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The map label for this gene is lon [H]

Identifier: 110633524

GI number: 110633524

Start: 1280249

End: 1282663

Strand: Direct

Name: lon [H]

Synonym: Meso_1171

Alternate gene names: 110633524

Gene position: 1280249-1282663 (Clockwise)

Preceding gene: 110633523

Following gene: 110633525

Centisome position: 29.01

GC content: 61.95

Gene sequence:

>2415_bases
ATGACAGAAGCTCCGAAAACTCCGAGCGAGGCCGTGTTCCCGGTGTTGCCTTTGCGCGACATCGTCGTGTTCCCGCACAT
GATCGTGCCGCTTTTTGTAGGGCGCGAGAAGTCGATCAAGGCTCTCGAAGAAGTAATGGGCGCCGAGAAGCAGGTTCTTC
TGGCGACCCAGATGAACGCGGCCGACGACGATCCGGATCCGAGCAAGATCTACGACATCGGCACGCTCGCAAATGTGCTG
CAGCTGCTAAAGCTTCCCGATGGCACTGTGAAAGTGCTGGTGGAGGGTGCTTCGCGCGCCCGCATTTCCGGCTTCACGGA
TCGGCAGGATTTCCATGAGGCTCGTGCCGTGGCGCTGGCCGAGCCCGAGGAAGACGAGGTCGAGATCGAGGCGCTCGCGC
GCTCTGTGGTTGCCGACTTCGAGAACTATGTGAAGCTCAACAAGAAGATCTCGCCCGAGGTCGTCGGCGCGACGAGCCAG
ATTGAGGATTATTCCAAGCTGGCGGACACGGTTGCCTCGCACCTGGCGATCAAGATCCCCGAAAAGCAGGAGATGCTTGC
GACGCTTTCCATCCGCGAGCGGCTTGAGAAGGCCATGGGCTTCATGGAAGCCGAGATCTCCGTGTTGCAGGTGGAAAAGC
GCATCCGCTCGCGCGTCAAGCGCCAGATGGAGAAGACGCAGCGCGAATATTACCTCAACGAGCAGATGAAGGCGATCCAG
AAGGAGCTCGGCGAGGGCGAGGACGGCCGCAACGAGGTGGCCGAGCTTGAGGAGCGCATCAAGAAGACCAAGCTCTCCAA
GGAGGCGCGCGAGAAGGCGGAAGCCGAGCTCAAGAAGTTGCAGACCATGTCGCCCATGTCCGCAGAGGCGACGGTCGTGC
GCAACTATCTCGATTGGCTGCTGTCGATCCCGTGGAAGAAGAGTTCCAAGGTCCGGCGCGACCTCGGTTTTGCCGAGGAG
GTGCTCGACGCCGATCACTTCGGCCTGGAGAAGGTGAAGGAACGCATCATCGAGTATCTGGCCGTGCAAAGCCGGCAGGA
TAAGATCAAGGGTCCGATCCTCTGCCTCGTCGGCCCTCCCGGCGTCGGTAAGACCTCGCTTGGCAAATCGATCGCCAAGG
CGACCGGGCGCGAGTTCGTGCGCATGGCGCTGGGCGGCGTGCGTGACGAGGCCGAGATTCGCGGTCACCGGCGCACCTAT
ATCGGCTCGATGCCCGGCAAGGTCATCCAGTCGATGAGGAAGGCCAAGAAGTCCAATCCGCTCTTCCTGCTCGACGAGAT
CGACAAGATGGGCATGGATTTCCGCGGCGATCCTTCCTCGGCGCTGCTTGAGGTGCTCGATCCGGAGCAGAACGCGACCT
TCATGGACCATTACCTCGAGGTCGAATACGACCTGTCGAGCGTGATGTTCGTGACGACGGCGAATACGCTCAACATCCCG
CCGGCGCTTATGGACCGCATGGAGATCATCCGCATCGCCGGTTACACGGAAGATGAAAAGGTGGAGATCGCAAAGCGGCA
CCTTCTGCCGAAGGCCGTTCGCGAGCATGCGCTGAAGCCCAGCGAGTTCTCCGTCACCGATGAGGCCCTGCAGACCGTCA
TCCGCACCTACACGCGGGAAGCCGGTGTGCGTAACCTCGAGCGCGAGTTGATGAAGCTGGCGCGCAAGGCGGTCACCGAG
ATCCTCAAGACCGGCAAAACTTCCGTCGAGGTGACCGAGGCCAATCTGGCCGATTATCTCGGTGTGCCGCGGTTCCGCTT
CGGCCAGGTCGAAGGCGAGGATCAGGTCGGCGTGGTCACGGGCCTCGCCTGGACCGAGGTGGGTGGCGAGCTGCTTACGA
TCGAAGGCGTCATGATGCCCGGCAAGGGCCGCATGACGGTTACCGGCAACTTGCGCGACGTGATGAAGGAATCGATTTCC
GCAGCGGCCTCTTATGTTCGTTCAAGGGCTGTCGATTTCGGCATCGAGCCGCCCTTCTTCGACAAGAGGGACATCCACGT
GCACGTGCCGGAAGGCGCGACACCCAAGGACGGTCCGTCGGCTGGTGTCGCGATGGCGACGGCGATCGTGTCGGTGCTCA
CCGGGATTCCGGTCCGCAAGGATGTCGCGATGACGGGTGAGATCACGCTGCGCGGCCGGGTCCTGCCGATCGGCGGGCTC
AAGGAGAAACTCCTCGCAGCCCTTCGCGGCGGCATCAAAAAGGTGCTGATCCCGGAAGAGAACGCCAAGGATTTGGTGGA
TATCCCGGAGAACGTGAAGAGCGGCATGGAGATCGTTCCCGTCAGCCGCGTGGGCGAGGTTCTGGAGCATGCGCTGGTAC
GCTTGCCCGAGCCGATCGAGTGGGTGGAGCCCGTCACCACACCCGCCACGGCGGACGTGTCTGAAGACGCAGGCCAGCCC
GCGGTTGCCCACTAA

Upstream 100 bases:

>100_bases
AGCGGTGTTGCGGTTGACAAGCCCATCCTTGCGGAAAGATGCCCCATAACAGTATGGTCCGGCCGGCTCCCAAGCGGTCG
CGGCCAGAAAGGCTGAAAAA

Downstream 100 bases:

>100_bases
GCTGCCATTTCCAGCAAAAAGATAAAAGCCGGCCCCGTCAGGGCCGGCTTTTTTCGCTGAAAACCGCAGAAATGCGGGGA
TTTTTTGAGAATCCCCAGCA

Product: Lon-A peptidase

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 804; Mature: 803

Protein sequence:

>804_residues
MTEAPKTPSEAVFPVLPLRDIVVFPHMIVPLFVGREKSIKALEEVMGAEKQVLLATQMNAADDDPDPSKIYDIGTLANVL
QLLKLPDGTVKVLVEGASRARISGFTDRQDFHEARAVALAEPEEDEVEIEALARSVVADFENYVKLNKKISPEVVGATSQ
IEDYSKLADTVASHLAIKIPEKQEMLATLSIRERLEKAMGFMEAEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAIQ
KELGEGEDGRNEVAELEERIKKTKLSKEAREKAEAELKKLQTMSPMSAEATVVRNYLDWLLSIPWKKSSKVRRDLGFAEE
VLDADHFGLEKVKERIIEYLAVQSRQDKIKGPILCLVGPPGVGKTSLGKSIAKATGREFVRMALGGVRDEAEIRGHRRTY
IGSMPGKVIQSMRKAKKSNPLFLLDEIDKMGMDFRGDPSSALLEVLDPEQNATFMDHYLEVEYDLSSVMFVTTANTLNIP
PALMDRMEIIRIAGYTEDEKVEIAKRHLLPKAVREHALKPSEFSVTDEALQTVIRTYTREAGVRNLERELMKLARKAVTE
ILKTGKTSVEVTEANLADYLGVPRFRFGQVEGEDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLRDVMKESIS
AAASYVRSRAVDFGIEPPFFDKRDIHVHVPEGATPKDGPSAGVAMATAIVSVLTGIPVRKDVAMTGEITLRGRVLPIGGL
KEKLLAALRGGIKKVLIPEENAKDLVDIPENVKSGMEIVPVSRVGEVLEHALVRLPEPIEWVEPVTTPATADVSEDAGQP
AVAH

Sequences:

>Translated_804_residues
MTEAPKTPSEAVFPVLPLRDIVVFPHMIVPLFVGREKSIKALEEVMGAEKQVLLATQMNAADDDPDPSKIYDIGTLANVL
QLLKLPDGTVKVLVEGASRARISGFTDRQDFHEARAVALAEPEEDEVEIEALARSVVADFENYVKLNKKISPEVVGATSQ
IEDYSKLADTVASHLAIKIPEKQEMLATLSIRERLEKAMGFMEAEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAIQ
KELGEGEDGRNEVAELEERIKKTKLSKEAREKAEAELKKLQTMSPMSAEATVVRNYLDWLLSIPWKKSSKVRRDLGFAEE
VLDADHFGLEKVKERIIEYLAVQSRQDKIKGPILCLVGPPGVGKTSLGKSIAKATGREFVRMALGGVRDEAEIRGHRRTY
IGSMPGKVIQSMRKAKKSNPLFLLDEIDKMGMDFRGDPSSALLEVLDPEQNATFMDHYLEVEYDLSSVMFVTTANTLNIP
PALMDRMEIIRIAGYTEDEKVEIAKRHLLPKAVREHALKPSEFSVTDEALQTVIRTYTREAGVRNLERELMKLARKAVTE
ILKTGKTSVEVTEANLADYLGVPRFRFGQVEGEDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLRDVMKESIS
AAASYVRSRAVDFGIEPPFFDKRDIHVHVPEGATPKDGPSAGVAMATAIVSVLTGIPVRKDVAMTGEITLRGRVLPIGGL
KEKLLAALRGGIKKVLIPEENAKDLVDIPENVKSGMEIVPVSRVGEVLEHALVRLPEPIEWVEPVTTPATADVSEDAGQP
AVAH
>Mature_803_residues
TEAPKTPSEAVFPVLPLRDIVVFPHMIVPLFVGREKSIKALEEVMGAEKQVLLATQMNAADDDPDPSKIYDIGTLANVLQ
LLKLPDGTVKVLVEGASRARISGFTDRQDFHEARAVALAEPEEDEVEIEALARSVVADFENYVKLNKKISPEVVGATSQI
EDYSKLADTVASHLAIKIPEKQEMLATLSIRERLEKAMGFMEAEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAIQK
ELGEGEDGRNEVAELEERIKKTKLSKEAREKAEAELKKLQTMSPMSAEATVVRNYLDWLLSIPWKKSSKVRRDLGFAEEV
LDADHFGLEKVKERIIEYLAVQSRQDKIKGPILCLVGPPGVGKTSLGKSIAKATGREFVRMALGGVRDEAEIRGHRRTYI
GSMPGKVIQSMRKAKKSNPLFLLDEIDKMGMDFRGDPSSALLEVLDPEQNATFMDHYLEVEYDLSSVMFVTTANTLNIPP
ALMDRMEIIRIAGYTEDEKVEIAKRHLLPKAVREHALKPSEFSVTDEALQTVIRTYTREAGVRNLERELMKLARKAVTEI
LKTGKTSVEVTEANLADYLGVPRFRFGQVEGEDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLRDVMKESISA
AASYVRSRAVDFGIEPPFFDKRDIHVHVPEGATPKDGPSAGVAMATAIVSVLTGIPVRKDVAMTGEITLRGRVLPIGGLK
EKLLAALRGGIKKVLIPEENAKDLVDIPENVKSGMEIVPVSRVGEVLEHALVRLPEPIEWVEPVTTPATADVSEDAGQPA
VAH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=829, Percent_Identity=38.2388419782871, Blast_Score=536, Evalue=1e-152,
Organism=Homo sapiens, GI31377667, Length=566, Percent_Identity=46.643109540636, Blast_Score=513, Evalue=1e-145,
Organism=Escherichia coli, GI1786643, Length=771, Percent_Identity=64.0726329442283, Blast_Score=997, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=702, Percent_Identity=41.1680911680912, Blast_Score=521, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17556486, Length=780, Percent_Identity=33.0769230769231, Blast_Score=437, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319449, Length=714, Percent_Identity=40.7563025210084, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI221513036, Length=650, Percent_Identity=42.1538461538462, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24666867, Length=650, Percent_Identity=42.1538461538462, Blast_Score=522, Evalue=1e-148,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 88900; Mature: 88769

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAPKTPSEAVFPVLPLRDIVVFPHMIVPLFVGREKSIKALEEVMGAEKQVLLATQMNA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCC
ADDDPDPSKIYDIGTLANVLQLLKLPDGTVKVLVEGASRARISGFTDRQDFHEARAVALA
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHCCCCCHHHHHHHHHHHCC
EPEEDEVEIEALARSVVADFENYVKLNKKISPEVVGATSQIEDYSKLADTVASHLAIKIP
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHEEECC
EKQEMLATLSIRERLEKAMGFMEAEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAIQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KELGEGEDGRNEVAELEERIKKTKLSKEAREKAEAELKKLQTMSPMSAEATVVRNYLDWL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LSIPWKKSSKVRRDLGFAEEVLDADHFGLEKVKERIIEYLAVQSRQDKIKGPILCLVGPP
HCCCCCCCHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
GVGKTSLGKSIAKATGREFVRMALGGVRDEAEIRGHRRTYIGSMPGKVIQSMRKAKKSNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCC
LFLLDEIDKMGMDFRGDPSSALLEVLDPEQNATFMDHYLEVEYDLSSVMFVTTANTLNIP
EEEEECHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHEEEEECCCEEEEEEECCCCCCC
PALMDRMEIIRIAGYTEDEKVEIAKRHLLPKAVREHALKPSEFSVTDEALQTVIRTYTRE
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
AGVRNLERELMKLARKAVTEILKTGKTSVEVTEANLADYLGVPRFRFGQVEGEDQVGVVT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCEECCCCCCCCCEEEE
GLAWTEVGGELLTIEGVMMPGKGRMTVTGNLRDVMKESISAAASYVRSRAVDFGIEPPFF
CCHHHHCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DKRDIHVHVPEGATPKDGPSAGVAMATAIVSVLTGIPVRKDVAMTGEITLRGRVLPIGGL
CCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECEEEEEEEEEECCCH
KEKLLAALRGGIKKVLIPEENAKDLVDIPENVKSGMEIVPVSRVGEVLEHALVRLPEPIE
HHHHHHHHHCCCEEEECCCCCCCHHHCCCHHHHCCCEEEEHHHHHHHHHHHHHHCCCCHH
WVEPVTTPATADVSEDAGQPAVAH
HHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEAPKTPSEAVFPVLPLRDIVVFPHMIVPLFVGREKSIKALEEVMGAEKQVLLATQMNA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCC
ADDDPDPSKIYDIGTLANVLQLLKLPDGTVKVLVEGASRARISGFTDRQDFHEARAVALA
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHCCCCCHHHHHHHHHHHCC
EPEEDEVEIEALARSVVADFENYVKLNKKISPEVVGATSQIEDYSKLADTVASHLAIKIP
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHEEECC
EKQEMLATLSIRERLEKAMGFMEAEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAIQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KELGEGEDGRNEVAELEERIKKTKLSKEAREKAEAELKKLQTMSPMSAEATVVRNYLDWL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LSIPWKKSSKVRRDLGFAEEVLDADHFGLEKVKERIIEYLAVQSRQDKIKGPILCLVGPP
HCCCCCCCHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
GVGKTSLGKSIAKATGREFVRMALGGVRDEAEIRGHRRTYIGSMPGKVIQSMRKAKKSNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCC
LFLLDEIDKMGMDFRGDPSSALLEVLDPEQNATFMDHYLEVEYDLSSVMFVTTANTLNIP
EEEEECHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHEEEEECCCEEEEEEECCCCCCC
PALMDRMEIIRIAGYTEDEKVEIAKRHLLPKAVREHALKPSEFSVTDEALQTVIRTYTRE
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
AGVRNLERELMKLARKAVTEILKTGKTSVEVTEANLADYLGVPRFRFGQVEGEDQVGVVT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCEECCCCCCCCCEEEE
GLAWTEVGGELLTIEGVMMPGKGRMTVTGNLRDVMKESISAAASYVRSRAVDFGIEPPFF
CCHHHHCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DKRDIHVHVPEGATPKDGPSAGVAMATAIVSVLTGIPVRKDVAMTGEITLRGRVLPIGGL
CCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECEEEEEEEEEECCCH
KEKLLAALRGGIKKVLIPEENAKDLVDIPENVKSGMEIVPVSRVGEVLEHALVRLPEPIE
HHHHHHHHHCCCEEEECCCCCCCHHHCCCHHHHCCCEEEEHHHHHHHHHHHHHHCCCCHH
WVEPVTTPATADVSEDAGQPAVAH
HHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA