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The map label for this gene is uvrD [H]

Identifier: 110634338

GI number: 110634338

Start: 2130253

End: 2132883

Strand: Direct

Name: uvrD [H]

Synonym: Meso_1988

Alternate gene names: 110634338

Gene position: 2130253-2132883 (Clockwise)

Preceding gene: 110634336

Following gene: 110634342

Centisome position: 48.28

GC content: 63.32

Gene sequence:

>2631_bases
ATGCCAGGTTTTCCAGACGATCTGCCTTTCTTCGGCGATGACGAAGCACCCCACCCCGCTCCGCGCGAGGGCGGCATCGC
CGCGCGCGCCATGGCCGCGCGCCAGGCTCAGGCCCCCCGCTACCTCGAAGGGCTCAACCCGGAACAGCGCCTTGCCGTGG
AAACCACAGAGGGTCCGGTTCTGGTGCTCGCGGGCGCGGGCACCGGCAAGACCCGCGTCCTGACCACACGCATCGCCCAC
ATCCTCGCGACGGGACGCGCCTACCCGTCGCAAATTCTCGCCGTCACCTTCACCAACAAGGCCGCGCGCGAAATGAAGAC
GCGAATCGGCGTTCTCGTGGGCCAGGCGATCGAGGGCATGCCGTGGCTGGGCACGTTCCACTCCATCGGGGTAAAGCTGC
TGCGCCGCCACGCCGAACTTGCGGGCCTCACCTCCTCTTTCACCATTCTCGATACGGATGATCAGGTCCGGCTTTTAAAG
CAGCTCATCCAGGCCGAGGCGCTGGACGACAAGCGCTGGCCGGCGCGGCAGCTGGCCATGATGATCGACGGGTGGAAGAA
CAAGGGTCTCGGCCCCGCCGATATACCGGAGGGGGATGCCCGGGCCTTCGGCAACGGCAAGGGGCGCGCGCTCTATGCCG
CCTATCAGCAGCGCCTGAAAACGCTCAATGCCACCGATTTCGGCGATCTCCTGCTGCACCCGATCCGGATCTTCCGCGAA
CACCCGGATGTGCTTCGCGAATATCACGCCAAATTCAAATACATCCTGGTTGATGAGTATCAGGATACGAACACCGCCCA
ATATATGTGGCTTCGTCTTCTCGCACAGCGGCCCGGCAGCCCAGGCACGGGCGGTCTTCCAGCCGAAGGCAGAGCGCGCG
GCCACGCACTGGGCGACGTTTCGCAAGCACACGCGGCCGGCGGCCCCGGAGCCAGTCCGGGGCAGCGGCCGGGCGGCGCG
AGCGCAAACAAGGTCAATATCTGCTGCGTGGGCGACGACGATCAGTCGATTTACGGCTGGCGCGGCGCGGAAGTGGACAA
CATCCTTCGTTTCGAGAAGGATTTTCCGGGCGCGACGGTGATCCGGCTGGAGCGCAACTATCGCTCGACCGCGCATATTC
TGGGAGCCGCTTCCCACCTCATCGCCCACAATGAGGGCCGGTTAGGCAAGACGCTCTTCACCGAGCACTCCGATCCCGAC
GCACCGAGGGTGAAGGTGCATGCCGCTTGGGATTCCGAGGAGGAGGCGCGTGCTCTCGGTGAGGAGATCGAGGCTTTGCA
AGCCAAGGGTCATGCTCTGAACGACATGGCAATTCTTGTACGGGCCTCATTTCAGATGCGCGAGTTCGAGGACCGGTTCG
TTACACTTGGCCTGAGCTACAGGGTCATCGGCGGCCCCCGCTTCTACGAGCGGCAGGAAATCCGCGACGCGCTCGCCTAT
TTCCGCGTCGTCGCTCAAGGCGCTGACGATCTTGCTTTCGAGCGCATCGTCAACGTGCCGAAACGAGGCTTGGGCGAATC
CGCGGTGCGTCAGATTCACGACGTGGCGCGCATGCGCGGCGTGCCCCTCCTCCAAGCGGCGCGAGACTTGGTGGGGACGG
AGGAACTGAAGCCGAAGCCGCGAGCCTCCCTGCGCAATCTGGTGGAAAGCTTCGAGCGCTGGCAGGGCCTTCTCGACCGC
ACGCGGCACATCGAGCTCGCAGAGACGATTCTCGAGGAATCGGGCTACACCGACATGTGGAAGAACGACCGCTCGGCCGA
GGCGCCGGGCAGGCTGGAAAACCTCAAGGAGCTGATCCGCTCCATGGAGGAATATGAGAGCCTGCGCGCCTTTTTGGAGC
ATGTGGCGCTGGTGATGGATGCCGAGCGCGACGAGGAACTCGACGCCGTGAGCCTAATGACGCTGCATTCGGCCAAAGGT
CTGGAATTCGATACGGTCTTTCTGCCGGGTTGGGAGGAAGGTCTCTTTCCGCATCAAAGATCCCTGGATGAAGGCGGGCG
ATCGGGGCTCGAAGAGGAACGCCGCCTTGCTTATGTCGGCGTCACCCGGGCGAAGAAGAACCTGCACATCTGGTTTACAT
CCAACCGCCGCATTCACGGGCTTTGGCAGTCCACGATTCCCTCACGCTTCCTGGATGAACTGCCGGAAAAGCATGTGGAG
GTTACGGATGACGGCGGAAGCTTCGGGGGCTATGGGCGTCCCATTGCGGACCGGCAGCCGGGCCGGCCAAACCCCTACGG
CTCATCGCGCTTCGACAATATGGGCGAGGTGTTCTCCAACAGCTACGCCACGCCGGGCTGGCAGCGCGCCCAGAAAAACC
GCACGGAAGCAACCGCGCGAAACTGGGGATCGCGCTCAGGCCATCAGGTGGAACGTATCGGCTATGGCGAGCCGGACTCC
GGCTACGGTCTTGGCAAAGGCTCGGTCAAGGGCCGGACCATCGAGGGTGAGCTTGTCGCGAAATCCGTTTCTGATGGTCC
GTCGGCCTTCAAGGTCGGCGATCGGGTATTCCACCTGAAATTCGGCAACGGCAACGTTGCCGCGGTGGACGGAAACAAGC
TCACCGTCGATTTCGACAAAGCGGGACAGAAGCGCGTCCTCGATGGCTTCGTGGAGCGCCTCCCGCATTGA

Upstream 100 bases:

>100_bases
CTCTCATTTCCTCCAAGGCCGGCCTTGGCCCACGCGCCGCAAACCGGTACAAAAAGAAAACGCTTGGGGCCTAGGCCTCG
AATCACCATATGCGACGGTA

Downstream 100 bases:

>100_bases
TGCAATCGGCTAGAGCTGCCGGCTCCTGCGTTACTTGTAGTAAACGTAGTTGCCTTCGCTGCTCTTCTCGCGCTTCAGCA
CACCTTTTTTGGCAAGCCGC

Product: ATP-dependent DNA helicase Rep

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 876; Mature: 875

Protein sequence:

>876_residues
MPGFPDDLPFFGDDEAPHPAPREGGIAARAMAARQAQAPRYLEGLNPEQRLAVETTEGPVLVLAGAGTGKTRVLTTRIAH
ILATGRAYPSQILAVTFTNKAAREMKTRIGVLVGQAIEGMPWLGTFHSIGVKLLRRHAELAGLTSSFTILDTDDQVRLLK
QLIQAEALDDKRWPARQLAMMIDGWKNKGLGPADIPEGDARAFGNGKGRALYAAYQQRLKTLNATDFGDLLLHPIRIFRE
HPDVLREYHAKFKYILVDEYQDTNTAQYMWLRLLAQRPGSPGTGGLPAEGRARGHALGDVSQAHAAGGPGASPGQRPGGA
SANKVNICCVGDDDQSIYGWRGAEVDNILRFEKDFPGATVIRLERNYRSTAHILGAASHLIAHNEGRLGKTLFTEHSDPD
APRVKVHAAWDSEEEARALGEEIEALQAKGHALNDMAILVRASFQMREFEDRFVTLGLSYRVIGGPRFYERQEIRDALAY
FRVVAQGADDLAFERIVNVPKRGLGESAVRQIHDVARMRGVPLLQAARDLVGTEELKPKPRASLRNLVESFERWQGLLDR
TRHIELAETILEESGYTDMWKNDRSAEAPGRLENLKELIRSMEEYESLRAFLEHVALVMDAERDEELDAVSLMTLHSAKG
LEFDTVFLPGWEEGLFPHQRSLDEGGRSGLEEERRLAYVGVTRAKKNLHIWFTSNRRIHGLWQSTIPSRFLDELPEKHVE
VTDDGGSFGGYGRPIADRQPGRPNPYGSSRFDNMGEVFSNSYATPGWQRAQKNRTEATARNWGSRSGHQVERIGYGEPDS
GYGLGKGSVKGRTIEGELVAKSVSDGPSAFKVGDRVFHLKFGNGNVAAVDGNKLTVDFDKAGQKRVLDGFVERLPH

Sequences:

>Translated_876_residues
MPGFPDDLPFFGDDEAPHPAPREGGIAARAMAARQAQAPRYLEGLNPEQRLAVETTEGPVLVLAGAGTGKTRVLTTRIAH
ILATGRAYPSQILAVTFTNKAAREMKTRIGVLVGQAIEGMPWLGTFHSIGVKLLRRHAELAGLTSSFTILDTDDQVRLLK
QLIQAEALDDKRWPARQLAMMIDGWKNKGLGPADIPEGDARAFGNGKGRALYAAYQQRLKTLNATDFGDLLLHPIRIFRE
HPDVLREYHAKFKYILVDEYQDTNTAQYMWLRLLAQRPGSPGTGGLPAEGRARGHALGDVSQAHAAGGPGASPGQRPGGA
SANKVNICCVGDDDQSIYGWRGAEVDNILRFEKDFPGATVIRLERNYRSTAHILGAASHLIAHNEGRLGKTLFTEHSDPD
APRVKVHAAWDSEEEARALGEEIEALQAKGHALNDMAILVRASFQMREFEDRFVTLGLSYRVIGGPRFYERQEIRDALAY
FRVVAQGADDLAFERIVNVPKRGLGESAVRQIHDVARMRGVPLLQAARDLVGTEELKPKPRASLRNLVESFERWQGLLDR
TRHIELAETILEESGYTDMWKNDRSAEAPGRLENLKELIRSMEEYESLRAFLEHVALVMDAERDEELDAVSLMTLHSAKG
LEFDTVFLPGWEEGLFPHQRSLDEGGRSGLEEERRLAYVGVTRAKKNLHIWFTSNRRIHGLWQSTIPSRFLDELPEKHVE
VTDDGGSFGGYGRPIADRQPGRPNPYGSSRFDNMGEVFSNSYATPGWQRAQKNRTEATARNWGSRSGHQVERIGYGEPDS
GYGLGKGSVKGRTIEGELVAKSVSDGPSAFKVGDRVFHLKFGNGNVAAVDGNKLTVDFDKAGQKRVLDGFVERLPH
>Mature_875_residues
PGFPDDLPFFGDDEAPHPAPREGGIAARAMAARQAQAPRYLEGLNPEQRLAVETTEGPVLVLAGAGTGKTRVLTTRIAHI
LATGRAYPSQILAVTFTNKAAREMKTRIGVLVGQAIEGMPWLGTFHSIGVKLLRRHAELAGLTSSFTILDTDDQVRLLKQ
LIQAEALDDKRWPARQLAMMIDGWKNKGLGPADIPEGDARAFGNGKGRALYAAYQQRLKTLNATDFGDLLLHPIRIFREH
PDVLREYHAKFKYILVDEYQDTNTAQYMWLRLLAQRPGSPGTGGLPAEGRARGHALGDVSQAHAAGGPGASPGQRPGGAS
ANKVNICCVGDDDQSIYGWRGAEVDNILRFEKDFPGATVIRLERNYRSTAHILGAASHLIAHNEGRLGKTLFTEHSDPDA
PRVKVHAAWDSEEEARALGEEIEALQAKGHALNDMAILVRASFQMREFEDRFVTLGLSYRVIGGPRFYERQEIRDALAYF
RVVAQGADDLAFERIVNVPKRGLGESAVRQIHDVARMRGVPLLQAARDLVGTEELKPKPRASLRNLVESFERWQGLLDRT
RHIELAETILEESGYTDMWKNDRSAEAPGRLENLKELIRSMEEYESLRAFLEHVALVMDAERDEELDAVSLMTLHSAKGL
EFDTVFLPGWEEGLFPHQRSLDEGGRSGLEEERRLAYVGVTRAKKNLHIWFTSNRRIHGLWQSTIPSRFLDELPEKHVEV
TDDGGSFGGYGRPIADRQPGRPNPYGSSRFDNMGEVFSNSYATPGWQRAQKNRTEATARNWGSRSGHQVERIGYGEPDSG
YGLGKGSVKGRTIEGELVAKSVSDGPSAFKVGDRVFHLKFGNGNVAAVDGNKLTVDFDKAGQKRVLDGFVERLPH

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=716, Percent_Identity=41.8994413407821, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI48994965, Length=693, Percent_Identity=37.2294372294372, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1787196, Length=404, Percent_Identity=27.2277227722772, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322369, Length=794, Percent_Identity=26.5743073047859, Blast_Score=184, Evalue=6e-47,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 96938; Mature: 96807

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGFPDDLPFFGDDEAPHPAPREGGIAARAMAARQAQAPRYLEGLNPEQRLAVETTEGPV
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCHHHEEEEEECCCCE
LVLAGAGTGKTRVLTTRIAHILATGRAYPSQILAVTFTNKAAREMKTRIGVLVGQAIEGM
EEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCC
PWLGTFHSIGVKLLRRHAELAGLTSSFTILDTDDQVRLLKQLIQAEALDDKRWPARQLAM
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHH
MIDGWKNKGLGPADIPEGDARAFGNGKGRALYAAYQQRLKTLNATDFGDLLLHPIRIFRE
HHHCCCCCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
HPDVLREYHAKFKYILVDEYQDTNTAQYMWLRLLAQRPGSPGTGGLPAEGRARGHALGDV
CHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCH
SQAHAAGGPGASPGQRPGGASANKVNICCVGDDDQSIYGWRGAEVDNILRFEKDFPGATV
HHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCEE
IRLERNYRSTAHILGAASHLIAHNEGRLGKTLFTEHSDPDAPRVKVHAAWDSEEEARALG
EEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCEEEEEECCCCHHHHHHHH
EEIEALQAKGHALNDMAILVRASFQMREFEDRFVTLGLSYRVIGGPRFYERQEIRDALAY
HHHHHHHHCCCCCCHHHEEHHHHHHHHHHCCCEEEEEEEEEEECCCCHHHHHHHHHHHHH
FRVVAQGADDLAFERIVNVPKRGLGESAVRQIHDVARMRGVPLLQAARDLVGTEELKPKP
HHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHCCCCH
RASLRNLVESFERWQGLLDRTRHIELAETILEESGYTDMWKNDRSAEAPGRLENLKELIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHH
SMEEYESLRAFLEHVALVMDAERDEELDAVSLMTLHSAKGLEFDTVFLPGWEEGLFPHQR
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHH
SLDEGGRSGLEEERRLAYVGVTRAKKNLHIWFTSNRRIHGLWQSTIPSRFLDELPEKHVE
HHHHHHHCCCHHHHHEEEEEEEECCCEEEEEEECCCEEEEHHHHHHHHHHHHHCCHHCEE
VTDDGGSFGGYGRPIADRQPGRPNPYGSSRFDNMGEVFSNSYATPGWQRAQKNRTEATAR
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHH
NWGSRSGHQVERIGYGEPDSGYGLGKGSVKGRTIEGELVAKSVSDGPSAFKVGDRVFHLK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECHHHHHHHCCCCCCCEEECCEEEEEE
FGNGNVAAVDGNKLTVDFDKAGQKRVLDGFVERLPH
ECCCCEEEECCCEEEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
PGFPDDLPFFGDDEAPHPAPREGGIAARAMAARQAQAPRYLEGLNPEQRLAVETTEGPV
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCHHHEEEEEECCCCE
LVLAGAGTGKTRVLTTRIAHILATGRAYPSQILAVTFTNKAAREMKTRIGVLVGQAIEGM
EEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCC
PWLGTFHSIGVKLLRRHAELAGLTSSFTILDTDDQVRLLKQLIQAEALDDKRWPARQLAM
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHH
MIDGWKNKGLGPADIPEGDARAFGNGKGRALYAAYQQRLKTLNATDFGDLLLHPIRIFRE
HHHCCCCCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
HPDVLREYHAKFKYILVDEYQDTNTAQYMWLRLLAQRPGSPGTGGLPAEGRARGHALGDV
CHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCH
SQAHAAGGPGASPGQRPGGASANKVNICCVGDDDQSIYGWRGAEVDNILRFEKDFPGATV
HHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCEE
IRLERNYRSTAHILGAASHLIAHNEGRLGKTLFTEHSDPDAPRVKVHAAWDSEEEARALG
EEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCEEEEEECCCCHHHHHHHH
EEIEALQAKGHALNDMAILVRASFQMREFEDRFVTLGLSYRVIGGPRFYERQEIRDALAY
HHHHHHHHCCCCCCHHHEEHHHHHHHHHHCCCEEEEEEEEEEECCCCHHHHHHHHHHHHH
FRVVAQGADDLAFERIVNVPKRGLGESAVRQIHDVARMRGVPLLQAARDLVGTEELKPKP
HHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHCCCCH
RASLRNLVESFERWQGLLDRTRHIELAETILEESGYTDMWKNDRSAEAPGRLENLKELIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHH
SMEEYESLRAFLEHVALVMDAERDEELDAVSLMTLHSAKGLEFDTVFLPGWEEGLFPHQR
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHH
SLDEGGRSGLEEERRLAYVGVTRAKKNLHIWFTSNRRIHGLWQSTIPSRFLDELPEKHVE
HHHHHHHCCCHHHHHEEEEEEEECCCEEEEEEECCCEEEEHHHHHHHHHHHHHCCHHCEE
VTDDGGSFGGYGRPIADRQPGRPNPYGSSRFDNMGEVFSNSYATPGWQRAQKNRTEATAR
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHH
NWGSRSGHQVERIGYGEPDSGYGLGKGSVKGRTIEGELVAKSVSDGPSAFKVGDRVFHLK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECHHHHHHHCCCCCCCEEECCEEEEEE
FGNGNVAAVDGNKLTVDFDKAGQKRVLDGFVERLPH
ECCCCEEEECCCEEEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]