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The map label for this gene is pepQ [H]

Identifier: 110634344

GI number: 110634344

Start: 2136939

End: 2138765

Strand: Direct

Name: pepQ [H]

Synonym: Meso_1994

Alternate gene names: 110634344

Gene position: 2136939-2138765 (Clockwise)

Preceding gene: 110634343

Following gene: 110634370

Centisome position: 48.43

GC content: 61.25

Gene sequence:

>1827_bases
ATGTTCCAATCCTTCGATAGCAAGTCCGATCCCACGCAGGCGGGACCAAGGCTGGAGCGCCTTCGGGCGCTGATGGCCAC
GGCCGGGCACGACATAGTCCTTGTTCCCCACAGCGACGAGCATCAGAGCGAATACCTTCCGTCCAGCGCCGAGCGGCTGG
CATGGTTGACCGGGTTTACCGGCTCGGCGGGCGCGGCGCTCATTCTGCGGGATCGGGCCATTCTCTTCGTGGATGGCCGC
TATACGCTGCAGGCGCGCGAACAGGTGGATCCAAACCTATTTGAGATCGAAAATCTCGTCGAAAATCCACCGCGCGAGTG
GCTGAAGGCCAATCCTTCAAGGGGGTCGCGGGTCGGCTTCGATCCATGGCTACACACGATCGACGATGTGACGGGCCTGA
GAAAGGTCGCGGACAAGATCGGGGTCGAGCTCGTACCGCTCGATCGCAATCCCATCGATACGATTTGGGAAGATCGTCCT
GCGCCTCCCGCCGAGCCCGTGCGCATCCACCCGCTGGAATTCGCGGGCGAACCGGCGGAGGAGAAGCTGAAGCGCCTCGC
CTCCCGCCTGGCGGAGGAGGCCGTCGACCATACCGTTCTTACAAATGCGGCTTCATTGGCCTGGGCTTTCAACATTCGAG
GCGGAGACGTGGCCCATACGCCGTTGTCGCTTGGCTTCGCGGTGCTCTCCGCTTCGGCTCGGCCAAAACTCTTCCTCGAC
GCAAGGAAGCTTGATGGTGAAGCGAAAACCTACCTCGCCAGCCTTGCGGATCTTCATACGCCGTCTGAGCTTGAGCCGGC
ATTATCCTCCCTTGCCGGCGAGAAGGTGAAGTTCGGGCTGGATTTCGGGCTCGCATCCGAGCGCCTGCGCCTTCTCATTG
AAGAAAACGGCGGCTCGGTCGTGGATTTCACCGATCCGACCACGCTTCCCCGCGCCATCAAGAATGAAACGGAGCTGAGG
GGCGCGCGCGCAGCACATCTGCGGGACGGCGCCGCACTTGCGCGGTTTCTTGCCTGGGTGGACGCGCAGAAGCCTGAAAC
CTTGGACGAGATCACGATTGTGAAGCAACTGGAGGAATTCCGCCGCCGCATGGGCGAGGAAACTCAGATGCCCCTCCGCG
ACATCTCATTCGACACTATATCCGGCTCCGGGCCGAATGGTGCAATCGTGCATTACCGCGTGACGGAAAAGACCAACCGC
CGGCTCTCCGCCGGAGAGCTTCTTCTGGTCGATTCCGGAGCCCAGTTTCAAGACGGGACCACGGACGTGACCCGCACGAT
AGCCCTCGGTTCTCCGAGCGAGGAGATGCGCAACCGCTTCACGCTGGTCCTGAAGGGGATGATTGCCATCTCGATGTTGC
GTTTCCCTCCCGGCACACGCGGCCTGGATATCGACGCATTTGCCCGGGCGAATCTCTGGAAAGCCGGTCTCGACTATGGT
CATGGGACGGGCCATGGCGTCGGATCGTATCTCGGCGTGCACGAGGGGCCTCAGCGGATTGCCCGAACCGGGAAGGAGAA
GCTGCTGTCAGGCATGATCATCTCCAACGAGCCGGGTTATTATCGTCAGGGACATTACGGCATCCGCATCGAAAACCTGA
TTGTCGTCTCGTCCCCTGAACCGATTCCAGGCGGCGAGATCGACATGCACGGCTTCGAAACCCTAACGCTGGTCCCGATA
GACCGTAGGCTGATCGATCCCGCTCTGCTGACAGAGCAGGAACGCGATTGGCTCAATACCTATCACCGGCGCGTCTGGGA
GGAGATCGGTCCATTGGTCGACGGCGAAACAGCGGACTGGCTAGAGCAGGCAACGTCGCCCGTCTAG

Upstream 100 bases:

>100_bases
GCAACGCAGCATGAGCGCCTTTGGAACGGCTCATTGGTCCGATTGCTTGTGCCCGCGAGGCCGTTTAGGGTCGCCAAATC
TTTGCCGACAGGACGCTCCC

Downstream 100 bases:

>100_bases
CTCAAAAAATGCCGCAACGCGATCAGCACGGCGCCGCCGCTGAAAAAGATCGTCATCATGCCGCCGCCGAGGAACGAAAC
GACCGCGCCGGTGGCGAGCG

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MFQSFDSKSDPTQAGPRLERLRALMATAGHDIVLVPHSDEHQSEYLPSSAERLAWLTGFTGSAGAALILRDRAILFVDGR
YTLQAREQVDPNLFEIENLVENPPREWLKANPSRGSRVGFDPWLHTIDDVTGLRKVADKIGVELVPLDRNPIDTIWEDRP
APPAEPVRIHPLEFAGEPAEEKLKRLASRLAEEAVDHTVLTNAASLAWAFNIRGGDVAHTPLSLGFAVLSASARPKLFLD
ARKLDGEAKTYLASLADLHTPSELEPALSSLAGEKVKFGLDFGLASERLRLLIEENGGSVVDFTDPTTLPRAIKNETELR
GARAAHLRDGAALARFLAWVDAQKPETLDEITIVKQLEEFRRRMGEETQMPLRDISFDTISGSGPNGAIVHYRVTEKTNR
RLSAGELLLVDSGAQFQDGTTDVTRTIALGSPSEEMRNRFTLVLKGMIAISMLRFPPGTRGLDIDAFARANLWKAGLDYG
HGTGHGVGSYLGVHEGPQRIARTGKEKLLSGMIISNEPGYYRQGHYGIRIENLIVVSSPEPIPGGEIDMHGFETLTLVPI
DRRLIDPALLTEQERDWLNTYHRRVWEEIGPLVDGETADWLEQATSPV

Sequences:

>Translated_608_residues
MFQSFDSKSDPTQAGPRLERLRALMATAGHDIVLVPHSDEHQSEYLPSSAERLAWLTGFTGSAGAALILRDRAILFVDGR
YTLQAREQVDPNLFEIENLVENPPREWLKANPSRGSRVGFDPWLHTIDDVTGLRKVADKIGVELVPLDRNPIDTIWEDRP
APPAEPVRIHPLEFAGEPAEEKLKRLASRLAEEAVDHTVLTNAASLAWAFNIRGGDVAHTPLSLGFAVLSASARPKLFLD
ARKLDGEAKTYLASLADLHTPSELEPALSSLAGEKVKFGLDFGLASERLRLLIEENGGSVVDFTDPTTLPRAIKNETELR
GARAAHLRDGAALARFLAWVDAQKPETLDEITIVKQLEEFRRRMGEETQMPLRDISFDTISGSGPNGAIVHYRVTEKTNR
RLSAGELLLVDSGAQFQDGTTDVTRTIALGSPSEEMRNRFTLVLKGMIAISMLRFPPGTRGLDIDAFARANLWKAGLDYG
HGTGHGVGSYLGVHEGPQRIARTGKEKLLSGMIISNEPGYYRQGHYGIRIENLIVVSSPEPIPGGEIDMHGFETLTLVPI
DRRLIDPALLTEQERDWLNTYHRRVWEEIGPLVDGETADWLEQATSPV
>Mature_608_residues
MFQSFDSKSDPTQAGPRLERLRALMATAGHDIVLVPHSDEHQSEYLPSSAERLAWLTGFTGSAGAALILRDRAILFVDGR
YTLQAREQVDPNLFEIENLVENPPREWLKANPSRGSRVGFDPWLHTIDDVTGLRKVADKIGVELVPLDRNPIDTIWEDRP
APPAEPVRIHPLEFAGEPAEEKLKRLASRLAEEAVDHTVLTNAASLAWAFNIRGGDVAHTPLSLGFAVLSASARPKLFLD
ARKLDGEAKTYLASLADLHTPSELEPALSSLAGEKVKFGLDFGLASERLRLLIEENGGSVVDFTDPTTLPRAIKNETELR
GARAAHLRDGAALARFLAWVDAQKPETLDEITIVKQLEEFRRRMGEETQMPLRDISFDTISGSGPNGAIVHYRVTEKTNR
RLSAGELLLVDSGAQFQDGTTDVTRTIALGSPSEEMRNRFTLVLKGMIAISMLRFPPGTRGLDIDAFARANLWKAGLDYG
HGTGHGVGSYLGVHEGPQRIARTGKEKLLSGMIISNEPGYYRQGHYGIRIENLIVVSSPEPIPGGEIDMHGFETLTLVPI
DRRLIDPALLTEQERDWLNTYHRRVWEEIGPLVDGETADWLEQATSPV

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=636, Percent_Identity=37.8930817610063, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI264681565, Length=636, Percent_Identity=36.0062893081761, Blast_Score=360, Evalue=3e-99,
Organism=Homo sapiens, GI93141226, Length=608, Percent_Identity=35.0328947368421, Blast_Score=356, Evalue=3e-98,
Organism=Escherichia coli, GI1788728, Length=198, Percent_Identity=36.3636363636364, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1789275, Length=195, Percent_Identity=28.2051282051282, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17509539, Length=622, Percent_Identity=35.048231511254, Blast_Score=338, Evalue=6e-93,
Organism=Caenorhabditis elegans, GI25149105, Length=626, Percent_Identity=30.1916932907348, Blast_Score=259, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6322999, Length=652, Percent_Identity=33.2822085889571, Blast_Score=323, Evalue=4e-89,
Organism=Drosophila melanogaster, GI17137632, Length=622, Percent_Identity=34.2443729903537, Blast_Score=322, Evalue=5e-88,
Organism=Drosophila melanogaster, GI161078230, Length=584, Percent_Identity=30.6506849315068, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI21357287, Length=584, Percent_Identity=30.6506849315068, Blast_Score=246, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 67111; Mature: 67111

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQSFDSKSDPTQAGPRLERLRALMATAGHDIVLVPHSDEHQSEYLPSSAERLAWLTGFT
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHCCCCHHHHEEEEECCC
GSAGAALILRDRAILFVDGRYTLQAREQVDPNLFEIENLVENPPREWLKANPSRGSRVGF
CCCCCEEEEECCEEEEECCCEEEEEHHHCCCCHHHHHHHHCCCCHHHHCCCCCCCCCCCC
DPWLHTIDDVTGLRKVADKIGVELVPLDRNPIDTIWEDRPAPPAEPVRIHPLEFAGEPAE
CHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHCCCCCCCCCCEEEEEHHCCCCCHH
EKLKRLASRLAEEAVDHTVLTNAASLAWAFNIRGGDVAHTPLSLGFAVLSASARPKLFLD
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEECCHHHHHHHHHHCCCCCCEEEE
ARKLDGEAKTYLASLADLHTPSELEPALSSLAGEKVKFGLDFGLASERLRLLIEENGGSV
HHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHEEEEEECCCCEE
VDFTDPTTLPRAIKNETELRGARAAHLRDGAALARFLAWVDAQKPETLDEITIVKQLEEF
EECCCCCHHHHHHCCHHHHCCCHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
RRRMGEETQMPLRDISFDTISGSGPNGAIVHYRVTEKTNRRLSAGELLLVDSGAQFQDGT
HHHCCCCCCCCHHHCCCEECCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCC
TDVTRTIALGSPSEEMRNRFTLVLKGMIAISMLRFPPGTRGLDIDAFARANLWKAGLDYG
CHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
HGTGHGVGSYLGVHEGPQRIARTGKEKLLSGMIISNEPGYYRQGHYGIRIENLIVVSSPE
CCCCCCCHHHCCCCCCHHHHHHCCHHHHHHCEEEECCCCCEECCCCCEEEEEEEEEECCC
PIPGGEIDMHGFETLTLVPIDRRLIDPALLTEQERDWLNTYHRRVWEEIGPLVDGETADW
CCCCCCEECCCCCEEEEEECCHHHCCHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LEQATSPV
HHHHCCCC
>Mature Secondary Structure
MFQSFDSKSDPTQAGPRLERLRALMATAGHDIVLVPHSDEHQSEYLPSSAERLAWLTGFT
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHCCCCHHHHEEEEECCC
GSAGAALILRDRAILFVDGRYTLQAREQVDPNLFEIENLVENPPREWLKANPSRGSRVGF
CCCCCEEEEECCEEEEECCCEEEEEHHHCCCCHHHHHHHHCCCCHHHHCCCCCCCCCCCC
DPWLHTIDDVTGLRKVADKIGVELVPLDRNPIDTIWEDRPAPPAEPVRIHPLEFAGEPAE
CHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHCCCCCCCCCCEEEEEHHCCCCCHH
EKLKRLASRLAEEAVDHTVLTNAASLAWAFNIRGGDVAHTPLSLGFAVLSASARPKLFLD
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEECCHHHHHHHHHHCCCCCCEEEE
ARKLDGEAKTYLASLADLHTPSELEPALSSLAGEKVKFGLDFGLASERLRLLIEENGGSV
HHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHEEEEEECCCCEE
VDFTDPTTLPRAIKNETELRGARAAHLRDGAALARFLAWVDAQKPETLDEITIVKQLEEF
EECCCCCHHHHHHCCHHHHCCCHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
RRRMGEETQMPLRDISFDTISGSGPNGAIVHYRVTEKTNRRLSAGELLLVDSGAQFQDGT
HHHCCCCCCCCHHHCCCEECCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCC
TDVTRTIALGSPSEEMRNRFTLVLKGMIAISMLRFPPGTRGLDIDAFARANLWKAGLDYG
CHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
HGTGHGVGSYLGVHEGPQRIARTGKEKLLSGMIISNEPGYYRQGHYGIRIENLIVVSSPE
CCCCCCCHHHCCCCCCHHHHHHCCHHHHHHCEEEECCCCCEECCCCCEEEEEEEEEECCC
PIPGGEIDMHGFETLTLVPIDRRLIDPALLTEQERDWLNTYHRRVWEEIGPLVDGETADW
CCCCCCEECCCCCEEEEEECCHHHCCHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LEQATSPV
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]