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The map label for this gene is lrp [H]

Identifier: 110634462

GI number: 110634462

Start: 2270472

End: 2270945

Strand: Direct

Name: lrp [H]

Synonym: Meso_2113

Alternate gene names: 110634462

Gene position: 2270472-2270945 (Clockwise)

Preceding gene: 110634459

Following gene: 110634468

Centisome position: 51.46

GC content: 60.55

Gene sequence:

>474_bases
ATGCCGTTAAAGGCCGATCTCGACGCCATTGACTGGAAAATTCTGCGCGAGCTGCAAAAGGATGGCCGCATCACGAATGT
CGAGCTCTCCAAGCGGGTCGGTATTTCCGCTCCGCCTTGCCTGCGCCGGGTGCGCCGCCTGGAAGAAGGCGGCATCATCA
AGGGCTACCGTGCGCTTCTCAACAGTCCCGTGCTCGGCTTCGACGTGGTGGCTTTTTGCCTCGTAGGGCTGCATCATCAA
TCTGAAGCGGAGCTTAGGACCTTTGCCGAACGGGCGCGCAACTGGCCCATCGTGAGGCGTGCCTGGATGGTTTCCGGCGA
TTCGGACTTCCTGCTGCATTGCGTCGCAGCCGATCTCGGCGCCTTCCAGTCATTCGTTATCGAGGAACTGACTTCCGCAC
CGAATGTCGACACCGTCCGCACCGCGCTCACCATCCGGCAAGTGAAGGACGAAGGACTGGTGGCGATCGGGTGA

Upstream 100 bases:

>100_bases
TCCCTTAGCCTCGGTGCTTGGCGAACACAGGAGCTTGGCGTAAATTTGTTGCGCAACTGCGACAGATTCGTGCGCGGGAG
AACGCGCTGAGGGGCTATCA

Downstream 100 bases:

>100_bases
ACCGAGATGGCGCCGGTATTCCAGCATCAGGAATGCGGCAGATCAGGCAAACTTCACGAACACCCACTTCTTATCCGTCA
AAAGGCCAGATGCCAGTCTT

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 157; Mature: 156

Protein sequence:

>157_residues
MPLKADLDAIDWKILRELQKDGRITNVELSKRVGISAPPCLRRVRRLEEGGIIKGYRALLNSPVLGFDVVAFCLVGLHHQ
SEAELRTFAERARNWPIVRRAWMVSGDSDFLLHCVAADLGAFQSFVIEELTSAPNVDTVRTALTIRQVKDEGLVAIG

Sequences:

>Translated_157_residues
MPLKADLDAIDWKILRELQKDGRITNVELSKRVGISAPPCLRRVRRLEEGGIIKGYRALLNSPVLGFDVVAFCLVGLHHQ
SEAELRTFAERARNWPIVRRAWMVSGDSDFLLHCVAADLGAFQSFVIEELTSAPNVDTVRTALTIRQVKDEGLVAIG
>Mature_156_residues
PLKADLDAIDWKILRELQKDGRITNVELSKRVGISAPPCLRRVRRLEEGGIIKGYRALLNSPVLGFDVVAFCLVGLHHQS
EAELRTFAERARNWPIVRRAWMVSGDSDFLLHCVAADLGAFQSFVIEELTSAPNVDTVRTALTIRQVKDEGLVAIG

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=151, Percent_Identity=42.3841059602649, Blast_Score=119, Evalue=7e-29,
Organism=Escherichia coli, GI87081742, Length=143, Percent_Identity=30.7692307692308, Blast_Score=84, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17478; Mature: 17346

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLKADLDAIDWKILRELQKDGRITNVELSKRVGISAPPCLRRVRRLEEGGIIKGYRALL
CCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHH
NSPVLGFDVVAFCLVGLHHQSEAELRTFAERARNWPIVRRAWMVSGDSDFLLHCVAADLG
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHEEEECCCCHHHHHHHHHHHH
AFQSFVIEELTSAPNVDTVRTALTIRQVKDEGLVAIG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEECC
>Mature Secondary Structure 
PLKADLDAIDWKILRELQKDGRITNVELSKRVGISAPPCLRRVRRLEEGGIIKGYRALL
CCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHH
NSPVLGFDVVAFCLVGLHHQSEAELRTFAERARNWPIVRRAWMVSGDSDFLLHCVAADLG
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHEEEECCCCHHHHHHHHHHHH
AFQSFVIEELTSAPNVDTVRTALTIRQVKDEGLVAIG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11157937; 11481430 [H]