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The map label for this gene is clcA [H]

Identifier: 110633400

GI number: 110633400

Start: 1149040

End: 1150389

Strand: Reverse

Name: clcA [H]

Synonym: Meso_1046

Alternate gene names: 110633400

Gene position: 1150389-1149040 (Counterclockwise)

Preceding gene: 110633401

Following gene: 110633399

Centisome position: 26.07

GC content: 61.26

Gene sequence:

>1350_bases
GTGAGACGACGCATATCAAGGACTGGCCTGATAAGGCGTTCGTCCGTACTCGTAGCTTCTCCACGTCTTTGGAAGCCACG
GTTGGTCTTCTGGACCGGCGCCATTGCGATCGGCATCATCAGTGTGGGTTTTGACAGGCTTGCCGACGAAGCCCAAACAA
TTTTTGCCCATGCCATCAATGTAGAGGGATGGCTTCGCTTCTTGCCGATCCTCGTGACGCCATGCGGCTTCGTCATATGC
GCATGGATGGCCTGGCGCTTCTTTCCGGGTTCGCAAGGTAGCGGCATTCCGCAAACCATCGCCGCCCGGCACCTGCGTGA
GGAAGTTGAGGTCGGTCAAATCCTGTCTCTGAAAACGGCCGCGGGAAAAATCCTGTTGACGGTTGCAGGGCTGCTCTGCG
GCGCTTCCGTGGGACGCGAAGGGCCAACGGTGCAAGTCGGTGCATCGCTGATGCTCCAGGCGGCGCGTTGGGGCGGCATG
GCGCGGGCACGCGGCCTCATTCTGGCCGGATCGGCGGCCGGGATCGCTGCTGCGTTCAACACTCCCCTCGCCGGCATCGT
CTTTGCAATCGAGGAGATGAGCCGGACCTACCAGTCCCGAACCAACGGGCTCGTGCTTTCGGCGGTCATCCTGGCGGGCG
TGGCGTCCCTGGGGATCCTTGGAAACTACACCTATTTCGGCGTCGCTCACAGCAGCGCGACATTCCCCGGCGACTGGCCG
ATTGTAGTCTCCTGCGGCGTGATCGGCGGTGCGCTTGGGGCAAGCTTCTCCTACCTCACGCTGCGCCTAACAAGGCGCAT
CCGGCGCTGGCAACCGCATGATCCTTTCCGACGCATGCTTATCGTAGCAGCGCTAAGTGGCATGTTTGTCGCCGTCATAG
GGGTGGCCACCGGAGGGTTGACCTTCGGCACCGGCTACGCCGAGGCTCGCGACGCGGTGGAAGGAAACGCCCTGCCCGTA
TCGTTTTTTGCCGCAAAGCTCGTCGTGACGCTTGCCTCGACCGTTTCGGGTATTCCAGGAGGTCTTTTTGCGCCTTCGCT
CTCGGTCGGGGCAGGCTTGGGATCAACTCTCGGCGTGATTCTGGGCGCTGACATCGGTCTGGCAGCCGTCCTCGGAATGG
CAGGCTATTTTGCCGGGGTTGTCCAGGCGCCGATGACGGCATTCGTCATCATCCTGGAAATGACAGGCAACCATGCCAAT
GTGATTCCCCTTATGACCGCCTCGATGCTCGGCTATGGAACCGCACGGCTTGTTTCGCCGGAGCCGCTCTACCATGCACT
GTCGCGCCTGTTCATTGCCGACGTGCTGCGGCGGCAAAGAGCAAACAAGGCGGTTGATGACAGGTCCTGA

Upstream 100 bases:

>100_bases
CGGGGGAGTGCATCTAACTCTTCCAACCCGGGCAGCATCCGGATACAAGCTGAGTACCCGCCCCATTCATTCAGCCAAGC
TCCATTCCCTTGGAGAAAAT

Downstream 100 bases:

>100_bases
ATATCAGCCGCGTCCTGCCAGGTCCGTCATCAGCAGGTGTTTCATTCACTTAGCCGGCAGCTGCTTCGAAAAAGGTCAAG
AACGCCCACCGCCCGCACCT

Product: Cl- channel, voltage gated

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MRRRISRTGLIRRSSVLVASPRLWKPRLVFWTGAIAIGIISVGFDRLADEAQTIFAHAINVEGWLRFLPILVTPCGFVIC
AWMAWRFFPGSQGSGIPQTIAARHLREEVEVGQILSLKTAAGKILLTVAGLLCGASVGREGPTVQVGASLMLQAARWGGM
ARARGLILAGSAAGIAAAFNTPLAGIVFAIEEMSRTYQSRTNGLVLSAVILAGVASLGILGNYTYFGVAHSSATFPGDWP
IVVSCGVIGGALGASFSYLTLRLTRRIRRWQPHDPFRRMLIVAALSGMFVAVIGVATGGLTFGTGYAEARDAVEGNALPV
SFFAAKLVVTLASTVSGIPGGLFAPSLSVGAGLGSTLGVILGADIGLAAVLGMAGYFAGVVQAPMTAFVIILEMTGNHAN
VIPLMTASMLGYGTARLVSPEPLYHALSRLFIADVLRRQRANKAVDDRS

Sequences:

>Translated_449_residues
MRRRISRTGLIRRSSVLVASPRLWKPRLVFWTGAIAIGIISVGFDRLADEAQTIFAHAINVEGWLRFLPILVTPCGFVIC
AWMAWRFFPGSQGSGIPQTIAARHLREEVEVGQILSLKTAAGKILLTVAGLLCGASVGREGPTVQVGASLMLQAARWGGM
ARARGLILAGSAAGIAAAFNTPLAGIVFAIEEMSRTYQSRTNGLVLSAVILAGVASLGILGNYTYFGVAHSSATFPGDWP
IVVSCGVIGGALGASFSYLTLRLTRRIRRWQPHDPFRRMLIVAALSGMFVAVIGVATGGLTFGTGYAEARDAVEGNALPV
SFFAAKLVVTLASTVSGIPGGLFAPSLSVGAGLGSTLGVILGADIGLAAVLGMAGYFAGVVQAPMTAFVIILEMTGNHAN
VIPLMTASMLGYGTARLVSPEPLYHALSRLFIADVLRRQRANKAVDDRS
>Mature_449_residues
MRRRISRTGLIRRSSVLVASPRLWKPRLVFWTGAIAIGIISVGFDRLADEAQTIFAHAINVEGWLRFLPILVTPCGFVIC
AWMAWRFFPGSQGSGIPQTIAARHLREEVEVGQILSLKTAAGKILLTVAGLLCGASVGREGPTVQVGASLMLQAARWGGM
ARARGLILAGSAAGIAAAFNTPLAGIVFAIEEMSRTYQSRTNGLVLSAVILAGVASLGILGNYTYFGVAHSSATFPGDWP
IVVSCGVIGGALGASFSYLTLRLTRRIRRWQPHDPFRRMLIVAALSGMFVAVIGVATGGLTFGTGYAEARDAVEGNALPV
SFFAAKLVVTLASTVSGIPGGLFAPSLSVGAGLGSTLGVILGADIGLAAVLGMAGYFAGVVQAPMTAFVIILEMTGNHAN
VIPLMTASMLGYGTARLVSPEPLYHALSRLFIADVLRRQRANKAVDDRS

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=435, Percent_Identity=27.816091954023, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081943, Length=393, Percent_Identity=26.2086513994911, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 47093; Mature: 47093

Theoretical pI: Translated: 11.12; Mature: 11.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRRISRTGLIRRSSVLVASPRLWKPRLVFWTGAIAIGIISVGFDRLADEAQTIFAHAIN
CCCCCCHHCCEEECCEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VEGWLRFLPILVTPCGFVICAWMAWRFFPGSQGSGIPQTIAARHLREEVEVGQILSLKTA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AGKILLTVAGLLCGASVGREGPTVQVGASLMLQAARWGGMARARGLILAGSAAGIAAAFN
HHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCHHHHCCEEEECCCCCHHHHHC
TPLAGIVFAIEEMSRTYQSRTNGLVLSAVILAGVASLGILGNYTYFGVAHSSATFPGDWP
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
IVVSCGVIGGALGASFSYLTLRLTRRIRRWQPHDPFRRMLIVAALSGMFVAVIGVATGGL
EEEECCHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
TFGTGYAEARDAVEGNALPVSFFAAKLVVTLASTVSGIPGGLFAPSLSVGAGLGSTLGVI
EECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCHHHHHH
LGADIGLAAVLGMAGYFAGVVQAPMTAFVIILEMTGNHANVIPLMTASMLGYGTARLVSP
HCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCHHHHHHHHHCCCCEEECCC
EPLYHALSRLFIADVLRRQRANKAVDDRS
CHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRRRISRTGLIRRSSVLVASPRLWKPRLVFWTGAIAIGIISVGFDRLADEAQTIFAHAIN
CCCCCCHHCCEEECCEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VEGWLRFLPILVTPCGFVICAWMAWRFFPGSQGSGIPQTIAARHLREEVEVGQILSLKTA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AGKILLTVAGLLCGASVGREGPTVQVGASLMLQAARWGGMARARGLILAGSAAGIAAAFN
HHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCHHHHCCEEEECCCCCHHHHHC
TPLAGIVFAIEEMSRTYQSRTNGLVLSAVILAGVASLGILGNYTYFGVAHSSATFPGDWP
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
IVVSCGVIGGALGASFSYLTLRLTRRIRRWQPHDPFRRMLIVAALSGMFVAVIGVATGGL
EEEECCHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
TFGTGYAEARDAVEGNALPVSFFAAKLVVTLASTVSGIPGGLFAPSLSVGAGLGSTLGVI
EECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCHHHHHH
LGADIGLAAVLGMAGYFAGVVQAPMTAFVIILEMTGNHANVIPLMTASMLGYGTARLVSP
HCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCHHHHHHHHHCCCCEEECCC
EPLYHALSRLFIADVLRRQRANKAVDDRS
CHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA