BacMap

Definition	Mesorhizobium sp. BNC1, complete genome.
Accession	NC_008254
Length	4,412,446

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The map label for this gene is ppi [H]

Identifier: 110633757

GI number: 110633757

Start: 1500538

End: 1501014

Strand: Direct

Name: ppi [H]

Synonym: Meso_1404

Alternate gene names: 110633757

Gene position: 1500538-1501014 (Clockwise)

Preceding gene: 110633756

Following gene: 110633758

Centisome position: 34.01

GC content: 61.01

Gene sequence:

>477_bases
ATGACTAAAAAGAAAGACCCGGAAAACACAATCGTCATGGAGACGACCAAGGGCAATGTGGTGATTGAGCTATTCCCGGA
TGTGGCGCCCGCCCATGTGGCGCGCATCAAGGAGCTGGCCCGCGAGGGATTTTACGACGGGATTGTCTTCCACCGCGTGA
TCGACGGCTTCATGGCTCAGACGGGCGACCCCACGGGCACCGGCATGGGCGGTTCCGACAAACCGGACCTCAAGGCCGAG
TTCTCGAACGTGCCGCATGTGCGCGGCACCTGCTCCATGGCCCGCTCGCAGAACCCCAACTCCGCCAACTCGCAGTTCTT
CATCTGCTTCGGGGAGGCGCCCTGGCTCAACAAGCAATATTCCGTCTGGGGCCAGGTAGTCGAGGGCATGGACAATATCG
ACAAGATCAAGCGCGGCGAGCCCGTGCGCGATCCGGATTCGATCGTCTCGATGCGGGTGGCGGCGGATATTGCGTAG

Upstream 100 bases:

>100_bases
AGGGCGATCCGGCGGCGAACGGGCTGGTGCAGGATCCCGATCGCATGCTGAGCGTGCGGATCGCGGCAGACGAATAGAAA
CGACAGAAGAGAGGCGTCTC

Downstream 100 bases:

>100_bases
AAGCAGTTAGGGAGTAGCGAATAGCGGGTGGGGACGAGTAGGCTGCACTATTCGCAACTCACTATTCGCTCTTTCGCTCA
CCCATGCGTGTCGATCTCTT

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MTKKKDPENTIVMETTKGNVVIELFPDVAPAHVARIKELAREGFYDGIVFHRVIDGFMAQTGDPTGTGMGGSDKPDLKAE
FSNVPHVRGTCSMARSQNPNSANSQFFICFGEAPWLNKQYSVWGQVVEGMDNIDKIKRGEPVRDPDSIVSMRVAADIA

Sequences:

>Translated_158_residues
MTKKKDPENTIVMETTKGNVVIELFPDVAPAHVARIKELAREGFYDGIVFHRVIDGFMAQTGDPTGTGMGGSDKPDLKAE
FSNVPHVRGTCSMARSQNPNSANSQFFICFGEAPWLNKQYSVWGQVVEGMDNIDKIKRGEPVRDPDSIVSMRVAADIA
>Mature_157_residues
TKKKDPENTIVMETTKGNVVIELFPDVAPAHVARIKELAREGFYDGIVFHRVIDGFMAQTGDPTGTGMGGSDKPDLKAEF
SNVPHVRGTCSMARSQNPNSANSQFFICFGEAPWLNKQYSVWGQVVEGMDNIDKIKRGEPVRDPDSIVSMRVAADIA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=133, Percent_Identity=38.3458646616541, Blast_Score=104, Evalue=4e-23,
Organism=Homo sapiens, GI24308049, Length=132, Percent_Identity=40.9090909090909, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI7706339, Length=136, Percent_Identity=36.0294117647059, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI64276486, Length=121, Percent_Identity=37.1900826446281, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI5031987, Length=130, Percent_Identity=43.8461538461538, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI22547212, Length=126, Percent_Identity=43.6507936507937, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI7657473, Length=126, Percent_Identity=43.6507936507937, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI22547215, Length=126, Percent_Identity=43.6507936507937, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI10863927, Length=128, Percent_Identity=39.84375, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI20911035, Length=139, Percent_Identity=35.9712230215827, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI310110104, Length=129, Percent_Identity=35.6589147286822, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI310127646, Length=128, Percent_Identity=37.5, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI310114371, Length=128, Percent_Identity=37.5, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI310119221, Length=128, Percent_Identity=37.5, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI310129267, Length=129, Percent_Identity=36.4341085271318, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI310120620, Length=129, Percent_Identity=36.4341085271318, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI256017253, Length=128, Percent_Identity=35.9375, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI221139811, Length=128, Percent_Identity=35.9375, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI256017251, Length=128, Percent_Identity=35.9375, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI178057341, Length=132, Percent_Identity=34.0909090909091, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI4505991, Length=129, Percent_Identity=37.984496124031, Blast_Score=64, Evalue=4e-11,
Organism=Homo sapiens, GI169163387, Length=127, Percent_Identity=35.4330708661417, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1786736, Length=136, Percent_Identity=40.4411764705882, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1789763, Length=144, Percent_Identity=38.1944444444444, Blast_Score=91, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71980590, Length=132, Percent_Identity=37.8787878787879, Blast_Score=92, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71980594, Length=132, Percent_Identity=37.8787878787879, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17506311, Length=133, Percent_Identity=37.593984962406, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17539496, Length=136, Percent_Identity=35.2941176470588, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17532641, Length=151, Percent_Identity=35.0993377483444, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17539498, Length=148, Percent_Identity=37.1621621621622, Blast_Score=79, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI32563659, Length=138, Percent_Identity=34.0579710144928, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71997782, Length=128, Percent_Identity=35.9375, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565860, Length=140, Percent_Identity=34.2857142857143, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17559074, Length=163, Percent_Identity=31.9018404907975, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17552780, Length=127, Percent_Identity=37.7952755905512, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17506307, Length=151, Percent_Identity=37.0860927152318, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17566266, Length=134, Percent_Identity=33.5820895522388, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17552782, Length=134, Percent_Identity=32.8358208955224, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=143, Percent_Identity=37.7622377622378, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321848, Length=137, Percent_Identity=37.956204379562, Blast_Score=66, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=132, Percent_Identity=35.6060606060606, Blast_Score=66, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17986117, Length=155, Percent_Identity=37.4193548387097, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24652460, Length=133, Percent_Identity=36.8421052631579, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19922376, Length=134, Percent_Identity=35.0746268656716, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI45549139, Length=129, Percent_Identity=40.3100775193798, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19922912, Length=135, Percent_Identity=42.2222222222222, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24664125, Length=129, Percent_Identity=40.3100775193798, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21357783, Length=129, Percent_Identity=40.3100775193798, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17647301, Length=128, Percent_Identity=37.5, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355677, Length=138, Percent_Identity=34.7826086956522, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357249, Length=135, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24650807, Length=140, Percent_Identity=35.7142857142857, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17345; Mature: 17214

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKKDPENTIVMETTKGNVVIELFPDVAPAHVARIKELAREGFYDGIVFHRVIDGFMAQ
CCCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
TGDPTGTGMGGSDKPDLKAEFSNVPHVRGTCSMARSQNPNSANSQFFICFGEAPWLNKQY
CCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCCCCCHH
SVWGQVVEGMDNIDKIKRGEPVRDPDSIVSMRVAADIA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKKKDPENTIVMETTKGNVVIELFPDVAPAHVARIKELAREGFYDGIVFHRVIDGFMAQ
CCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
TGDPTGTGMGGSDKPDLKAEFSNVPHVRGTCSMARSQNPNSANSQFFICFGEAPWLNKQY
CCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCCCCCHH
SVWGQVVEGMDNIDKIKRGEPVRDPDSIVSMRVAADIA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA