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The map label for this gene is pyrE [H]

Identifier: 110633829

GI number: 110633829

Start: 1573871

End: 1574575

Strand: Direct

Name: pyrE [H]

Synonym: Meso_1476

Alternate gene names: 110633829

Gene position: 1573871-1574575 (Clockwise)

Preceding gene: 110633828

Following gene: 110633830

Centisome position: 35.67

GC content: 60.28

Gene sequence:

>705_bases
ATGTTTGCCAACACCTTTCCCGACAAGGCCCTGATCGCCGAGACGGTGGCCAAGATGCTTCTGGAGATCGAGGCGGTCCA
CATCCGTGCGAACGAGCCCTATACCTTCACCTCCGGCATCAAGGCGCCCGTCTATATCGATTGCCGAAAGCTCATCTCCT
ATCCTCGCATCCGCTCGGCTGTCATGGATTTTGGCGCGTCGGTGATCCTGCGTGGCGCCGGCTTCGAGCAGTTCGATGTG
GTTGCGGGCGGCGAGACGGCCGGCATTCCCTTCGCTGCCTGGCTTTCCGAAAAGCTCGGCTTGCCGATGCTTTATGTGCG
AAAGAAGCCAAAGGGGTTTGGCCGCAACGCGCAGATCGAAGGCAATCTGCCGGACGGCGCGCGCGTTCTTTTGGTCGAGG
ATCTAACCACGGATGGCGGGAGCAAGATCAAGTTCGCCGAAGCCATCCGCAATGCCGGCGCTACGGTGAGCGACACTTTT
GCCGTCTTTTATTACGACATCTTCCCCGATACGCCGGACCGGCTTAAAGCCGCCGGCATGCGGCTCCATTATCTCACCAC
CTGGTGGGATGTCCTCGCCGTCTGCCGAAAGGAAAACCGTTTCGGCACTGAAGCGCTGGATCAGGCGGAAGCCTTCCTCA
AGGAGCCGCTCAAATGGTCTGCCAGCCACGGCGGCATCTCGGAGCTCCCCCGCACGGAGAGTTGA

Upstream 100 bases:

>100_bases
GGGAGAGAAAGCGATTTCTTGGTTTGGCGAAGCCAAAATCTTAGAAATTGCAAGTGAGGGGTATATTGTTGAAGACGGTC
CGAAGGAACCAAGCCCGCCC

Downstream 100 bases:

>100_bases
GATTGCCGGTACGATCACGAATTGTTACAAGAGGAACGATTGGCGTAAGATCCGCATTGTCAGCATCAGGGCGTCCTAAT
GGAGAACCCCTATGCACGCA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MFANTFPDKALIAETVAKMLLEIEAVHIRANEPYTFTSGIKAPVYIDCRKLISYPRIRSAVMDFGASVILRGAGFEQFDV
VAGGETAGIPFAAWLSEKLGLPMLYVRKKPKGFGRNAQIEGNLPDGARVLLVEDLTTDGGSKIKFAEAIRNAGATVSDTF
AVFYYDIFPDTPDRLKAAGMRLHYLTTWWDVLAVCRKENRFGTEALDQAEAFLKEPLKWSASHGGISELPRTES

Sequences:

>Translated_234_residues
MFANTFPDKALIAETVAKMLLEIEAVHIRANEPYTFTSGIKAPVYIDCRKLISYPRIRSAVMDFGASVILRGAGFEQFDV
VAGGETAGIPFAAWLSEKLGLPMLYVRKKPKGFGRNAQIEGNLPDGARVLLVEDLTTDGGSKIKFAEAIRNAGATVSDTF
AVFYYDIFPDTPDRLKAAGMRLHYLTTWWDVLAVCRKENRFGTEALDQAEAFLKEPLKWSASHGGISELPRTES
>Mature_234_residues
MFANTFPDKALIAETVAKMLLEIEAVHIRANEPYTFTSGIKAPVYIDCRKLISYPRIRSAVMDFGASVILRGAGFEQFDV
VAGGETAGIPFAAWLSEKLGLPMLYVRKKPKGFGRNAQIEGNLPDGARVLLVEDLTTDGGSKIKFAEAIRNAGATVSDTF
AVFYYDIFPDTPDRLKAAGMRLHYLTTWWDVLAVCRKENRFGTEALDQAEAFLKEPLKWSASHGGISELPRTES

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=202, Percent_Identity=30.1980198019802, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17508631, Length=131, Percent_Identity=39.6946564885496, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17554964, Length=179, Percent_Identity=27.9329608938547, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 25813; Mature: 25813

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFANTFPDKALIAETVAKMLLEIEAVHIRANEPYTFTSGIKAPVYIDCRKLISYPRIRSA
CCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCEEECCCCCCCEEEEHHHHHCCHHHHHH
VMDFGASVILRGAGFEQFDVVAGGETAGIPFAAWLSEKLGLPMLYVRKKPKGFGRNAQIE
HHHCCCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCEEE
GNLPDGARVLLVEDLTTDGGSKIKFAEAIRNAGATVSDTFAVFYYDIFPDTPDRLKAAGM
CCCCCCCEEEEEEECCCCCCCEEHHHHHHHHCCCCCCCCEEEEEEEECCCCHHHHHHHCE
RLHYLTTWWDVLAVCRKENRFGTEALDQAEAFLKEPLKWSASHGGISELPRTES
EEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure
MFANTFPDKALIAETVAKMLLEIEAVHIRANEPYTFTSGIKAPVYIDCRKLISYPRIRSA
CCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCEEECCCCCCCEEEEHHHHHCCHHHHHH
VMDFGASVILRGAGFEQFDVVAGGETAGIPFAAWLSEKLGLPMLYVRKKPKGFGRNAQIE
HHHCCCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCEEE
GNLPDGARVLLVEDLTTDGGSKIKFAEAIRNAGATVSDTFAVFYYDIFPDTPDRLKAAGM
CCCCCCCEEEEEEECCCCCCCEEHHHHHHHHCCCCCCCCEEEEEEEECCCCHHHHHHHCE
RLHYLTTWWDVLAVCRKENRFGTEALDQAEAFLKEPLKWSASHGGISELPRTES
EEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA