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The map label for this gene is gyaR [H]

Identifier: 110633412

GI number: 110633412

Start: 1161618

End: 1162646

Strand: Reverse

Name: gyaR [H]

Synonym: Meso_1058

Alternate gene names: 110633412

Gene position: 1162646-1161618 (Counterclockwise)

Preceding gene: 110633413

Following gene: 110633411

Centisome position: 26.35

GC content: 62.97

Gene sequence:

>1029_bases
ATGCCCATGAGCTCGTCCAACAAATTCAAAGTCGCCGTCGTCGGCCGTGCTTTCGGGCCGGAGGCCCAAGCCATCATACA
GGAAGTGGCGCCGCCGGAATTCGATCTCTCCTTCTCGGTGGATACGACAGAGAAAGCTCATCCGCTCATCCGTGAGAGCG
ATTTCTGCCTGGTGACGACCGCGATCACCGAGAAGCTGCTGCAGGAATCGCCAAAGCTCAGGCTCGTCCACAAATGGGGC
ATCGGCATCGACAAGATCGATCTCGAAGGCGCCGAGCGGCAAGGTGTCTACGTGGCGATTACGGCCGGCTCCAATGCCGG
CGCGGTGGCCGAACATACGATCATGCTCATCCTGGCCGCGCTGCGGCGGCTGGCACTCGCAGACCAGTCGATGCGCGAGG
GCAAGTGGATCTATACCGAATTGCGCCCCCTCTGCCGCAAGCTTTCGGGCAAAACGGTCGGTATCCTGGGTTTCGGCAAT
ATTGGCCGCAATGTCGCGCAACGCCTGCAGGGCTTTGATGTCGAGATCATCTACCACGATCCCTTCCGCGCGCCGCCGGA
GGTCGAGGATCGTCTCAAGGCTACCTATGTCTCCTTCGACGAGCTGATAAAGAGGAGCAACATTCTCACGCTCCACTGCC
CCGGCGGAGCGGCCAATCACCACATCATCAATGCGTCGGCGCTCGCCAAGATGCAGCGCGGCTCGGTCTTGGTGAACTGC
GCGCGCGGCGACGTGGTCGACGAGGAAGCGATGGTGGCCGCACTTCAGTCCGGCCAGTTGCTCGCGGCTGGCCTCGATGC
GTTCGAGCCCGAGCCCCTGCCTGCTTCAAGCAAGCTCACCCAGCTGACGAGCGTGGTGCTGACGCCACATACGGCGGGCA
GCGTGCTGGACAATGTCGCGCCCGTGGCTCAGCACGCCTTCGGCAACATGCTGCGCATGATCCGGGGCGAGGCGCTGCCC
AAATCCGATCTCGTTGTGGTCCCCGACAAGCCGCGCCAGTTCGCCGGTGCGGGCCCGGTGGCGGTGTAA

Upstream 100 bases:

>100_bases
CCACCCCGCATCGCAACAGAGGCCACGGGCGTCCCGGCTTGCCGGGCCGCTTTGATAACGGCGCGTGCCGCTAACGACCG
AAGACCTGACGGAGAAGACC

Downstream 100 bases:

>100_bases
TCCCAAACGAGAGGCATTCCACGATGGCGAACCTCGCTCTGGAAAGACTAAGACGGCAGGAGCTGTCCCTCGGCGTCGTC
CTGCGCCAGGCGCGTAGCGT

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MPMSSSNKFKVAVVGRAFGPEAQAIIQEVAPPEFDLSFSVDTTEKAHPLIRESDFCLVTTAITEKLLQESPKLRLVHKWG
IGIDKIDLEGAERQGVYVAITAGSNAGAVAEHTIMLILAALRRLALADQSMREGKWIYTELRPLCRKLSGKTVGILGFGN
IGRNVAQRLQGFDVEIIYHDPFRAPPEVEDRLKATYVSFDELIKRSNILTLHCPGGAANHHIINASALAKMQRGSVLVNC
ARGDVVDEEAMVAALQSGQLLAAGLDAFEPEPLPASSKLTQLTSVVLTPHTAGSVLDNVAPVAQHAFGNMLRMIRGEALP
KSDLVVVPDKPRQFAGAGPVAV

Sequences:

>Translated_342_residues
MPMSSSNKFKVAVVGRAFGPEAQAIIQEVAPPEFDLSFSVDTTEKAHPLIRESDFCLVTTAITEKLLQESPKLRLVHKWG
IGIDKIDLEGAERQGVYVAITAGSNAGAVAEHTIMLILAALRRLALADQSMREGKWIYTELRPLCRKLSGKTVGILGFGN
IGRNVAQRLQGFDVEIIYHDPFRAPPEVEDRLKATYVSFDELIKRSNILTLHCPGGAANHHIINASALAKMQRGSVLVNC
ARGDVVDEEAMVAALQSGQLLAAGLDAFEPEPLPASSKLTQLTSVVLTPHTAGSVLDNVAPVAQHAFGNMLRMIRGEALP
KSDLVVVPDKPRQFAGAGPVAV
>Mature_341_residues
PMSSSNKFKVAVVGRAFGPEAQAIIQEVAPPEFDLSFSVDTTEKAHPLIRESDFCLVTTAITEKLLQESPKLRLVHKWGI
GIDKIDLEGAERQGVYVAITAGSNAGAVAEHTIMLILAALRRLALADQSMREGKWIYTELRPLCRKLSGKTVGILGFGNI
GRNVAQRLQGFDVEIIYHDPFRAPPEVEDRLKATYVSFDELIKRSNILTLHCPGGAANHHIINASALAKMQRGSVLVNCA
RGDVVDEEAMVAALQSGQLLAAGLDAFEPEPLPASSKLTQLTSVVLTPHTAGSVLDNVAPVAQHAFGNMLRMIRGEALPK
SDLVVVPDKPRQFAGAGPVAV

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=260, Percent_Identity=34.2307692307692, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI6912396, Length=268, Percent_Identity=30.9701492537313, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI145580578, Length=241, Percent_Identity=32.7800829875519, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI4557499, Length=241, Percent_Identity=32.7800829875519, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI4557497, Length=241, Percent_Identity=33.195020746888, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI61743967, Length=241, Percent_Identity=33.195020746888, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI145580575, Length=245, Percent_Identity=31.4285714285714, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI87082289, Length=259, Percent_Identity=32.4324324324324, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1787645, Length=272, Percent_Identity=26.8382352941176, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1789279, Length=273, Percent_Identity=28.9377289377289, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788660, Length=262, Percent_Identity=29.7709923664122, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI87081824, Length=282, Percent_Identity=28.7234042553192, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=261, Percent_Identity=33.3333333333333, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI25147481, Length=233, Percent_Identity=32.1888412017167, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=217, Percent_Identity=40.5529953917051, Blast_Score=152, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6322116, Length=247, Percent_Identity=29.5546558704453, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6320925, Length=247, Percent_Identity=28.7449392712551, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=262, Percent_Identity=27.4809160305344, Blast_Score=109, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6325144, Length=156, Percent_Identity=33.974358974359, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6321253, Length=185, Percent_Identity=31.3513513513514, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324980, Length=188, Percent_Identity=25, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574286, Length=326, Percent_Identity=30.9815950920245, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI28574284, Length=258, Percent_Identity=32.5581395348837, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24585514, Length=258, Percent_Identity=32.5581395348837, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28574282, Length=258, Percent_Identity=32.5581395348837, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI45551003, Length=258, Percent_Identity=32.5581395348837, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI45552429, Length=258, Percent_Identity=32.5581395348837, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28571528, Length=272, Percent_Identity=33.0882352941176, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24646446, Length=241, Percent_Identity=34.0248962655602, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24646448, Length=241, Percent_Identity=34.0248962655602, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24646452, Length=241, Percent_Identity=34.0248962655602, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24646450, Length=241, Percent_Identity=34.0248962655602, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI62472511, Length=241, Percent_Identity=34.0248962655602, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24585516, Length=250, Percent_Identity=32.4, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI19921140, Length=242, Percent_Identity=35.5371900826446, Blast_Score=128, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36793; Mature: 36662

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMSSSNKFKVAVVGRAFGPEAQAIIQEVAPPEFDLSFSVDTTEKAHPLIRESDFCLVTT
CCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEECCCCHHHCCCCCCCCCEEEEH
AITEKLLQESPKLRLVHKWGIGIDKIDLEGAERQGVYVAITAGSNAGAVAEHTIMLILAA
HHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHH
LRRLALADQSMREGKWIYTELRPLCRKLSGKTVGILGFGNIGRNVAQRLQGFDVEIIYHD
HHHHHHHCCHHHCCCEEHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHCCCCEEEEEEC
PFRAPPEVEDRLKATYVSFDELIKRSNILTLHCPGGAANHHIINASALAKMQRGSVLVNC
CCCCCCCHHHHHHHHHCCHHHHHHHCCEEEEECCCCCCCCEEECHHHHHHHHCCCEEEEE
ARGDVVDEEAMVAALQSGQLLAAGLDAFEPEPLPASSKLTQLTSVVLTPHTAGSVLDNVA
CCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHEECCCCHHHHHHHHH
PVAQHAFGNMLRMIRGEALPKSDLVVVPDKPRQFAGAGPVAV
HHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHCCCCCCCC
>Mature Secondary Structure 
PMSSSNKFKVAVVGRAFGPEAQAIIQEVAPPEFDLSFSVDTTEKAHPLIRESDFCLVTT
CCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEECCCCHHHCCCCCCCCCEEEEH
AITEKLLQESPKLRLVHKWGIGIDKIDLEGAERQGVYVAITAGSNAGAVAEHTIMLILAA
HHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHH
LRRLALADQSMREGKWIYTELRPLCRKLSGKTVGILGFGNIGRNVAQRLQGFDVEIIYHD
HHHHHHHCCHHHCCCEEHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHCCCCEEEEEEC
PFRAPPEVEDRLKATYVSFDELIKRSNILTLHCPGGAANHHIINASALAKMQRGSVLVNC
CCCCCCCHHHHHHHHHCCHHHHHHHCCEEEEECCCCCCCCEEECHHHHHHHHCCCEEEEE
ARGDVVDEEAMVAALQSGQLLAAGLDAFEPEPLPASSKLTQLTSVVLTPHTAGSVLDNVA
CCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHEECCCCHHHHHHHHH
PVAQHAFGNMLRMIRGEALPKSDLVVVPDKPRQFAGAGPVAV
HHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA