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The map label for this gene is degP [H]

Identifier: 110634003

GI number: 110634003

Start: 1780137

End: 1781615

Strand: Reverse

Name: degP [H]

Synonym: Meso_1651

Alternate gene names: 110634003

Gene position: 1781615-1780137 (Counterclockwise)

Preceding gene: 110634005

Following gene: 110634002

Centisome position: 40.38

GC content: 63.96

Gene sequence:

>1479_bases
ATGAAAGTGAGATTTTTTGTTCTTCGCGTGCTCTTCGTTCTTTGTGCGCTTTCACTGCCGGCCCATGCGCAGGACCGCCC
GGCAGAATCGCTGCTTGATCCGCTGAGGCAGCTCCTGCGCGGCGGCGAAGACGCTTCCAAGCCGACGACCGGCGAGGCCC
AGCGCCGCGTCCCCTTCAGCCAGCAGGAAATCCAGCTCTCCTTTGCGCCCCTGGTTCGTCAGGTCGCACCCGCCGTTGTC
AACGTCTATGCCTCGACGCGTGTGCAGGCTCGCTCGCCCTTCATGGGAGATCCATTCTTCGAGCGCTTCTTCGATTTTCC
GCAAATGCCTCCGCGCGTGCAGTCCTCATTAGGCTCCGGCGTGCTGGTCGATGCCTCCGGCATCGTGGTGACCAACTACC
ACGTGATCCGCGAGGCGGATGAAGTGAAGGTCGCACTCGCCGACGGACGGGAATTCGAAAGCACTATCCTGCTCAAGGAT
GAAGGGCTCGATCTCGCCGTTTTGAAGGTCGAAGGCTCGGATCCTTTCCCGGCCGCCGCGCTCGGAGATTCGGAAGCGCT
TGAGGTCGGTGACCTAGTTCTGGCGATCGGCAACCCCTTCGGCGTCGGCCAGACCACGACGAGCGGCATCGTCTCGGCCG
TGGCGCGCAGCTTGGGTGGCGTTTCCGACTTCGGCTTCTTCATACAGACGGATGCGGCCATCAATCCCGGCAATTCGGGC
GGTGCGCTCATCAACATGGCCGGCGAGGTGATTGGAATCAACACGGCGATCTATAGCCGCTCGGGTGGGTCGATCGGGAT
CGGCTTCGCGATTCCGGCGAACATCGTGCGCGCCGTGGTCGAATCGGCGAAAAACGGTAAGGACTTCTTCGAGCGTCCTT
ATTTGGGCGCGAGCTTCGATCGGGTGACGCCCAATATCGCCGAGGCGCTCGGCATGGCCAGGCCAGCGGGTGCTCTCGTC
ACCAATATCGCCCCGGACAGCCCGGCCGCCAAGGCGGGACTGAAAAGCGGCGACGTTGTGGTTGCGGTGGACGGCAGGCC
TGTGGATACGCCTGAGGCGCTGGATTACCGCCTCGCCACCGTACCAATCGGCGAGACGGCCCAAGTGGAGGTGCTGCGCA
ATGGCGAGGAGATGGCGCTTTCCATGCCGGTCGAACGCGCGCCTGAAGGCGATGGCAGGGAGCTCGAGATCGGTGGCGTA
GGGCCCTTTGCCGGCGCCAGGGTGGCGGAGGTGTCGCCGGCGCTCGCCCAGCGCCTGCGTCTCCCGGTTACTGGAAAAGG
CGTTGTCATCACGGATCTGGCGCGCAATTCCCCCGCCGCCAGCATCGGCCTGCGACCCGGCGATATCGTGCGGGAACTCA
ACGGGGAGGAAGTCACCGATGCCGCGCAGATGAAAGCGCTCGCGGAGGCCGATGGCCGCTGGTGGCGGTTCACCATTGAT
CGCGGCGGGCAGATTATCCGGCAGACGATGCGGTTCTAG

Upstream 100 bases:

>100_bases
AATCATCCGCCGTTTTGCGGCGCACTCGTCCGGCGTCGTTGGCCTTTTCTTGTGCACAATCCTATCCGATGATGCGCGAA
CCAGTGGCCCAGGGAGTCCG

Downstream 100 bases:

>100_bases
CGCATCGGACCGAGAGTGATACCGGTTGGAGAAGTCCGATGCTGAAACAAAGAGATGGATCGCCACCTCCGCGCCCGGAA
GGGTGTATGGCGATCTAGTG

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MKVRFFVLRVLFVLCALSLPAHAQDRPAESLLDPLRQLLRGGEDASKPTTGEAQRRVPFSQQEIQLSFAPLVRQVAPAVV
NVYASTRVQARSPFMGDPFFERFFDFPQMPPRVQSSLGSGVLVDASGIVVTNYHVIREADEVKVALADGREFESTILLKD
EGLDLAVLKVEGSDPFPAAALGDSEALEVGDLVLAIGNPFGVGQTTTSGIVSAVARSLGGVSDFGFFIQTDAAINPGNSG
GALINMAGEVIGINTAIYSRSGGSIGIGFAIPANIVRAVVESAKNGKDFFERPYLGASFDRVTPNIAEALGMARPAGALV
TNIAPDSPAAKAGLKSGDVVVAVDGRPVDTPEALDYRLATVPIGETAQVEVLRNGEEMALSMPVERAPEGDGRELEIGGV
GPFAGARVAEVSPALAQRLRLPVTGKGVVITDLARNSPAASIGLRPGDIVRELNGEEVTDAAQMKALAEADGRWWRFTID
RGGQIIRQTMRF

Sequences:

>Translated_492_residues
MKVRFFVLRVLFVLCALSLPAHAQDRPAESLLDPLRQLLRGGEDASKPTTGEAQRRVPFSQQEIQLSFAPLVRQVAPAVV
NVYASTRVQARSPFMGDPFFERFFDFPQMPPRVQSSLGSGVLVDASGIVVTNYHVIREADEVKVALADGREFESTILLKD
EGLDLAVLKVEGSDPFPAAALGDSEALEVGDLVLAIGNPFGVGQTTTSGIVSAVARSLGGVSDFGFFIQTDAAINPGNSG
GALINMAGEVIGINTAIYSRSGGSIGIGFAIPANIVRAVVESAKNGKDFFERPYLGASFDRVTPNIAEALGMARPAGALV
TNIAPDSPAAKAGLKSGDVVVAVDGRPVDTPEALDYRLATVPIGETAQVEVLRNGEEMALSMPVERAPEGDGRELEIGGV
GPFAGARVAEVSPALAQRLRLPVTGKGVVITDLARNSPAASIGLRPGDIVRELNGEEVTDAAQMKALAEADGRWWRFTID
RGGQIIRQTMRF
>Mature_492_residues
MKVRFFVLRVLFVLCALSLPAHAQDRPAESLLDPLRQLLRGGEDASKPTTGEAQRRVPFSQQEIQLSFAPLVRQVAPAVV
NVYASTRVQARSPFMGDPFFERFFDFPQMPPRVQSSLGSGVLVDASGIVVTNYHVIREADEVKVALADGREFESTILLKD
EGLDLAVLKVEGSDPFPAAALGDSEALEVGDLVLAIGNPFGVGQTTTSGIVSAVARSLGGVSDFGFFIQTDAAINPGNSG
GALINMAGEVIGINTAIYSRSGGSIGIGFAIPANIVRAVVESAKNGKDFFERPYLGASFDRVTPNIAEALGMARPAGALV
TNIAPDSPAAKAGLKSGDVVVAVDGRPVDTPEALDYRLATVPIGETAQVEVLRNGEEMALSMPVERAPEGDGRELEIGGV
GPFAGARVAEVSPALAQRLRLPVTGKGVVITDLARNSPAASIGLRPGDIVRELNGEEVTDAAQMKALAEADGRWWRFTID
RGGQIIRQTMRF

Specific function: Serine protease that is required at high temperature. Involved in the degradation of damaged proteins. Shared specificity with hhoA/degQ [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=374, Percent_Identity=33.4224598930481, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI4506141, Length=358, Percent_Identity=32.6815642458101, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI24308541, Length=332, Percent_Identity=32.5301204819277, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI7019477, Length=303, Percent_Identity=35.3135313531353, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1786356, Length=450, Percent_Identity=35.7777777777778, Blast_Score=264, Evalue=9e-72,
Organism=Escherichia coli, GI1789629, Length=437, Percent_Identity=37.7574370709382, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1789630, Length=336, Percent_Identity=36.3095238095238, Blast_Score=190, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24646839, Length=426, Percent_Identity=29.1079812206573, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 51970; Mature: 51970

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVRFFVLRVLFVLCALSLPAHAQDRPAESLLDPLRQLLRGGEDASKPTTGEAQRRVPFS
CCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCC
QQEIQLSFAPLVRQVAPAVVNVYASTRVQARSPFMGDPFFERFFDFPQMPPRVQSSLGSG
HHHHEEHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHCCCCCCHHHHHHCCCC
VLVDASGIVVTNYHVIREADEVKVALADGREFESTILLKDEGLDLAVLKVEGSDPFPAAA
EEEECCCEEEEEEHEEECCCCEEEEEECCCCCCEEEEEEECCCCEEEEEEECCCCCCCHH
LGDSEALEVGDLVLAIGNPFGVGQTTTSGIVSAVARSLGGVSDFGFFIQTDAAINPGNSG
CCCCCCEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCEECCCCCC
GALINMAGEVIGINTAIYSRSGGSIGIGFAIPANIVRAVVESAKNGKDFFERPYLGASFD
CEEEEECCCEEEEEEEEEECCCCCEEEEECCHHHHHHHHHHHCCCCHHHHHCCCCCCCHH
RVTPNIAEALGMARPAGALVTNIAPDSPAAKAGLKSGDVVVAVDGRPVDTPEALDYRLAT
HCCCHHHHHHCCCCCCCHHEECCCCCCCHHHCCCCCCCEEEEECCCCCCCCHHHCEEEEE
VPIGETAQVEVLRNGEEMALSMPVERAPEGDGRELEIGGVGPFAGARVAEVSPALAQRLR
ECCCCCCEEEEEECCCEEEEECCHHHCCCCCCCEEEECCCCCCCCCHHHHCCHHHHHHHC
LPVTGKGVVITDLARNSPAASIGLRPGDIVRELNGEEVTDAAQMKALAEADGRWWRFTID
CCCCCCCEEEEECCCCCCCCEECCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEC
RGGQIIRQTMRF
CCHHHHHHHHCC
>Mature Secondary Structure
MKVRFFVLRVLFVLCALSLPAHAQDRPAESLLDPLRQLLRGGEDASKPTTGEAQRRVPFS
CCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCC
QQEIQLSFAPLVRQVAPAVVNVYASTRVQARSPFMGDPFFERFFDFPQMPPRVQSSLGSG
HHHHEEHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHCCCCCCHHHHHHCCCC
VLVDASGIVVTNYHVIREADEVKVALADGREFESTILLKDEGLDLAVLKVEGSDPFPAAA
EEEECCCEEEEEEHEEECCCCEEEEEECCCCCCEEEEEEECCCCEEEEEEECCCCCCCHH
LGDSEALEVGDLVLAIGNPFGVGQTTTSGIVSAVARSLGGVSDFGFFIQTDAAINPGNSG
CCCCCCEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCEECCCCCC
GALINMAGEVIGINTAIYSRSGGSIGIGFAIPANIVRAVVESAKNGKDFFERPYLGASFD
CEEEEECCCEEEEEEEEEECCCCCEEEEECCHHHHHHHHHHHCCCCHHHHHCCCCCCCHH
RVTPNIAEALGMARPAGALVTNIAPDSPAAKAGLKSGDVVVAVDGRPVDTPEALDYRLAT
HCCCHHHHHHCCCCCCCHHEECCCCCCCHHHCCCCCCCEEEEECCCCCCCCHHHCEEEEE
VPIGETAQVEVLRNGEEMALSMPVERAPEGDGRELEIGGVGPFAGARVAEVSPALAQRLR
ECCCCCCEEEEEECCCEEEEECCHHHCCCCCCCEEEECCCCCCCCCHHHHCCHHHHHHHC
LPVTGKGVVITDLARNSPAASIGLRPGDIVRELNGEEVTDAAQMKALAEADGRWWRFTID
CCCCCCCEEEEECCCCCCCCEECCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEC
RGGQIIRQTMRF
CCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1645840; 11677609 [H]