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The map label for this gene is sul [H]

Identifier: 110633765

GI number: 110633765

Start: 1511583

End: 1512419

Strand: Direct

Name: sul [H]

Synonym: Meso_1412

Alternate gene names: 110633765

Gene position: 1511583-1512419 (Clockwise)

Preceding gene: 110633763

Following gene: 110633766

Centisome position: 34.26

GC content: 61.89

Gene sequence:

>837_bases
ATGACCGAACCGCGGCAGTGGACATTGGCTCATGGGCGCACCCTGGAGCTCGGAGGGGATGCCCTGATCATGGGCATCCT
CAACGTCACGCCGGACAGCTTTTCAGATGGCGGACGCCTGCTGTCCGTGGAAAGTGCGGTTGCGGCGGCTCGTATAATGG
CCGCTGAGGGGGCCTCTATCATCGATGTCGGGGGAGAATCCACGCGGCCTGGCGCCGAACCCGTGAGCGCAATTGAGGAA
CAAAGAAGGGTTCTGCCCGTCATCGAGGCGCTTGCCGGGGAAGACGGCTTCGTGCTGTCGATTGACACCTATCGTTCGGA
AACGGCCGAGCTTGCCGTTCGCGCCGGCGCCCATATCGTCAACGACATTTTCGGCGTGCAAAGGGATCCGGCCGTTGCCA
CGGCTGCCGCGAATGCTGGTGCGGGCCTGATTCTCATGCACACCGGGCGGGGAAGGCAAAAGCTGCCTGACGTCATCGCC
GATCAGTTCTTCTATTTGCGCAAGTCGATCGAAATCGCCCATCAGGCAGGCAACCGGGACGAGCAGATCGTTCTCGATCC
GGGATTCGGGTTTGCCAAGGAATGGCACGAGGATATCGAGATCATGGCCCGTTTCGGAGAACTGAGGGGGCTGGGATTTC
CGCTTCTCGTCGGCACCTCGCGCAAACGCTTTATCGGCCGCATCACGGAACGCGAGGTGGGCGATCGAGACACTGCAACG
GCGGCAACAAGCACCTTGCTGCGATTGAAAGGGGCCTCGGTCTTCCGCGTGCACAATGTTGCGGCGAACAGGGACGCGCT
GCGGATCGCAGACGCCACCCGCGCCGCCGAAAGGTAA

Upstream 100 bases:

>100_bases
ACGCATCTTCCTTTAGGTAAAAAGCATGTATGACCCGGCCGTGGCAGTTGATTCTGCGGGCAAGGAGCCGCACATGAATT
TGATCGCATGGATTTAGGAA

Downstream 100 bases:

>100_bases
GGGAGGATTCCCGTGTACTCCATCCGATTGAGGAATTGCGCGTTCTACGCTCGGCATGGCTTGCTCGACGAGGAGGCGGC
GCTGGGCCAGCGATTCTATG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MTEPRQWTLAHGRTLELGGDALIMGILNVTPDSFSDGGRLLSVESAVAAARIMAAEGASIIDVGGESTRPGAEPVSAIEE
QRRVLPVIEALAGEDGFVLSIDTYRSETAELAVRAGAHIVNDIFGVQRDPAVATAAANAGAGLILMHTGRGRQKLPDVIA
DQFFYLRKSIEIAHQAGNRDEQIVLDPGFGFAKEWHEDIEIMARFGELRGLGFPLLVGTSRKRFIGRITEREVGDRDTAT
AATSTLLRLKGASVFRVHNVAANRDALRIADATRAAER

Sequences:

>Translated_278_residues
MTEPRQWTLAHGRTLELGGDALIMGILNVTPDSFSDGGRLLSVESAVAAARIMAAEGASIIDVGGESTRPGAEPVSAIEE
QRRVLPVIEALAGEDGFVLSIDTYRSETAELAVRAGAHIVNDIFGVQRDPAVATAAANAGAGLILMHTGRGRQKLPDVIA
DQFFYLRKSIEIAHQAGNRDEQIVLDPGFGFAKEWHEDIEIMARFGELRGLGFPLLVGTSRKRFIGRITEREVGDRDTAT
AATSTLLRLKGASVFRVHNVAANRDALRIADATRAAER
>Mature_277_residues
TEPRQWTLAHGRTLELGGDALIMGILNVTPDSFSDGGRLLSVESAVAAARIMAAEGASIIDVGGESTRPGAEPVSAIEEQ
RRVLPVIEALAGEDGFVLSIDTYRSETAELAVRAGAHIVNDIFGVQRDPAVATAAANAGAGLILMHTGRGRQKLPDVIAD
QFFYLRKSIEIAHQAGNRDEQIVLDPGFGFAKEWHEDIEIMARFGELRGLGFPLLVGTSRKRFIGRITEREVGDRDTATA
ATSTLLRLKGASVFRVHNVAANRDALRIADATRAAER

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=275, Percent_Identity=41.4545454545455, Blast_Score=196, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6324073, Length=314, Percent_Identity=33.4394904458599, Blast_Score=129, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29849; Mature: 29718

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPRQWTLAHGRTLELGGDALIMGILNVTPDSFSDGGRLLSVESAVAAARIMAAEGASI
CCCCCCEEECCCEEEEECCCEEEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCEE
IDVGGESTRPGAEPVSAIEEQRRVLPVIEALAGEDGFVLSIDTYRSETAELAVRAGAHIV
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHH
NDIFGVQRDPAVATAAANAGAGLILMHTGRGRQKLPDVIADQFFYLRKSIEIAHQAGNRD
HHHHCCCCCCCCEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EQIVLDPGFGFAKEWHEDIEIMARFGELRGLGFPLLVGTSRKRFIGRITEREVGDRDTAT
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCHHHH
AATSTLLRLKGASVFRVHNVAANRDALRIADATRAAER
HHHHHHHHHCCCCEEEEECCCCCCCCEEEHHHHHHCCC
>Mature Secondary Structure 
TEPRQWTLAHGRTLELGGDALIMGILNVTPDSFSDGGRLLSVESAVAAARIMAAEGASI
CCCCCEEECCCEEEEECCCEEEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCEE
IDVGGESTRPGAEPVSAIEEQRRVLPVIEALAGEDGFVLSIDTYRSETAELAVRAGAHIV
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHH
NDIFGVQRDPAVATAAANAGAGLILMHTGRGRQKLPDVIADQFFYLRKSIEIAHQAGNRD
HHHHCCCCCCCCEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EQIVLDPGFGFAKEWHEDIEIMARFGELRGLGFPLLVGTSRKRFIGRITEREVGDRDTAT
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCHHHH
AATSTLLRLKGASVFRVHNVAANRDALRIADATRAAER
HHHHHHHHHCCCCEEEEECCCCCCCCEEEHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]