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The map label for this gene is gyaR [H]

Identifier: 110633429

GI number: 110633429

Start: 1178995

End: 1179933

Strand: Direct

Name: gyaR [H]

Synonym: Meso_1075

Alternate gene names: 110633429

Gene position: 1178995-1179933 (Clockwise)

Preceding gene: 110633428

Following gene: 110633433

Centisome position: 26.72

GC content: 61.45

Gene sequence:

>939_bases
ATGAAACCCGAGGTGATTGTCCGTGTGCCCTTTCCGCCCGAAAGCATCGCGCTTTTGGAGGAGGATTTCACTGTCTATTA
TGCGCCCACGCTTCCAGAGCTCGAAAAGGCAATCCGCGAGCATGGCGCCACGACACGAGGCGTTGTCACCAACGGGTCCA
TCGGTCTCACCGGTGATCAGATTCGCGCGATTCCCCATCTGGAAATGATCCATACCGTCGGCGTCGGCTACGAAAAGATC
GACATGGAAGCGGTAAGGGAGAAAAAGATCATCGTCGCCAACAATGCCGGCACGAACGCGTTTTCGGTGGCAGAGCAAGC
TCTGGGGTTGCTTTTGGCGGTCCTGCGCGACATTCCGGCAGCGGAGCGGGCGGTTCGCTCGGGTATCTGGGAAGAAGCAC
GCTATCCCCGCCCTCTGATCTTCGAAAAGCGTGTCGGCATTGTCGGGCTCGGGGAGGTCGGTCTGGGCGTCGCCAAACGC
GTCCAAGCCTTTGAAGCCACCGTGCTCTACCACAATCGCAGGCCCCGCGAAGGCGCCCCCTACGAATACTATTCCACAAC
CAGGGAACTCGCCGCAGCCTCCGACATCCTCATCATCTCCTGCCCGGGCGGAGAGGAAACGCGCCACCTGGTCAACCGCG
ACGTGCTGGCAGCGCTGGGCCCATCCGGTGTTCTCATCAATGTCGGCCGCGGCAGCGTGGTCGATACGGCAGCACTCGTC
GAGGCGCTGCATGGAAAGGTTATCGCCGCCGCCGGCCTGGATGTCTGGGAAGGCGAGCCGGTGATTTCGCCGGAGTTGGC
CGGCGCACCGAATGTGATCCTCAGCCCGCACATCGGCGGCCGCTCCCCGGAAGCGGTGGTCTTTGCCAGGCGGCAGATAT
CCAAGAACCTGAAGGCGCATTTCTTCGGGAAGGGAGATATCGTGCACCGGATAGCGTGA

Upstream 100 bases:

>100_bases
GGTTGGGGCGCGGATGTGAACGAGGAGGCGCTCCGGGCGCATCCGCCCGTAGCCGCCAAGCATTGATTTTGCTCAGTTAT
TACGCAGTTGGGGAATGCTC

Downstream 100 bases:

>100_bases
CCAAAATTCCCCTCTCTTGCGTTTCCAAGCACGTGCTCGGGTAAAAGCCCGCTCGCAGATGCAGGAAAACGCTTTCTCTC
CCACAAGGGGAGAGATAACG

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKPEVIVRVPFPPESIALLEEDFTVYYAPTLPELEKAIREHGATTRGVVTNGSIGLTGDQIRAIPHLEMIHTVGVGYEKI
DMEAVREKKIIVANNAGTNAFSVAEQALGLLLAVLRDIPAAERAVRSGIWEEARYPRPLIFEKRVGIVGLGEVGLGVAKR
VQAFEATVLYHNRRPREGAPYEYYSTTRELAAASDILIISCPGGEETRHLVNRDVLAALGPSGVLINVGRGSVVDTAALV
EALHGKVIAAAGLDVWEGEPVISPELAGAPNVILSPHIGGRSPEAVVFARRQISKNLKAHFFGKGDIVHRIA

Sequences:

>Translated_312_residues
MKPEVIVRVPFPPESIALLEEDFTVYYAPTLPELEKAIREHGATTRGVVTNGSIGLTGDQIRAIPHLEMIHTVGVGYEKI
DMEAVREKKIIVANNAGTNAFSVAEQALGLLLAVLRDIPAAERAVRSGIWEEARYPRPLIFEKRVGIVGLGEVGLGVAKR
VQAFEATVLYHNRRPREGAPYEYYSTTRELAAASDILIISCPGGEETRHLVNRDVLAALGPSGVLINVGRGSVVDTAALV
EALHGKVIAAAGLDVWEGEPVISPELAGAPNVILSPHIGGRSPEAVVFARRQISKNLKAHFFGKGDIVHRIA
>Mature_312_residues
MKPEVIVRVPFPPESIALLEEDFTVYYAPTLPELEKAIREHGATTRGVVTNGSIGLTGDQIRAIPHLEMIHTVGVGYEKI
DMEAVREKKIIVANNAGTNAFSVAEQALGLLLAVLRDIPAAERAVRSGIWEEARYPRPLIFEKRVGIVGLGEVGLGVAKR
VQAFEATVLYHNRRPREGAPYEYYSTTRELAAASDILIISCPGGEETRHLVNRDVLAALGPSGVLINVGRGSVVDTAALV
EALHGKVIAAAGLDVWEGEPVISPELAGAPNVILSPHIGGRSPEAVVFARRQISKNLKAHFFGKGDIVHRIA

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=244, Percent_Identity=29.9180327868852, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI6912396, Length=225, Percent_Identity=33.7777777777778, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI61743967, Length=271, Percent_Identity=28.0442804428044, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4557497, Length=271, Percent_Identity=28.0442804428044, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI145580578, Length=328, Percent_Identity=24.6951219512195, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI4557499, Length=328, Percent_Identity=24.6951219512195, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI145580575, Length=271, Percent_Identity=26.5682656826568, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI87082289, Length=297, Percent_Identity=32.6599326599327, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1789279, Length=238, Percent_Identity=30.672268907563, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1787645, Length=239, Percent_Identity=24.2677824267782, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788660, Length=223, Percent_Identity=30.4932735426009, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=302, Percent_Identity=27.1523178807947, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25147481, Length=275, Percent_Identity=24.7272727272727, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324055, Length=225, Percent_Identity=34.6666666666667, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=277, Percent_Identity=27.4368231046931, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=277, Percent_Identity=27.7978339350181, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6324964, Length=277, Percent_Identity=25.2707581227437, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6325144, Length=173, Percent_Identity=26.5895953757225, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=151, Percent_Identity=27.1523178807947, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI28574286, Length=308, Percent_Identity=30.1948051948052, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI45552429, Length=289, Percent_Identity=30.1038062283737, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24585514, Length=288, Percent_Identity=30.2083333333333, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI28574282, Length=288, Percent_Identity=30.2083333333333, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI28574284, Length=288, Percent_Identity=30.2083333333333, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI45551003, Length=288, Percent_Identity=30.2083333333333, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28571528, Length=248, Percent_Identity=34.2741935483871, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646446, Length=244, Percent_Identity=31.1475409836066, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24646448, Length=244, Percent_Identity=31.1475409836066, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24646452, Length=244, Percent_Identity=31.1475409836066, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24646450, Length=244, Percent_Identity=31.1475409836066, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI62472511, Length=238, Percent_Identity=31.5126050420168, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24585516, Length=229, Percent_Identity=27.9475982532751, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19921140, Length=239, Percent_Identity=25.1046025104602, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 33586; Mature: 33586

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPEVIVRVPFPPESIALLEEDFTVYYAPTLPELEKAIREHGATTRGVVTNGSIGLTGDQ
CCCCEEEECCCCCCHHEEEECCCEEEECCCCHHHHHHHHHCCCCCCCEEECCCEECCHHH
IRAIPHLEMIHTVGVGYEKIDMEAVREKKIIVANNAGTNAFSVAEQALGLLLAVLRDIPA
HCCCCCHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCH
AERAVRSGIWEEARYPRPLIFEKRVGIVGLGEVGLGVAKRVQAFEATVLYHNRRPREGAP
HHHHHHHCCHHHHCCCCCEEEECCCCEEEECHHHHHHHHHHHHHHEEEEEECCCCCCCCC
YEYYSTTRELAAASDILIISCPGGEETRHLVNRDVLAALGPSGVLINVGRGSVVDTAALV
CHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHH
EALHGKVIAAAGLDVWEGEPVISPELAGAPNVILSPHIGGRSPEAVVFARRQISKNLKAH
HHHCCCEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCEE
FFGKGDIVHRIA
EECCCCEEEECC
>Mature Secondary Structure
MKPEVIVRVPFPPESIALLEEDFTVYYAPTLPELEKAIREHGATTRGVVTNGSIGLTGDQ
CCCCEEEECCCCCCHHEEEECCCEEEECCCCHHHHHHHHHCCCCCCCEEECCCEECCHHH
IRAIPHLEMIHTVGVGYEKIDMEAVREKKIIVANNAGTNAFSVAEQALGLLLAVLRDIPA
HCCCCCHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCH
AERAVRSGIWEEARYPRPLIFEKRVGIVGLGEVGLGVAKRVQAFEATVLYHNRRPREGAP
HHHHHHHCCHHHHCCCCCEEEECCCCEEEECHHHHHHHHHHHHHHEEEEEECCCCCCCCC
YEYYSTTRELAAASDILIISCPGGEETRHLVNRDVLAALGPSGVLINVGRGSVVDTAALV
CHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHH
EALHGKVIAAAGLDVWEGEPVISPELAGAPNVILSPHIGGRSPEAVVFARRQISKNLKAH
HHHCCCEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCEE
FFGKGDIVHRIA
EECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA