Click here to switch to the map view.

The map label for this gene is fabH

Identifier: 110633499

GI number: 110633499

Start: 1252963

End: 1253934

Strand: Direct

Name: fabH

Synonym: Meso_1146

Alternate gene names: 110633499

Gene position: 1252963-1253934 (Clockwise)

Preceding gene: 110633498

Following gene: 110633500

Centisome position: 28.4

GC content: 61.93

Gene sequence:

>972_bases
ATGATCAGATCCACCGTGCGTGGTGTAGGCGCGGCCCTGCCACGCCGAGTCGTGACGAACAAGGACTTGGAGACGCGGCT
GGAAACGTCCGACGAATGGATCGTTCAACGGACCGGGATCCGCCAGCGACATATTGCATCGGACGACGAGACGACAGCCT
CGCTCGGCGAGGCTGCGGCACTCCGCGCCTTGGATGCCGCGGGTCTTGCCCCTGCTGATATCGATTTGATCGTGGTGGCG
ACGTCGACGCCCAACAACACCTTCCCCGCCACCGCGGTGGAAATTCAGGAGCGGCTCGGTATACGCCAGGGCTTCGCCTT
CGACATGCAGGCGGTCTGCAGCGGTTTCGTCTACGCGGTCACCACGGCCGACCTTTACATTCGCGGCGGTATGGCCAAGC
GCGCGCTGGTCATCGGGGCGGAAACGTTCTCGCGCATCCTGGACTGGACGGATCGTACGACCTGCGTTCTGTTCGGCGAT
GGAGCCGGGGCTATCGTCCTGGAAGCGGAGGAAGGGCAGGGGGACATAAGCGATCGCGGCATACTTGCCGAGGCGTTGCG
CTCCGACGGATCACACAAGGAAAAGCTTTATGTGGACGGGGGGCCCTCGACCACACGTACCGTGGGGCACCTGCGGATGC
AGGGGCGTGAGGTGTTCAAACATGCTGTCGGAATGATCACGGATGTGATCGAGGACGTTTTCGGTCAGGCCGGAATCACG
GCCGAAGACATCGACTGGTTTGTCTCCCACCAGGCAAACAAGCGAATCATCGACGCTTCCGCGAAGAAACTGGGCATTGC
GGAAGAAAAGGTGGTTATCACCGTAGATCTCCACGGCAACACTTCCGCAGCTTCCGTTCCGCTGGCGCTCAACCACGCGG
TATCACAGGGCAAGATCCAGAAGGGGGATCTGGTGCTTCTGGAAGCCATGGGGGGCGGCTTCACCTGGGGCGCGGTGCTG
CTGCGGTGGTAG

Upstream 100 bases:

>100_bases
GAGCGGACTGTTGGATAAGACGCGCGCCACGCTTGATCTTTATCATGCGCGCCGCCCTGTGGCACCTGCCGGAGCTGTCT
CCAATGCATAGGGAAACAGA

Downstream 100 bases:

>100_bases
CTTTTTTGGATGCATGAGCGCGTTTTCTGGTTCTTGACCTCGCCCGTCCAATTTCTTAACGTTCCGGCCGCACTAGTATT
TTCAATAGTTTCGATTGGAT

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MIRSTVRGVGAALPRRVVTNKDLETRLETSDEWIVQRTGIRQRHIASDDETTASLGEAAALRALDAAGLAPADIDLIVVA
TSTPNNTFPATAVEIQERLGIRQGFAFDMQAVCSGFVYAVTTADLYIRGGMAKRALVIGAETFSRILDWTDRTTCVLFGD
GAGAIVLEAEEGQGDISDRGILAEALRSDGSHKEKLYVDGGPSTTRTVGHLRMQGREVFKHAVGMITDVIEDVFGQAGIT
AEDIDWFVSHQANKRIIDASAKKLGIAEEKVVITVDLHGNTSAASVPLALNHAVSQGKIQKGDLVLLEAMGGGFTWGAVL
LRW

Sequences:

>Translated_323_residues
MIRSTVRGVGAALPRRVVTNKDLETRLETSDEWIVQRTGIRQRHIASDDETTASLGEAAALRALDAAGLAPADIDLIVVA
TSTPNNTFPATAVEIQERLGIRQGFAFDMQAVCSGFVYAVTTADLYIRGGMAKRALVIGAETFSRILDWTDRTTCVLFGD
GAGAIVLEAEEGQGDISDRGILAEALRSDGSHKEKLYVDGGPSTTRTVGHLRMQGREVFKHAVGMITDVIEDVFGQAGIT
AEDIDWFVSHQANKRIIDASAKKLGIAEEKVVITVDLHGNTSAASVPLALNHAVSQGKIQKGDLVLLEAMGGGFTWGAVL
LRW
>Mature_323_residues
MIRSTVRGVGAALPRRVVTNKDLETRLETSDEWIVQRTGIRQRHIASDDETTASLGEAAALRALDAAGLAPADIDLIVVA
TSTPNNTFPATAVEIQERLGIRQGFAFDMQAVCSGFVYAVTTADLYIRGGMAKRALVIGAETFSRILDWTDRTTCVLFGD
GAGAIVLEAEEGQGDISDRGILAEALRSDGSHKEKLYVDGGPSTTRTVGHLRMQGREVFKHAVGMITDVIEDVFGQAGIT
AEDIDWFVSHQANKRIIDASAKKLGIAEEKVVITVDLHGNTSAASVPLALNHAVSQGKIQKGDLVLLEAMGGGFTWGAVL
LRW

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=326, Percent_Identity=48.159509202454, Blast_Score=303, Evalue=1e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_MESSB (Q11J83)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673707.1
- ProteinModelPortal:   Q11J83
- SMR:   Q11J83
- STRING:   Q11J83
- GeneID:   4180737
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1146
- NMPDR:   fig|266779.1.peg.2440
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   ICATSTP
- PhylomeDB:   Q11J83
- ProtClustDB:   PRK09352
- BioCyc:   MSP266779:MESO_1146-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 34568; Mature: 34568

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: ACT_SITE 113-113 ACT_SITE 250-250 ACT_SITE 280-280

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRSTVRGVGAALPRRVVTNKDLETRLETSDEWIVQRTGIRQRHIASDDETTASLGEAAA
CCCCHHHHHHHHHCHHHHCCCCHHHHHCCCCCEEEECCCCCHHHCCCCCCHHHHHHHHHH
LRALDAAGLAPADIDLIVVATSTPNNTFPATAVEIQERLGIRQGFAFDMQAVCSGFVYAV
HHHHHHCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHCCEEEEE
TTADLYIRGGMAKRALVIGAETFSRILDWTDRTTCVLFGDGAGAIVLEAEEGQGDISDRG
EEEEEEEECCCCCEEEEEEHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCH
ILAEALRSDGSHKEKLYVDGGPSTTRTVGHLRMQGREVFKHAVGMITDVIEDVFGQAGIT
HHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AEDIDWFVSHQANKRIIDASAKKLGIAEEKVVITVDLHGNTSAASVPLALNHAVSQGKIQ
HHHHHHHHHCCCCCEEEECCHHHCCCCCCEEEEEEEECCCCCCCCCCEEEHHHHCCCCCC
KGDLVLLEAMGGGFTWGAVLLRW
CCCEEEEEECCCCEEEHHHEECC
>Mature Secondary Structure
MIRSTVRGVGAALPRRVVTNKDLETRLETSDEWIVQRTGIRQRHIASDDETTASLGEAAA
CCCCHHHHHHHHHCHHHHCCCCHHHHHCCCCCEEEECCCCCHHHCCCCCCHHHHHHHHHH
LRALDAAGLAPADIDLIVVATSTPNNTFPATAVEIQERLGIRQGFAFDMQAVCSGFVYAV
HHHHHHCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHCCEEEEE
TTADLYIRGGMAKRALVIGAETFSRILDWTDRTTCVLFGDGAGAIVLEAEEGQGDISDRG
EEEEEEEECCCCCEEEEEEHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCH
ILAEALRSDGSHKEKLYVDGGPSTTRTVGHLRMQGREVFKHAVGMITDVIEDVFGQAGIT
HHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AEDIDWFVSHQANKRIIDASAKKLGIAEEKVVITVDLHGNTSAASVPLALNHAVSQGKIQ
HHHHHHHHHCCCCCEEEECCHHHCCCCCCEEEEEEEECCCCCCCCCCEEEHHHHCCCCCC
KGDLVLLEAMGGGFTWGAVLLRW
CCCEEEEEECCCCEEEHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA