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The map label for this gene is clpA [C]

Identifier: 110633726

GI number: 110633726

Start: 1465583

End: 1468042

Strand: Direct

Name: clpA [C]

Synonym: Meso_1373

Alternate gene names: 110633726

Gene position: 1465583-1468042 (Clockwise)

Preceding gene: 110633725

Following gene: 110633727

Centisome position: 33.21

GC content: 62.36

Gene sequence:

>2460_bases
ATGCCGGCTTTCTCGCAAGGCCTGGAACGCGCGCTACATCAAGCGCTGACCTATGCCAATGAGCGCCATCATGAATATGC
GACGCTCGAGCACCTGCTGCTCGCACTGATCGACGATAATGACGCGGCCGCCGTGATGCGGGCGTGCAATGTCGATCTGG
ACGAGCTGAGGCGCACCGTCACCGACTACATCGATACCGAACTCGACAACCTCGTCACCGGTTATGACGAGGATTCCAAG
CCGACGGCCGGATTTCAGCGCGTGATCCAGCGCGCCGTAATTCATGTGCAGTCGTCGGGCCGGGAAGAGGTGTCCGGGGC
CAATGTGCTTGTTGCGATCTTCGCCGAGCGCGAGAGCCACGCCGCTTACTTCCTGCAGGAACAGCAGATGACCCGCTATG
ACGCGGTCAACTATATCAGCCATGGCATCGCCAAGCGTCCGGGCGCTTCCGAAGCGCGCACGCCGCGCGGCGCCGACGAG
GACCAGGCGGGCTCGACCGGCGCGGAGACGGAGGAAGGAGCCAAGAAGAAGCAGCAGCAGGACGCGCTTTCGGCCTATTG
CGTCAATCTGAACGCGAAGGCGAGGGCAGGGCGCATCGATCCGCTCATCGGCCGCGAGAGCGAAATCAGCCGCACGATCC
AGGTACTTTGCCGCCGTTCCAAGAACAACCCGCTCTATGTGGGTGATCCGGGCGTGGGCAAAACCGCGATCGCGGAGGGC
CTTGCAAAGCGGATCGTGGAAGGCGACGTACCCGACGTTCTTGCCGATGCTACTATCTTCGCGCTCGATATGGGCACACT
GCTCGCCGGCACCCGCTATCGCGGCGACTTCGAGGAGCGGCTGAAGCAGGTCGTCAAGGAACTGGAGGATTTCCCCGGCG
CCATCCTCTTCATTGACGAGATACATACGGTCATTGGTGCCGGCGCTACGTCGGGCGGCGCGATGGATGCGTCCAACCTG
CTCAAGCCGGCGCTTTCCTCGGGCGCAATCCGCTGTATCGGCTCAACGACTTACAAGGAGTTTCGCCAGTTCTTCGAGAA
GGACCGGGCGCTGGTGCGCCGGTTCCAAAAGATCGACGTGAACGAGCCGACGGTGCTGGACGCGATCGAGATCATGAAGG
GGCTGAAGCCCTATTTCGAAGATTTCCATCGCGTGAAGTACACGAACGAGGCGGTGAAGGCCGCGGTGGAGCTCTCGGCG
CGCTACATCAACGACCGCAAGCTGCCCGACAAGGCGATCGACGTGATCGACGAGACCGGCGCCTCGCAGAAGCTCCTGCC
CGAATCCAAGCGGCGCAAGACGATCACCGTAAAGGAGATCGAGACCACCATCGCCACCATGGCCCGTATCCCGCCGAAGA
CCGTATCGGCCGACGACGAGAAAGTGCTGGCGGGGCTCGAAACCGAATTGAAGCGCGTGGTCTACGGCCAGGATAAGGCC
ATCGAGGCGCTTGCCTCGGCGATCAAGCTTGCCCGCGCCGGCCTGCGAGAGCCCGAAAAGCCAATTGGTTCCTATCTCTT
CTCCGGCCCCACGGGCGTCGGCAAGACGGAGGTTGCCAAGCAGCTTGCGGCATCGCTGGGCGTGGAACTGCTGCGCTTTG
ACATGTCGGAATACATGGAGCGCCACACGGTCTCACGGCTCATCGGCGCGCCTCCCGGCTATGTCGGCTTCGACCAGGGC
GGGCTTTTGACCGACGGTGTCGATCAGCATCCGCACTGCGTGCTGCTTCTCGACGAGATCGAGAAGGCGCATCCGGACCT
GTTCAACATTCTCTTGCAGGTCATGGATCACGGCAAGCTGACGGACCATAATGGCAAGCGCATCGACTTCCGCAACGTCA
TCCTGATCATGACGACCAATGCGGGCGCGGCGGATATGGCCAAGCCGGCCATCGGCTTCGGCTCGTCCAAGCGTGAAGGC
GACGATATGGAGGCGATCAACCGGCTGTTCACACCGGAGTTTCGCAACCGGCTCGATGCCGTCATTGCCTTTGGCTCCCT
GCCCATGCCAGTTGTGCACCAGGTGGTGCAAAAGTTCGTCATGCAGCTCGAAGCACAGCTTGCCGAGAGGAAGGTCACCT
TTGACCTTTCCGAGGAGGCAATCGCCTGGCTGGCCGACAGGGGCTATGACGAACGCATGGGCGCCCGCCCGCTCGGTCGC
GTGATCCAGGAGCACATCAAGAAGCCGCTGGCGGAAGAGGTGCTCTTTGGCAAGCTCAGGCGTGGCGGCACGGTGAAGGT
CACAGTGGAGTCGAAGGACGGCGGTGAAACCGGCCTGAAGCTGGAGACGATCCCTGATGATGCGCCCGTGAAGCCAAAAC
GCGAATCTCCGCCGGCACGCAAGACCGCGGCGAAGCGGAATTCGGCTAAAAAGACGAAGCCGAAGGCGGCGAAGCGGCCC
CCGGCGCTGCCGGAGCCGCCGAAGCGTAGCCTTGTGCCGCAGCTGCCGCGCAAGAGTTGA

Upstream 100 bases:

>100_bases
CGTTCGAAGTGGCCGAGACAAAGGTGTCCCAGGTCATGGATTTTGCCCGTCAGCACCAGCATCCGCTGCAATGCGTGATG
GAGAAGAAATGAGGTTTTGA

Downstream 100 bases:

>100_bases
CGCGGTTGTATCAGAAATGATGGCGTGGGTTTCAGGCCCGCGCCATTTTTCTTTTCAGCAAAGGGCCGGTGCAAGCGGCG
CCGCAAATGGTTTGCCGCGC

Product: ATP-dependent Clp protease ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 819; Mature: 818

Protein sequence:

>819_residues
MPAFSQGLERALHQALTYANERHHEYATLEHLLLALIDDNDAAAVMRACNVDLDELRRTVTDYIDTELDNLVTGYDEDSK
PTAGFQRVIQRAVIHVQSSGREEVSGANVLVAIFAERESHAAYFLQEQQMTRYDAVNYISHGIAKRPGASEARTPRGADE
DQAGSTGAETEEGAKKKQQQDALSAYCVNLNAKARAGRIDPLIGRESEISRTIQVLCRRSKNNPLYVGDPGVGKTAIAEG
LAKRIVEGDVPDVLADATIFALDMGTLLAGTRYRGDFEERLKQVVKELEDFPGAILFIDEIHTVIGAGATSGGAMDASNL
LKPALSSGAIRCIGSTTYKEFRQFFEKDRALVRRFQKIDVNEPTVLDAIEIMKGLKPYFEDFHRVKYTNEAVKAAVELSA
RYINDRKLPDKAIDVIDETGASQKLLPESKRRKTITVKEIETTIATMARIPPKTVSADDEKVLAGLETELKRVVYGQDKA
IEALASAIKLARAGLREPEKPIGSYLFSGPTGVGKTEVAKQLAASLGVELLRFDMSEYMERHTVSRLIGAPPGYVGFDQG
GLLTDGVDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGKLTDHNGKRIDFRNVILIMTTNAGAADMAKPAIGFGSSKREG
DDMEAINRLFTPEFRNRLDAVIAFGSLPMPVVHQVVQKFVMQLEAQLAERKVTFDLSEEAIAWLADRGYDERMGARPLGR
VIQEHIKKPLAEEVLFGKLRRGGTVKVTVESKDGGETGLKLETIPDDAPVKPKRESPPARKTAAKRNSAKKTKPKAAKRP
PALPEPPKRSLVPQLPRKS

Sequences:

>Translated_819_residues
MPAFSQGLERALHQALTYANERHHEYATLEHLLLALIDDNDAAAVMRACNVDLDELRRTVTDYIDTELDNLVTGYDEDSK
PTAGFQRVIQRAVIHVQSSGREEVSGANVLVAIFAERESHAAYFLQEQQMTRYDAVNYISHGIAKRPGASEARTPRGADE
DQAGSTGAETEEGAKKKQQQDALSAYCVNLNAKARAGRIDPLIGRESEISRTIQVLCRRSKNNPLYVGDPGVGKTAIAEG
LAKRIVEGDVPDVLADATIFALDMGTLLAGTRYRGDFEERLKQVVKELEDFPGAILFIDEIHTVIGAGATSGGAMDASNL
LKPALSSGAIRCIGSTTYKEFRQFFEKDRALVRRFQKIDVNEPTVLDAIEIMKGLKPYFEDFHRVKYTNEAVKAAVELSA
RYINDRKLPDKAIDVIDETGASQKLLPESKRRKTITVKEIETTIATMARIPPKTVSADDEKVLAGLETELKRVVYGQDKA
IEALASAIKLARAGLREPEKPIGSYLFSGPTGVGKTEVAKQLAASLGVELLRFDMSEYMERHTVSRLIGAPPGYVGFDQG
GLLTDGVDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGKLTDHNGKRIDFRNVILIMTTNAGAADMAKPAIGFGSSKREG
DDMEAINRLFTPEFRNRLDAVIAFGSLPMPVVHQVVQKFVMQLEAQLAERKVTFDLSEEAIAWLADRGYDERMGARPLGR
VIQEHIKKPLAEEVLFGKLRRGGTVKVTVESKDGGETGLKLETIPDDAPVKPKRESPPARKTAAKRNSAKKTKPKAAKRP
PALPEPPKRSLVPQLPRKS
>Mature_818_residues
PAFSQGLERALHQALTYANERHHEYATLEHLLLALIDDNDAAAVMRACNVDLDELRRTVTDYIDTELDNLVTGYDEDSKP
TAGFQRVIQRAVIHVQSSGREEVSGANVLVAIFAERESHAAYFLQEQQMTRYDAVNYISHGIAKRPGASEARTPRGADED
QAGSTGAETEEGAKKKQQQDALSAYCVNLNAKARAGRIDPLIGRESEISRTIQVLCRRSKNNPLYVGDPGVGKTAIAEGL
AKRIVEGDVPDVLADATIFALDMGTLLAGTRYRGDFEERLKQVVKELEDFPGAILFIDEIHTVIGAGATSGGAMDASNLL
KPALSSGAIRCIGSTTYKEFRQFFEKDRALVRRFQKIDVNEPTVLDAIEIMKGLKPYFEDFHRVKYTNEAVKAAVELSAR
YINDRKLPDKAIDVIDETGASQKLLPESKRRKTITVKEIETTIATMARIPPKTVSADDEKVLAGLETELKRVVYGQDKAI
EALASAIKLARAGLREPEKPIGSYLFSGPTGVGKTEVAKQLAASLGVELLRFDMSEYMERHTVSRLIGAPPGYVGFDQGG
LLTDGVDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGKLTDHNGKRIDFRNVILIMTTNAGAADMAKPAIGFGSSKREGD
DMEAINRLFTPEFRNRLDAVIAFGSLPMPVVHQVVQKFVMQLEAQLAERKVTFDLSEEAIAWLADRGYDERMGARPLGRV
IQEHIKKPLAEEVLFGKLRRGGTVKVTVESKDGGETGLKLETIPDDAPVKPKRESPPARKTAAKRNSAKKTKPKAAKRPP
ALPEPPKRSLVPQLPRKS

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=325, Percent_Identity=33.5384615384615, Blast_Score=166, Evalue=6e-41,
Organism=Escherichia coli, GI1787109, Length=749, Percent_Identity=59.2790387182911, Blast_Score=908, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=432, Percent_Identity=40.9722222222222, Blast_Score=295, Evalue=9e-81,
Organism=Saccharomyces cerevisiae, GI6320464, Length=331, Percent_Identity=43.8066465256798, Blast_Score=280, Evalue=7e-76,
Organism=Saccharomyces cerevisiae, GI6323002, Length=376, Percent_Identity=39.3617021276596, Blast_Score=248, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 90105; Mature: 89974

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAFSQGLERALHQALTYANERHHEYATLEHLLLALIDDNDAAAVMRACNVDLDELRRTV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHH
TDYIDTELDNLVTGYDEDSKPTAGFQRVIQRAVIHVQSSGREEVSGANVLVAIFAERESH
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHCCCCEEEEEEECCCCH
AAYFLQEQQMTRYDAVNYISHGIAKRPGASEARTPRGADEDQAGSTGAETEEGAKKKQQQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
DALSAYCVNLNAKARAGRIDPLIGRESEISRTIQVLCRRSKNNPLYVGDPGVGKTAIAEG
HHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHH
LAKRIVEGDVPDVLADATIFALDMGTLLAGTRYRGDFEERLKQVVKELEDFPGAILFIDE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHH
IHTVIGAGATSGGAMDASNLLKPALSSGAIRCIGSTTYKEFRQFFEKDRALVRRFQKIDV
HHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCC
NEPTVLDAIEIMKGLKPYFEDFHRVKYTNEAVKAAVELSARYINDRKLPDKAIDVIDETG
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
ASQKLLPESKRRKTITVKEIETTIATMARIPPKTVSADDEKVLAGLETELKRVVYGQDKA
CCCCCCCCHHCCCEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHH
IEALASAIKLARAGLREPEKPIGSYLFSGPTGVGKTEVAKQLAASLGVELLRFDMSEYME
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RHTVSRLIGAPPGYVGFDQGGLLTDGVDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGKL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCHHHHHHHHHHHHCCCC
TDHNGKRIDFRNVILIMTTNAGAADMAKPAIGFGSSKREGDDMEAINRLFTPEFRNRLDA
CCCCCCEEEECCEEEEEECCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHH
VIAFGSLPMPVVHQVVQKFVMQLEAQLAERKVTFDLSEEAIAWLADRGYDERMGARPLGR
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHCCCHHHCCCCHHHH
VIQEHIKKPLAEEVLFGKLRRGGTVKVTVESKDGGETGLKLETIPDDAPVKPKRESPPAR
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCHH
KTAAKRNSAKKTKPKAAKRPPALPEPPKRSLVPQLPRKS
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PAFSQGLERALHQALTYANERHHEYATLEHLLLALIDDNDAAAVMRACNVDLDELRRTV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHH
TDYIDTELDNLVTGYDEDSKPTAGFQRVIQRAVIHVQSSGREEVSGANVLVAIFAERESH
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHCCCCEEEEEEECCCCH
AAYFLQEQQMTRYDAVNYISHGIAKRPGASEARTPRGADEDQAGSTGAETEEGAKKKQQQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
DALSAYCVNLNAKARAGRIDPLIGRESEISRTIQVLCRRSKNNPLYVGDPGVGKTAIAEG
HHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHH
LAKRIVEGDVPDVLADATIFALDMGTLLAGTRYRGDFEERLKQVVKELEDFPGAILFIDE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHH
IHTVIGAGATSGGAMDASNLLKPALSSGAIRCIGSTTYKEFRQFFEKDRALVRRFQKIDV
HHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCC
NEPTVLDAIEIMKGLKPYFEDFHRVKYTNEAVKAAVELSARYINDRKLPDKAIDVIDETG
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
ASQKLLPESKRRKTITVKEIETTIATMARIPPKTVSADDEKVLAGLETELKRVVYGQDKA
CCCCCCCCHHCCCEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHH
IEALASAIKLARAGLREPEKPIGSYLFSGPTGVGKTEVAKQLAASLGVELLRFDMSEYME
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RHTVSRLIGAPPGYVGFDQGGLLTDGVDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGKL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCHHHHHHHHHHHHCCCC
TDHNGKRIDFRNVILIMTTNAGAADMAKPAIGFGSSKREGDDMEAINRLFTPEFRNRLDA
CCCCCCEEEECCEEEEEECCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHH
VIAFGSLPMPVVHQVVQKFVMQLEAQLAERKVTFDLSEEAIAWLADRGYDERMGARPLGR
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHCCCHHHCCCCHHHH
VIQEHIKKPLAEEVLFGKLRRGGTVKVTVESKDGGETGLKLETIPDDAPVKPKRESPPAR
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCHH
KTAAKRNSAKKTKPKAAKRPPALPEPPKRSLVPQLPRKS
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]