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The map label for this gene is lpxB [H]

Identifier: 110633746

GI number: 110633746

Start: 1486438

End: 1487616

Strand: Direct

Name: lpxB [H]

Synonym: Meso_1393

Alternate gene names: 110633746

Gene position: 1486438-1487616 (Clockwise)

Preceding gene: 110633745

Following gene: 110633750

Centisome position: 33.69

GC content: 65.14

Gene sequence:

>1179_bases
ATGAGTGAGGTCCGCCCACTGCGCATCGCGGTGATCGCCGGCGAGGAATCGGGCGACCTGCTCGGCGCGGATCTGGTGGA
CACCATTAAGCGGCAGACTGGCCGCCCTGTTGAGCTTCTGGGCGTCGGCGGGCGTAATCTGCAAGCGCTCGGCCTTCGAT
CGCTTTTCAGCGCCGACGACATCGCCATCATGGGCATTTCCGCCGTGCTGCGAGACCTGCCGCGGCTTTTAAAGCGCATC
AGCGATGCCGCCAAGGCGATCGCTGCGGCCAAACCCGACTGCCTCGTGACGATCGACAGCCCGGATTTCGGCCTGCGTGT
GGCGCGGAAGGTGAGGGCGGCCGAGCCTGCCGTCCCGATCGTTCATTATGTAAGCCCAAGCGTATGGGCATGGCGGCCTG
GCCGGGCAGCCGCCATGCGGCCTTATGTCGATCATGTGCTGTGCCTCCTGCCGTTCGAGCCCAAGGAGCTTGCCCGCCTC
GGCGGCCCTCCTGGCACCTTTGTCGGTCATCGCCTCACGAGCGATCCCGATCTGGCAGCCGCTGCGCGCGCGCAACTCGG
TCGCAAAGGGAAAGGGCAGCGGGAACGGAAAACGCTTCTTTTGCTGCCAGGCTCTCGCAAGGGAGAGGTGCGGCGCCTGA
TCGGCCCTTTCGGCGAAACGGTAAGGGAGCTCGCCGCCGCCGGCCACGGATTCGATCTCCTGTTGCCCACCGTTCCCCAT
GTCGCGGCGCTTGTGGAGGAAGGTGTGCGCGATTGGCCGGTACGGCCGGAAATCATTCTGGACCGGGAAGGCAAGTGGCG
CGCCTTTGCAGCGGCCGATGCGGCTCTGGCCTGCTCGGGAACCGTGGCTCTGGAACTGGCGCTTTCGCGCGTACCTTTTA
TCAGCGTCTACAAGACGGATACGATCGGCGGCATGGTCGGCCCGCTGCTGGTCAAGGTTTGGTCGGCATCGCTGCCGAAC
CTGATTGCCGGCTGGCCCGTCGTTCCGGAGTTCTTCAACGAGTTCGTGCGGCCTGCCTATCTTGCAAGGCTGCTTCCCAA
ACTTTGGCAGGATACGCCAACCCGCCGCGCTCAGCGCGAGGGATTTGCCGAGGTGGCGGAGGCGGTCGCCGGTCCAAAGC
CTTCGGGCGAAATCGCCGCCGAGGTCGTTTTGCGCACCGCCGGAGCGATGAAGGAATAG

Upstream 100 bases:

>100_bases
TTGAGAGCGAGCGGAGCTTGATTCTTGAGTGCGGTGAGACTGTGCGCCTTGCGAACCTCCTTGGGCTTTTTCTGCTGGGT
TTTAAGAGAGGGCGCGACGA

Downstream 100 bases:

>100_bases
GCTTTCGCAGCTTCGCTTACTTGTCCACGCGCTCCATGAGGGCCCGGGCCGCATGTGGCGCGCGGATTTTGCCTTCGTGA
ATGAAATAGACGAAAACGTC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSEVRPLRIAVIAGEESGDLLGADLVDTIKRQTGRPVELLGVGGRNLQALGLRSLFSADDIAIMGISAVLRDLPRLLKRI
SDAAKAIAAAKPDCLVTIDSPDFGLRVARKVRAAEPAVPIVHYVSPSVWAWRPGRAAAMRPYVDHVLCLLPFEPKELARL
GGPPGTFVGHRLTSDPDLAAAARAQLGRKGKGQRERKTLLLLPGSRKGEVRRLIGPFGETVRELAAAGHGFDLLLPTVPH
VAALVEEGVRDWPVRPEIILDREGKWRAFAAADAALACSGTVALELALSRVPFISVYKTDTIGGMVGPLLVKVWSASLPN
LIAGWPVVPEFFNEFVRPAYLARLLPKLWQDTPTRRAQREGFAEVAEAVAGPKPSGEIAAEVVLRTAGAMKE

Sequences:

>Translated_392_residues
MSEVRPLRIAVIAGEESGDLLGADLVDTIKRQTGRPVELLGVGGRNLQALGLRSLFSADDIAIMGISAVLRDLPRLLKRI
SDAAKAIAAAKPDCLVTIDSPDFGLRVARKVRAAEPAVPIVHYVSPSVWAWRPGRAAAMRPYVDHVLCLLPFEPKELARL
GGPPGTFVGHRLTSDPDLAAAARAQLGRKGKGQRERKTLLLLPGSRKGEVRRLIGPFGETVRELAAAGHGFDLLLPTVPH
VAALVEEGVRDWPVRPEIILDREGKWRAFAAADAALACSGTVALELALSRVPFISVYKTDTIGGMVGPLLVKVWSASLPN
LIAGWPVVPEFFNEFVRPAYLARLLPKLWQDTPTRRAQREGFAEVAEAVAGPKPSGEIAAEVVLRTAGAMKE
>Mature_391_residues
SEVRPLRIAVIAGEESGDLLGADLVDTIKRQTGRPVELLGVGGRNLQALGLRSLFSADDIAIMGISAVLRDLPRLLKRIS
DAAKAIAAAKPDCLVTIDSPDFGLRVARKVRAAEPAVPIVHYVSPSVWAWRPGRAAAMRPYVDHVLCLLPFEPKELARLG
GPPGTFVGHRLTSDPDLAAAARAQLGRKGKGQRERKTLLLLPGSRKGEVRRLIGPFGETVRELAAAGHGFDLLLPTVPHV
AALVEEGVRDWPVRPEIILDREGKWRAFAAADAALACSGTVALELALSRVPFISVYKTDTIGGMVGPLLVKVWSASLPNL
IAGWPVVPEFFNEFVRPAYLARLLPKLWQDTPTRRAQREGFAEVAEAVAGPKPSGEIAAEVVLRTAGAMKE

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=394, Percent_Identity=35.7868020304569, Blast_Score=179, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42128; Mature: 41996

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVRPLRIAVIAGEESGDLLGADLVDTIKRQTGRPVELLGVGGRNLQALGLRSLFSADD
CCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCC
IAIMGISAVLRDLPRLLKRISDAAKAIAAAKPDCLVTIDSPDFGLRVARKVRAAEPAVPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCCE
VHYVSPSVWAWRPGRAAAMRPYVDHVLCLLPFEPKELARLGGPPGTFVGHRLTSDPDLAA
EEECCCCCEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHH
AARAQLGRKGKGQRERKTLLLLPGSRKGEVRRLIGPFGETVRELAAAGHGFDLLLPTVPH
HHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHH
VAALVEEGVRDWPVRPEIILDREGKWRAFAAADAALACSGTVALELALSRVPFISVYKTD
HHHHHHHHHHCCCCCCCEEEECCCCEEEEECCCHHHHCCCHHHHHHHHHHCCEEEEEECC
TIGGMVGPLLVKVWSASLPNLIAGWPVVPEFFNEFVRPAYLARLLPKLWQDTPTRRAQRE
CHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHC
GFAEVAEAVAGPKPSGEIAAEVVLRTAGAMKE
CHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SEVRPLRIAVIAGEESGDLLGADLVDTIKRQTGRPVELLGVGGRNLQALGLRSLFSADD
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCC
IAIMGISAVLRDLPRLLKRISDAAKAIAAAKPDCLVTIDSPDFGLRVARKVRAAEPAVPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCCE
VHYVSPSVWAWRPGRAAAMRPYVDHVLCLLPFEPKELARLGGPPGTFVGHRLTSDPDLAA
EEECCCCCEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHH
AARAQLGRKGKGQRERKTLLLLPGSRKGEVRRLIGPFGETVRELAAAGHGFDLLLPTVPH
HHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHH
VAALVEEGVRDWPVRPEIILDREGKWRAFAAADAALACSGTVALELALSRVPFISVYKTD
HHHHHHHHHHCCCCCCCEEEECCCCEEEEECCCHHHHCCCHHHHHHHHHHCCEEEEEECC
TIGGMVGPLLVKVWSASLPNLIAGWPVVPEFFNEFVRPAYLARLLPKLWQDTPTRRAQRE
CHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHC
GFAEVAEAVAGPKPSGEIAAEVVLRTAGAMKE
CHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA