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The map label for this gene is glyA [H]

Identifier: 110633487

GI number: 110633487

Start: 1241806

End: 1243119

Strand: Direct

Name: glyA [H]

Synonym: Meso_1134

Alternate gene names: 110633487

Gene position: 1241806-1243119 (Clockwise)

Preceding gene: 110633486

Following gene: 110633488

Centisome position: 28.14

GC content: 62.48

Gene sequence:

>1314_bases
ATGGCACAAGCATCGACCGTCGCGGCCGAGACCGAGACCTTTTTCTCCCGGCCGCTCGAGGAAACCGATTCCGAGATATT
CTCGGCAATTCGCAGCGAACTCGGCCGCCAGCGGCATGAGATTGAGCTGATCGCCTCCGAAAATATCGTCTCGCGCGCAG
TGCTCGAGGCGCAGGGTACGGTGCTCACCAACAAATATGCCGAGGGTTATCCGGGTAAGCGTTATTACGGCGGCTGCCAG
TTCGTCGACGTGGTGGAGCAGCTTGCGATCGACCGCGCCAAGAAGCTTTTCAATTGCCAGTTTGCAAATGTGCAGCCCCA
TTCGGGCAGCCAGATGAACCAGGCGGTGTTCCTGGCGCTGCTCCAGCCGGGCGACACCTTCATGGGGCTCGACCTGAATT
CGGGCGGCCACCTTACCCACGGCTCCCCCGTCAACATGTCGGGAAAGTGGTTCAACGTCGTTTCCTATGGCGTGCGCCGC
GACGATAACCTCCTCGATATGGACGAGGTGGAGCGGCTCGCCACGGAGCACAAGCCGAAGCTGATCCTGGCCGGCGGCAC
GGCCTATTCGCGGATTTGGGACTGGAAGCGCTTCCGCGAAATCGCCGATAGCGTCGGCGCCTATCTGATGGTCGATATGG
CGCATATCGCGGGCCTCGTGGCAGGCGGCGCGCATCCTTCTCCGCTGCCGCATGCGCATGTGGTCACCACGACGACGCAC
AAATCGCTGCGCGGCCCGCGCGGCGGCATGGTCCTCACCAATGACGAGGATATCGCCAAAAAGGTGAACTCCGCCGTGTT
CCCGGGCCTGCAGGGCGGGCCGCTGATGCATGTGATTGCCGCCAAGGCGGTGGCGCTCGGCGAGGCGTTGCAGCCCGAAT
TCAAAGCCTATGCGCACCAGGTGGTGGCGAATGCCCGCGCGCTTGCGGCAAGCCTTCAGGAGACAGGGCTGGAGATCGTC
TCCGGCGGCACGGACAATCACCTGATGCTGGTGGATCTCAGGCCCAAAAACGCCACGGGCAAGCGGGCGGAGGCCGCCCT
TGGCCGCGCCAACATCACCTGCAACAAGAACGGCATTCCCTTTGATCCCGAGAAGCCCTTCGTGACCTCTGGCATCCGGC
TTGGCACGCCCGCTGGCACCACGCGCGGCTTCGGCGTAGCCGAATTCAGCCAGATCGGCCAGCTTATCGCTGAGGTCCTG
GATGGGCTGCGCGCCGTCAACTCCGACGATGGCAATATCGCCGTCGAGGAGGCGGTGAAGAAAAAGGTGATTGCCCTTAC
CGAACGTTTCCCGCTCTATTCATATCTGGACTGA

Upstream 100 bases:

>100_bases
GGCCCACCTGCAAAAAATCCTCTCAAGGCGTGGTGACAAGCGCGGAAAAATGGTAATGCGCTGGCTCCGCCGATAGAGAG
CCTCACAAAGGGTGATTGCA

Downstream 100 bases:

>100_bases
GCGCTGAGAAGCGCGGGTTTGACGAGCGGAAGCTGAGATGCGCTGTCCCTATTGCCAGTCGGAAGACACCCAGGTGAAGG
ATTCGCGGCCCGCCGAAGAT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MAQASTVAAETETFFSRPLEETDSEIFSAIRSELGRQRHEIELIASENIVSRAVLEAQGTVLTNKYAEGYPGKRYYGGCQ
FVDVVEQLAIDRAKKLFNCQFANVQPHSGSQMNQAVFLALLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVRR
DDNLLDMDEVERLATEHKPKLILAGGTAYSRIWDWKRFREIADSVGAYLMVDMAHIAGLVAGGAHPSPLPHAHVVTTTTH
KSLRGPRGGMVLTNDEDIAKKVNSAVFPGLQGGPLMHVIAAKAVALGEALQPEFKAYAHQVVANARALAASLQETGLEIV
SGGTDNHLMLVDLRPKNATGKRAEAALGRANITCNKNGIPFDPEKPFVTSGIRLGTPAGTTRGFGVAEFSQIGQLIAEVL
DGLRAVNSDDGNIAVEEAVKKKVIALTERFPLYSYLD

Sequences:

>Translated_437_residues
MAQASTVAAETETFFSRPLEETDSEIFSAIRSELGRQRHEIELIASENIVSRAVLEAQGTVLTNKYAEGYPGKRYYGGCQ
FVDVVEQLAIDRAKKLFNCQFANVQPHSGSQMNQAVFLALLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVRR
DDNLLDMDEVERLATEHKPKLILAGGTAYSRIWDWKRFREIADSVGAYLMVDMAHIAGLVAGGAHPSPLPHAHVVTTTTH
KSLRGPRGGMVLTNDEDIAKKVNSAVFPGLQGGPLMHVIAAKAVALGEALQPEFKAYAHQVVANARALAASLQETGLEIV
SGGTDNHLMLVDLRPKNATGKRAEAALGRANITCNKNGIPFDPEKPFVTSGIRLGTPAGTTRGFGVAEFSQIGQLIAEVL
DGLRAVNSDDGNIAVEEAVKKKVIALTERFPLYSYLD
>Mature_436_residues
AQASTVAAETETFFSRPLEETDSEIFSAIRSELGRQRHEIELIASENIVSRAVLEAQGTVLTNKYAEGYPGKRYYGGCQF
VDVVEQLAIDRAKKLFNCQFANVQPHSGSQMNQAVFLALLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVRRD
DNLLDMDEVERLATEHKPKLILAGGTAYSRIWDWKRFREIADSVGAYLMVDMAHIAGLVAGGAHPSPLPHAHVVTTTTHK
SLRGPRGGMVLTNDEDIAKKVNSAVFPGLQGGPLMHVIAAKAVALGEALQPEFKAYAHQVVANARALAASLQETGLEIVS
GGTDNHLMLVDLRPKNATGKRAEAALGRANITCNKNGIPFDPEKPFVTSGIRLGTPAGTTRGFGVAEFSQIGQLIAEVLD
GLRAVNSDDGNIAVEEAVKKKVIALTERFPLYSYLD

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI22547186, Length=435, Percent_Identity=47.5862068965517, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI19923315, Length=403, Percent_Identity=47.6426799007444, Blast_Score=348, Evalue=5e-96,
Organism=Homo sapiens, GI261862352, Length=403, Percent_Identity=47.6426799007444, Blast_Score=348, Evalue=5e-96,
Organism=Homo sapiens, GI261862350, Length=403, Percent_Identity=47.6426799007444, Blast_Score=348, Evalue=5e-96,
Organism=Homo sapiens, GI261862348, Length=403, Percent_Identity=47.6426799007444, Blast_Score=348, Evalue=5e-96,
Organism=Homo sapiens, GI261862346, Length=403, Percent_Identity=47.6426799007444, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI22547189, Length=421, Percent_Identity=45.1306413301663, Blast_Score=328, Evalue=6e-90,
Organism=Escherichia coli, GI1788902, Length=418, Percent_Identity=60.2870813397129, Blast_Score=494, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI25144732, Length=446, Percent_Identity=45.5156950672646, Blast_Score=363, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI25144729, Length=446, Percent_Identity=45.5156950672646, Blast_Score=362, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6319739, Length=408, Percent_Identity=46.5686274509804, Blast_Score=368, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6323087, Length=406, Percent_Identity=46.3054187192118, Blast_Score=349, Evalue=5e-97,
Organism=Drosophila melanogaster, GI24640005, Length=459, Percent_Identity=42.7015250544662, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI221329721, Length=459, Percent_Identity=42.7015250544662, Blast_Score=355, Evalue=3e-98,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 47148; Mature: 47017

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQASTVAAETETFFSRPLEETDSEIFSAIRSELGRQRHEIELIASENIVSRAVLEAQGT
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHEEEEEECCCHHHHHHHHHCCC
VLTNKYAEGYPGKRYYGGCQFVDVVEQLAIDRAKKLFNCQFANVQPHSGSQMNQAVFLAL
EEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCEEEEEE
LQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVRRDDNLLDMDEVERLATEHKPK
ECCCCEEEEEEECCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCHHHHHHHHHCCCCC
LILAGGTAYSRIWDWKRFREIADSVGAYLMVDMAHIAGLVAGGAHPSPLPHAHVVTTTTH
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECH
KSLRGPRGGMVLTNDEDIAKKVNSAVFPGLQGGPLMHVIAAKAVALGEALQPEFKAYAHQ
HHHCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
VVANARALAASLQETGLEIVSGGTDNHLMLVDLRPKNATGKRAEAALGRANITCNKNGIP
HHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEECCCCCCCCHHHHHHCCCEEEECCCCCC
FDPEKPFVTSGIRLGTPAGTTRGFGVAEFSQIGQLIAEVLDGLRAVNSDDGNIAVEEAVK
CCCCCCHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHH
KKVIALTERFPLYSYLD
HHHHHHHHCCCCHHCCC
>Mature Secondary Structure 
AQASTVAAETETFFSRPLEETDSEIFSAIRSELGRQRHEIELIASENIVSRAVLEAQGT
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHEEEEEECCCHHHHHHHHHCCC
VLTNKYAEGYPGKRYYGGCQFVDVVEQLAIDRAKKLFNCQFANVQPHSGSQMNQAVFLAL
EEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCEEEEEE
LQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVRRDDNLLDMDEVERLATEHKPK
ECCCCEEEEEEECCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCHHHHHHHHHCCCCC
LILAGGTAYSRIWDWKRFREIADSVGAYLMVDMAHIAGLVAGGAHPSPLPHAHVVTTTTH
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECH
KSLRGPRGGMVLTNDEDIAKKVNSAVFPGLQGGPLMHVIAAKAVALGEALQPEFKAYAHQ
HHHCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
VVANARALAASLQETGLEIVSGGTDNHLMLVDLRPKNATGKRAEAALGRANITCNKNGIP
HHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEECCCCCCCCHHHHHHCCCEEEECCCCCC
FDPEKPFVTSGIRLGTPAGTTRGFGVAEFSQIGQLIAEVLDGLRAVNSDDGNIAVEEAVK
CCCCCCHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHH
KKVIALTERFPLYSYLD
HHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA