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The map label for this gene is pcm [H]

Identifier: 110634152

GI number: 110634152

Start: 1931914

End: 1932564

Strand: Reverse

Name: pcm [H]

Synonym: Meso_1801

Alternate gene names: 110634152

Gene position: 1932564-1931914 (Counterclockwise)

Preceding gene: 110634153

Following gene: 110634151

Centisome position: 43.8

GC content: 61.9

Gene sequence:

>651_bases
ATGACGGTCGGCGAGGCGGAACGGGAGGGCTTTGCCGCTTTCATTCTGCGCATGCGCGCGCGGGGCATCGATTCCAAGGC
GCTTTTCTCCGCCATGGAGGCCACACCGCGGGCCAGTTTCGTGCCCGCCGAATGGAAAAACTGGGTCTGGTCCAACCGCA
CCCTTCCGATCGAATGCGGAGAAAGCTTCGAGCCGTGCGATCTGCAAGGCGCTGTGCTGCACGCGCTTGATCTCAAGCCG
GGCCTGCGCGTTCTCGAGATCGGAACCGGCACGGGCTATACCTCCGCCATCATCGCGCGCATCGCCGAACGTGTATTGAC
GCTCGACCGATACAAGACGCTCTGCAAACAGGCCCAGCAGCGCCACGAGGCATGCGGCCTTTCCAATATTCTTGTTCGCC
AGGCAGATGGAGCTGATGGCGCGGCGGATGGTCCCTTCGACAGAATCGTCGTCTGGGCAGCCTTCGAAGAGCTTCCAAGG
CGGTTCGTGGACCTGCTCGCAAGCGGCGGGATCATGGTTGCGCCTCTGGGCCCCGGCGATGATGTGCAGATAATGGCCAG
GTTTACTAAGATCGGCAGCAGATTCGAGCGCGTTGATCTGGAGTTCGTGCGCCTGCAGCCTTTGATCAGGGGCATTGCGC
AGGCCCTCTGA

Upstream 100 bases:

>100_bases
CCGATCAGGCGGCCATACGGGATGGCTATGTCTCCGTCACGCCGCTCCATCTCGACCTTACCGCGCATGCGGTGCGCGAC
CGGCTGGCGAAGGCGCTTGC

Downstream 100 bases:

>100_bases
GCCCGTTTGAGAAGAGTCTCGTGTGAAATTTTCGAAGCTTAACGGCCCGGTAAGATTAACGCGCTTTAATCGGACTGGGT
CAACGGGATTGCGCGGATAG

Product: protein-L-isoaspartate O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MTVGEAEREGFAAFILRMRARGIDSKALFSAMEATPRASFVPAEWKNWVWSNRTLPIECGESFEPCDLQGAVLHALDLKP
GLRVLEIGTGTGYTSAIIARIAERVLTLDRYKTLCKQAQQRHEACGLSNILVRQADGADGAADGPFDRIVVWAAFEELPR
RFVDLLASGGIMVAPLGPGDDVQIMARFTKIGSRFERVDLEFVRLQPLIRGIAQAL

Sequences:

>Translated_216_residues
MTVGEAEREGFAAFILRMRARGIDSKALFSAMEATPRASFVPAEWKNWVWSNRTLPIECGESFEPCDLQGAVLHALDLKP
GLRVLEIGTGTGYTSAIIARIAERVLTLDRYKTLCKQAQQRHEACGLSNILVRQADGADGAADGPFDRIVVWAAFEELPR
RFVDLLASGGIMVAPLGPGDDVQIMARFTKIGSRFERVDLEFVRLQPLIRGIAQAL
>Mature_215_residues
TVGEAEREGFAAFILRMRARGIDSKALFSAMEATPRASFVPAEWKNWVWSNRTLPIECGESFEPCDLQGAVLHALDLKPG
LRVLEIGTGTGYTSAIIARIAERVLTLDRYKTLCKQAQQRHEACGLSNILVRQADGADGAADGPFDRIVVWAAFEELPRR
FVDLLASGGIMVAPLGPGDDVQIMARFTKIGSRFERVDLEFVRLQPLIRGIAQAL

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins [H]

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789100, Length=200, Percent_Identity=36.5, Blast_Score=125, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000682 [H]

Pfam domain/function: PF01135 PCMT [H]

EC number: =2.1.1.77 [H]

Molecular weight: Translated: 23759; Mature: 23628

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVGEAEREGFAAFILRMRARGIDSKALFSAMEATPRASFVPAEWKNWVWSNRTLPIECG
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEECC
ESFEPCDLQGAVLHALDLKPGLRVLEIGTGTGYTSAIIARIAERVLTLDRYKTLCKQAQQ
CCCCCCCCCHHHHHEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHEACGLSNILVRQADGADGAADGPFDRIVVWAAFEELPRRFVDLLASGGIMVAPLGPGD
HHHHCCHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
DVQIMARFTKIGSRFERVDLEFVRLQPLIRGIAQAL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TVGEAEREGFAAFILRMRARGIDSKALFSAMEATPRASFVPAEWKNWVWSNRTLPIECG
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEECC
ESFEPCDLQGAVLHALDLKPGLRVLEIGTGTGYTSAIIARIAERVLTLDRYKTLCKQAQQ
CCCCCCCCCHHHHHEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHEACGLSNILVRQADGADGAADGPFDRIVVWAAFEELPRRFVDLLASGGIMVAPLGPGD
HHHHCCHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
DVQIMARFTKIGSRFERVDLEFVRLQPLIRGIAQAL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9304864; 11481430 [H]