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The map label for this gene is ubiE [C]

Identifier: 110634799

GI number: 110634799

Start: 2634572

End: 2636317

Strand: Direct

Name: ubiE [C]

Synonym: Meso_2458

Alternate gene names: 110634799

Gene position: 2634572-2636317 (Clockwise)

Preceding gene: 110634798

Following gene: 110634803

Centisome position: 59.71

GC content: 63.8

Gene sequence:

>1746_bases
ATGACCATTACCGATACTGCAGCGGCCAAGCAGCCACCCAACACGCATGAACAAAAAGCGATGGCCGGCAGTGCCCGTGA
GCTTCTGCTCTCCGGCTTGCCGGTCACGGAGCGTCGACTCCACCTAGCGGGCATTTCGACGGCCGTATTGGAAGGCGGAG
ACGGTCCGCCAATCATTCTCCTGCACGGTCCAGGCGAATATGCGGCCAAATGGCTGCGGATCTTGCCCGAGCTGGTCAAG
ACGCATCGCGTGATCGCGCCCGATCTGCCCGGGCACGGCGCGACTGAAGCGGTTGGCCCGATCGATCGCGATCGCGTGCT
GGCCTGGCTTGACGAACTGATCACACGGACATGCAAAACGCCGCCCATTCTTGTCGGCCAGATCATTGGCGGCGCGATCG
CCCTACGCTTTGCCGCCGCGCATGGGGAGCGGCTGCGTGGCTTGATCCTCTCTGACACGCTCGGCTTGGCAAGCTTTCAG
CCTGCGCCTGAATTCGCCGAGGCCCTTGCCGCGTTCGTGACGGAGCCGAGTCCGGAAAATCATGACAGACTTTGGCAGCG
GTGCGCGTTCGATCTCGACGCATTGCGTGATGGAATGGGCCGGAGCTGGGATTATCTGCGCACGTATAATCTGGACCGGG
CGCAGCTTGCGGATTTGAAGCCGACCCAGCAAAGCCTCTTCGAGCAGTTCGCGCTGCCAGCGACTCCCCAGGAGGAGTTG
GAGCGCGTACAGATTCCGACCTTCCTGATCTGGGGACGGCATGATCTAGCAACCCCGCTGCAGATCGCCGAGGCGGCAAG
CACCCGCTTCGGCTGGCCGCTCCATGTCATCGACGGTGCCGCCGACGATCCTCCGATAGAACAGCCGGCCGCATTCATGA
AGGTGCTCCGCACCGTGCTGGCGGAGCGAACCGTTATAGAATCCGCATCGATTGCGCGAGAGGCTTGGAACCGGATCGCG
CCGGGATACGACCGGTACATCACGCCGTCTCATTTTTGGCTCGCCCAAGAGGGCCTTCGCCGCGCGGGGCTGCGCCCCGG
CATGCGGTTCCTGGACGTGGCGGCAGGCAGTGGTGGCCTTTCAATTCCGGCAGCGCGCCTGGGGGCGGATGTCGTGGCGA
CGGATATTTCGCCCGCGATGATCGAGAAGCTGCGCGCCCGCGCTGCCGGCGAAGGCCTCGCGATTGAAGCCCGCGTCATG
GACGGACACGCGCTCGAGCTGGCGGACGAAAGCTTCGATATGGCCGGTTCTCAGTTCGGTGTCATGCTGTTTCCCGACAT
GCCGAGGGGCATTCGGGAAATGGTTCGCGTGGTCAGGCCCGGCGGACGCGTTCTTCTCACCGCCTTCGGTGATCCGCGCA
GGATCGATTTCCTCGCCTTCTTTATCGAAGCGATCAAGGCTGTCCGTCCCGCCTTTGCGGGACTTCCGGCGGACCCACCG
CCCCTGCCCTTCCAGCTTCGCGACCCGGAACGGCTCCGCTTTGAGCTTGAGACCGCCGGGCTGCAGGATGTTCGGGTCGA
GTCGACCACCGAGCGCCTTGAATTCACGGCGGGCGAGCAGTTGTGGCAATGGCTGACGCAGAGCAACCCCATTCCCGGTG
CCGTTTTGGCCGGGCTTGAGCTGAGCGAGGAGGAAAGAGGGAAGATCCGGCAGGCGCTCGATCGTCTTGTCGCGGCCCGC
GCAAAGGCTGACGGCACGGCGGTGCTCACCAGCCCCATCAACATTGGCATTGGGACCAAGCGTTAG

Upstream 100 bases:

>100_bases
ATAAAGCGCTTTGCGACAAATTGGGGAATCTTGCCGAAGCGGCGCGTAGACAACGGTCATAGGCTTTGCCGAGCCTCAAC
GCATGAGCTTGGAGGAAGCC

Downstream 100 bases:

>100_bases
GCTCCATTGACGGAGGTAGCAGTGGCTTGTCCCGCCGGCCGGTTGGCGCCCTGGCCGGCGGGACTTGGCCCCTTGCTCAC
GCGGCTCTCAACTCGGCGGT

Product: methyltransferase type 11

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 581; Mature: 580

Protein sequence:

>581_residues
MTITDTAAAKQPPNTHEQKAMAGSARELLLSGLPVTERRLHLAGISTAVLEGGDGPPIILLHGPGEYAAKWLRILPELVK
THRVIAPDLPGHGATEAVGPIDRDRVLAWLDELITRTCKTPPILVGQIIGGAIALRFAAAHGERLRGLILSDTLGLASFQ
PAPEFAEALAAFVTEPSPENHDRLWQRCAFDLDALRDGMGRSWDYLRTYNLDRAQLADLKPTQQSLFEQFALPATPQEEL
ERVQIPTFLIWGRHDLATPLQIAEAASTRFGWPLHVIDGAADDPPIEQPAAFMKVLRTVLAERTVIESASIAREAWNRIA
PGYDRYITPSHFWLAQEGLRRAGLRPGMRFLDVAAGSGGLSIPAARLGADVVATDISPAMIEKLRARAAGEGLAIEARVM
DGHALELADESFDMAGSQFGVMLFPDMPRGIREMVRVVRPGGRVLLTAFGDPRRIDFLAFFIEAIKAVRPAFAGLPADPP
PLPFQLRDPERLRFELETAGLQDVRVESTTERLEFTAGEQLWQWLTQSNPIPGAVLAGLELSEEERGKIRQALDRLVAAR
AKADGTAVLTSPINIGIGTKR

Sequences:

>Translated_581_residues
MTITDTAAAKQPPNTHEQKAMAGSARELLLSGLPVTERRLHLAGISTAVLEGGDGPPIILLHGPGEYAAKWLRILPELVK
THRVIAPDLPGHGATEAVGPIDRDRVLAWLDELITRTCKTPPILVGQIIGGAIALRFAAAHGERLRGLILSDTLGLASFQ
PAPEFAEALAAFVTEPSPENHDRLWQRCAFDLDALRDGMGRSWDYLRTYNLDRAQLADLKPTQQSLFEQFALPATPQEEL
ERVQIPTFLIWGRHDLATPLQIAEAASTRFGWPLHVIDGAADDPPIEQPAAFMKVLRTVLAERTVIESASIAREAWNRIA
PGYDRYITPSHFWLAQEGLRRAGLRPGMRFLDVAAGSGGLSIPAARLGADVVATDISPAMIEKLRARAAGEGLAIEARVM
DGHALELADESFDMAGSQFGVMLFPDMPRGIREMVRVVRPGGRVLLTAFGDPRRIDFLAFFIEAIKAVRPAFAGLPADPP
PLPFQLRDPERLRFELETAGLQDVRVESTTERLEFTAGEQLWQWLTQSNPIPGAVLAGLELSEEERGKIRQALDRLVAAR
AKADGTAVLTSPINIGIGTKR
>Mature_580_residues
TITDTAAAKQPPNTHEQKAMAGSARELLLSGLPVTERRLHLAGISTAVLEGGDGPPIILLHGPGEYAAKWLRILPELVKT
HRVIAPDLPGHGATEAVGPIDRDRVLAWLDELITRTCKTPPILVGQIIGGAIALRFAAAHGERLRGLILSDTLGLASFQP
APEFAEALAAFVTEPSPENHDRLWQRCAFDLDALRDGMGRSWDYLRTYNLDRAQLADLKPTQQSLFEQFALPATPQEELE
RVQIPTFLIWGRHDLATPLQIAEAASTRFGWPLHVIDGAADDPPIEQPAAFMKVLRTVLAERTVIESASIAREAWNRIAP
GYDRYITPSHFWLAQEGLRRAGLRPGMRFLDVAAGSGGLSIPAARLGADVVATDISPAMIEKLRARAAGEGLAIEARVMD
GHALELADESFDMAGSQFGVMLFPDMPRGIREMVRVVRPGGRVLLTAFGDPRRIDFLAFFIEAIKAVRPAFAGLPADPPP
LPFQLRDPERLRFELETAGLQDVRVESTTERLEFTAGEQLWQWLTQSNPIPGAVLAGLELSEEERGKIRQALDRLVAARA
KADGTAVLTSPINIGIGTKR

Specific function: Methyltransferase Required For The Conversion Of Dimethylmenaquinone (Dmkh2) To Menaquinone (Mkh2) And The Conversion Of 2-Polyprenyl-6-Methoxy-1,4-Benzoquinol (Ddmqh2) To 2-Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol (Dmqh2). [C]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To M.tuberculosis Rv1403c [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 63375; Mature: 63243

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITDTAAAKQPPNTHEQKAMAGSARELLLSGLPVTERRLHLAGISTAVLEGGDGPPIIL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHEEECCCCCEEEE
LHGPGEYAAKWLRILPELVKTHRVIAPDLPGHGATEAVGPIDRDRVLAWLDELITRTCKT
EECCCHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
PPILVGQIIGGAIALRFAAAHGERLRGLILSDTLGLASFQPAPEFAEALAAFVTEPSPEN
CCHHHHHHHHHHHHHHHHHHCCHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
HDRLWQRCAFDLDALRDGMGRSWDYLRTYNLDRAQLADLKPTQQSLFEQFALPATPQEEL
HHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHCCCCHHHHHHHHHHCCCCCCHHHH
ERVQIPTFLIWGRHDLATPLQIAEAASTRFGWPLHVIDGAADDPPIEQPAAFMKVLRTVL
HHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
AERTVIESASIAREAWNRIAPGYDRYITPSHFWLAQEGLRRAGLRPGMRFLDVAAGSGGL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHEEECCCCCC
SIPAARLGADVVATDISPAMIEKLRARAAGEGLAIEARVMDGHALELADESFDMAGSQFG
CCCHHHHCCCHHCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCHHHCCCCCCC
VMLFPDMPRGIREMVRVVRPGGRVLLTAFGDPRRIDFLAFFIEAIKAVRPAFAGLPADPP
EEECCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
PLPFQLRDPERLRFELETAGLQDVRVESTTERLEFTAGEQLWQWLTQSNPIPGAVLAGLE
CCCEEECCHHHHEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCC
LSEEERGKIRQALDRLVAARAKADGTAVLTSPINIGIGTKR
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEECCCCCCC
>Mature Secondary Structure 
TITDTAAAKQPPNTHEQKAMAGSARELLLSGLPVTERRLHLAGISTAVLEGGDGPPIIL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHEEECCCCCEEEE
LHGPGEYAAKWLRILPELVKTHRVIAPDLPGHGATEAVGPIDRDRVLAWLDELITRTCKT
EECCCHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
PPILVGQIIGGAIALRFAAAHGERLRGLILSDTLGLASFQPAPEFAEALAAFVTEPSPEN
CCHHHHHHHHHHHHHHHHHHCCHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
HDRLWQRCAFDLDALRDGMGRSWDYLRTYNLDRAQLADLKPTQQSLFEQFALPATPQEEL
HHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHCCCCHHHHHHHHHHCCCCCCHHHH
ERVQIPTFLIWGRHDLATPLQIAEAASTRFGWPLHVIDGAADDPPIEQPAAFMKVLRTVL
HHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
AERTVIESASIAREAWNRIAPGYDRYITPSHFWLAQEGLRRAGLRPGMRFLDVAAGSGGL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHEEECCCCCC
SIPAARLGADVVATDISPAMIEKLRARAAGEGLAIEARVMDGHALELADESFDMAGSQFG
CCCHHHHCCCHHCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCHHHCCCCCCC
VMLFPDMPRGIREMVRVVRPGGRVLLTAFGDPRRIDFLAFFIEAIKAVRPAFAGLPADPP
EEECCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
PLPFQLRDPERLRFELETAGLQDVRVESTTERLEFTAGEQLWQWLTQSNPIPGAVLAGLE
CCCEEECCHHHHEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCC
LSEEERGKIRQALDRLVAARAKADGTAVLTSPINIGIGTKR
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]