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The map label for this gene is csd [H]

Identifier: 110634129

GI number: 110634129

Start: 1898648

End: 1899889

Strand: Reverse

Name: csd [H]

Synonym: Meso_1778

Alternate gene names: 110634129

Gene position: 1899889-1898648 (Counterclockwise)

Preceding gene: 110634130

Following gene: 110634128

Centisome position: 43.06

GC content: 61.27

Gene sequence:

>1242_bases
ATGGATCAGAAACTCGAAAACAACATCTATGACGTCGAGGCGATCCGCCGGGATTTCCCGATCCTAGCGCGCGAGGTCTA
CGGCAAACCGCTCGTCTATCTCGACAACGCCGCTTCTGCCCAGAAACCGCAGGCGGTGATCGATGCGGTCACGCAGGCCT
ATTCCAACGAATATGCCAATGTGCATCGCGGGCTTCACTTCCTCTCCAACGCAGCCACGGACGCCTATGAGAAGGCACGC
GAGACGGTAAGGCGGTTCCTTAACGCCGGAAGCGCGGAGGAGATCGTCTTCACGAAATCCGCCACGGAAGCCATCAACAC
CGTCGCCTATGGCTATGCCATGCCGCGGATCGGGGAGGGCGATGAGATCGTGGTCTCCATCATGGAGCACCATTCCAACA
TCGTGCCCTGGCATTTTCTGCGCGAACGGAAGGGTGCCAAGCTCGTCTGGGCGCCGGTGGCCGACGACGGCAGCTTTCAC
ATCGACGAATTCGAGAAATGCCTGACGGAGCGGACGAAGCTCGTCGCCATCACGCATATGTCGAATATGCTGGGCACGGT
GACGCCCGTGGCCGACATCGTGCGAATCGCGCATGAACGGGGCATTCCCGTGCTGGTGGACGGGAGCCAGGGGGCCGTGC
ACCAGCCGGTCGATGTCAGGGCTCTCGATTGCGATTTTTATATCTGCACCGGGCACAAGCTCTACGGGCCGTCAGGCATC
GGCGTTCTCTATGGCAAGCGTGAGAAGCTTCAGGAGATGCGCCCCTTCCAGGGCGGCGGCGAGATGATCGAGGACGTCTC
GGTTGACAACGTCACCTATAACGATCCGCCGCATCGCTTCGAGGCCGGCACGCCGCCCATCGTGCAGGCGATCGGGCTTG
GAGCCGCGCTCGACTACATGGAGGCGATCGGCCGCGAGAAGATCGCCGCCCACGAGGCGGAAATTTCGAAATATGCGCAT
GAGCGGCTTGGCCAGATCAATTCGCTGCGCGTTTTCGGCACCGCGCCAGGCAAGGGGGCAATTCTCTCCTTCGAGCTTGC
CGGACTCCATGCCCATGACGTGGCGATGGTGATCGACCGCTCCGGTGTTGCCGTACGCGCCGGTACGCATTGTGCCCAGC
CGCTGCTCAAGCGTTTCGGCGTGACCTCGACATGCCGCGCCTCATTCGCCATGTATAATACGAAAGCCGAGGTGGATGCC
TTGGCCGAGGCGCTCGACAAGGCGCGCAAATTCTTCGGGTGA

Upstream 100 bases:

>100_bases
CGCGCGGCACCTCTTTCCCCTTGAGGGAATGGAAATCGCGGTAGCGAAGCCGAACGGGCGAGGGAGCGCTTGCAGCGCTG
AACGCTGAAGCGGATCGGAT

Downstream 100 bases:

>100_bases
AAATATGAGCGAAGCCGAAAACAAGCCGGAAACCGGCGAAAGGGAAAAGGCTGCGGACGCAGTATTCACTTCGTCGGCCA
TTCCGCAGGAAGAATTGGCG

Product: SufS subfamily cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MDQKLENNIYDVEAIRRDFPILAREVYGKPLVYLDNAASAQKPQAVIDAVTQAYSNEYANVHRGLHFLSNAATDAYEKAR
ETVRRFLNAGSAEEIVFTKSATEAINTVAYGYAMPRIGEGDEIVVSIMEHHSNIVPWHFLRERKGAKLVWAPVADDGSFH
IDEFEKCLTERTKLVAITHMSNMLGTVTPVADIVRIAHERGIPVLVDGSQGAVHQPVDVRALDCDFYICTGHKLYGPSGI
GVLYGKREKLQEMRPFQGGGEMIEDVSVDNVTYNDPPHRFEAGTPPIVQAIGLGAALDYMEAIGREKIAAHEAEISKYAH
ERLGQINSLRVFGTAPGKGAILSFELAGLHAHDVAMVIDRSGVAVRAGTHCAQPLLKRFGVTSTCRASFAMYNTKAEVDA
LAEALDKARKFFG

Sequences:

>Translated_413_residues
MDQKLENNIYDVEAIRRDFPILAREVYGKPLVYLDNAASAQKPQAVIDAVTQAYSNEYANVHRGLHFLSNAATDAYEKAR
ETVRRFLNAGSAEEIVFTKSATEAINTVAYGYAMPRIGEGDEIVVSIMEHHSNIVPWHFLRERKGAKLVWAPVADDGSFH
IDEFEKCLTERTKLVAITHMSNMLGTVTPVADIVRIAHERGIPVLVDGSQGAVHQPVDVRALDCDFYICTGHKLYGPSGI
GVLYGKREKLQEMRPFQGGGEMIEDVSVDNVTYNDPPHRFEAGTPPIVQAIGLGAALDYMEAIGREKIAAHEAEISKYAH
ERLGQINSLRVFGTAPGKGAILSFELAGLHAHDVAMVIDRSGVAVRAGTHCAQPLLKRFGVTSTCRASFAMYNTKAEVDA
LAEALDKARKFFG
>Mature_413_residues
MDQKLENNIYDVEAIRRDFPILAREVYGKPLVYLDNAASAQKPQAVIDAVTQAYSNEYANVHRGLHFLSNAATDAYEKAR
ETVRRFLNAGSAEEIVFTKSATEAINTVAYGYAMPRIGEGDEIVVSIMEHHSNIVPWHFLRERKGAKLVWAPVADDGSFH
IDEFEKCLTERTKLVAITHMSNMLGTVTPVADIVRIAHERGIPVLVDGSQGAVHQPVDVRALDCDFYICTGHKLYGPSGI
GVLYGKREKLQEMRPFQGGGEMIEDVSVDNVTYNDPPHRFEAGTPPIVQAIGLGAALDYMEAIGREKIAAHEAEISKYAH
ERLGQINSLRVFGTAPGKGAILSFELAGLHAHDVAMVIDRSGVAVRAGTHCAQPLLKRFGVTSTCRASFAMYNTKAEVDA
LAEALDKARKFFG

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=390, Percent_Identity=26.4102564102564, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI156713448, Length=430, Percent_Identity=27.906976744186, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1787970, Length=406, Percent_Identity=48.7684729064039, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1789175, Length=405, Percent_Identity=43.2098765432099, Blast_Score=338, Evalue=4e-94,
Organism=Escherichia coli, GI48994898, Length=396, Percent_Identity=26.5151515151515, Blast_Score=106, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI25143064, Length=296, Percent_Identity=27.7027027027027, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI193211090, Length=385, Percent_Identity=25.7142857142857, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319831, Length=237, Percent_Identity=28.2700421940928, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI20129463, Length=278, Percent_Identity=31.294964028777, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45310; Mature: 45310

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQKLENNIYDVEAIRRDFPILAREVYGKPLVYLDNAASAQKPQAVIDAVTQAYSNEYAN
CCCCHHCCCHHHHHHHHCCHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
VHRGLHFLSNAATDAYEKARETVRRFLNAGSAEEIVFTKSATEAINTVAYGYAMPRIGEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCC
DEIVVSIMEHHSNIVPWHFLRERKGAKLVWAPVADDGSFHIDEFEKCLTERTKLVAITHM
HHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHCHHEEEEEHH
SNMLGTVTPVADIVRIAHERGIPVLVDGSQGAVHQPVDVRALDCDFYICTGHKLYGPSGI
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEECCEEEEECCEEECCCCC
GVLYGKREKLQEMRPFQGGGEMIEDVSVDNVTYNDPPHRFEAGTPPIVQAIGLGAALDYM
EEEECCHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EAIGREKIAAHEAEISKYAHERLGQINSLRVFGTAPGKGAILSFELAGLHAHDVAMVIDR
HHHCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCCCEEEEEEC
SGVAVRAGTHCAQPLLKRFGVTSTCRASFAMYNTKAEVDALAEALDKARKFFG
CCCEEECCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDQKLENNIYDVEAIRRDFPILAREVYGKPLVYLDNAASAQKPQAVIDAVTQAYSNEYAN
CCCCHHCCCHHHHHHHHCCHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
VHRGLHFLSNAATDAYEKARETVRRFLNAGSAEEIVFTKSATEAINTVAYGYAMPRIGEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCC
DEIVVSIMEHHSNIVPWHFLRERKGAKLVWAPVADDGSFHIDEFEKCLTERTKLVAITHM
HHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHCHHEEEEEHH
SNMLGTVTPVADIVRIAHERGIPVLVDGSQGAVHQPVDVRALDCDFYICTGHKLYGPSGI
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEECCEEEEECCEEECCCCC
GVLYGKREKLQEMRPFQGGGEMIEDVSVDNVTYNDPPHRFEAGTPPIVQAIGLGAALDYM
EEEECCHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EAIGREKIAAHEAEISKYAHERLGQINSLRVFGTAPGKGAILSFELAGLHAHDVAMVIDR
HHHCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCCCEEEEEEC
SGVAVRAGTHCAQPLLKRFGVTSTCRASFAMYNTKAEVDALAEALDKARKFFG
CCCEEECCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]