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The map label for this gene is pth

Identifier: 110634507

GI number: 110634507

Start: 2308314

End: 2309033

Strand: Direct

Name: pth

Synonym: Meso_2158

Alternate gene names: 110634507

Gene position: 2308314-2309033 (Clockwise)

Preceding gene: 110634506

Following gene: 110634508

Centisome position: 52.31

GC content: 60.14

Gene sequence:

>720_bases
ATGCTTCTCCTTGCTGGGCTCGGCAATCCGGGTCCGCAATACCAAAACCACCGGCACAATGTCGGCTTCATGGCGGCGGA
TGCTATTTTTCGCCGCCATTCCTTTTCGCCCTGGTCGAAAAAATTCAGCGCGCTCGTAGCCGAAGGCAGGGTCGGCACCG
AAAAACTGCTGCTCGTGAAGCCGCAGACCTTCATGAACCTTTCCGGCCAGGCTGTCGGCGAGGCCATGCGCTTTTACAAG
CTTCAGCCGTCCGACATAATTGTATTTTACGACGAGCTTGATCTTGCTCCCGGCAAGGTGCGAGTGAAGCGCGGCAGCGG
CAGCGGCGGCCACAATGGCATTAAATCCATTGACGCCCATTGCGGTCAGGATTACCGCCGCGTGCGCATCGGCATCGGCC
ATCCAGGTGATAAGGCGCGGGTTACGCCCCATGTGCTCGGCGATTTTGCCAAGGCCGATCATGCCTGGCTCGATCCGCTG
CTCGATGCGATGGCGGAAAATGTCGATTTGCTCATCACGGGCGACGAGTCCGGCTTCATGAACAAGGCCAGCCTAGCCGT
GCAGGGTAAGGCTGCGGACATCGAGATGGCCGGCGAGAAACCGGCTCAGAAGGGGCGCAGCCACATCCGCCAGGCGCGGC
CAAAGGCGCCGCCGGCGGAACTTCCATCAAGCGGCCCGATGGCCGCCATGCTGAAGAAGCTCTTCGGCGGTAAAGAATAA

Upstream 100 bases:

>100_bases
CGCCGGCCTGAAGTCCGAGGGAGCCGAAGGCGGCGAAGCAGAAGCGGGACAGGCGGAAGAGGGCGAGGAGTAATCCTCCC
CTCCCCATGGGAGGCAATCC

Downstream 100 bases:

>100_bases
GTCCGGAAGGCCAAAGGCAGGATTTGAAAGCTTTTCCGGGCTTGACGATGGTCGGTTCCTTCGCCCATAGCCCCTCCCAG
CATTACTTGAACGGCTACCA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MLLLAGLGNPGPQYQNHRHNVGFMAADAIFRRHSFSPWSKKFSALVAEGRVGTEKLLLVKPQTFMNLSGQAVGEAMRFYK
LQPSDIIVFYDELDLAPGKVRVKRGSGSGGHNGIKSIDAHCGQDYRRVRIGIGHPGDKARVTPHVLGDFAKADHAWLDPL
LDAMAENVDLLITGDESGFMNKASLAVQGKAADIEMAGEKPAQKGRSHIRQARPKAPPAELPSSGPMAAMLKKLFGGKE

Sequences:

>Translated_239_residues
MLLLAGLGNPGPQYQNHRHNVGFMAADAIFRRHSFSPWSKKFSALVAEGRVGTEKLLLVKPQTFMNLSGQAVGEAMRFYK
LQPSDIIVFYDELDLAPGKVRVKRGSGSGGHNGIKSIDAHCGQDYRRVRIGIGHPGDKARVTPHVLGDFAKADHAWLDPL
LDAMAENVDLLITGDESGFMNKASLAVQGKAADIEMAGEKPAQKGRSHIRQARPKAPPAELPSSGPMAAMLKKLFGGKE
>Mature_239_residues
MLLLAGLGNPGPQYQNHRHNVGFMAADAIFRRHSFSPWSKKFSALVAEGRVGTEKLLLVKPQTFMNLSGQAVGEAMRFYK
LQPSDIIVFYDELDLAPGKVRVKRGSGSGGHNGIKSIDAHCGQDYRRVRIGIGHPGDKARVTPHVLGDFAKADHAWLDPL
LDAMAENVDLLITGDESGFMNKASLAVQGKAADIEMAGEKPAQKGRSHIRQARPKAPPAELPSSGPMAAMLKKLFGGKE

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=164, Percent_Identity=34.1463414634146, Blast_Score=91, Evalue=8e-19,
Organism=Escherichia coli, GI1787455, Length=175, Percent_Identity=40, Blast_Score=108, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6321983, Length=162, Percent_Identity=32.0987654320988, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_MESSB (Q11GC5)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674715.1
- ProteinModelPortal:   Q11GC5
- SMR:   Q11GC5
- STRING:   Q11GC5
- GeneID:   4182470
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_2158
- NMPDR:   fig|266779.1.peg.1742
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   HIRERSQ
- PhylomeDB:   Q11GC5
- ProtClustDB:   PRK05426
- BioCyc:   MSP266779:MESO_2158-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 25831; Mature: 25831

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLLAGLGNPGPQYQNHRHNVGFMAADAIFRRHSFSPWSKKFSALVAEGRVGTEKLLLVK
CEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEC
PQTFMNLSGQAVGEAMRFYKLQPSDIIVFYDELDLAPGKVRVKRGSGSGGHNGIKSIDAH
CHHHHCCCCHHHHHHHHHEECCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHH
CGQDYRRVRIGIGHPGDKARVTPHVLGDFAKADHAWLDPLLDAMAENVDLLITGDESGFM
CCCCEEEEEEECCCCCCCCEECHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCC
NKASLAVQGKAADIEMAGEKPAQKGRSHIRQARPKAPPAELPSSGPMAAMLKKLFGGKE
CCCEEEEECCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MLLLAGLGNPGPQYQNHRHNVGFMAADAIFRRHSFSPWSKKFSALVAEGRVGTEKLLLVK
CEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEC
PQTFMNLSGQAVGEAMRFYKLQPSDIIVFYDELDLAPGKVRVKRGSGSGGHNGIKSIDAH
CHHHHCCCCHHHHHHHHHEECCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHH
CGQDYRRVRIGIGHPGDKARVTPHVLGDFAKADHAWLDPLLDAMAENVDLLITGDESGFM
CCCCEEEEEEECCCCCCCCEECHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCC
NKASLAVQGKAADIEMAGEKPAQKGRSHIRQARPKAPPAELPSSGPMAAMLKKLFGGKE
CCCEEEEECCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA