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The map label for this gene is thyA

Identifier: 110634102

GI number: 110634102

Start: 1870524

End: 1871318

Strand: Reverse

Name: thyA

Synonym: Meso_1751

Alternate gene names: 110634102

Gene position: 1871318-1870524 (Counterclockwise)

Preceding gene: 110634103

Following gene: 110634101

Centisome position: 42.41

GC content: 59.62

Gene sequence:

>795_bases
ATGCGCCAATATCTCGATCTGCTTGCCCATGTGCTCGAAAACGGCATCGACCGCGAAGACCGGACTGGCACCGGCACGCG
CGGCGTCTTCGGGTATCAGATGCGCTTCGACCTTTCGGACGGGTTTCCGGTGCTGACCACGAAAAAGCTGCATCTCCGGT
CGATCATCTATGAGCTTTTATGGTTCCTGAAGGGCGATACCAATATCCGCTACCTTCAGGAGAACGGTGTGACGATATGG
GACGAGTGGGCCGATGAGAACGGCGACCTCGGGCCAGTTTATGGCGCGCAGTGGCGATCCTGGCCCGCGCCGGACGGGCG
GCATATCGACCAGATTGCGAATCTTCTCAATGGATTGAGGGAAAATCCTTATTCGCGGCGTCACATCGTGACGGCCTGGA
ACCCGGCTGAGATCGACGGGATGGCCTTGCCGCCCTGCCATTGCCTTTTCCAATTCCATGTGGCCGAGGGGCGTCTCTCA
TGCCAGCTCTACCAGCGCTCGGCGGACATCTTCCTTGGCGTGCCCTTCAACATCGCCTCCTATGCGCTGCTTACCATGAT
GATCGCGCAGGTTACCGGCCTGAAGCCGGGCGACTTCGTTCACACGCTTGGCGATGCGCATCTTTACAAGAACCACTTCG
ACCAGGCGCGCGAGCAGCTGACGCGCACGCCGAAGCCGCTGCCGACGATGTGGATCAACCCGGAGGTGGATGATCTCTTC
GCCTTTGGCTACGAGGATTTTCGTTTGGAGGGCTATGTGGCCGATCCGACGATCCGCGCGCCCATCGCCGTATAG

Upstream 100 bases:

>100_bases
AACTATCTTCGCTTTAAAGCCGGTACTCCACCGGCGGGCATTTTTCCGCTCGCCGGTTCGGCTTATGCTGCTCCGCTAAA
GACCTCCGATTCGGTTCCCC

Downstream 100 bases:

>100_bases
GCCAACAGATTGCGAGCGTCGAATGAAGCTTTCTCTCGTCGTGGCTGTCGCCAATAACGGCGTCATCGGCCACCAAGGTG
ATTTGCCGTGGCGGTTGTCC

Product: thymidylate synthase

Products: NA

Alternate protein names: TS; TSase

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MRQYLDLLAHVLENGIDREDRTGTGTRGVFGYQMRFDLSDGFPVLTTKKLHLRSIIYELLWFLKGDTNIRYLQENGVTIW
DEWADENGDLGPVYGAQWRSWPAPDGRHIDQIANLLNGLRENPYSRRHIVTAWNPAEIDGMALPPCHCLFQFHVAEGRLS
CQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLKPGDFVHTLGDAHLYKNHFDQAREQLTRTPKPLPTMWINPEVDDLF
AFGYEDFRLEGYVADPTIRAPIAV

Sequences:

>Translated_264_residues
MRQYLDLLAHVLENGIDREDRTGTGTRGVFGYQMRFDLSDGFPVLTTKKLHLRSIIYELLWFLKGDTNIRYLQENGVTIW
DEWADENGDLGPVYGAQWRSWPAPDGRHIDQIANLLNGLRENPYSRRHIVTAWNPAEIDGMALPPCHCLFQFHVAEGRLS
CQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLKPGDFVHTLGDAHLYKNHFDQAREQLTRTPKPLPTMWINPEVDDLF
AFGYEDFRLEGYVADPTIRAPIAV
>Mature_264_residues
MRQYLDLLAHVLENGIDREDRTGTGTRGVFGYQMRFDLSDGFPVLTTKKLHLRSIIYELLWFLKGDTNIRYLQENGVTIW
DEWADENGDLGPVYGAQWRSWPAPDGRHIDQIANLLNGLRENPYSRRHIVTAWNPAEIDGMALPPCHCLFQFHVAEGRLS
CQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLKPGDFVHTLGDAHLYKNHFDQAREQLTRTPKPLPTMWINPEVDDLF
AFGYEDFRLEGYVADPTIRAPIAV

Specific function: Provides the sole de novo source of dTMP for DNA biosynthesis

COG id: COG0207

COG function: function code F; Thymidylate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate synthase family. Bacterial- type thyA subfamily

Homologues:

Organism=Homo sapiens, GI4507751, Length=282, Percent_Identity=50.354609929078, Blast_Score=285, Evalue=4e-77,
Organism=Escherichia coli, GI1789191, Length=264, Percent_Identity=64.3939393939394, Blast_Score=371, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71993377, Length=283, Percent_Identity=45.2296819787986, Blast_Score=251, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6324648, Length=291, Percent_Identity=42.6116838487972, Blast_Score=212, Evalue=5e-56,
Organism=Drosophila melanogaster, GI17137556, Length=283, Percent_Identity=53.356890459364, Blast_Score=295, Evalue=2e-80,

Paralogues:

None

Copy number: 391 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): TYSY_MESSB (Q11HI0)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674310.1
- ProteinModelPortal:   Q11HI0
- SMR:   Q11HI0
- STRING:   Q11HI0
- GeneID:   4181187
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1751
- NMPDR:   fig|266779.1.peg.3833
- eggNOG:   COG0207
- HOGENOM:   HBG588098
- OMA:   RMALAPC
- PhylomeDB:   Q11HI0
- BioCyc:   MSP266779:MESO_1751-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00008
- InterPro:   IPR000398
- InterPro:   IPR020940
- Gene3D:   G3DSA:3.30.572.10
- PANTHER:   PTHR11549:SF2
- PRINTS:   PR00108
- TIGRFAMs:   TIGR03284

Pfam domain/function: PF00303 Thymidylat_synt; SSF55831 Thymidylat_synth_C

EC number: =2.1.1.45

Molecular weight: Translated: 30196; Mature: 30196

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00091 THYMIDYLATE_SYNTHASE

Important sites: ACT_SITE 146-146

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQYLDLLAHVLENGIDREDRTGTGTRGVFGYQMRFDLSDGFPVLTTKKLHLRSIIYELL
CHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEECCHHHHHHHHHHHH
WFLKGDTNIRYLQENGVTIWDEWADENGDLGPVYGAQWRSWPAPDGRHIDQIANLLNGLR
HHHCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
ENPYSRRHIVTAWNPAEIDGMALPPCHCLFQFHVAEGRLSCQLYQRSADIFLGVPFNIAS
CCCCCCCEEEEECCCCCCCCCCCCHHHHHEEEEECCCCEEEEEEECCCCEEEECCHHHHH
YALLTMMIAQVTGLKPGDFVHTLGDAHLYKNHFDQAREQLTRTPKPLPTMWINPEVDDLF
HHHHHHHHHHHHCCCCCCHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHH
AFGYEDFRLEGYVADPTIRAPIAV
HCCCCCEEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MRQYLDLLAHVLENGIDREDRTGTGTRGVFGYQMRFDLSDGFPVLTTKKLHLRSIIYELL
CHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEECCHHHHHHHHHHHH
WFLKGDTNIRYLQENGVTIWDEWADENGDLGPVYGAQWRSWPAPDGRHIDQIANLLNGLR
HHHCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
ENPYSRRHIVTAWNPAEIDGMALPPCHCLFQFHVAEGRLSCQLYQRSADIFLGVPFNIAS
CCCCCCCEEEEECCCCCCCCCCCCHHHHHEEEEECCCCEEEEEEECCCCEEEECCHHHHH
YALLTMMIAQVTGLKPGDFVHTLGDAHLYKNHFDQAREQLTRTPKPLPTMWINPEVDDLF
HHHHHHHHHHHHCCCCCCHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHH
AFGYEDFRLEGYVADPTIRAPIAV
HCCCCCEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA