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The map label for this gene is tyrS [H]

Identifier: 110634136

GI number: 110634136

Start: 1906589

End: 1907842

Strand: Direct

Name: tyrS [H]

Synonym: Meso_1785

Alternate gene names: 110634136

Gene position: 1906589-1907842 (Clockwise)

Preceding gene: 110634135

Following gene: 110634138

Centisome position: 43.21

GC content: 61.48

Gene sequence:

>1254_bases
ATGCCCGATTTCAAGTCAGATTTTCTGCGCATCCTGTCCGAGCGCGGCTTCATCCACCAGATCTCCGACGAGGCGGGCCT
GGATGAGCTGTTCCTGCGCGAGACCGTGACAGGCTATATCGGGTATGATCCGACGGCCGCCAGTCTCCATGTCGGGCATC
TCACTCAAATCATGATGCTCCACTGGCTCCAGCAGACTGGGCACAGGCCGATCGCGCTGATGGGCGGCGGCACCGGGATG
ATCGGCGATCCGTCTTTCAAGGACGAAGCGCGCAAGCTGCTTACCCCTGAAGCCATCGGGCAGAACCTAGCCGGCATGAA
GAAGTCCTTCAGCCGCTATCTTAAATTCGGCGATGGCCCTACCGATGCGATCATGGCCAACAATGCCGACTGGCTGCTCG
ATCTCAATTACGTGACCTTCCTGCGCGATGTCGGCCGCCACTTCTCGGTTAACCGGATGCTGTCCTTCGAGTCGGTAAAA
CTCCGGCTCGACCGGGAGCAGTCGCTTTCCTTCCTGGAATTCAACTACATGATTCTCCAGGCCTACGACTTCGTGGAACT
GCAGCGCCGCTACGGCTGCCGCCTGCAGATGGGCGGGTCGGACCAGTGGGGCAACATCGTCAACGGCATCGATCTCGGCC
GGCGCATGGAGGATACAACGCTCTTCGCGCTTACCTCTCCGCTGCTGACGACCGCGTCCGGCGCCAAGATGGGCAAGTCC
GAGAGCGGCGCCGTCTGGCTGGATCCGGCAATGTTGAGCCCTTATGACTTCTGGCAATACTGGCGCAACACGGAGGATGC
GGATGTCGGCCGCTTCCTGAAGCTCTACACCACGCTGCCTTTGGACGAGATCGACCGTCTGGAGAAGCTCGGCGGTGCTG
AGATCAACGAAGCCAAGAAGATCCTGGCCACGGAAGTGACGGCCATGTTGCACGGGCGCGCTGCGGCGGAAGAAGCGGCG
GAGACGGCCCGCAAGACCTTCGAGGAAGGCGCGCTTGCCGAAAGCCTGCCCACGATCGAGGTGCCGCGGGCACAAATGGA
GGCGGGCATCGGTGTTCTGAACGCGGTGGTCCTTGCCGGTCTTGCCGCGACAAACGGCGAGGTGCGCCGCGCGATCGCCA
ACAATGCGATCCGTGTGAATGACGAAACCATTACCGACGACCGCGCAACCATCGGCGCCGGTGACATTACGGCAGAGGGT
GTCGTCAAGCTTTCCTTCGGTCGCAAGAAGCACGTCCTTCTGCGCCCGCGCTGA

Upstream 100 bases:

>100_bases
GCCCGGACTTCTCTGGCTCGCGGTCCGCTTGTGCGCGGCGCGTGAGTGGTGCTAAACGCGCGGTCATCTTCCCAGCCCGT
TCCCGCGAAGGGATTTTGCA

Downstream 100 bases:

>100_bases
TAGGGTCTTCTTTCGGCTCAGCGGAACTCGAAGATCTCGCGCAGGAAGCCAGGGGCGACCGCGGAAAGCGGGTTCACCTC
GAGTCTGGGGTTTTCGACGG

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MPDFKSDFLRILSERGFIHQISDEAGLDELFLRETVTGYIGYDPTAASLHVGHLTQIMMLHWLQQTGHRPIALMGGGTGM
IGDPSFKDEARKLLTPEAIGQNLAGMKKSFSRYLKFGDGPTDAIMANNADWLLDLNYVTFLRDVGRHFSVNRMLSFESVK
LRLDREQSLSFLEFNYMILQAYDFVELQRRYGCRLQMGGSDQWGNIVNGIDLGRRMEDTTLFALTSPLLTTASGAKMGKS
ESGAVWLDPAMLSPYDFWQYWRNTEDADVGRFLKLYTTLPLDEIDRLEKLGGAEINEAKKILATEVTAMLHGRAAAEEAA
ETARKTFEEGALAESLPTIEVPRAQMEAGIGVLNAVVLAGLAATNGEVRRAIANNAIRVNDETITDDRATIGAGDITAEG
VVKLSFGRKKHVLLRPR

Sequences:

>Translated_417_residues
MPDFKSDFLRILSERGFIHQISDEAGLDELFLRETVTGYIGYDPTAASLHVGHLTQIMMLHWLQQTGHRPIALMGGGTGM
IGDPSFKDEARKLLTPEAIGQNLAGMKKSFSRYLKFGDGPTDAIMANNADWLLDLNYVTFLRDVGRHFSVNRMLSFESVK
LRLDREQSLSFLEFNYMILQAYDFVELQRRYGCRLQMGGSDQWGNIVNGIDLGRRMEDTTLFALTSPLLTTASGAKMGKS
ESGAVWLDPAMLSPYDFWQYWRNTEDADVGRFLKLYTTLPLDEIDRLEKLGGAEINEAKKILATEVTAMLHGRAAAEEAA
ETARKTFEEGALAESLPTIEVPRAQMEAGIGVLNAVVLAGLAATNGEVRRAIANNAIRVNDETITDDRATIGAGDITAEG
VVKLSFGRKKHVLLRPR
>Mature_416_residues
PDFKSDFLRILSERGFIHQISDEAGLDELFLRETVTGYIGYDPTAASLHVGHLTQIMMLHWLQQTGHRPIALMGGGTGMI
GDPSFKDEARKLLTPEAIGQNLAGMKKSFSRYLKFGDGPTDAIMANNADWLLDLNYVTFLRDVGRHFSVNRMLSFESVKL
RLDREQSLSFLEFNYMILQAYDFVELQRRYGCRLQMGGSDQWGNIVNGIDLGRRMEDTTLFALTSPLLTTASGAKMGKSE
SGAVWLDPAMLSPYDFWQYWRNTEDADVGRFLKLYTTLPLDEIDRLEKLGGAEINEAKKILATEVTAMLHGRAAAEEAAE
TARKTFEEGALAESLPTIEVPRAQMEAGIGVLNAVVLAGLAATNGEVRRAIANNAIRVNDETITDDRATIGAGDITAEGV
VKLSFGRKKHVLLRPR

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=429, Percent_Identity=34.4988344988345, Blast_Score=220, Evalue=2e-57,
Organism=Escherichia coli, GI1787925, Length=422, Percent_Identity=44.0758293838863, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI25145802, Length=294, Percent_Identity=36.0544217687075, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI25145805, Length=208, Percent_Identity=34.6153846153846, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6325160, Length=351, Percent_Identity=36.7521367521368, Blast_Score=222, Evalue=1e-58,
Organism=Drosophila melanogaster, GI20130383, Length=432, Percent_Identity=35.4166666666667, Blast_Score=251, Evalue=5e-67,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 46227; Mature: 46096

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS50889 S4 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDFKSDFLRILSERGFIHQISDEAGLDELFLRETVTGYIGYDPTAASLHVGHLTQIMML
CCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCHHEEEHHHHHHHHHH
HWLQQTGHRPIALMGGGTGMIGDPSFKDEARKLLTPEAIGQNLAGMKKSFSRYLKFGDGP
HHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHCCHHHHCCHHHHHHHHHHHHHHCCCCC
TDAIMANNADWLLDLNYVTFLRDVGRHFSVNRMLSFESVKLRLDREQSLSFLEFNYMILQ
CCCEEECCCCEEEECHHHHHHHHHHHCCCHHHHEEHHHHEEEECHHHCCCHHHHHHHHHH
AYDFVELQRRYGCRLQMGGSDQWGNIVNGIDLGRRMEDTTLFALTSPLLTTASGAKMGKS
HHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHCCCCCCCEEEEEHHHHHHCCCCCCCCCC
ESGAVWLDPAMLSPYDFWQYWRNTEDADVGRFLKLYTTLPLDEIDRLEKLGGAEINEAKK
CCCEEEECHHHCCHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHH
ILATEVTAMLHGRAAAEEAAETARKTFEEGALAESLPTIEVPRAQMEAGIGVLNAVVLAG
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
LAATNGEVRRAIANNAIRVNDETITDDRATIGAGDITAEGVVKLSFGRKKHVLLRPR
HHCCCHHHHHHHHCCCEEECCCEECCCCCCCCCCCCCCCCEEEEECCCCCCEEECCC
>Mature Secondary Structure 
PDFKSDFLRILSERGFIHQISDEAGLDELFLRETVTGYIGYDPTAASLHVGHLTQIMML
CCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCHHEEEHHHHHHHHHH
HWLQQTGHRPIALMGGGTGMIGDPSFKDEARKLLTPEAIGQNLAGMKKSFSRYLKFGDGP
HHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHCCHHHHCCHHHHHHHHHHHHHHCCCCC
TDAIMANNADWLLDLNYVTFLRDVGRHFSVNRMLSFESVKLRLDREQSLSFLEFNYMILQ
CCCEEECCCCEEEECHHHHHHHHHHHCCCHHHHEEHHHHEEEECHHHCCCHHHHHHHHHH
AYDFVELQRRYGCRLQMGGSDQWGNIVNGIDLGRRMEDTTLFALTSPLLTTASGAKMGKS
HHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHCCCCCCCEEEEEHHHHHHCCCCCCCCCC
ESGAVWLDPAMLSPYDFWQYWRNTEDADVGRFLKLYTTLPLDEIDRLEKLGGAEINEAKK
CCCEEEECHHHCCHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHH
ILATEVTAMLHGRAAAEEAAETARKTFEEGALAESLPTIEVPRAQMEAGIGVLNAVVLAG
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
LAATNGEVRRAIANNAIRVNDETITDDRATIGAGDITAEGVVKLSFGRKKHVLLRPR
HHCCCHHHHHHHHCCCEEECCCEECCCCCCCCCCCCCCCCEEEEECCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]