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The map label for this gene is hpcH [H]

Identifier: 110634844

GI number: 110634844

Start: 2682077

End: 2682835

Strand: Reverse

Name: hpcH [H]

Synonym: Meso_2503

Alternate gene names: 110634844

Gene position: 2682835-2682077 (Counterclockwise)

Preceding gene: 110634845

Following gene: 110634841

Centisome position: 60.8

GC content: 63.37

Gene sequence:

>759_bases
ATGCCAGCACCGAGGAACAGCTTCAAGGCGCGGTTGAAGAAGGGAGAGACCCAGATCGGTCTTTGGCTGGGACTTGCCGA
AGCAACCACGGCGGAGCTCGCGGCGGGAGCGGGCTTTGACTGGCTGGTGATCGACGGCGAACACGGACCCAACGGGCTGC
GGGATGTACTCGATCAGCTGCGGGCGATTGGCGACGCCTCCCATCCGGTGGTGCGGGTGCGAGACCATAACCGCGCTGAG
ATCAAGCAAATGCTGGATCTGGGAGCACAGACGCTGCTCGTGCCGATGATCGAAAGCGGCGCACAGGCCGCCGAGGTCGT
AAAATCCATGCGCTACCCGCCCGAGGGGGTTCGTGGCGTCGGCGCGTCACTTGCGCGCGCGTCGCGCTACAATGCAATCT
CCGATTATCTGCAAACGGCAAATGACGAAGTCTGCCTTTTGCTTCAGGTCGAAAGCCGCGCGGGCATCGCCGCGCTCGAT
GAAATCCTGGCGCTCGATGGGGTCGACGGTGTCTTTGTCGGTCCTGCCGACCTCGCTGCCGATATGGGCTATCGCGGCAA
ACCGGGTGCGCCGGAGGTGCAGGCGGTGGTCACGGACGCACTGGCTCGCATCCGCAGAGCCGGAAAGGCTGCGGGAATTT
TGACGTCAGACCAGACGCTCGCCAAAGGTTATGCGGAAATGGGGGTGGAGTTCCTGGCCGTCGGGTCCGACGTGGGGGTG
TTTTCTGCCGGGCTGAAAGCTCTGCGTGCCGCTTTCTGA

Upstream 100 bases:

>100_bases
GTTCATCGCACCGATCGAGTGCCCGCCAGGAACGAAGATCCATGCCGATTTCGGCAGTTTCGGATCTGCTTCGATTACCT
TTGCCTGAAAGGATTGCATC

Downstream 100 bases:

>100_bases
GCCGTAATTCGTTCACGGTGCCCGTGAGCATCTATGAGCGGTTGTTCCGGTTGGGACCCTAAACCTCTGCGGCCAGACTT
GTGATCGACGGGATCAGGAT

Product: HpcH/HpaI aldolase

Products: NA

Alternate protein names: 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; HHED aldolase; 4-hydroxy-2-ketoheptane-1,7-dioate aldolase; HKHD aldolase [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MPAPRNSFKARLKKGETQIGLWLGLAEATTAELAAGAGFDWLVIDGEHGPNGLRDVLDQLRAIGDASHPVVRVRDHNRAE
IKQMLDLGAQTLLVPMIESGAQAAEVVKSMRYPPEGVRGVGASLARASRYNAISDYLQTANDEVCLLLQVESRAGIAALD
EILALDGVDGVFVGPADLAADMGYRGKPGAPEVQAVVTDALARIRRAGKAAGILTSDQTLAKGYAEMGVEFLAVGSDVGV
FSAGLKALRAAF

Sequences:

>Translated_252_residues
MPAPRNSFKARLKKGETQIGLWLGLAEATTAELAAGAGFDWLVIDGEHGPNGLRDVLDQLRAIGDASHPVVRVRDHNRAE
IKQMLDLGAQTLLVPMIESGAQAAEVVKSMRYPPEGVRGVGASLARASRYNAISDYLQTANDEVCLLLQVESRAGIAALD
EILALDGVDGVFVGPADLAADMGYRGKPGAPEVQAVVTDALARIRRAGKAAGILTSDQTLAKGYAEMGVEFLAVGSDVGV
FSAGLKALRAAF
>Mature_251_residues
PAPRNSFKARLKKGETQIGLWLGLAEATTAELAAGAGFDWLVIDGEHGPNGLRDVLDQLRAIGDASHPVVRVRDHNRAEI
KQMLDLGAQTLLVPMIESGAQAAEVVKSMRYPPEGVRGVGASLARASRYNAISDYLQTANDEVCLLLQVESRAGIAALDE
ILALDGVDGVFVGPADLAADMGYRGKPGAPEVQAVVTDALARIRRAGKAAGILTSDQTLAKGYAEMGVEFLAVGSDVGVF
SAGLKALRAAF

Specific function: Catalyzes the reversible retro-aldol cleavage of 4- hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde [H]

COG id: COG3836

COG function: function code G; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1788578, Length=248, Percent_Identity=50.8064516129032, Blast_Score=256, Evalue=8e-70,
Organism=Escherichia coli, GI1789514, Length=248, Percent_Identity=43.1451612903226, Blast_Score=211, Evalue=5e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR012689
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: 4.1.2.-

Molecular weight: Translated: 26419; Mature: 26287

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAPRNSFKARLKKGETQIGLWLGLAEATTAELAAGAGFDWLVIDGEHGPNGLRDVLDQL
CCCCCHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH
RAIGDASHPVVRVRDHNRAEIKQMLDLGAQTLLVPMIESGAQAAEVVKSMRYPPEGVRGV
HHHCCCCCCEEEECCCCHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHH
GASLARASRYNAISDYLQTANDEVCLLLQVESRAGIAALDEILALDGVDGVFVGPADLAA
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEECHHHHHH
DMGYRGKPGAPEVQAVVTDALARIRRAGKAAGILTSDQTLAKGYAEMGVEFLAVGSDVGV
HCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHCEEEEEECCCCHH
FSAGLKALRAAF
HHHHHHHHHHCC
>Mature Secondary Structure 
PAPRNSFKARLKKGETQIGLWLGLAEATTAELAAGAGFDWLVIDGEHGPNGLRDVLDQL
CCCCHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH
RAIGDASHPVVRVRDHNRAEIKQMLDLGAQTLLVPMIESGAQAAEVVKSMRYPPEGVRGV
HHHCCCCCCEEEECCCCHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHH
GASLARASRYNAISDYLQTANDEVCLLLQVESRAGIAALDEILALDGVDGVFVGPADLAA
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEECHHHHHH
DMGYRGKPGAPEVQAVVTDALARIRRAGKAAGILTSDQTLAKGYAEMGVEFLAVGSDVGV
HCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHCEEEEEECCCCHH
FSAGLKALRAAF
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12384590; 12704152 [H]