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The map label for this gene is menB [C]

Identifier: 110634288

GI number: 110634288

Start: 2076270

End: 2077085

Strand: Reverse

Name: menB [C]

Synonym: Meso_1938

Alternate gene names: 110634288

Gene position: 2077085-2076270 (Counterclockwise)

Preceding gene: 110634295

Following gene: 110634287

Centisome position: 47.07

GC content: 54.29

Gene sequence:

>816_bases
TTGTCGTACGAATTGATCAAGGTCGATGTGCAGGCCGGAATTGGTTATCTGACCTGGAACCGGCCGCGAGTTCATAACGC
GATCTCGCCTGAAGTGATGACCGAGACGATGGATGCACTGTCAGTGCTGGGTGAACGGGACGATGTTCGCGTCATCATTT
TGTCAGGTGAAGGTAAATCATTCAGTTCCGGTTGCGATATAAGTGTTAAGGCGGACAGGGGGACGGAAGGCATCGACGAG
TGGCGCATACGCTATCAGAAGAGTCTGCAGTTCATGCTCAGTTTTTGGCGGTGTCCCAAGCCGATCATTGCCTCGATTCA
TGGCTATTGTCTGGCTGGCGGCTTTGAAGCGAGCCTTGCCTGCGACATCTCCGTAGCCGCTGAAAGTGCGCGCTTTGGCA
TGCCGGAAGCTAAGATGGGCTCACCGAGCATTTTGCTGATGTTGCCGTGGCTTGCTGGGCCCAAAATGGCGAAAGAGATT
TTGATATGCGCTGAGGATACCTTCTCCGCGGCCCGCGCGAAGGAAGCGGGTATCGTCAATCACGTCGTTCCGGATGAAGA
GCGAGAAAGTTTTGTCCGAGAGATTGCAAATCATATTGTCGGATCATCGCCCGTAGCCGTTGCCTATTTTAAGCGCGCGA
TCAATCAGACCTTTGAAATTATGGGCTTGATGCCCGCGCTGGAGGCCAACGTCGAGGCTGCCGCAAGCATGAAGGGCATT
GTTGACAAAGACCGAGATGAGTTTTTGCTTATCAGGAAGGAGCAGGGGCTCAAGGCAGCCGTCGCCTGGCGTGCCCAGCG
GGTTGGTGCGCAATGA

Upstream 100 bases:

>100_bases
GAGAAAACCCCATAAACCTCAAAGTATGGTGCTTGCATCCGTATGCATTATGTGCAAAGACTAGCCTCACCGCGTTCGAC
CAACAAGGGAGGAACCTCGA

Downstream 100 bases:

>100_bases
GCGTTGCTCGCTCGCAGGGGGGGCTAGTTGCAGGAGTGGGGCGTGGCGAACAGTTGAACCTACGTTCATTTCGCAATCGC
CCGGCCCTCTCTCTGCTTCC

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MSYELIKVDVQAGIGYLTWNRPRVHNAISPEVMTETMDALSVLGERDDVRVIILSGEGKSFSSGCDISVKADRGTEGIDE
WRIRYQKSLQFMLSFWRCPKPIIASIHGYCLAGGFEASLACDISVAAESARFGMPEAKMGSPSILLMLPWLAGPKMAKEI
LICAEDTFSAARAKEAGIVNHVVPDEERESFVREIANHIVGSSPVAVAYFKRAINQTFEIMGLMPALEANVEAAASMKGI
VDKDRDEFLLIRKEQGLKAAVAWRAQRVGAQ

Sequences:

>Translated_271_residues
MSYELIKVDVQAGIGYLTWNRPRVHNAISPEVMTETMDALSVLGERDDVRVIILSGEGKSFSSGCDISVKADRGTEGIDE
WRIRYQKSLQFMLSFWRCPKPIIASIHGYCLAGGFEASLACDISVAAESARFGMPEAKMGSPSILLMLPWLAGPKMAKEI
LICAEDTFSAARAKEAGIVNHVVPDEERESFVREIANHIVGSSPVAVAYFKRAINQTFEIMGLMPALEANVEAAASMKGI
VDKDRDEFLLIRKEQGLKAAVAWRAQRVGAQ
>Mature_270_residues
SYELIKVDVQAGIGYLTWNRPRVHNAISPEVMTETMDALSVLGERDDVRVIILSGEGKSFSSGCDISVKADRGTEGIDEW
RIRYQKSLQFMLSFWRCPKPIIASIHGYCLAGGFEASLACDISVAAESARFGMPEAKMGSPSILLMLPWLAGPKMAKEIL
ICAEDTFSAARAKEAGIVNHVVPDEERESFVREIANHIVGSSPVAVAYFKRAINQTFEIMGLMPALEANVEAAASMKGIV
DKDRDEFLLIRKEQGLKAAVAWRAQRVGAQ

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=210, Percent_Identity=30.4761904761905, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI70995211, Length=228, Percent_Identity=32.0175438596491, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI45643119, Length=204, Percent_Identity=30.8823529411765, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI260275230, Length=204, Percent_Identity=30.8823529411765, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI260274832, Length=204, Percent_Identity=30.8823529411765, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI31542718, Length=199, Percent_Identity=29.6482412060301, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4502327, Length=251, Percent_Identity=31.0756972111554, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1788597, Length=208, Percent_Identity=34.6153846153846, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1787659, Length=227, Percent_Identity=27.7533039647577, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI87082183, Length=220, Percent_Identity=32.7272727272727, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI221142681, Length=219, Percent_Identity=33.7899543378995, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787660, Length=216, Percent_Identity=27.3148148148148, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790281, Length=188, Percent_Identity=28.1914893617021, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788682, Length=165, Percent_Identity=28.4848484848485, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17554946, Length=221, Percent_Identity=31.6742081447964, Blast_Score=110, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17534483, Length=229, Percent_Identity=33.1877729257642, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25145438, Length=215, Percent_Identity=31.1627906976744, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17540714, Length=212, Percent_Identity=34.9056603773585, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17536985, Length=218, Percent_Identity=29.8165137614679, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17560910, Length=204, Percent_Identity=26.9607843137255, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17540306, Length=169, Percent_Identity=29.585798816568, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI20129971, Length=229, Percent_Identity=29.2576419213974, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24653477, Length=229, Percent_Identity=29.2576419213974, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24653139, Length=220, Percent_Identity=28.6363636363636, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19920382, Length=223, Percent_Identity=29.1479820627803, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21357171, Length=231, Percent_Identity=27.7056277056277, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922422, Length=221, Percent_Identity=25.3393665158371, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24654903, Length=194, Percent_Identity=26.8041237113402, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24650670, Length=181, Percent_Identity=27.6243093922652, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 29725; Mature: 29593

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYELIKVDVQAGIGYLTWNRPRVHNAISPEVMTETMDALSVLGERDDVRVIILSGEGKS
CCCEEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
FSSGCDISVKADRGTEGIDEWRIRYQKSLQFMLSFWRCPKPIIASIHGYCLAGGFEASLA
CCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCEEEECCCCCEEE
CDISVAAESARFGMPEAKMGSPSILLMLPWLAGPKMAKEILICAEDTFSAARAKEAGIVN
EEEEEHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHEEEECCCCHHHHHHHHCCCHH
HVVPDEERESFVREIANHIVGSSPVAVAYFKRAINQTFEIMGLMPALEANVEAAASMKGI
CCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCC
VDKDRDEFLLIRKEQGLKAAVAWRAQRVGAQ
CCCCCCCEEEEECCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SYELIKVDVQAGIGYLTWNRPRVHNAISPEVMTETMDALSVLGERDDVRVIILSGEGKS
CCEEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
FSSGCDISVKADRGTEGIDEWRIRYQKSLQFMLSFWRCPKPIIASIHGYCLAGGFEASLA
CCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCEEEECCCCCEEE
CDISVAAESARFGMPEAKMGSPSILLMLPWLAGPKMAKEILICAEDTFSAARAKEAGIVN
EEEEEHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHEEEECCCCHHHHHHHHCCCHH
HVVPDEERESFVREIANHIVGSSPVAVAYFKRAINQTFEIMGLMPALEANVEAAASMKGI
CCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCC
VDKDRDEFLLIRKEQGLKAAVAWRAQRVGAQ
CCCCCCCEEEEECCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA