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The map label for this gene is serA [H]

Identifier: 110634305

GI number: 110634305

Start: 2096134

End: 2097138

Strand: Direct

Name: serA [H]

Synonym: Meso_1955

Alternate gene names: 110634305

Gene position: 2096134-2097138 (Clockwise)

Preceding gene: 110634304

Following gene: 110634306

Centisome position: 47.51

GC content: 65.07

Gene sequence:

>1005_bases
ATGCGCGTGCTGGTCGACTGGGATATTCCGCCGGTGGAGCAGACGGTCATCGATGCCTGGCCCGCCGGTATCGAAGTGAT
CGAGGGCGGCAGCAAACTGACCGTCGAAGAGAAGCTGAAACTGGCGCCGAGCATCGACGTGCAGACCGGTCTGATGCGGG
TGATCAACCGGCCCTTCATCGATGCGGCGACCCGGCTCAAGCTGGTGCACATGACGGGCCATGGCGTTGACCTGCTGATG
CGCAACGGCATCCCCGACCTGATGCAGCAGCGCGGTATCCGGATAGCGACGGCCCATGCCGGCGACATACCGATCGCCGA
ATATGCAATCATGGCCATGGTCATGCTGTCGCGCCAGGTGCTGCGCTCGCATGCCGCGCTTACCAGCCGCGGCAAATGGG
AGAGCCAGCGGGGCCCGGAGCTGTTCGGCTCGACGCTCTGCATCGTCGGCTTCGGCAGCATCGGCAAGGCGACCGCTGTC
CGGGCCAGGGCCTTCGGCATGCAGGTCGGCATGGTGACGCTGCACCCCGAACGTCATGAGGACCATGACCTGGCCTTCGC
CCACACCTATGCCGATATCGACAAGGCACTGGCAGTGTCCGACTATGTGTTGGTCACCGCGCCGCTGACCTCGATCACCA
ATGGGCTGATGGATGCAGGACGGTTCGCGGCGATGAAGCCCGGCAGCTACCTGGTGTGCATCACCCGGGGTCCGCTGATC
GTCGAGCGGGCGCTTTACGAGGCGCTGCAATCGGGCCATCTGGCCGGCGCGGCGATGGACGGCTGGTGGCGCGAGGAAGA
GGACGGGACCGGCCGCGACGGCTATCCGGCCGACCTGCCGCTGCACCAGTTCAACATGCTGATGACGCCCCACAATTCCG
GCACCACCTTCGGCACGCGGCAGCGCGCGATCCGCCTGATCGGCGACAATATCGGCCGGTTGATGCGGGGTGAACCCCTG
ATCAACGAAGTGGCCCCCCACGACCTCAAGAAAATGGCGGTTTGA

Upstream 100 bases:

>100_bases
ACTCCTCGCCTTCGCTGGAGGGCGAGGTCGCAGCGGCGCCGGGCCGATCCTCCGACCTTACGACCGCGGCCCGGAGCCGC
ACTGAACTGGAGTCTTAGCT

Downstream 100 bases:

>100_bases
CTATGCAATTCGACAAGGACATGGAAATCACCCGGATCGGTGTGCGGGTGTTCTCCTATACATCGCAGATCCGGCGGGCC
TTCGGGCATTCGCATCCCGG

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MRVLVDWDIPPVEQTVIDAWPAGIEVIEGGSKLTVEEKLKLAPSIDVQTGLMRVINRPFIDAATRLKLVHMTGHGVDLLM
RNGIPDLMQQRGIRIATAHAGDIPIAEYAIMAMVMLSRQVLRSHAALTSRGKWESQRGPELFGSTLCIVGFGSIGKATAV
RARAFGMQVGMVTLHPERHEDHDLAFAHTYADIDKALAVSDYVLVTAPLTSITNGLMDAGRFAAMKPGSYLVCITRGPLI
VERALYEALQSGHLAGAAMDGWWREEEDGTGRDGYPADLPLHQFNMLMTPHNSGTTFGTRQRAIRLIGDNIGRLMRGEPL
INEVAPHDLKKMAV

Sequences:

>Translated_334_residues
MRVLVDWDIPPVEQTVIDAWPAGIEVIEGGSKLTVEEKLKLAPSIDVQTGLMRVINRPFIDAATRLKLVHMTGHGVDLLM
RNGIPDLMQQRGIRIATAHAGDIPIAEYAIMAMVMLSRQVLRSHAALTSRGKWESQRGPELFGSTLCIVGFGSIGKATAV
RARAFGMQVGMVTLHPERHEDHDLAFAHTYADIDKALAVSDYVLVTAPLTSITNGLMDAGRFAAMKPGSYLVCITRGPLI
VERALYEALQSGHLAGAAMDGWWREEEDGTGRDGYPADLPLHQFNMLMTPHNSGTTFGTRQRAIRLIGDNIGRLMRGEPL
INEVAPHDLKKMAV
>Mature_334_residues
MRVLVDWDIPPVEQTVIDAWPAGIEVIEGGSKLTVEEKLKLAPSIDVQTGLMRVINRPFIDAATRLKLVHMTGHGVDLLM
RNGIPDLMQQRGIRIATAHAGDIPIAEYAIMAMVMLSRQVLRSHAALTSRGKWESQRGPELFGSTLCIVGFGSIGKATAV
RARAFGMQVGMVTLHPERHEDHDLAFAHTYADIDKALAVSDYVLVTAPLTSITNGLMDAGRFAAMKPGSYLVCITRGPLI
VERALYEALQSGHLAGAAMDGWWREEEDGTGRDGYPADLPLHQFNMLMTPHNSGTTFGTRQRAIRLIGDNIGRLMRGEPL
INEVAPHDLKKMAV

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=341, Percent_Identity=27.2727272727273, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI6912396, Length=279, Percent_Identity=29.3906810035842, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI145580578, Length=151, Percent_Identity=33.112582781457, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4557499, Length=151, Percent_Identity=33.112582781457, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI145580575, Length=151, Percent_Identity=33.112582781457, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI61743967, Length=246, Percent_Identity=26.4227642276423, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI4557497, Length=246, Percent_Identity=26.4227642276423, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI87082289, Length=224, Percent_Identity=31.6964285714286, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789279, Length=236, Percent_Identity=32.6271186440678, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1787645, Length=280, Percent_Identity=25.3571428571429, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=321, Percent_Identity=30.2180685358255, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25147481, Length=208, Percent_Identity=28.3653846153846, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320925, Length=223, Percent_Identity=30.0448430493274, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6322116, Length=203, Percent_Identity=31.0344827586207, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45552429, Length=321, Percent_Identity=27.1028037383178, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24585514, Length=321, Percent_Identity=27.1028037383178, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28574282, Length=321, Percent_Identity=27.1028037383178, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28574284, Length=321, Percent_Identity=27.1028037383178, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45551003, Length=321, Percent_Identity=27.1028037383178, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574286, Length=323, Percent_Identity=27.2445820433437, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585516, Length=297, Percent_Identity=27.6094276094276, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19921140, Length=202, Percent_Identity=29.7029702970297, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28571528, Length=200, Percent_Identity=29.5, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646446, Length=149, Percent_Identity=32.8859060402685, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24646448, Length=149, Percent_Identity=32.8859060402685, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24646452, Length=149, Percent_Identity=32.8859060402685, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24646450, Length=149, Percent_Identity=32.8859060402685, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI62472511, Length=149, Percent_Identity=32.8859060402685, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 36531; Mature: 36531

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVDWDIPPVEQTVIDAWPAGIEVIEGGSKLTVEEKLKLAPSIDVQTGLMRVINRPFI
CEEEEECCCCCHHHHHHHHCCCCEEEEECCCEEEHHHHHHCCCCCCHHHHHHHHHCCCHH
DAATRLKLVHMTGHGVDLLMRNGIPDLMQQRGIRIATAHAGDIPIAEYAIMAMVMLSRQV
CHHHEEEEEEECCCCHHHHHHCCCHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
LRSHAALTSRGKWESQRGPELFGSTLCIVGFGSIGKATAVRARAFGMQVGMVTLHPERHE
HHHHHHHHCCCCCCCCCCCHHHCCEEEEEECCCCCCHHHHHHHHHCEEEEEEEECCCCCC
DHDLAFAHTYADIDKALAVSDYVLVTAPLTSITNGLMDAGRFAAMKPGSYLVCITRGPLI
CCCEEEEHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHCCCEEEECCCCEEEEEECCCHH
VERALYEALQSGHLAGAAMDGWWREEEDGTGRDGYPADLPLHQFNMLMTPHNSGTTFGTR
HHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCCHHHHEEEECCCCCCCCCCHH
QRAIRLIGDNIGRLMRGEPLINEVAPHDLKKMAV
HHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHCC
>Mature Secondary Structure
MRVLVDWDIPPVEQTVIDAWPAGIEVIEGGSKLTVEEKLKLAPSIDVQTGLMRVINRPFI
CEEEEECCCCCHHHHHHHHCCCCEEEEECCCEEEHHHHHHCCCCCCHHHHHHHHHCCCHH
DAATRLKLVHMTGHGVDLLMRNGIPDLMQQRGIRIATAHAGDIPIAEYAIMAMVMLSRQV
CHHHEEEEEEECCCCHHHHHHCCCHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
LRSHAALTSRGKWESQRGPELFGSTLCIVGFGSIGKATAVRARAFGMQVGMVTLHPERHE
HHHHHHHHCCCCCCCCCCCHHHCCEEEEEECCCCCCHHHHHHHHHCEEEEEEEECCCCCC
DHDLAFAHTYADIDKALAVSDYVLVTAPLTSITNGLMDAGRFAAMKPGSYLVCITRGPLI
CCCEEEEHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHCCCEEEECCCCEEEEEECCCHH
VERALYEALQSGHLAGAAMDGWWREEEDGTGRDGYPADLPLHQFNMLMTPHNSGTTFGTR
HHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCCHHHHEEEECCCCCCCCCCHH
QRAIRLIGDNIGRLMRGEPLINEVAPHDLKKMAV
HHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]