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The map label for this gene is ggt [H]

Identifier: 110633398

GI number: 110633398

Start: 1146128

End: 1147888

Strand: Reverse

Name: ggt [H]

Synonym: Meso_1044

Alternate gene names: 110633398

Gene position: 1147888-1146128 (Counterclockwise)

Preceding gene: 110633399

Following gene: 110633397

Centisome position: 26.01

GC content: 64.0

Gene sequence:

>1761_bases
ATGGGTGTAAGAGAAACACTCGCCAAGGGCGCAATGGCTCTCGGCCTTCTCCTTGCCACACCCGCCCTGGCCCAGCAGGC
GGCCGACACGCTTGCTCCCGAGATCGCCAGCGGTACGGAGGAAAAGGCGCCCGTCAAGGCGCGCCGCCAGATGGTCGTCG
CAGCCAATCCGCTTGCCGCCGAGGCGGGCCTGAAAATCCTGCGCGAGGGCGGCAGCGCGGCCGACGCGCTCGTTGCCGTG
CAGACGGTGCTCGGTCTCGTCGAGCCACAATCCTCCGGCGTCGGCGGTGGCGCCTTCCTGGTCTGGTATGACGCTGAAAA
TGGAACGCTGACCACCTTCGACGGCCGTGAAACCGCGCCCGAAGCTGCGACGGCAGAGCTCTTCCTCGACGAGAAGGGCG
AGCCGCTTGCCTTCTTCGATGCCGTCGTGGGCGGACGCTCCGTCGGGACACCGGGCGTGGTGCGGCTGATGGAAAAGGCG
CACGAGCGCTACGGAACGCTTGATTGGAACATACTCTTCCAGCCTGCCATTACGCTGGCCGAGAACGGCTTTGAAGTCTC
GCCACGGCTTCATGCGCTGATCGCCGCCGACAAAGGCAAGCTCGATAAGGAGGAAGCTGCGCGCGCCTACTTCTATGATG
CGGACGGCGAGCCGCTGGACGAGGGCACGCTTTTGAAAAACCCTGACTACGCGCAGACATTGCGGGCGATCGGGGAAAAG
GGCGCGGATGCTTTTTATACCGGAGAGATCGCCGAGAAGATCGTCGCTGCCGTGCAGAACCACCCGACAAATGCGGGGCT
CCTCAGCCTTGAAGATCTCGCCGCATACGAAGTCAGGGAGCGCCCGGCGGTCTGCGCGCCCTATCGCGGCTACGAACTGT
GCGGCATGGGGCCGCCCTCCTCTGGTGCACTCACGATCGGGCAGATCCTTGGCATGGTCTCGCATTTCGACCTTGGAGGG
CTCGGCTCGGACGATCCGGAGAGCTGGCGCATTATCGGAGACGCGACCCGGCTCGCCTTCGCCGACCGGGAGCTTTACAT
GGCCGACAGCGATTTCGTCTCCATGCCGCAGGGGCTGCTGAACCCGGATTATCTAAAAGACCGCGCGTCCCTTATCCGCC
GCCCGACCGCCCTTCCCGCGGAGGAGGTCAAGGCCGGTACTCCGCCGTGGGACAAGGCTGAGCTGCGCATCCCCGGTATC
GACATGGAGCAGCCCTCGACGTCGCATTTCGTCATTGTGGACGAGGCAGGCAACATCGCCTCAATGACCACTTCCATCGA
GAATGGTTTCGGCTCGCGGCAGATGGCGGCAGGCTTCCTGCTCAACAACCAGCTCACCGATTTCTCCTTCACCCCGGAGG
AGGACGGAAAGGCCGTCGCCAACCGGGTGGAGCCGGGCAAGCGCCCCCGCTCCTCCATGTCGCCCACTGTCGTGTTGCAG
GACGGCAGGCCAGTCTTCGCCCTCGGTTCGCCCGGCGGCAGCAACATCATTCCCTATGTCGCCAACACCCTCATCGCGCT
TATCGACTGGGATATGGACATGCAGCAGGCCATCTCGCTGCCCCATCTGACGAACCGCTTCGGCACCTATATATTGGAAG
CCGGCACGCCGGCCGAGGAACTTGCCGATGACCTCACAGCATTGGGCTTTGAGGTTGAAGCCGGCGAACTCAATTCCGGC
CTGCACGGCATCGCCTTCACATCAGAAGGGCTTGAAGGCGGCGCCGACCCGCGGCGAGAGGGCGTGGCGCTAGGTGACTA
A

Upstream 100 bases:

>100_bases
ATGGCCGATTTCGACGTTGCGCTAAAGGAAGCGTTCGAGGAGGTCTTCGGGGCAGCAGAGCCGCTTTTCGAAACGGATTC
CCTGAAAAGGAGTGCCTGAC

Downstream 100 bases:

>100_bases
GCCGTCCATCCGCAGGGCAGCACCGCGCAAATAACGGCGGCTACAGGGCAAGAATCCAGGTGACGGCAACAAGAACGAAG
GAGCTGACTGCGACCAGCGA

Product: gamma-glutamyltransferase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 586; Mature: 585

Protein sequence:

>586_residues
MGVRETLAKGAMALGLLLATPALAQQAADTLAPEIASGTEEKAPVKARRQMVVAANPLAAEAGLKILREGGSAADALVAV
QTVLGLVEPQSSGVGGGAFLVWYDAENGTLTTFDGRETAPEAATAELFLDEKGEPLAFFDAVVGGRSVGTPGVVRLMEKA
HERYGTLDWNILFQPAITLAENGFEVSPRLHALIAADKGKLDKEEAARAYFYDADGEPLDEGTLLKNPDYAQTLRAIGEK
GADAFYTGEIAEKIVAAVQNHPTNAGLLSLEDLAAYEVRERPAVCAPYRGYELCGMGPPSSGALTIGQILGMVSHFDLGG
LGSDDPESWRIIGDATRLAFADRELYMADSDFVSMPQGLLNPDYLKDRASLIRRPTALPAEEVKAGTPPWDKAELRIPGI
DMEQPSTSHFVIVDEAGNIASMTTSIENGFGSRQMAAGFLLNNQLTDFSFTPEEDGKAVANRVEPGKRPRSSMSPTVVLQ
DGRPVFALGSPGGSNIIPYVANTLIALIDWDMDMQQAISLPHLTNRFGTYILEAGTPAEELADDLTALGFEVEAGELNSG
LHGIAFTSEGLEGGADPRREGVALGD

Sequences:

>Translated_586_residues
MGVRETLAKGAMALGLLLATPALAQQAADTLAPEIASGTEEKAPVKARRQMVVAANPLAAEAGLKILREGGSAADALVAV
QTVLGLVEPQSSGVGGGAFLVWYDAENGTLTTFDGRETAPEAATAELFLDEKGEPLAFFDAVVGGRSVGTPGVVRLMEKA
HERYGTLDWNILFQPAITLAENGFEVSPRLHALIAADKGKLDKEEAARAYFYDADGEPLDEGTLLKNPDYAQTLRAIGEK
GADAFYTGEIAEKIVAAVQNHPTNAGLLSLEDLAAYEVRERPAVCAPYRGYELCGMGPPSSGALTIGQILGMVSHFDLGG
LGSDDPESWRIIGDATRLAFADRELYMADSDFVSMPQGLLNPDYLKDRASLIRRPTALPAEEVKAGTPPWDKAELRIPGI
DMEQPSTSHFVIVDEAGNIASMTTSIENGFGSRQMAAGFLLNNQLTDFSFTPEEDGKAVANRVEPGKRPRSSMSPTVVLQ
DGRPVFALGSPGGSNIIPYVANTLIALIDWDMDMQQAISLPHLTNRFGTYILEAGTPAEELADDLTALGFEVEAGELNSG
LHGIAFTSEGLEGGADPRREGVALGD
>Mature_585_residues
GVRETLAKGAMALGLLLATPALAQQAADTLAPEIASGTEEKAPVKARRQMVVAANPLAAEAGLKILREGGSAADALVAVQ
TVLGLVEPQSSGVGGGAFLVWYDAENGTLTTFDGRETAPEAATAELFLDEKGEPLAFFDAVVGGRSVGTPGVVRLMEKAH
ERYGTLDWNILFQPAITLAENGFEVSPRLHALIAADKGKLDKEEAARAYFYDADGEPLDEGTLLKNPDYAQTLRAIGEKG
ADAFYTGEIAEKIVAAVQNHPTNAGLLSLEDLAAYEVRERPAVCAPYRGYELCGMGPPSSGALTIGQILGMVSHFDLGGL
GSDDPESWRIIGDATRLAFADRELYMADSDFVSMPQGLLNPDYLKDRASLIRRPTALPAEEVKAGTPPWDKAELRIPGID
MEQPSTSHFVIVDEAGNIASMTTSIENGFGSRQMAAGFLLNNQLTDFSFTPEEDGKAVANRVEPGKRPRSSMSPTVVLQD
GRPVFALGSPGGSNIIPYVANTLIALIDWDMDMQQAISLPHLTNRFGTYILEAGTPAEELADDLTALGFEVEAGELNSGL
HGIAFTSEGLEGGADPRREGVALGD

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=560, Percent_Identity=29.8214285714286, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI73915090, Length=560, Percent_Identity=29.8214285714286, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI73915096, Length=560, Percent_Identity=29.8214285714286, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI73915094, Length=560, Percent_Identity=29.8214285714286, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI113429324, Length=543, Percent_Identity=29.2817679558011, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI113429326, Length=547, Percent_Identity=28.5191956124314, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI109148539, Length=531, Percent_Identity=28.060263653484, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI153266901, Length=500, Percent_Identity=26.2, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI153266885, Length=499, Percent_Identity=26.4529058116232, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI153266907, Length=499, Percent_Identity=24.8496993987976, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI30581157, Length=128, Percent_Identity=36.71875, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI30581155, Length=128, Percent_Identity=36.71875, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1789856, Length=559, Percent_Identity=36.4937388193202, Blast_Score=307, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI193208247, Length=564, Percent_Identity=30.4964539007092, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI193208245, Length=564, Percent_Identity=30.4964539007092, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI212646519, Length=537, Percent_Identity=30.9124767225326, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI72000294, Length=537, Percent_Identity=30.9124767225326, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17542894, Length=496, Percent_Identity=29.2338709677419, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17506189, Length=505, Percent_Identity=26.9306930693069, Blast_Score=162, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17564448, Length=439, Percent_Identity=25.2847380410023, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI72001495, Length=230, Percent_Identity=26.5217391304348, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI72001497, Length=230, Percent_Identity=26.5217391304348, Blast_Score=85, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6323330, Length=234, Percent_Identity=28.2051282051282, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI18859893, Length=475, Percent_Identity=30.7368421052632, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI161077496, Length=522, Percent_Identity=27.7777777777778, Blast_Score=162, Evalue=7e-40,
Organism=Drosophila melanogaster, GI161077878, Length=547, Percent_Identity=25.7769652650823, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI161077880, Length=547, Percent_Identity=25.7769652650823, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24642670, Length=547, Percent_Identity=25.7769652650823, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24642666, Length=547, Percent_Identity=25.7769652650823, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI45551474, Length=547, Percent_Identity=25.7769652650823, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI18859741, Length=556, Percent_Identity=24.1007194244604, Blast_Score=128, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62058; Mature: 61927

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVRETLAKGAMALGLLLATPALAQQAADTLAPEIASGTEEKAPVKARRQMVVAANPLAA
CCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCHHHHCCCCCCCCHHHHHEEEEECCCHHH
EAGLKILREGGSAADALVAVQTVLGLVEPQSSGVGGGAFLVWYDAENGTLTTFDGRETAP
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEECCCCCCC
EAATAELFLDEKGEPLAFFDAVVGGRSVGTPGVVRLMEKAHERYGTLDWNILFQPAITLA
CHHEEEEEECCCCCCEEHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCEEEC
ENGFEVSPRLHALIAADKGKLDKEEAARAYFYDADGEPLDEGTLLKNPDYAQTLRAIGEK
CCCCCCCCCEEEEEECCCCCCCHHHHCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCC
GADAFYTGEIAEKIVAAVQNHPTNAGLLSLEDLAAYEVRERPAVCAPYRGYELCGMGPPS
CCCCEEEHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCCCEECCCCCCEEECCCCCC
SGALTIGQILGMVSHFDLGGLGSDDPESWRIIGDATRLAFADRELYMADSDFVSMPQGLL
CCCEEHHHHHHHHHHCCCCCCCCCCCCCEEEEECHHHEEEECCEEEEECCCHHHCCHHCC
NPDYLKDRASLIRRPTALPAEEVKAGTPPWDKAELRIPGIDMEQPSTSHFVIVDEAGNIA
CHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCEE
SMTTSIENGFGSRQMAAGFLLNNQLTDFSFTPEEDGKAVANRVEPGKRPRSSMSPTVVLQ
HHHHHHHCCCCCHHHHHHHEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEE
DGRPVFALGSPGGSNIIPYVANTLIALIDWDMDMQQAISLPHLTNRFGTYILEAGTPAEE
CCCEEEEECCCCCCCCHHHHHHHHHEEHCCCCCHHHHHCCCHHHHHHCCEEEECCCCHHH
LADDLTALGFEVEAGELNSGLHGIAFTSEGLEGGADPRREGVALGD
HHHHHHHHCCEEECCCCCCCCCEEEEECCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure 
GVRETLAKGAMALGLLLATPALAQQAADTLAPEIASGTEEKAPVKARRQMVVAANPLAA
CHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCHHHHCCCCCCCCHHHHHEEEEECCCHHH
EAGLKILREGGSAADALVAVQTVLGLVEPQSSGVGGGAFLVWYDAENGTLTTFDGRETAP
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEECCCCCCC
EAATAELFLDEKGEPLAFFDAVVGGRSVGTPGVVRLMEKAHERYGTLDWNILFQPAITLA
CHHEEEEEECCCCCCEEHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCEEEC
ENGFEVSPRLHALIAADKGKLDKEEAARAYFYDADGEPLDEGTLLKNPDYAQTLRAIGEK
CCCCCCCCCEEEEEECCCCCCCHHHHCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCC
GADAFYTGEIAEKIVAAVQNHPTNAGLLSLEDLAAYEVRERPAVCAPYRGYELCGMGPPS
CCCCEEEHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCCCEECCCCCCEEECCCCCC
SGALTIGQILGMVSHFDLGGLGSDDPESWRIIGDATRLAFADRELYMADSDFVSMPQGLL
CCCEEHHHHHHHHHHCCCCCCCCCCCCCEEEEECHHHEEEECCEEEEECCCHHHCCHHCC
NPDYLKDRASLIRRPTALPAEEVKAGTPPWDKAELRIPGIDMEQPSTSHFVIVDEAGNIA
CHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCEE
SMTTSIENGFGSRQMAAGFLLNNQLTDFSFTPEEDGKAVANRVEPGKRPRSSMSPTVVLQ
HHHHHHHCCCCCHHHHHHHEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEE
DGRPVFALGSPGGSNIIPYVANTLIALIDWDMDMQQAISLPHLTNRFGTYILEAGTPAEE
CCCEEEEECCCCCCCCHHHHHHHHHEEHCCCCCHHHHHCCCHHHHHHCCEEEECCCCHHH
LADDLTALGFEVEAGELNSGLHGIAFTSEGLEGGADPRREGVALGD
HHHHHHHHCCEEECCCCCCCCCEEEEECCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA