Click here to switch to the map view.

The map label for this gene is lpxD [H]

Identifier: 110633742

GI number: 110633742

Start: 1483159

End: 1484256

Strand: Direct

Name: lpxD [H]

Synonym: Meso_1389

Alternate gene names: 110633742

Gene position: 1483159-1484256 (Clockwise)

Preceding gene: 110633741

Following gene: 110633743

Centisome position: 33.61

GC content: 64.94

Gene sequence:

>1098_bases
ATGTTGTCCGGGCGGCCTGACGGTGCGCCCGGACGAGAAGGCATCATGACGGAACCGGCTTTTTTTGCTCCCGCACGCCG
CTTTGAGGTGGGCGAGATTGCTGCCTTGACGGGCGCGCGCCTGAGGGATGCCTCGCAGGAAAAGATCACGATCAGCCGAT
TGGCGCCCGCTGCCGAGGGCGGCGAGGAAACATTGGTTTTCATCGACGGAAGGCGCCATGCCTCCCGGATTGGTTCGGTG
CGCGCGGCGGCGCTCTTGTGCTCGGAAGAGTTGGCGGAAAATGCGCCGGACGGGGTCGCGGTGCTTGTCAGCCCGAAGCC
GCAGCAGGCCTTTGCCATGGTGGCGCGCCTCCTCTTTCCCGAGGCAAACCGGCCGCAGCCGGTAACTGGCGAGACGGGGG
TCTCCCCACGGGCCGTGATCGCCGAGGGAGCTGTCGTCGAGGACGGCGCGATCATAGAGGCAGGCGCGGTGATCGGCGTC
GGCGCCTCGGTGGGGCGCGGAACGATTGTGGGCCCAAACACCGTTATCGGCGCCCGCTGCAGCATCGGCCGCGACGGCTA
TGTGGGGCCGAACGTGATGCTGCAATATGCTGTCATCGGAGATCGCGTCATTATCCATCCTGGCGCGCAGATCGGGCAGG
ACGGGTTCGGCTTCCTGCCGGGGCCGAACGGGTTCGAGAAGAACCCGCAGATCGGCCGCGTGATCATTCAGGATGACGTT
GAAATCGGCGCCAACACCACCATCGACCGCGGCGCTCTGTCCGACACCATAATCGGCGAGGGCACCAAGATCGATAATCT
TGTGCAAATCGGGCACAACGTGCATATCGGCCGACGCTGCGTCATCGCCGGCCTTTGCGGTCTCTCGGGCTCGGTTAAGC
TCGGCGACTATGTCATGCTCGGCGGGCAGGTGGGCATTGCCGATCACATTACGATCGGCAATCGCGCGCAGCTCGCCGCC
TCGAGCGGTGTGATGGACGATGTACCCGAAGGCGAAAGATGGGCCGGCGTGCCGGCCAAGCCCATGCGGCAGGCGTTCCG
CGAAATCGCGGCGCTGCGCAGCCTGGTGCAGGATATGCGGAAGGGGAGTAAGGGATAA

Upstream 100 bases:

>100_bases
CGCTGCGCGTCGACTATGCCGAACCGGTGGTCAAGGAAGATACCGATCGCATTCGCCACTGGAATTTCGGCATCTCCACC
CGGTTTTAGGGCTTCACCGT

Downstream 100 bases:

>100_bases
TGGCCGACGGTGTGTCGCCCGCGATGGAAAGCCTCGACATTTTGAACGTGCTGCGACTCCTGCCGCACCGCTATCCATTT
CTGCTGGTGGACAGGATTGT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MLSGRPDGAPGREGIMTEPAFFAPARRFEVGEIAALTGARLRDASQEKITISRLAPAAEGGEETLVFIDGRRHASRIGSV
RAAALLCSEELAENAPDGVAVLVSPKPQQAFAMVARLLFPEANRPQPVTGETGVSPRAVIAEGAVVEDGAIIEAGAVIGV
GASVGRGTIVGPNTVIGARCSIGRDGYVGPNVMLQYAVIGDRVIIHPGAQIGQDGFGFLPGPNGFEKNPQIGRVIIQDDV
EIGANTTIDRGALSDTIIGEGTKIDNLVQIGHNVHIGRRCVIAGLCGLSGSVKLGDYVMLGGQVGIADHITIGNRAQLAA
SSGVMDDVPEGERWAGVPAKPMRQAFREIAALRSLVQDMRKGSKG

Sequences:

>Translated_365_residues
MLSGRPDGAPGREGIMTEPAFFAPARRFEVGEIAALTGARLRDASQEKITISRLAPAAEGGEETLVFIDGRRHASRIGSV
RAAALLCSEELAENAPDGVAVLVSPKPQQAFAMVARLLFPEANRPQPVTGETGVSPRAVIAEGAVVEDGAIIEAGAVIGV
GASVGRGTIVGPNTVIGARCSIGRDGYVGPNVMLQYAVIGDRVIIHPGAQIGQDGFGFLPGPNGFEKNPQIGRVIIQDDV
EIGANTTIDRGALSDTIIGEGTKIDNLVQIGHNVHIGRRCVIAGLCGLSGSVKLGDYVMLGGQVGIADHITIGNRAQLAA
SSGVMDDVPEGERWAGVPAKPMRQAFREIAALRSLVQDMRKGSKG
>Mature_365_residues
MLSGRPDGAPGREGIMTEPAFFAPARRFEVGEIAALTGARLRDASQEKITISRLAPAAEGGEETLVFIDGRRHASRIGSV
RAAALLCSEELAENAPDGVAVLVSPKPQQAFAMVARLLFPEANRPQPVTGETGVSPRAVIAEGAVVEDGAIIEAGAVIGV
GASVGRGTIVGPNTVIGARCSIGRDGYVGPNVMLQYAVIGDRVIIHPGAQIGQDGFGFLPGPNGFEKNPQIGRVIIQDDV
EIGANTTIDRGALSDTIIGEGTKIDNLVQIGHNVHIGRRCVIAGLCGLSGSVKLGDYVMLGGQVGIADHITIGNRAQLAA
SSGVMDDVPEGERWAGVPAKPMRQAFREIAALRSLVQDMRKGSKG

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=336, Percent_Identity=34.8214285714286, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1786378, Length=248, Percent_Identity=29.4354838709677, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 37870; Mature: 37870

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSGRPDGAPGREGIMTEPAFFAPARRFEVGEIAALTGARLRDASQEKITISRLAPAAEG
CCCCCCCCCCCCCCCCCCCHHHCCHHHCCCHHHHHHCCCHHCCCCCCEEEHHHHCCCCCC
GEETLVFIDGRRHASRIGSVRAAALLCSEELAENAPDGVAVLVSPKPQQAFAMVARLLFP
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCC
EANRPQPVTGETGVSPRAVIAEGAVVEDGAIIEAGAVIGVGASVGRGTIVGPNTVIGARC
CCCCCCCCCCCCCCCCCEEEECCCEECCCCEEECCCEEECCCCCCCCEEECCCCEEECEE
SIGRDGYVGPNVMLQYAVIGDRVIIHPGAQIGQDGFGFLPGPNGFEKNPQIGRVIIQDDV
CCCCCCCCCHHHEEEEEEECCEEEECCCHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCC
EIGANTTIDRGALSDTIIGEGTKIDNLVQIGHNVHIGRRCVIAGLCGLSGSVKLGDYVML
CCCCCCCCCCCCCCCCEECCCCCHHHHHHHCCCCCCCCEEEEEECCCCCCCCEECCEEEE
GGQVGIADHITIGNRAQLAASSGVMDDVPEGERWAGVPAKPMRQAFREIAALRSLVQDMR
CCEECCEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KGSKG
CCCCC
>Mature Secondary Structure
MLSGRPDGAPGREGIMTEPAFFAPARRFEVGEIAALTGARLRDASQEKITISRLAPAAEG
CCCCCCCCCCCCCCCCCCCHHHCCHHHCCCHHHHHHCCCHHCCCCCCEEEHHHHCCCCCC
GEETLVFIDGRRHASRIGSVRAAALLCSEELAENAPDGVAVLVSPKPQQAFAMVARLLFP
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCC
EANRPQPVTGETGVSPRAVIAEGAVVEDGAIIEAGAVIGVGASVGRGTIVGPNTVIGARC
CCCCCCCCCCCCCCCCCEEEECCCEECCCCEEECCCEEECCCCCCCCEEECCCCEEECEE
SIGRDGYVGPNVMLQYAVIGDRVIIHPGAQIGQDGFGFLPGPNGFEKNPQIGRVIIQDDV
CCCCCCCCCHHHEEEEEEECCEEEECCCHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCC
EIGANTTIDRGALSDTIIGEGTKIDNLVQIGHNVHIGRRCVIAGLCGLSGSVKLGDYVML
CCCCCCCCCCCCCCCCEECCCCCHHHHHHHCCCCCCCCEEEEEECCCCCCCCEECCEEEE
GGQVGIADHITIGNRAQLAASSGVMDDVPEGERWAGVPAKPMRQAFREIAALRSLVQDMR
CCEECCEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KGSKG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA