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The map label for this gene is drrB [H]

Identifier: 110634449

GI number: 110634449

Start: 2253986

End: 2254789

Strand: Reverse

Name: drrB [H]

Synonym: Meso_2100

Alternate gene names: 110634449

Gene position: 2254789-2253986 (Counterclockwise)

Preceding gene: 110634450

Following gene: 110634447

Centisome position: 51.1

GC content: 62.81

Gene sequence:

>804_bases
ATGAGCGAGATTCAACAAGCCCTGCTCACCAATGTGCAGCGGCCGACACCACCTTCGGCAATTTCCAACGCGCTCGTCTT
CGGCTGGCGCGCGGTGCTGAAGTTCAAGCACGTGCCGGAGCAGCTCTTCGACCTTGTCATGACGCCGCTGATGTTCACGC
TGCTCTTCACCTTCGTGTTCGGCGGCGCGCTGGCTGGCTCACCGGGCGAATATCTGCAGTTCTTCCTGCCGGGGATTCTG
GTGCAGACGGTGGTCTTCAACTCGGTCTATTCCGGCATGGGGCTTTCGACAGACCTCTCGAAAGGGCTGTTCGAGCGCTT
CCGGTCGCTCCCCGTCTGGCCGCTCGCGCCCTTTGCCGGGCTGATGGTGGGCGATGTGCTGCGCCATGTGATCGCGGGCG
CCATCATCCTCGGAATCGGCCTCATCCTCGGCTACAGGCCGGAAGCGGGAATCGGGGGCGTGCTTGCCTCCTTCCTGCTC
TTGATCGCCATCGGCTTCGGTACGGGCTGGATCTTCATTGTGCTGGGGTTGATCATCCGTACGCCCATGACGGTGATGAC
GATCGGCTTCACCTTTATCTTCCCGCTGGTCTTCGCCTCCAATATCATGGTGCAGCCGGAAACCATGCCCGGCTGGCTTG
CGGCCTTCGTCAACCACAACCCGGTGTCCTTCATGGCTACGGCGCTGCGCGGGCTGATGGCGGGCACGGCGACGGCACAG
GAGGTGTTGCTGGCGCTTGCCGCGCCGGTTAGCCTGACGATCGTGCTGGCGCCGGTCGTGCTGTGGCTTTACCGGCGCCA
TTAA

Upstream 100 bases:

>100_bases
AGCTTTCCGACTTTTCGATGGGCTCGCCAAGTCTCGATGAGGTCTTCTTCGCGCTTACGGGCGCGCCAGCGGAAAATCAT
GAGCAGAAGGAAGCCGCCCA

Downstream 100 bases:

>100_bases
GGCATCCGAAAAAATGCGCCCGCCACGGAGCGTGACGGGCGCAAGTTCCTGAAGGACCATTACTGGCAGTTCGGCTGGCC
TGGCGCGCAGGGCATAACCT

Product: ABC-2 type transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSEIQQALLTNVQRPTPPSAISNALVFGWRAVLKFKHVPEQLFDLVMTPLMFTLLFTFVFGGALAGSPGEYLQFFLPGIL
VQTVVFNSVYSGMGLSTDLSKGLFERFRSLPVWPLAPFAGLMVGDVLRHVIAGAIILGIGLILGYRPEAGIGGVLASFLL
LIAIGFGTGWIFIVLGLIIRTPMTVMTIGFTFIFPLVFASNIMVQPETMPGWLAAFVNHNPVSFMATALRGLMAGTATAQ
EVLLALAAPVSLTIVLAPVVLWLYRRH

Sequences:

>Translated_267_residues
MSEIQQALLTNVQRPTPPSAISNALVFGWRAVLKFKHVPEQLFDLVMTPLMFTLLFTFVFGGALAGSPGEYLQFFLPGIL
VQTVVFNSVYSGMGLSTDLSKGLFERFRSLPVWPLAPFAGLMVGDVLRHVIAGAIILGIGLILGYRPEAGIGGVLASFLL
LIAIGFGTGWIFIVLGLIIRTPMTVMTIGFTFIFPLVFASNIMVQPETMPGWLAAFVNHNPVSFMATALRGLMAGTATAQ
EVLLALAAPVSLTIVLAPVVLWLYRRH
>Mature_266_residues
SEIQQALLTNVQRPTPPSAISNALVFGWRAVLKFKHVPEQLFDLVMTPLMFTLLFTFVFGGALAGSPGEYLQFFLPGILV
QTVVFNSVYSGMGLSTDLSKGLFERFRSLPVWPLAPFAGLMVGDVLRHVIAGAIILGIGLILGYRPEAGIGGVLASFLLL
IAIGFGTGWIFIVLGLIIRTPMTVMTIGFTFIFPLVFASNIMVQPETMPGWLAAFVNHNPVSFMATALRGLMAGTATAQE
VLLALAAPVSLTIVLAPVVLWLYRRH

Specific function: Part of the ABC transporter complex drrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 28850; Mature: 28719

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIQQALLTNVQRPTPPSAISNALVFGWRAVLKFKHVPEQLFDLVMTPLMFTLLFTFVF
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
GGALAGSPGEYLQFFLPGILVQTVVFNSVYSGMGLSTDLSKGLFERFRSLPVWPLAPFAG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
LMVGDVLRHVIAGAIILGIGLILGYRPEAGIGGVLASFLLLIAIGFGTGWIFIVLGLIIR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
TPMTVMTIGFTFIFPLVFASNIMVQPETMPGWLAAFVNHNPVSFMATALRGLMAGTATAQ
CCHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
EVLLALAAPVSLTIVLAPVVLWLYRRH
HHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEIQQALLTNVQRPTPPSAISNALVFGWRAVLKFKHVPEQLFDLVMTPLMFTLLFTFVF
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
GGALAGSPGEYLQFFLPGILVQTVVFNSVYSGMGLSTDLSKGLFERFRSLPVWPLAPFAG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
LMVGDVLRHVIAGAIILGIGLILGYRPEAGIGGVLASFLLLIAIGFGTGWIFIVLGLIIR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
TPMTVMTIGFTFIFPLVFASNIMVQPETMPGWLAAFVNHNPVSFMATALRGLMAGTATAQ
CCHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
EVLLALAAPVSLTIVLAPVVLWLYRRH
HHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1924314 [H]