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The map label for this gene is pdhB [H]

Identifier: 110634613

GI number: 110634613

Start: 2420643

End: 2421614

Strand: Direct

Name: pdhB [H]

Synonym: Meso_2267

Alternate gene names: 110634613

Gene position: 2420643-2421614 (Clockwise)

Preceding gene: 110634612

Following gene: 110634614

Centisome position: 54.86

GC content: 63.17

Gene sequence:

>972_bases
ATGGCACGCAAAAGCTGGATGTACTCGGTCCTTGAGGCCGTACAGCACGAAATGCTGGAAGATCCGAATATGGTCTGGAT
CTTCGAACTCACCCCGCCGGTGGCCTCCAACCCCGGCAGGCTTGTCATCAACCTGGAGAAGCAATTCGGACGCAACCGGG
TGGTGAACACCGGGATCGACGAGAACTGGATGGCCTCGGCTACGCTTGGCGCGGGCTTGGCGGGCTCGCGGGCAGCCACC
TACGTGCCCTACCAGGGCGCGTGCATGCCCTTTCAGGTGATCCAGAACCACGCCGGCAAGCTGCGCCACATGACCGGCGG
AAAGGCATCCATGCCCGTCGTCTTCATCATGGAGATGACCGGCCAGACACCGGGCTTCGCCGGGCAGCACTCCGATTACG
AGATCGACACCTACTACGCGCACATCCCCGGCGTGAAGACGGTGATACCGTCCACGCCCTATGACGCCAAGGGCATGATG
GTATCGGCCCTAAGAGACCCAAACCCGGTCGTCTATCTCTACCCTGCAGGCCTGCGCGAGCTCATCGAAGAGGTGCCCGA
CGAGCAATATGAAGTGCCGCTCGACAAGGCGATCGTCCGCATGGAAGGCAGCGATCTCACCATCGTGGGCTCCGGCGCGA
GCATGCCGGAGGTCCTGAAGGCGGCAGAAACGCTGAAGGCGGCCGGCATGAACGTCGAGGCGATCGACCTCAGAAGCCTC
AAGCCGATGGATACGGAGACACTGGTGAAGTCGGTGGCCAAGACAAAGCGGCTGCTCACCGTCGACCAGTCCTACTACAC
GCTCTGCCCCGGCGCGGAGGTGATCGCCCGCGTGGCCGAAAATGTCGATGGCGCCCGCTACAAGCGCGTGGCCTTCCCGG
ACGCGCCGCCGCCGGCCTCGCCAGAGATGTTTCTCTGGATGCGGCCCAACGCCGACCACATCGTTGGTGCGGCGAAGAAG
CTGGTTGGCTGA

Upstream 100 bases:

>100_bases
CTTCGTCGAAGGCACCGTCGAGGCGCGCCAGTTCGGTTGAGAGGCGACGTCGGCAGGTCCGGTCTCCCTCTCCCTGGCAG
CAATTGGAAAGGTACGTGAA

Downstream 100 bases:

>100_bases
CCTCCTCCCACCGGCCAACTCCGGGCACGAACGCGAAAATCGGCTCGTGCCCGGATCTTTCAACCCCAGGAGCACCCCAT
GCACGCACCCACCGCTCATC

Product: transketolase-like

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MARKSWMYSVLEAVQHEMLEDPNMVWIFELTPPVASNPGRLVINLEKQFGRNRVVNTGIDENWMASATLGAGLAGSRAAT
YVPYQGACMPFQVIQNHAGKLRHMTGGKASMPVVFIMEMTGQTPGFAGQHSDYEIDTYYAHIPGVKTVIPSTPYDAKGMM
VSALRDPNPVVYLYPAGLRELIEEVPDEQYEVPLDKAIVRMEGSDLTIVGSGASMPEVLKAAETLKAAGMNVEAIDLRSL
KPMDTETLVKSVAKTKRLLTVDQSYYTLCPGAEVIARVAENVDGARYKRVAFPDAPPPASPEMFLWMRPNADHIVGAAKK
LVG

Sequences:

>Translated_323_residues
MARKSWMYSVLEAVQHEMLEDPNMVWIFELTPPVASNPGRLVINLEKQFGRNRVVNTGIDENWMASATLGAGLAGSRAAT
YVPYQGACMPFQVIQNHAGKLRHMTGGKASMPVVFIMEMTGQTPGFAGQHSDYEIDTYYAHIPGVKTVIPSTPYDAKGMM
VSALRDPNPVVYLYPAGLRELIEEVPDEQYEVPLDKAIVRMEGSDLTIVGSGASMPEVLKAAETLKAAGMNVEAIDLRSL
KPMDTETLVKSVAKTKRLLTVDQSYYTLCPGAEVIARVAENVDGARYKRVAFPDAPPPASPEMFLWMRPNADHIVGAAKK
LVG
>Mature_322_residues
ARKSWMYSVLEAVQHEMLEDPNMVWIFELTPPVASNPGRLVINLEKQFGRNRVVNTGIDENWMASATLGAGLAGSRAATY
VPYQGACMPFQVIQNHAGKLRHMTGGKASMPVVFIMEMTGQTPGFAGQHSDYEIDTYYAHIPGVKTVIPSTPYDAKGMMV
SALRDPNPVVYLYPAGLRELIEEVPDEQYEVPLDKAIVRMEGSDLTIVGSGASMPEVLKAAETLKAAGMNVEAIDLRSLK
PMDTETLVKSVAKTKRLLTVDQSYYTLCPGAEVIARVAENVDGARYKRVAFPDAPPPASPEMFLWMRPNADHIVGAAKKL
VG

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=309, Percent_Identity=33.0097087378641, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4557353, Length=303, Percent_Identity=32.6732673267327, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI34101272, Length=303, Percent_Identity=32.6732673267327, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI291084858, Length=309, Percent_Identity=31.0679611650485, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1786622, Length=156, Percent_Identity=29.4871794871795, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17538422, Length=326, Percent_Identity=33.7423312883436, Blast_Score=149, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17506935, Length=327, Percent_Identity=31.1926605504587, Blast_Score=120, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6319698, Length=288, Percent_Identity=33.6805555555556, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI21358145, Length=327, Percent_Identity=32.7217125382263, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24650940, Length=327, Percent_Identity=32.7217125382263, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI160714832, Length=271, Percent_Identity=32.8413284132841, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI160714828, Length=271, Percent_Identity=32.8413284132841, Blast_Score=131, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35315; Mature: 35184

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKSWMYSVLEAVQHEMLEDPNMVWIFELTPPVASNPGRLVINLEKQFGRNRVVNTGID
CCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEEEHHHCCCCCEEECCCC
ENWMASATLGAGLAGSRAATYVPYQGACMPFQVIQNHAGKLRHMTGGKASMPVVFIMEMT
CCCEEHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHCHHHEEECCCCCCCCCEEEEEEEC
GQTPGFAGQHSDYEIDTYYAHIPGVKTVIPSTPYDAKGMMVSALRDPNPVVYLYPAGLRE
CCCCCCCCCCCCEEEEEEEEECCCCCEECCCCCCCCCCEEEEECCCCCCEEEECCHHHHH
LIEEVPDEQYEVPLDKAIVRMEGSDLTIVGSGASMPEVLKAAETLKAAGMNVEAIDLRSL
HHHHCCCCCCCCCHHHEEEEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCC
KPMDTETLVKSVAKTKRLLTVDQSYYTLCPGAEVIARVAENVDGARYKRVAFPDAPPPAS
CCCCHHHHHHHHHHHHHEEEECCCEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCCCCC
PEMFLWMRPNADHIVGAAKKLVG
CCEEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure 
ARKSWMYSVLEAVQHEMLEDPNMVWIFELTPPVASNPGRLVINLEKQFGRNRVVNTGID
CCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEEEHHHCCCCCEEECCCC
ENWMASATLGAGLAGSRAATYVPYQGACMPFQVIQNHAGKLRHMTGGKASMPVVFIMEMT
CCCEEHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHCHHHEEECCCCCCCCCEEEEEEEC
GQTPGFAGQHSDYEIDTYYAHIPGVKTVIPSTPYDAKGMMVSALRDPNPVVYLYPAGLRE
CCCCCCCCCCCCEEEEEEEEECCCCCEECCCCCCCCCCEEEEECCCCCCEEEECCHHHHH
LIEEVPDEQYEVPLDKAIVRMEGSDLTIVGSGASMPEVLKAAETLKAAGMNVEAIDLRSL
HHHHCCCCCCCCCHHHEEEEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCC
KPMDTETLVKSVAKTKRLLTVDQSYYTLCPGAEVIARVAENVDGARYKRVAFPDAPPPAS
CCCCHHHHHHHHHHHHHEEEECCCEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCCCCC
PEMFLWMRPNADHIVGAAKKLVG
CCEEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2200674; 2253629 [H]