Click here to switch to the map view.

The map label for this gene is lrp [C]

Identifier: 110634759

GI number: 110634759

Start: 2590931

End: 2591410

Strand: Direct

Name: lrp [C]

Synonym: Meso_2418

Alternate gene names: 110634759

Gene position: 2590931-2591410 (Clockwise)

Preceding gene: 110634756

Following gene: 110634760

Centisome position: 58.72

GC content: 56.67

Gene sequence:

>480_bases
ATGAAGCCCCTCGATCGCGCTGACGTCGCCCTTCTGCGTGCAGTCCAAATCAACAACCGCCTCAGCTCGGAAGAGCTCGC
GGAAATCGCACATCTTTCACCGACAGCTTGCCAGCGCCGGCTTAAACGGTTGCGAGCGGAGGGCGTGATCGAGAGCGATG
TCGCAATTGTTTCGCCCAAGGCCGTAGGCCGACCGATAATCATGGTGGTCAGCGTATCGCTGGAGCGGGAACGCGCCGAC
ATTATCGACAAGTTCAAGCGCGCAATCCGCAAATCGCCGGAAGTGATGACCGGCTATTACGTTACCGGTGACGCAGATTT
CGTCTTGGTGATCACCGCAAGAGACATGGAGACCTACGAGGCGTTTACCCGCCGCTTTTTCTACGAAAATCCAGACATCA
AGAACTTCAAGACGCTGGTCGTTATGGATCGCGTCAAGGCCGGCCTCGCCATTCCGATCGAGGAGCCGGATATCGAGTAA

Upstream 100 bases:

>100_bases
CCCCATGCAGATTATCCTATCCCATGGACGGTTTTCGGCGCTAAAATGGGACATGCGCCGAATTTCGGCTCTCATCGGCA
TGTTTTTACAGGAATCCTGC

Downstream 100 bases:

>100_bases
GATGCAAAGCACTGAACACTGACGCGACCCTATGAAACCACAAGCCTACGCGCCGGAAAATCATTATCGTTTTGGAAAAG
CCTCGGCCTCATAACCAGCC

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MKPLDRADVALLRAVQINNRLSSEELAEIAHLSPTACQRRLKRLRAEGVIESDVAIVSPKAVGRPIIMVVSVSLERERAD
IIDKFKRAIRKSPEVMTGYYVTGDADFVLVITARDMETYEAFTRRFFYENPDIKNFKTLVVMDRVKAGLAIPIEEPDIE

Sequences:

>Translated_159_residues
MKPLDRADVALLRAVQINNRLSSEELAEIAHLSPTACQRRLKRLRAEGVIESDVAIVSPKAVGRPIIMVVSVSLERERAD
IIDKFKRAIRKSPEVMTGYYVTGDADFVLVITARDMETYEAFTRRFFYENPDIKNFKTLVVMDRVKAGLAIPIEEPDIE
>Mature_159_residues
MKPLDRADVALLRAVQINNRLSSEELAEIAHLSPTACQRRLKRLRAEGVIESDVAIVSPKAVGRPIIMVVSVSLERERAD
IIDKFKRAIRKSPEVMTGYYVTGDADFVLVITARDMETYEAFTRRFFYENPDIKNFKTLVVMDRVKAGLAIPIEEPDIE

Specific function: Mediates A Global Response To Leucine. Exogenous Leucine Affects The Expression Of A Number Of Different Operons; Lrp Mediates This Effect For At Least Some Of These Operons. For Example It Is Regulator Of The Branched-Chain Amino Acid Transport Genes. [

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=145, Percent_Identity=31.7241379310345, Blast_Score=89, Evalue=1e-19,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=27.8145695364238, Blast_Score=86, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR013196
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg; PF08279 HTH_11 [H]

EC number: NA

Molecular weight: Translated: 18021; Mature: 18021

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLDRADVALLRAVQINNRLSSEELAEIAHLSPTACQRRLKRLRAEGVIESDVAIVSPK
CCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEECCH
AVGRPIIMVVSVSLERERADIIDKFKRAIRKSPEVMTGYYVTGDADFVLVITARDMETYE
HCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEEECCCHHHH
AFTRRFFYENPDIKNFKTLVVMDRVKAGLAIPIEEPDIE
HHHHHHHCCCCCCCCHHHHEEEHHHHCCEEECCCCCCCC
>Mature Secondary Structure
MKPLDRADVALLRAVQINNRLSSEELAEIAHLSPTACQRRLKRLRAEGVIESDVAIVSPK
CCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEECCH
AVGRPIIMVVSVSLERERADIIDKFKRAIRKSPEVMTGYYVTGDADFVLVITARDMETYE
HCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEEECCCHHHH
AFTRRFFYENPDIKNFKTLVVMDRVKAGLAIPIEEPDIE
HHHHHHHCCCCCCCCHHHHEEEHHHHCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]