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The map label for this gene is ppi [H]

Identifier: 110633756

GI number: 110633756

Start: 1499933

End: 1500514

Strand: Direct

Name: ppi [H]

Synonym: Meso_1403

Alternate gene names: 110633756

Gene position: 1499933-1500514 (Clockwise)

Preceding gene: 110633755

Following gene: 110633757

Centisome position: 33.99

GC content: 63.06

Gene sequence:

>582_bases
ATGCGCCCTTTTTCTCGCTTTGCACCTCTTTGCGTTGCCGCCGTTTTGGCCTTCGGCTCCGCCGCACTTGCCGCGGAACC
CGAAAACACGATGATCATCAAGCTCAAGGATGGCGATGTGGTGATCGGGCTGCGGCCCGACCTCGCGCCCAAGCACGTGG
AGCAGATCAAGACGCTTGTGCGCCAGGGCGCCTATGACAATGTCGCCTTCCACCGCGTGATCGACGGCTTCATGGCGCAG
ACGGGCGACGTCCAGTTCGGCGATCTGGAAGACGGCTTCAGCGCTGAGCGCGCGGGCACCGGCGGCTCGGACCTGCCGGA
CCTGCCGGCCGAGTTCACCAACACCGCCTTTGATCGTGGTACGGTCGGCATGGCGCGATCGCAGGATCCCAACTCAGCCA
ACTCGCAGTTTTTCATCATGTTCGCACCGGCATCGCATCTGAACGGCGCCTACACTGTGGTAGGGCAGGTGGAAACGGGC
ATGGAGCTCGTCGACAACATCAAGAAGGGCGATCCGGCGGCGAACGGGCTGGTGCAGGATCCCGATCGCATGCTGAGCGT
GCGGATCGCGGCAGACGAATAG

Upstream 100 bases:

>100_bases
GGCAGATCGCATCCATGGGCGGCAATGTCGCGCCTTTCGTGCCGGCCGTCGTGGCGGCGGCCCTGAAAGAAAAATTTTCA
GCCTAACCGGGAGAGATTTG

Downstream 100 bases:

>100_bases
AAACGACAGAAGAGAGGCGTCTCATGACTAAAAAGAAAGACCCGGAAAACACAATCGTCATGGAGACGACCAAGGGCAAT
GTGGTGATTGAGCTATTCCC

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MRPFSRFAPLCVAAVLAFGSAALAAEPENTMIIKLKDGDVVIGLRPDLAPKHVEQIKTLVRQGAYDNVAFHRVIDGFMAQ
TGDVQFGDLEDGFSAERAGTGGSDLPDLPAEFTNTAFDRGTVGMARSQDPNSANSQFFIMFAPASHLNGAYTVVGQVETG
MELVDNIKKGDPAANGLVQDPDRMLSVRIAADE

Sequences:

>Translated_193_residues
MRPFSRFAPLCVAAVLAFGSAALAAEPENTMIIKLKDGDVVIGLRPDLAPKHVEQIKTLVRQGAYDNVAFHRVIDGFMAQ
TGDVQFGDLEDGFSAERAGTGGSDLPDLPAEFTNTAFDRGTVGMARSQDPNSANSQFFIMFAPASHLNGAYTVVGQVETG
MELVDNIKKGDPAANGLVQDPDRMLSVRIAADE
>Mature_193_residues
MRPFSRFAPLCVAAVLAFGSAALAAEPENTMIIKLKDGDVVIGLRPDLAPKHVEQIKTLVRQGAYDNVAFHRVIDGFMAQ
TGDVQFGDLEDGFSAERAGTGGSDLPDLPAEFTNTAFDRGTVGMARSQDPNSANSQFFIMFAPASHLNGAYTVVGQVETG
MELVDNIKKGDPAANGLVQDPDRMLSVRIAADE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=134, Percent_Identity=35.0746268656716, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI24308049, Length=172, Percent_Identity=33.7209302325581, Blast_Score=71, Evalue=7e-13,
Organism=Escherichia coli, GI1786736, Length=151, Percent_Identity=34.4370860927152, Blast_Score=77, Evalue=6e-16,
Organism=Escherichia coli, GI1789763, Length=165, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=142, Percent_Identity=38.0281690140845, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71980594, Length=169, Percent_Identity=33.1360946745562, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71980590, Length=156, Percent_Identity=33.974358974359, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=147, Percent_Identity=29.2517006802721, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322492, Length=167, Percent_Identity=31.1377245508982, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=153, Percent_Identity=32.0261437908497, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6320359, Length=144, Percent_Identity=34.0277777777778, Blast_Score=62, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17986117, Length=153, Percent_Identity=34.640522875817, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24661775, Length=158, Percent_Identity=33.5443037974684, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21355237, Length=158, Percent_Identity=33.5443037974684, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24661771, Length=158, Percent_Identity=33.5443037974684, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI19922912, Length=165, Percent_Identity=33.9393939393939, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20572; Mature: 20572

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPFSRFAPLCVAAVLAFGSAALAAEPENTMIIKLKDGDVVIGLRPDLAPKHVEQIKTLV
CCCHHHHHHHHHHHHHHHCCHHEECCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHH
RQGAYDNVAFHRVIDGFMAQTGDVQFGDLEDGFSAERAGTGGSDLPDLPAEFTNTAFDRG
HCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCC
TVGMARSQDPNSANSQFFIMFAPASHLNGAYTVVGQVETGMELVDNIKKGDPAANGLVQD
CCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCCCC
PDRMLSVRIAADE
CCCEEEEEEEECC
>Mature Secondary Structure
MRPFSRFAPLCVAAVLAFGSAALAAEPENTMIIKLKDGDVVIGLRPDLAPKHVEQIKTLV
CCCHHHHHHHHHHHHHHHCCHHEECCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHH
RQGAYDNVAFHRVIDGFMAQTGDVQFGDLEDGFSAERAGTGGSDLPDLPAEFTNTAFDRG
HCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCC
TVGMARSQDPNSANSQFFIMFAPASHLNGAYTVVGQVETGMELVDNIKKGDPAANGLVQD
CCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCCCC
PDRMLSVRIAADE
CCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA