminic acid transporter; Neu5Ac permease [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSLEAFYAVSALIVLLLTGIPIALALTLAGAFGLWLLDFPMLVVIQRFAAGSESFVLLAIPFFILAGAVMEAGGISRRLI
GFCDACLGYLPGGLANANIGASMVFGGISGSAVADTSAVGSVMIPAMEREGYSRRYSAAVTAAASPVGMIIPPSIPMIVW
SYISGQSLNELFMAGIVPGILITLALALVSTWICQRRGFQRGFRPFRAGFFLSSLKDGLLALGAPVIIIGGILIGAFTPT
EASVVALAYALILSFGVYRELSPRKLAAVFVQAGKTSASIMFIICGATVFSFFLTVSGMPAQIGSLILSVSETPLGFIIA
AGLLMFVLGMFLDTTTTILMAGPIIIPLFSQVGVDPLVATMVIMVILAIGLITPPVGLCLFVVSSITPVKVWDVARECVP
FILAMTAVAALIWIFPPLVTWVVP

Sequences:

>Translated_424_residues
MSLEAFYAVSALIVLLLTGIPIALALTLAGAFGLWLLDFPMLVVIQRFAAGSESFVLLAIPFFILAGAVMEAGGISRRLI
GFCDACLGYLPGGLANANIGASMVFGGISGSAVADTSAVGSVMIPAMEREGYSRRYSAAVTAAASPVGMIIPPSIPMIVW
SYISGQSLNELFMAGIVPGILITLALALVSTWICQRRGFQRGFRPFRAGFFLSSLKDGLLALGAPVIIIGGILIGAFTPT
EASVVALAYALILSFGVYRELSPRKLAAVFVQAGKTSASIMFIICGATVFSFFLTVSGMPAQIGSLILSVSETPLGFIIA
AGLLMFVLGMFLDTTTTILMAGPIIIPLFSQVGVDPLVATMVIMVILAIGLITPPVGLCLFVVSSITPVKVWDVARECVP
FILAMTAVAALIWIFPPLVTWVVP
>Mature_423_residues
SLEAFYAVSALIVLLLTGIPIALALTLAGAFGLWLLDFPMLVVIQRFAAGSESFVLLAIPFFILAGAVMEAGGISRRLIG
FCDACLGYLPGGLANANIGASMVFGGISGSAVADTSAVGSVMIPAMEREGYSRRYSAAVTAAASPVGMIIPPSIPMIVWS
YISGQSLNELFMAGIVPGILITLALALVSTWICQRRGFQRGFRPFRAGFFLSSLKDGLLALGAPVIIIGGILIGAFTPTE
ASVVALAYALILSFGVYRELSPRKLAAVFVQAGKTSASIMFIICGATVFSFFLTVSGMPAQIGSLILSVSETPLGFIIAA
GLLMFVLGMFLDTTTTILMAGPIIIPLFSQVGVDPLVATMVIMVILAIGLITPPVGLCLFVVSSITPVKVWDVARECVPF
ILAMTAVAALIWIFPPLVTWVVP

Specific function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system siaPT involved in the uptake of sialic acid [H]

COG id: COG1593

COG function: function code G; TRAP-type C4-dicarboxylate transport system, large permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the TRAP transporter large permease family [H]

Homologues:

Organism=Escherichia coli, GI48994950, Length=383, Percent_Identity=37.8590078328982, Blast_Score=212, Evalue=3e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010656
- InterPro:   IPR007387
- InterPro:   IPR004681 [H]

Pfam domain/function: PF06808 DctM; PF04290 DctQ [H]

EC number: NA

Molecular weight: Translated: 44326; Mature: 44195

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLEAFYAVSALIVLLLTGIPIALALTLAGAFGLWLLDFPMLVVIQRFAAGSESFVLLAI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
PFFILAGAVMEAGGISRRLIGFCDACLGYLPGGLANANIGASMVFGGISGSAVADTSAVG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEECCCCCCCCCCHHHHH
SVMIPAMEREGYSRRYSAAVTAAASPVGMIIPPSIPMIVWSYISGQSLNELFMAGIVPGI
HHHHHHHHCCCCHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHH
LITLALALVSTWICQRRGFQRGFRPFRAGFFLSSLKDGLLALGAPVIIIGGILIGAFTPT
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
EASVVALAYALILSFGVYRELSPRKLAAVFVQAGKTSASIMFIICGATVFSFFLTVSGMP
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCH
AQIGSLILSVSETPLGFIIAAGLLMFVLGMFLDTTTTILMAGPIIIPLFSQVGVDPLVAT
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHH
MVIMVILAIGLITPPVGLCLFVVSSITPVKVWDVARECVPFILAMTAVAALIWIFPPLVT
HHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WVVP
HCCC
>Mature Secondary Structure 
SLEAFYAVSALIVLLLTGIPIALALTLAGAFGLWLLDFPMLVVIQRFAAGSESFVLLAI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
PFFILAGAVMEAGGISRRLIGFCDACLGYLPGGLANANIGASMVFGGISGSAVADTSAVG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEECCCCCCCCCCHHHHH
SVMIPAMEREGYSRRYSAAVTAAASPVGMIIPPSIPMIVWSYISGQSLNELFMAGIVPGI
HHHHHHHHCCCCHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHH
LITLALALVSTWICQRRGFQRGFRPFRAGFFLSSLKDGLLALGAPVIIIGGILIGAFTPT
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
EASVVALAYALILSFGVYRELSPRKLAAVFVQAGKTSASIMFIICGATVFSFFLTVSGMP
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCH
AQIGSLILSVSETPLGFIIAAGLLMFVLGMFLDTTTTILMAGPIIIPLFSQVGVDPLVAT
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHH
MVIMVILAIGLITPPVGLCLFVVSSITPVKVWDVARECVPFILAMTAVAALIWIFPPLVT
HHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WVVP
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]