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The map label for this gene is lldD [H]

Identifier: 110634743

GI number: 110634743

Start: 2557772

End: 2558947

Strand: Reverse

Name: lldD [H]

Synonym: Meso_2401

Alternate gene names: 110634743

Gene position: 2558947-2557772 (Counterclockwise)

Preceding gene: 110634744

Following gene: 110634742

Centisome position: 57.99

GC content: 62.41

Gene sequence:

>1176_bases
ATGTTCCACCTTCCTATCTTCACGATGAAACGAGGATCTTTGGTCAACGTACAGGACTACCGCAAGGCCGCCCGGGCGGT
GCTGCCGCGAATGCTCTTTGACTTTGTTGACGGGAGTGCCCTTGACGGGCAGACAGCTTCCCGAAACTGCGCAGGCTTTT
CAGACTGGTGGTTCAGAGCGCACAGCTTCCGCTCAACGGCTGAGCCTGACATCTCGTGGTCGGCTTTCGGCCAGCGGCAT
GCCGCGCCGGTTATAATCGCGCCGACCGGCGCCTCTGGGCTGCTCTGGCCGTCGGGCGAGGCCGAGACGGCGGAGGCAGC
CGCCCGGCGGGGTCATGTGATGCAGGTCAGCGCCGGATCGCTGCTCTCGATGGAAGAGATCGCTGCAGGCGGGAAGGGTG
AGGGCGAACGTTGGCTGCAGCTCTTCCTCTACCGGGATCGCGGCTTGACCCGCGAATTCCTCCATCGAGCCAAGGCAGCG
GGATACACGGCGATCTGCGTCACCACAGACGCCCCGGTGCATGGTCGGCGCGAGCGCGATATGCGCAATGGCTTCACCAT
CGATCAGCGCTTGAGACTGAGCACACTGCTTGACGCGGCCATTCATTGCCGATGGTGGTTCCGCATGCGCGGCAGCGGCA
GGCTGACGCTAAAGAACTTTGCCGGCCGCGCCACCGGAAATATGAACGACATGGCTGCCTATATTGCATCGGTACTCGAC
CCGGACGTAACGTGGGACGATATCTCCTGGTTGCGCTCGGAGTGGGAAGGCCCTTTGATCATCAAGGGAATTCTTCACCC
GGACGATGCGTGCGAAGCTATCGCCCGCGGATGCGACGGCGTGCAGATTTCCAATCACGGCGGACGTCAGCTCGACGGCA
CGCTTTCCGCGATCGATGCGCTGCCTGCGGTGTCGGATGCAGTTGAGGGCCGAGTGCCGATCTTCCTTGATGGCGGGATC
GAGCGAGGAACTGACATTCTGAAGGCAATCGCGCTCGGGGCCACGGCCTGTGTCATCGGCCGCGCCCATCTTTGGGGACT
GGCGGTTGCCGGCGGAAAGGGCGTCGAAGCGGTTTGCGACGTTCTCGTTGCCGAGCTAAGGAATGCGATGGTGATCGGCG
GATGGAAGGCGCTATCTGATTTGGATCGGTCGGCAGTCACACGGCTCCCGCAGTAG

Upstream 100 bases:

>100_bases
ACGATAATTGGTGAAGTATGCCTTGACAGGCTCATGGATGTGATGACATTTTGTGATCATATTCAGCCCCTCAAGCGGGA
CGACAAACGAAAATAAGACT

Downstream 100 bases:

>100_bases
AAAGAGAGGCATTCATGAACGATATATCCCGGTTGCCAGGCACGGCCCGCATGAGTTCGGCCGTGATTGTGAACGGCATT
GTTTACACAAAGGGGATTAC

Product: FMN-dependent alpha-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MFHLPIFTMKRGSLVNVQDYRKAARAVLPRMLFDFVDGSALDGQTASRNCAGFSDWWFRAHSFRSTAEPDISWSAFGQRH
AAPVIIAPTGASGLLWPSGEAETAEAAARRGHVMQVSAGSLLSMEEIAAGGKGEGERWLQLFLYRDRGLTREFLHRAKAA
GYTAICVTTDAPVHGRRERDMRNGFTIDQRLRLSTLLDAAIHCRWWFRMRGSGRLTLKNFAGRATGNMNDMAAYIASVLD
PDVTWDDISWLRSEWEGPLIIKGILHPDDACEAIARGCDGVQISNHGGRQLDGTLSAIDALPAVSDAVEGRVPIFLDGGI
ERGTDILKAIALGATACVIGRAHLWGLAVAGGKGVEAVCDVLVAELRNAMVIGGWKALSDLDRSAVTRLPQ

Sequences:

>Translated_391_residues
MFHLPIFTMKRGSLVNVQDYRKAARAVLPRMLFDFVDGSALDGQTASRNCAGFSDWWFRAHSFRSTAEPDISWSAFGQRH
AAPVIIAPTGASGLLWPSGEAETAEAAARRGHVMQVSAGSLLSMEEIAAGGKGEGERWLQLFLYRDRGLTREFLHRAKAA
GYTAICVTTDAPVHGRRERDMRNGFTIDQRLRLSTLLDAAIHCRWWFRMRGSGRLTLKNFAGRATGNMNDMAAYIASVLD
PDVTWDDISWLRSEWEGPLIIKGILHPDDACEAIARGCDGVQISNHGGRQLDGTLSAIDALPAVSDAVEGRVPIFLDGGI
ERGTDILKAIALGATACVIGRAHLWGLAVAGGKGVEAVCDVLVAELRNAMVIGGWKALSDLDRSAVTRLPQ
>Mature_391_residues
MFHLPIFTMKRGSLVNVQDYRKAARAVLPRMLFDFVDGSALDGQTASRNCAGFSDWWFRAHSFRSTAEPDISWSAFGQRH
AAPVIIAPTGASGLLWPSGEAETAEAAARRGHVMQVSAGSLLSMEEIAAGGKGEGERWLQLFLYRDRGLTREFLHRAKAA
GYTAICVTTDAPVHGRRERDMRNGFTIDQRLRLSTLLDAAIHCRWWFRMRGSGRLTLKNFAGRATGNMNDMAAYIASVLD
PDVTWDDISWLRSEWEGPLIIKGILHPDDACEAIARGCDGVQISNHGGRQLDGTLSAIDALPAVSDAVEGRVPIFLDGGI
ERGTDILKAIALGATACVIGRAHLWGLAVAGGKGVEAVCDVLVAELRNAMVIGGWKALSDLDRSAVTRLPQ

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=377, Percent_Identity=38.9920424403183, Blast_Score=284, Evalue=9e-77,
Organism=Homo sapiens, GI54234014, Length=374, Percent_Identity=35.2941176470588, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI7705393, Length=374, Percent_Identity=35.2941176470588, Blast_Score=233, Evalue=3e-61,
Organism=Escherichia coli, GI1790033, Length=375, Percent_Identity=36.5333333333333, Blast_Score=256, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI193208036, Length=383, Percent_Identity=34.9869451697128, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI32566217, Length=293, Percent_Identity=32.4232081911263, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323587, Length=378, Percent_Identity=27.5132275132275, Blast_Score=151, Evalue=2e-37,
Organism=Drosophila melanogaster, GI281363140, Length=379, Percent_Identity=35.0923482849604, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI78707190, Length=379, Percent_Identity=35.0923482849604, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI78707188, Length=379, Percent_Identity=34.8284960422164, Blast_Score=226, Evalue=3e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 42437; Mature: 42437

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFHLPIFTMKRGSLVNVQDYRKAARAVLPRMLFDFVDGSALDGQTASRNCAGFSDWWFRA
CCCCCEEEECCCCEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
HSFRSTAEPDISWSAFGQRHAAPVIIAPTGASGLLWPSGEAETAEAAARRGHVMQVSAGS
HHCCCCCCCCCCHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEECCCC
LLSMEEIAAGGKGEGERWLQLFLYRDRGLTREFLHRAKAAGYTAICVTTDAPVHGRRERD
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHH
MRNGFTIDQRLRLSTLLDAAIHCRWWFRMRGSGRLTLKNFAGRATGNMNDMAAYIASVLD
HHCCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEHHCCCCCCCCHHHHHHHHHHHHC
PDVTWDDISWLRSEWEGPLIIKGILHPDDACEAIARGCDGVQISNHGGRQLDGTLSAIDA
CCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHH
LPAVSDAVEGRVPIFLDGGIERGTDILKAIALGATACVIGRAHLWGLAVAGGKGVEAVCD
HHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHH
VLVAELRNAMVIGGWKALSDLDRSAVTRLPQ
HHHHHHHCCEEEECHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFHLPIFTMKRGSLVNVQDYRKAARAVLPRMLFDFVDGSALDGQTASRNCAGFSDWWFRA
CCCCCEEEECCCCEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
HSFRSTAEPDISWSAFGQRHAAPVIIAPTGASGLLWPSGEAETAEAAARRGHVMQVSAGS
HHCCCCCCCCCCHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEECCCC
LLSMEEIAAGGKGEGERWLQLFLYRDRGLTREFLHRAKAAGYTAICVTTDAPVHGRRERD
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHH
MRNGFTIDQRLRLSTLLDAAIHCRWWFRMRGSGRLTLKNFAGRATGNMNDMAAYIASVLD
HHCCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEHHCCCCCCCCHHHHHHHHHHHHC
PDVTWDDISWLRSEWEGPLIIKGILHPDDACEAIARGCDGVQISNHGGRQLDGTLSAIDA
CCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHH
LPAVSDAVEGRVPIFLDGGIERGTDILKAIALGATACVIGRAHLWGLAVAGGKGVEAVCD
HHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHH
VLVAELRNAMVIGGWKALSDLDRSAVTRLPQ
HHHHHHHCCEEEECHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]